Q96N38 (ZN714_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 714

Gene names

Name:

ZNF714

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 14 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAH50468.2 differs from that shown. Reason: Erroneous initiation. The sequence CAD39077.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96N38-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96N38-2)

The sequence of this isoform differs from the canonical sequence as follows:
     517-524: RGLGEQIA → GGQGRWIT
     525-555: Missing.

Isoform 3 (identifier: Q96N38-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Zinc finger protein 714		PRO_0000331749
Regions
	Domain	1 – 47	47	KRAB
	Zinc finger	117 – 139	23	C2H2-type 1; degenerate
	Zinc finger	145 – 167	23	C2H2-type 2
	Zinc finger	173 – 195	23	C2H2-type 3
	Zinc finger	201 – 223	23	C2H2-type 4
	Zinc finger	229 – 251	23	C2H2-type 5
	Zinc finger	257 – 279	23	C2H2-type 6
	Zinc finger	285 – 307	23	C2H2-type 7
	Zinc finger	313 – 335	23	C2H2-type 8
	Zinc finger	341 – 363	23	C2H2-type 9
	Zinc finger	369 – 391	23	C2H2-type 10
	Zinc finger	397 – 419	23	C2H2-type 11
	Zinc finger	425 – 447	23	C2H2-type 12
	Zinc finger	453 – 475	23	C2H2-type 13
	Zinc finger	481 – 503	23	C2H2-type 14; degenerate
Natural variations
	Alternative sequence	1 – 155	155	Missing in isoform 3.		VSP_033319
	Alternative sequence	517 – 524	8	RGLGEQIA → GGQGRWIT in isoform 2.		VSP_033320
	Alternative sequence	525 – 555	31	Missing in isoform 2.		VSP_033321
	Natural variant	332	1	K → R. Ref.1 Ref.2 Ref.4 Corresponds to variant rs2884554 [ dbSNP | Ensembl ].		VAR_042936
	Natural variant	473	1	I → V. Corresponds to variant rs10427116 [ dbSNP | Ensembl ].		VAR_057448
	Natural variant	474	1	I → V. Corresponds to variant rs10427116 [ dbSNP | Ensembl ].		VAR_042937
Experimental info
	Sequence conflict	514	1	N → S in CAD39077. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2012. Version 2. Checksum: 923D6C7BF8F8165C	FASTA	555	63,997
	10 20 30 40 50 60 MNVMLENYKN LVFLAGIAVS KQDPITSLEQ EKEPWNMKIC EMVDESPAMC SSFTRDLWPE 70 80 90 100 110 120 QDIKDSFQQV ILRRHGKCEH ENLQLRKGSA NVVECKVYKK GYNELNQCLT TTQSKIFPCD 130 140 150 160 170 180 KYIKVFHKIF NSNRHKTRHT GEKPFKCKKC DESFCMLLHL HQHKRIHIRE NSYQCEECDK 190 200 210 220 230 240 VFKRFSTLTR HKRVHTGEKP FKCEECGKAF KHSSTLTTHK MIHTGEKPYR CEECGKAFYH 250 260 270 280 290 300 SSHLTTHKVI HTGEKPFKCE ECGKAFNHPS ALTTHKFIHV KEKPYKCEEC DKAFNRFSYL 310 320 330 340 350 360 TKHKIIHSGE KSYKCEQCGK GFNWSSTLTK HKRIHTGEKP YKCEECGKAF NVSSHLTTHK 370 380 390 400 410 420 MIHTGEKPYK CEECGKAFNH SSKLTIHKII HTGEKPYKCE ECGKAFNQSS NLTKHKIIHT 430 440 450 460 470 480 GEKLYKCEEC GKAFNRSSNL TTHKRIHTGE KPYKCEECGK AFNRSSNLTK HNIIHTGEKS 490 500 510 520 530 540 YKCEECGKAF NQSSTLTKHR KIQQGMVAHA CNPNTLRGLG EQIARSGVQD QPGQHGKTPS 550 LLKIQKFAGC GGRRL
	Isoform 2 [UniParc]. Checksum: 35AD58D7F2FF8D5B	FASTA	524	60,726
	10 20 30 40 50 60 MNVMLENYKN LVFLAGIAVS KQDPITSLEQ EKEPWNMKIC EMVDESPAMC SSFTRDLWPE 70 80 90 100 110 120 QDIKDSFQQV ILRRHGKCEH ENLQLRKGSA NVVECKVYKK GYNELNQCLT TTQSKIFPCD 130 140 150 160 170 180 KYIKVFHKIF NSNRHKTRHT GEKPFKCKKC DESFCMLLHL HQHKRIHIRE NSYQCEECDK 190 200 210 220 230 240 VFKRFSTLTR HKRVHTGEKP FKCEECGKAF KHSSTLTTHK MIHTGEKPYR CEECGKAFYH 250 260 270 280 290 300 SSHLTTHKVI HTGEKPFKCE ECGKAFNHPS ALTTHKFIHV KEKPYKCEEC DKAFNRFSYL 310 320 330 340 350 360 TKHKIIHSGE KSYKCEQCGK GFNWSSTLTK HKRIHTGEKP YKCEECGKAF NVSSHLTTHK 370 380 390 400 410 420 MIHTGEKPYK CEECGKAFNH SSKLTIHKII HTGEKPYKCE ECGKAFNQSS NLTKHKIIHT 430 440 450 460 470 480 GEKLYKCEEC GKAFNRSSNL TTHKRIHTGE KPYKCEECGK AFNRSSNLTK HNIIHTGEKS 490 500 510 520 YKCEECGKAF NQSSTLTKHR KIQQGMVAHA CNPNTLGGQG RWIT
	Isoform 3 [UniParc]. Checksum: 9AE799291B2195EB	FASTA	400	45,842
	10 20 30 40 50 60 MLLHLHQHKR IHIRENSYQC EECDKVFKRF STLTRHKRVH TGEKPFKCEE CGKAFKHSST 70 80 90 100 110 120 LTTHKMIHTG EKPYRCEECG KAFYHSSHLT THKVIHTGEK PFKCEECGKA FNHPSALTTH 130 140 150 160 170 180 KFIHVKEKPY KCEECDKAFN RFSYLTKHKI IHSGEKSYKC EQCGKGFNWS STLTKHKRIH 190 200 210 220 230 240 TGEKPYKCEE CGKAFNVSSH LTTHKMIHTG EKPYKCEECG KAFNHSSKLT IHKIIHTGEK 250 260 270 280 290 300 PYKCEECGKA FNQSSNLTKH KIIHTGEKLY KCEECGKAFN RSSNLTTHKR IHTGEKPYKC 310 320 330 340 350 360 EECGKAFNRS SNLTKHNIIH TGEKSYKCEE CGKAFNQSST LTKHRKIQQG MVAHACNPNT 370 380 390 400 LRGLGEQIAR SGVQDQPGQH GKTPSLLKIQ KFAGCGGRRL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-332.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-332. Tissue: Brain.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ARG-332. Tissue: Brain and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056006 mRNA. Translation: BAB71072.1. AL834415 mRNA. Translation: CAD39077.1. Different initiation. AC010620 Genomic DNA. No translation available. AC012627 Genomic DNA. No translation available. BC037782 mRNA. Translation: AAH37782.1. BC050468 mRNA. Translation: AAH50468.2. Different initiation.
IPI	IPI00455381. IPI00646004. IPI00890787.
RefSeq	NP_872321.2. NM_182515.3.
UniGene	Hs.729186.
3D structure databases
HSSP	HSSP built from PDB template 1X6E based on UniProtKB P17028.
ProteinModelPortal	Q96N38.
SMR	Q96N38. Positions 98-511.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000291770.
PTM databases
PhosphoSite	Q96N38.
Polymorphism databases
DMDM	74760994.
Proteomic databases
PaxDb	Q96N38.
PRIDE	Q96N38.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291770; ENSP00000291770; ENSG00000160352.
GeneID	148206.
KEGG	hsa:148206.
UCSC	uc002npl.3. human.
Organism-specific databases
CTD	148206.
GeneCards	GC19P021264.
HGNC	HGNC:27124. ZNF714.
neXtProt	NX_Q96N38.
PharmGKB	PA143485680.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q96N38.
KO	K09228.
OrthoDB	EOG4001HV.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q96N38.
CleanEx	HS_ZNF714.
Genevestigator	Q96N38.
Family and domain databases
Gene3D	3.30.160.60. 14 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 14 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	148206.
NextBio	85863.

Entry information

Entry name

ZN714_HUMAN

Accession

Primary (citable) accession number: Q96N38
Secondary accession number(s): Q49AI1, Q86W65, Q8ND40

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 16, 2012
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.