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Protein

PRELI domain containing protein 3A

Gene

PRELID3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei36 – 361Important for interaction with TRIAP11 Publication
Sitei49 – 491Important for interaction with TRIAP11 Publication

GO - Molecular functioni

  • phosphatidic acid transporter activity Source: HGNC

GO - Biological processi

  • phospholipid transport Source: HGNC
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
PRELI domain containing protein 3A
Alternative name(s):
Protein slowmo homolog 1
Gene namesi
Name:PRELID3A
Synonyms:C18orf43, SLMO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24639. PRELID3A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi36 – 361V → A: Impairs interaction with TRIAP1. 1 Publication

Organism-specific databases

PharmGKBiPA162403903.

Polymorphism and mutation databases

BioMutaiSLMO1.
DMDMi74732484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172PRELI domain containing protein 3APRO_0000295215Add
BLAST

Proteomic databases

MaxQBiQ96N28.
PaxDbiQ96N28.
PeptideAtlasiQ96N28.
PRIDEiQ96N28.

Expressioni

Gene expression databases

BgeeiENSG00000141391.
CleanExiHS_SLMO1.
ExpressionAtlasiQ96N28. baseline and differential.
GenevisibleiQ96N28. HS.

Interactioni

Subunit structurei

Interacts with TRIAP1.1 Publication

Protein-protein interaction databases

BioGridi115893. 3 interactions.
STRINGi9606.ENSP00000338988.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XZVX-ray3.58B/D/F/H1-172[»]
ProteinModelPortaliQ96N28.
SMRiQ96N28. Positions 6-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 172172PRELI/MSF1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the slowmo family.Curated
Contains 1 PRELI/MSF1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3336. Eukaryota.
ENOG410YBNZ. LUCA.
GeneTreeiENSGT00550000074707.
HOGENOMiHOG000187596.
HOVERGENiHBG009393.
InParanoidiQ96N28.
OMAiKEHSIVD.
PhylomeDBiQ96N28.
TreeFamiTF312873.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIWSSEHVF GHPWDTVIQA AMRKYPNPMN PSVLGVDVLQ RRVDGRGRLH
60 70 80 90 100
SLRLLSTEWG LPSLVRAILG TSRTLTYIRE HSVVDPVEKK MELCSTNITL
110 120 130 140 150
TNLVSVNERL VYTPHPENPE MTVLTQEAII TVKGISLGSY LESLMANTIS
160 170
SNAKKGWAAI EWIIEHSESA VS
Length:172
Mass (Da):19,247
Last modified:December 1, 2001 - v1
Checksum:i111C67F7E43805CD
GO
Isoform 2 (identifier: Q96N28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Note: No experimental confirmation available.
Show »
Length:151
Mass (Da):16,825
Checksum:i2FB5BBFF1D2C3D6A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform 2. 1 PublicationVSP_056666Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056046 mRNA. Translation: BAB71083.1.
AK303325 mRNA. Translation: BAG64391.1.
EF444975 Genomic DNA. Translation: ACA05988.1.
AP001029 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01547.1.
CH471113 Genomic DNA. Translation: EAX01548.1.
CH471113 Genomic DNA. Translation: EAX01549.1.
BC106750 mRNA. Translation: AAI06751.1.
CR627465 mRNA. Translation: CAH10669.1.
CCDSiCCDS11860.1. [Q96N28-1]
CCDS77154.1. [Q96N28-2]
RefSeqiNP_001135877.1. NM_001142405.1. [Q96N28-1]
NP_001135878.1. NM_001142406.1. [Q96N28-2]
NP_006544.2. NM_006553.3. [Q96N28-1]
UniGeneiHs.514718.

Genome annotation databases

EnsembliENST00000336990; ENSP00000338988; ENSG00000141391. [Q96N28-1]
ENST00000440960; ENSP00000404700; ENSG00000141391. [Q96N28-1]
ENST00000592149; ENSP00000466737; ENSG00000141391. [Q96N28-2]
GeneIDi10650.
KEGGihsa:10650.
UCSCiuc002kra.4. human. [Q96N28-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056046 mRNA. Translation: BAB71083.1.
AK303325 mRNA. Translation: BAG64391.1.
EF444975 Genomic DNA. Translation: ACA05988.1.
AP001029 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01547.1.
CH471113 Genomic DNA. Translation: EAX01548.1.
CH471113 Genomic DNA. Translation: EAX01549.1.
BC106750 mRNA. Translation: AAI06751.1.
CR627465 mRNA. Translation: CAH10669.1.
CCDSiCCDS11860.1. [Q96N28-1]
CCDS77154.1. [Q96N28-2]
RefSeqiNP_001135877.1. NM_001142405.1. [Q96N28-1]
NP_001135878.1. NM_001142406.1. [Q96N28-2]
NP_006544.2. NM_006553.3. [Q96N28-1]
UniGeneiHs.514718.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XZVX-ray3.58B/D/F/H1-172[»]
ProteinModelPortaliQ96N28.
SMRiQ96N28. Positions 6-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115893. 3 interactions.
STRINGi9606.ENSP00000338988.

Polymorphism and mutation databases

BioMutaiSLMO1.
DMDMi74732484.

Proteomic databases

MaxQBiQ96N28.
PaxDbiQ96N28.
PeptideAtlasiQ96N28.
PRIDEiQ96N28.

Protocols and materials databases

DNASUi10650.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336990; ENSP00000338988; ENSG00000141391. [Q96N28-1]
ENST00000440960; ENSP00000404700; ENSG00000141391. [Q96N28-1]
ENST00000592149; ENSP00000466737; ENSG00000141391. [Q96N28-2]
GeneIDi10650.
KEGGihsa:10650.
UCSCiuc002kra.4. human. [Q96N28-1]

Organism-specific databases

CTDi10650.
GeneCardsiSLMO1.
HGNCiHGNC:24639. PRELID3A.
MIMi616545. gene.
neXtProtiNX_Q96N28.
PharmGKBiPA162403903.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3336. Eukaryota.
ENOG410YBNZ. LUCA.
GeneTreeiENSGT00550000074707.
HOGENOMiHOG000187596.
HOVERGENiHBG009393.
InParanoidiQ96N28.
OMAiKEHSIVD.
PhylomeDBiQ96N28.
TreeFamiTF312873.

Miscellaneous databases

GenomeRNAii10650.
PROiQ96N28.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141391.
CleanExiHS_SLMO1.
ExpressionAtlasiQ96N28. baseline and differential.
GenevisibleiQ96N28. HS.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLD3A_HUMAN
AccessioniPrimary (citable) accession number: Q96N28
Secondary accession number(s): B0YJ10
, B4E0C9, D3DUJ1, Q6AHX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.