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Q96N38

- ZN714_HUMAN

UniProt

Q96N38 - ZN714_HUMAN

Protein

Zinc finger protein 714

Gene

ZNF714

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (24 Jul 2013)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri116 – 13823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri144 – 16623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 19423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 714
    Gene namesi
    Name:ZNF714
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:27124. ZNF714.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485680.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Zinc finger protein 714PRO_0000331749Add
    BLAST

    Proteomic databases

    PaxDbiQ96N38.
    PRIDEiQ96N38.

    PTM databases

    PhosphoSiteiQ96N38.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96N38.
    BgeeiQ96N38.
    CleanExiHS_ZNF714.
    GenevestigatoriQ96N38.

    Interactioni

    Protein-protein interaction databases

    BioGridi127129. 4 interactions.
    STRINGi9606.ENSP00000291770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96N38.
    SMRiQ96N38. Positions 98-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 4747KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri116 – 13823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri144 – 16623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 19423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96N38.
    KOiK09228.
    OMAiCKKCDES.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ96N38.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 14 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96N38-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNVMLENYKN LVFLAGIAVS KQDPITSLEQ EKEPWNMKIC EMVDESPAMC    50
    SSFTRDLWPE QDIKDSFQQV ILRRHGKCEH ENLQLRKGSA NVVECKVYKK 100
    GYELNQCLTT TQSKIFPCDK YIKVFHKIFN SNRHKTRHTG EKPFKCKKCD 150
    ESFCMLLHLH QHKRIHIREN SYQCEECDKV FKRFSTLTRH KRVHTGEKPF 200
    KCEECGKAFK HSSTLTTHKM IHTGEKPYRC EECGKAFYHS SHLTTHKVIH 250
    TGEKPFKCEE CGKAFNHPSA LTTHKFIHVK EKPYKCEECD KAFNRFSYLT 300
    KHKIIHSGEK SYKCEQCGKG FNWSSTLTKH KRIHTGEKPY KCEECGKAFN 350
    VSSHLTTHKM IHTGEKPYKC EECGKAFNHS SKLTIHKIIH TGEKPYKCEE 400
    CGKAFNQSSN LTKHKIIHTG EKLYKCEECG KAFNRSSNLT THKRIHTGEK 450
    PYKCEECGKA FNRSSNLTKH NIIHTGEKSY KCEECGKAFN QSSTLTKHRK 500
    IQQGMVAHAC NPNTLRGLGE QIARSGVQDQ PGQHGKTPSL LKIQKFAGCG 550
    GRRL 554
    Length:554
    Mass (Da):63,883
    Last modified:July 24, 2013 - v3
    Checksum:i09150D7B5CF383C4
    GO
    Isoform 2 (identifier: Q96N38-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         516-523: RGLGEQIA → GGQGRWIT
         524-554: Missing.

    Show »
    Length:523
    Mass (Da):60,612
    Checksum:i2ED3B283FDBB3673
    GO
    Isoform 3 (identifier: Q96N38-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-154: Missing.

    Show »
    Length:400
    Mass (Da):45,842
    Checksum:i9AE799291B2195EB
    GO

    Sequence cautioni

    The sequence AAH50468.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAD39077.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021Y → YN in BAB71072. (PubMed:14702039)Curated
    Sequence conflicti102 – 1021Y → YN in CAD39077. (PubMed:17974005)Curated
    Sequence conflicti102 – 1021Y → YN in AAH50468. (PubMed:15489334)Curated
    Sequence conflicti513 – 5131N → S in CAD39077. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti331 – 3311K → R.3 Publications
    Corresponds to variant rs2884554 [ dbSNP | Ensembl ].
    VAR_042936
    Natural varianti472 – 4721I → V.
    Corresponds to variant rs10427116 [ dbSNP | Ensembl ].
    VAR_057448
    Natural varianti473 – 4731I → V.
    Corresponds to variant rs10427116 [ dbSNP | Ensembl ].
    VAR_042937

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 154154Missing in isoform 3. 1 PublicationVSP_033319Add
    BLAST
    Alternative sequencei516 – 5238RGLGEQIA → GGQGRWIT in isoform 2. 1 PublicationVSP_033320
    Alternative sequencei524 – 55431Missing in isoform 2. 1 PublicationVSP_033321Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056006 mRNA. Translation: BAB71072.1.
    AL834415 mRNA. Translation: CAD39077.1. Different initiation.
    AC010620 Genomic DNA. No translation available.
    AC012627 Genomic DNA. No translation available.
    BC037782 mRNA. Translation: AAH37782.1.
    BC050468 mRNA. Translation: AAH50468.2. Different initiation.
    RefSeqiNP_872321.2. NM_182515.3.
    UniGeneiHs.729186.

    Genome annotation databases

    EnsembliENST00000596143; ENSP00000472368; ENSG00000160352. [Q96N38-1]
    ENST00000600435; ENSP00000468862; ENSG00000160352. [Q96N38-1]
    GeneIDi148206.
    KEGGihsa:148206.
    UCSCiuc002npl.3. human. [Q96N38-1]

    Polymorphism databases

    DMDMi527504073.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056006 mRNA. Translation: BAB71072.1 .
    AL834415 mRNA. Translation: CAD39077.1 . Different initiation.
    AC010620 Genomic DNA. No translation available.
    AC012627 Genomic DNA. No translation available.
    BC037782 mRNA. Translation: AAH37782.1 .
    BC050468 mRNA. Translation: AAH50468.2 . Different initiation.
    RefSeqi NP_872321.2. NM_182515.3.
    UniGenei Hs.729186.

    3D structure databases

    ProteinModelPortali Q96N38.
    SMRi Q96N38. Positions 98-530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127129. 4 interactions.
    STRINGi 9606.ENSP00000291770.

    PTM databases

    PhosphoSitei Q96N38.

    Polymorphism databases

    DMDMi 527504073.

    Proteomic databases

    PaxDbi Q96N38.
    PRIDEi Q96N38.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000596143 ; ENSP00000472368 ; ENSG00000160352 . [Q96N38-1 ]
    ENST00000600435 ; ENSP00000468862 ; ENSG00000160352 . [Q96N38-1 ]
    GeneIDi 148206.
    KEGGi hsa:148206.
    UCSCi uc002npl.3. human. [Q96N38-1 ]

    Organism-specific databases

    CTDi 148206.
    GeneCardsi GC19P021264.
    HGNCi HGNC:27124. ZNF714.
    neXtProti NX_Q96N38.
    PharmGKBi PA143485680.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96N38.
    KOi K09228.
    OMAi CKKCDES.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q96N38.
    TreeFami TF342117.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 148206.
    NextBioi 85863.
    PROi Q96N38.

    Gene expression databases

    ArrayExpressi Q96N38.
    Bgeei Q96N38.
    CleanExi HS_ZNF714.
    Genevestigatori Q96N38.

    Family and domain databases

    Gene3Di 3.30.160.60. 14 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-331.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-331.
      Tissue: Brain.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ARG-331.
      Tissue: Brain and Testis.

    Entry informationi

    Entry nameiZN714_HUMAN
    AccessioniPrimary (citable) accession number: Q96N38
    Secondary accession number(s): Q49AI1, Q86W65, Q8ND40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 24, 2013
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3