Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 714

Gene

ZNF714

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri116 – 13823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri144 – 16623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 714
Gene namesi
Name:ZNF714
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:27124. ZNF714.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Zinc finger protein 714PRO_0000331749Add
BLAST

Proteomic databases

PaxDbiQ96N38.
PRIDEiQ96N38.

PTM databases

PhosphoSiteiQ96N38.

Expressioni

Gene expression databases

BgeeiQ96N38.
CleanExiHS_ZNF714.
ExpressionAtlasiQ96N38. baseline and differential.
GenevestigatoriQ96N38.

Interactioni

Protein-protein interaction databases

BioGridi127129. 4 interactions.
STRINGi9606.ENSP00000291770.

Structurei

3D structure databases

ProteinModelPortaliQ96N38.
SMRiQ96N38. Positions 98-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4747KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri116 – 13823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri144 – 16623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N38.
KOiK09228.
OMAiCKKCDES.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96N38.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96N38-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVMLENYKN LVFLAGIAVS KQDPITSLEQ EKEPWNMKIC EMVDESPAMC
60 70 80 90 100
SSFTRDLWPE QDIKDSFQQV ILRRHGKCEH ENLQLRKGSA NVVECKVYKK
110 120 130 140 150
GYELNQCLTT TQSKIFPCDK YIKVFHKIFN SNRHKTRHTG EKPFKCKKCD
160 170 180 190 200
ESFCMLLHLH QHKRIHIREN SYQCEECDKV FKRFSTLTRH KRVHTGEKPF
210 220 230 240 250
KCEECGKAFK HSSTLTTHKM IHTGEKPYRC EECGKAFYHS SHLTTHKVIH
260 270 280 290 300
TGEKPFKCEE CGKAFNHPSA LTTHKFIHVK EKPYKCEECD KAFNRFSYLT
310 320 330 340 350
KHKIIHSGEK SYKCEQCGKG FNWSSTLTKH KRIHTGEKPY KCEECGKAFN
360 370 380 390 400
VSSHLTTHKM IHTGEKPYKC EECGKAFNHS SKLTIHKIIH TGEKPYKCEE
410 420 430 440 450
CGKAFNQSSN LTKHKIIHTG EKLYKCEECG KAFNRSSNLT THKRIHTGEK
460 470 480 490 500
PYKCEECGKA FNRSSNLTKH NIIHTGEKSY KCEECGKAFN QSSTLTKHRK
510 520 530 540 550
IQQGMVAHAC NPNTLRGLGE QIARSGVQDQ PGQHGKTPSL LKIQKFAGCG

GRRL
Length:554
Mass (Da):63,883
Last modified:July 24, 2013 - v3
Checksum:i09150D7B5CF383C4
GO
Isoform 2 (identifier: Q96N38-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-523: RGLGEQIA → GGQGRWIT
     524-554: Missing.

Show »
Length:523
Mass (Da):60,612
Checksum:i2ED3B283FDBB3673
GO
Isoform 3 (identifier: Q96N38-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Show »
Length:400
Mass (Da):45,842
Checksum:i9AE799291B2195EB
GO

Sequence cautioni

The sequence AAH50468.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD39077.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021Y → YN in BAB71072. (PubMed:14702039)Curated
Sequence conflicti102 – 1021Y → YN in CAD39077. (PubMed:17974005)Curated
Sequence conflicti102 – 1021Y → YN in AAH50468. (PubMed:15489334)Curated
Sequence conflicti513 – 5131N → S in CAD39077. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti331 – 3311K → R.3 Publications
Corresponds to variant rs2884554 [ dbSNP | Ensembl ].
VAR_042936
Natural varianti472 – 4721I → V.
Corresponds to variant rs10427116 [ dbSNP | Ensembl ].
VAR_057448
Natural varianti473 – 4731I → V.
Corresponds to variant rs10427116 [ dbSNP | Ensembl ].
VAR_042937

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 154154Missing in isoform 3. 1 PublicationVSP_033319Add
BLAST
Alternative sequencei516 – 5238RGLGEQIA → GGQGRWIT in isoform 2. 1 PublicationVSP_033320
Alternative sequencei524 – 55431Missing in isoform 2. 1 PublicationVSP_033321Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056006 mRNA. Translation: BAB71072.1.
AL834415 mRNA. Translation: CAD39077.1. Different initiation.
AC010620 Genomic DNA. No translation available.
AC012627 Genomic DNA. No translation available.
BC037782 mRNA. Translation: AAH37782.1.
BC050468 mRNA. Translation: AAH50468.2. Different initiation.
RefSeqiNP_872321.2. NM_182515.3.
UniGeneiHs.729186.

Genome annotation databases

EnsembliENST00000596143; ENSP00000472368; ENSG00000160352.
ENST00000600435; ENSP00000468862; ENSG00000160352.
GeneIDi148206.
KEGGihsa:148206.
UCSCiuc002npl.3. human. [Q96N38-1]

Polymorphism databases

DMDMi527504073.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056006 mRNA. Translation: BAB71072.1.
AL834415 mRNA. Translation: CAD39077.1. Different initiation.
AC010620 Genomic DNA. No translation available.
AC012627 Genomic DNA. No translation available.
BC037782 mRNA. Translation: AAH37782.1.
BC050468 mRNA. Translation: AAH50468.2. Different initiation.
RefSeqiNP_872321.2. NM_182515.3.
UniGeneiHs.729186.

3D structure databases

ProteinModelPortaliQ96N38.
SMRiQ96N38. Positions 98-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127129. 4 interactions.
STRINGi9606.ENSP00000291770.

PTM databases

PhosphoSiteiQ96N38.

Polymorphism databases

DMDMi527504073.

Proteomic databases

PaxDbiQ96N38.
PRIDEiQ96N38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000596143; ENSP00000472368; ENSG00000160352.
ENST00000600435; ENSP00000468862; ENSG00000160352.
GeneIDi148206.
KEGGihsa:148206.
UCSCiuc002npl.3. human. [Q96N38-1]

Organism-specific databases

CTDi148206.
GeneCardsiGC19P021264.
HGNCiHGNC:27124. ZNF714.
neXtProtiNX_Q96N38.
PharmGKBiPA143485680.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N38.
KOiK09228.
OMAiCKKCDES.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96N38.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii148206.
NextBioi85863.
PROiQ96N38.

Gene expression databases

BgeeiQ96N38.
CleanExiHS_ZNF714.
ExpressionAtlasiQ96N38. baseline and differential.
GenevestigatoriQ96N38.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-331.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-331.
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ARG-331.
    Tissue: Brain and Testis.

Entry informationi

Entry nameiZN714_HUMAN
AccessioniPrimary (citable) accession number: Q96N38
Secondary accession number(s): Q49AI1, Q86W65, Q8ND40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2013
Last modified: January 7, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.