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Protein

Zinc finger protein 714

Gene

ZNF714

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 138C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 714
Gene namesi
Name:ZNF714
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:27124. ZNF714.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485680.

Polymorphism and mutation databases

BioMutaiZNF714.
DMDMi527504073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003317491 – 554Zinc finger protein 714Add BLAST554

Proteomic databases

PaxDbiQ96N38.
PeptideAtlasiQ96N38.
PRIDEiQ96N38.

PTM databases

iPTMnetiQ96N38.
PhosphoSitePlusiQ96N38.

Expressioni

Gene expression databases

CleanExiHS_ZNF714.

Interactioni

Protein-protein interaction databases

BioGridi127129. 5 interactors.
STRINGi9606.ENSP00000468862.

Structurei

3D structure databases

ProteinModelPortaliQ96N38.
SMRiQ96N38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 47KRABPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 138C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N38.
KOiK09228.
PhylomeDBiQ96N38.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVMLENYKN LVFLAGIAVS KQDPITSLEQ EKEPWNMKIC EMVDESPAMC
60 70 80 90 100
SSFTRDLWPE QDIKDSFQQV ILRRHGKCEH ENLQLRKGSA NVVECKVYKK
110 120 130 140 150
GYELNQCLTT TQSKIFPCDK YIKVFHKIFN SNRHKTRHTG EKPFKCKKCD
160 170 180 190 200
ESFCMLLHLH QHKRIHIREN SYQCEECDKV FKRFSTLTRH KRVHTGEKPF
210 220 230 240 250
KCEECGKAFK HSSTLTTHKM IHTGEKPYRC EECGKAFYHS SHLTTHKVIH
260 270 280 290 300
TGEKPFKCEE CGKAFNHPSA LTTHKFIHVK EKPYKCEECD KAFNRFSYLT
310 320 330 340 350
KHKIIHSGEK SYKCEQCGKG FNWSSTLTKH KRIHTGEKPY KCEECGKAFN
360 370 380 390 400
VSSHLTTHKM IHTGEKPYKC EECGKAFNHS SKLTIHKIIH TGEKPYKCEE
410 420 430 440 450
CGKAFNQSSN LTKHKIIHTG EKLYKCEECG KAFNRSSNLT THKRIHTGEK
460 470 480 490 500
PYKCEECGKA FNRSSNLTKH NIIHTGEKSY KCEECGKAFN QSSTLTKHRK
510 520 530 540 550
IQQGMVAHAC NPNTLRGLGE QIARSGVQDQ PGQHGKTPSL LKIQKFAGCG

GRRL
Length:554
Mass (Da):63,883
Last modified:July 24, 2013 - v3
Checksum:i09150D7B5CF383C4
GO
Isoform 2 (identifier: Q96N38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-523: RGLGEQIA → GGQGRWIT
     524-554: Missing.

Show »
Length:523
Mass (Da):60,612
Checksum:i2ED3B283FDBB3673
GO
Isoform 3 (identifier: Q96N38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Show »
Length:400
Mass (Da):45,842
Checksum:i9AE799291B2195EB
GO

Sequence cautioni

The sequence AAH50468 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD39077 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102Y → YN in BAB71072 (PubMed:14702039).Curated1
Sequence conflicti102Y → YN in CAD39077 (PubMed:17974005).Curated1
Sequence conflicti102Y → YN in AAH50468 (PubMed:15489334).Curated1
Sequence conflicti513N → S in CAD39077 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042936331K → R3 PublicationsCorresponds to variant dbSNP:rs2884554Ensembl.1
Natural variantiVAR_057448472I → V. Corresponds to variant dbSNP:rs10427116Ensembl.1
Natural variantiVAR_042937473I → V. Corresponds to variant dbSNP:rs10427116Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0333191 – 154Missing in isoform 3. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_033320516 – 523RGLGEQIA → GGQGRWIT in isoform 2. 1 Publication8
Alternative sequenceiVSP_033321524 – 554Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056006 mRNA. Translation: BAB71072.1.
AL834415 mRNA. Translation: CAD39077.1. Different initiation.
AC010620 Genomic DNA. No translation available.
AC012627 Genomic DNA. No translation available.
BC037782 mRNA. Translation: AAH37782.1.
BC050468 mRNA. Translation: AAH50468.2. Different initiation.
RefSeqiNP_872321.2. NM_182515.3.
UniGeneiHs.729186.

Genome annotation databases

EnsembliENST00000596143; ENSP00000472368; ENSG00000160352.
ENST00000600435; ENSP00000468862; ENSG00000160352.
GeneIDi148206.
KEGGihsa:148206.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN714_HUMAN
AccessioniPrimary (citable) accession number: Q96N38
Secondary accession number(s): Q49AI1, Q86W65, Q8ND40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2013
Last modified: November 22, 2017
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families