Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96N20 (ZN75A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 75A
Gene names
Name:ZNF75A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Zinc finger protein 75A
PRO_0000047385

Regions

Domain1 – 6666KRAB
Zinc finger161 – 18323C2H2-type 1
Zinc finger189 – 21123C2H2-type 2
Zinc finger217 – 23923C2H2-type 3
Zinc finger245 – 26723C2H2-type 4
Zinc finger273 – 29523C2H2-type 5

Natural variations

Natural variant841V → A.
Corresponds to variant rs17611866 [ dbSNP | Ensembl ].
VAR_033545
Natural variant2281Q → E in a breast cancer sample; somatic mutation. Ref.4
VAR_035570

Sequences

Sequence LengthMass (Da)Tools
Q96N20 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D8EBD7023CA726AA

FASTA29634,694
        10         20         30         40         50         60 
MYFSQEEWEL LDPTQKALYN DVMQENYETV ISLALFVLPK PKVISCLEQG EEPWVQVSPE 

        70         80         90        100        110        120 
FKDSAGKSPT GLKLKNDTEN HQPVSLSDLE IQASAGVISK KAKVKVPQKT AGKENHFDMH 

       130        140        150        160        170        180 
RVGKWHQDFP VKKRKKLSTW KQELLKLMDR HKKDCAREKP FKCQECGKTF RVSSDLIKHQ 

       190        200        210        220        230        240 
RIHTEEKPYK CQQCDKRFRW SSDLNKHLTT HQGIKPYKCS WCGKSFSQNT NLHTHQRTHT 

       250        260        270        280        290 
GEKPFTCHEC GKKFSQNSHL IKHRRTHTGE QPYTCSICRR NFSRRSSLLR HQKLHL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes."
Villa A., Strina D., Frattini A., Faranda S., Macchi P., Finelli P., Bozzi F., Susani L., Archidiacono N., Rocchi M., Vezzoni P.
Genomics 35:312-320(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-291.
Tissue: Peripheral blood.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056091 mRNA. Translation: BAB71092.1.
BC119652 mRNA. Translation: AAI19653.1.
BC119653 mRNA. Translation: AAI19654.1.
X91826 Genomic DNA. Translation: CAA62935.1.
CCDSCCDS10501.1.
RefSeqNP_694573.1. NM_153028.2.
UniGeneHs.513292.

3D structure databases

ProteinModelPortalQ96N20.
SMRQ96N20. Positions 129-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113446. 1 interaction.
STRING9606.ENSP00000293995.

Polymorphism databases

DMDM68566224.

Proteomic databases

PaxDbQ96N20.
PRIDEQ96N20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000574298; ENSP00000459566; ENSG00000162086.
GeneID7627.
KEGGhsa:7627.
UCSCuc002cut.4. human.

Organism-specific databases

CTD7627.
GeneCardsGC16P003355.
HGNCHGNC:13146. ZNF75A.
HPAHPA001665.
MIM601473. gene.
neXtProtNX_Q96N20.
PharmGKBPA37720.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ96N20.
KOK09229.
OMADMHRVGK.
OrthoDBEOG73NG31.
PhylomeDBQ96N20.
TreeFamTF340832.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ96N20.
BgeeQ96N20.
CleanExHS_ZNF75A.
GenevestigatorQ96N20.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF75A. human.
GenomeRNAi7627.
NextBio29726.
PROQ96N20.
SOURCESearch...

Entry information

Entry nameZN75A_HUMAN
AccessionPrimary (citable) accession number: Q96N20
Secondary accession number(s): Q0VDI8, Q92669
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM