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Protein

Zinc finger protein 681

Gene

ZNF681

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33270-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 681
Gene namesi
Name:ZNF681
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26457. ZNF681.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196172.
PharmGKBiPA142670482.

Polymorphism and mutation databases

BioMutaiZNF681.
DMDMi308153533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051371 – 645Zinc finger protein 681Add BLAST645

Proteomic databases

EPDiQ96N22.
MaxQBiQ96N22.
PaxDbiQ96N22.
PeptideAtlasiQ96N22.
PRIDEiQ96N22.

PTM databases

iPTMnetiQ96N22.
PhosphoSitePlusiQ96N22.

Expressioni

Gene expression databases

BgeeiENSG00000196172.
CleanExiHS_ZNF681.
ExpressionAtlasiQ96N22. baseline and differential.
GenevisibleiQ96N22. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384000.

Structurei

3D structure databases

ProteinModelPortaliQ96N22.
SMRiQ96N22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N22.
OMAiSKHKRNY.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96N22.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPLKFRDVA IEFSLEEWQC LDTIQQNLYR NVMLENYRNL VFLGIVVSKP
60 70 80 90 100
DLITCLEQEK EPWTRKRHRM VAEPPVICSH FAQDFSPEQN IKDSFQKVTP
110 120 130 140 150
RRYGKCEHEN LQLSKSVDEC KVQKGGYNGL NQCLPTTQSK IFQCDKYMKI
160 170 180 190 200
FHKFSNLNGH KVRHTRKKPF KYKEFGKSFC IFSNLTQHKI ICTRVNFYKC
210 220 230 240 250
EDCGKAFNGS SIFTKHKRIH IGEKSYICEE CGKACNQFTN LTTHKIIYTR
260 270 280 290 300
DKLYKREECS KAFNLSSHIT THTIIHTGEN PYKREECDKA FNQSLTLTTH
310 320 330 340 350
KIIHTREKLN EYKECGKAFN QSSHLTRHKI IHTGEKPYKC EECGKAFNQS
360 370 380 390 400
SHLTRHKIIH TGEKPYRCEE CGKAFRQSSH LTTHKIIHTG EKPYKCEECG
410 420 430 440 450
KAFNKSSHLT RHKSIHTGEK PYQCEKCGKA SNQSSNLTEH KNIHTEEKPY
460 470 480 490 500
KCEECGKAFN QFSNLTTHKR IHTGEKPYKC EECGKAFNQS SILTTHKRIH
510 520 530 540 550
TGEKSYKCEE CGKAFYRSSK LTEHKKIHTG EKPYTCEECG KAFNHSSHLA
560 570 580 590 600
THKVIHTGEK PYQCEECGKA FNQSSHLTRH KRIHTGEKPY QCEKCGKAFN
610 620 630 640
QSSNLTGHKK IHTGEKLYKP KRCNSDFENT SKFSKHKRNY AGEKS
Length:645
Mass (Da):75,059
Last modified:October 5, 2010 - v2
Checksum:i05B30D15368A1B3B
GO
Isoform 2 (identifier: Q96N22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:576
Mass (Da):66,653
Checksum:i8EF9482D2F3E19AF
GO

Sequence cautioni

The sequence BC062216 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98V → A in BAG53769 (PubMed:14702039).Curated1
Sequence conflicti134L → S in BC062216 (PubMed:15489334).Curated1
Sequence conflicti188H → Q in BC062216 (PubMed:15489334).Curated1
Sequence conflicti224K → R in BAG53769 (PubMed:14702039).Curated1
Sequence conflicti282Y → C in BAG53769 (PubMed:14702039).Curated1
Sequence conflicti485K → R in BAG53769 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03516784D → H.2 PublicationsCorresponds to variant rs7248674dbSNPEnsembl.1
Natural variantiVAR_035168295L → S.1 PublicationCorresponds to variant rs1818989dbSNPEnsembl.1
Natural variantiVAR_063679367R → K.1 PublicationCorresponds to variant rs1818990dbSNPEnsembl.1
Natural variantiVAR_063680548H → Q.Corresponds to variant rs1852433dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398781 – 69Missing in isoform 2. 2 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056088 mRNA. Translation: BAB71090.1.
AK122869 mRNA. Translation: BAG53769.1.
AC073544 Genomic DNA. No translation available.
AC139769 Genomic DNA. No translation available.
BC062216 mRNA. No translation available.
CCDSiCCDS12414.2. [Q96N22-1]
RefSeqiNP_612143.2. NM_138286.2. [Q96N22-1]
UniGeneiHs.399952.
Hs.735840.

Genome annotation databases

EnsembliENST00000402377; ENSP00000384000; ENSG00000196172. [Q96N22-1]
GeneIDi148213.
KEGGihsa:148213.
UCSCiuc002nrk.4. human. [Q96N22-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056088 mRNA. Translation: BAB71090.1.
AK122869 mRNA. Translation: BAG53769.1.
AC073544 Genomic DNA. No translation available.
AC139769 Genomic DNA. No translation available.
BC062216 mRNA. No translation available.
CCDSiCCDS12414.2. [Q96N22-1]
RefSeqiNP_612143.2. NM_138286.2. [Q96N22-1]
UniGeneiHs.399952.
Hs.735840.

3D structure databases

ProteinModelPortaliQ96N22.
SMRiQ96N22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384000.

PTM databases

iPTMnetiQ96N22.
PhosphoSitePlusiQ96N22.

Polymorphism and mutation databases

BioMutaiZNF681.
DMDMi308153533.

Proteomic databases

EPDiQ96N22.
MaxQBiQ96N22.
PaxDbiQ96N22.
PeptideAtlasiQ96N22.
PRIDEiQ96N22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402377; ENSP00000384000; ENSG00000196172. [Q96N22-1]
GeneIDi148213.
KEGGihsa:148213.
UCSCiuc002nrk.4. human. [Q96N22-1]

Organism-specific databases

CTDi148213.
GeneCardsiZNF681.
HGNCiHGNC:26457. ZNF681.
neXtProtiNX_Q96N22.
OpenTargetsiENSG00000196172.
PharmGKBiPA142670482.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N22.
OMAiSKHKRNY.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96N22.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:G66-33270-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii148213.
PROiQ96N22.

Gene expression databases

BgeeiENSG00000196172.
CleanExiHS_ZNF681.
ExpressionAtlasiQ96N22. baseline and differential.
GenevisibleiQ96N22. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN681_HUMAN
AccessioniPrimary (citable) accession number: Q96N22
Secondary accession number(s): B3KVF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.