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Protein

Zinc finger protein 75A

Gene

ZNF75A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 75A
Gene namesi
Name:ZNF75A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13146. ZNF75A.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Zinc finger protein 75APRO_0000047385Add
BLAST

Proteomic databases

PaxDbiQ96N20.
PRIDEiQ96N20.

Expressioni

Gene expression databases

BgeeiQ96N20.
CleanExiHS_ZNF75A.
ExpressionAtlasiQ96N20. baseline and differential.
GenevestigatoriQ96N20.

Organism-specific databases

HPAiHPA001665.

Interactioni

Protein-protein interaction databases

BioGridi113446. 1 interaction.
STRINGi9606.ENSP00000293995.

Structurei

3D structure databases

ProteinModelPortaliQ96N20.
SMRiQ96N20. Positions 158-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6666KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120624.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N20.
KOiK09229.
OMAiDMHRVGK.
OrthoDBiEOG73NG31.
PhylomeDBiQ96N20.
TreeFamiTF340832.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96N20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFSQEEWEL LDPTQKALYN DVMQENYETV ISLALFVLPK PKVISCLEQG
60 70 80 90 100
EEPWVQVSPE FKDSAGKSPT GLKLKNDTEN HQPVSLSDLE IQASAGVISK
110 120 130 140 150
KAKVKVPQKT AGKENHFDMH RVGKWHQDFP VKKRKKLSTW KQELLKLMDR
160 170 180 190 200
HKKDCAREKP FKCQECGKTF RVSSDLIKHQ RIHTEEKPYK CQQCDKRFRW
210 220 230 240 250
SSDLNKHLTT HQGIKPYKCS WCGKSFSQNT NLHTHQRTHT GEKPFTCHEC
260 270 280 290
GKKFSQNSHL IKHRRTHTGE QPYTCSICRR NFSRRSSLLR HQKLHL
Length:296
Mass (Da):34,694
Last modified:December 1, 2001 - v1
Checksum:iD8EBD7023CA726AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841V → A.
Corresponds to variant rs17611866 [ dbSNP | Ensembl ].
VAR_033545
Natural varianti228 – 2281Q → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_035570

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056091 mRNA. Translation: BAB71092.1.
BC119652 mRNA. Translation: AAI19653.1.
BC119653 mRNA. Translation: AAI19654.1.
X91826 Genomic DNA. Translation: CAA62935.1.
CCDSiCCDS10501.1.
RefSeqiNP_001289038.1. NM_001302109.1.
NP_694573.1. NM_153028.3.
UniGeneiHs.513292.

Genome annotation databases

EnsembliENST00000574298; ENSP00000459566; ENSG00000162086.
ENST00000617839; ENSP00000482769; ENSG00000162086.
GeneIDi7627.
KEGGihsa:7627.
UCSCiuc002cut.4. human.

Polymorphism databases

DMDMi68566224.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056091 mRNA. Translation: BAB71092.1.
BC119652 mRNA. Translation: AAI19653.1.
BC119653 mRNA. Translation: AAI19654.1.
X91826 Genomic DNA. Translation: CAA62935.1.
CCDSiCCDS10501.1.
RefSeqiNP_001289038.1. NM_001302109.1.
NP_694573.1. NM_153028.3.
UniGeneiHs.513292.

3D structure databases

ProteinModelPortaliQ96N20.
SMRiQ96N20. Positions 158-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113446. 1 interaction.
STRINGi9606.ENSP00000293995.

Polymorphism databases

DMDMi68566224.

Proteomic databases

PaxDbiQ96N20.
PRIDEiQ96N20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000574298; ENSP00000459566; ENSG00000162086.
ENST00000617839; ENSP00000482769; ENSG00000162086.
GeneIDi7627.
KEGGihsa:7627.
UCSCiuc002cut.4. human.

Organism-specific databases

CTDi7627.
GeneCardsiGC16P003355.
HGNCiHGNC:13146. ZNF75A.
HPAiHPA001665.
MIMi601473. gene.
neXtProtiNX_Q96N20.
PharmGKBiPA37720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120624.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N20.
KOiK09229.
OMAiDMHRVGK.
OrthoDBiEOG73NG31.
PhylomeDBiQ96N20.
TreeFamiTF340832.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF75A. human.
GenomeRNAii7627.
NextBioi29726.
PROiQ96N20.
SOURCEiSearch...

Gene expression databases

BgeeiQ96N20.
CleanExiHS_ZNF75A.
ExpressionAtlasiQ96N20. baseline and differential.
GenevestigatoriQ96N20.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes."
    Villa A., Strina D., Frattini A., Faranda S., Macchi P., Finelli P., Bozzi F., Susani L., Archidiacono N., Rocchi M., Vezzoni P.
    Genomics 35:312-320(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-291.
    Tissue: Peripheral blood.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-228.

Entry informationi

Entry nameiZN75A_HUMAN
AccessioniPrimary (citable) accession number: Q96N20
Secondary accession number(s): Q0VDI8, Q92669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.