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Q96N20

- ZN75A_HUMAN

UniProt

Q96N20 - ZN75A_HUMAN

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Protein
Zinc finger protein 75A
Gene
ZNF75A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1
Add
BLAST
Zinc fingeri189 – 21123C2H2-type 2
Add
BLAST
Zinc fingeri217 – 23923C2H2-type 3
Add
BLAST
Zinc fingeri245 – 26723C2H2-type 4
Add
BLAST
Zinc fingeri273 – 29523C2H2-type 5
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 75A
Gene namesi
Name:ZNF75A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:13146. ZNF75A.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Zinc finger protein 75A
PRO_0000047385Add
BLAST

Proteomic databases

PaxDbiQ96N20.
PRIDEiQ96N20.

Expressioni

Gene expression databases

ArrayExpressiQ96N20.
BgeeiQ96N20.
CleanExiHS_ZNF75A.
GenevestigatoriQ96N20.

Organism-specific databases

HPAiHPA001665.

Interactioni

Protein-protein interaction databases

BioGridi113446. 1 interaction.
STRINGi9606.ENSP00000293995.

Structurei

3D structure databases

ProteinModelPortaliQ96N20.
SMRiQ96N20. Positions 129-295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6666KRAB
Add
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96N20.
KOiK09229.
OMAiDMHRVGK.
OrthoDBiEOG73NG31.
PhylomeDBiQ96N20.
TreeFamiTF340832.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96N20-1 [UniParc]FASTAAdd to Basket

« Hide

MYFSQEEWEL LDPTQKALYN DVMQENYETV ISLALFVLPK PKVISCLEQG    50
EEPWVQVSPE FKDSAGKSPT GLKLKNDTEN HQPVSLSDLE IQASAGVISK 100
KAKVKVPQKT AGKENHFDMH RVGKWHQDFP VKKRKKLSTW KQELLKLMDR 150
HKKDCAREKP FKCQECGKTF RVSSDLIKHQ RIHTEEKPYK CQQCDKRFRW 200
SSDLNKHLTT HQGIKPYKCS WCGKSFSQNT NLHTHQRTHT GEKPFTCHEC 250
GKKFSQNSHL IKHRRTHTGE QPYTCSICRR NFSRRSSLLR HQKLHL 296
Length:296
Mass (Da):34,694
Last modified:December 1, 2001 - v1
Checksum:iD8EBD7023CA726AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841V → A.
Corresponds to variant rs17611866 [ dbSNP | Ensembl ].
VAR_033545
Natural varianti228 – 2281Q → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_035570

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056091 mRNA. Translation: BAB71092.1.
BC119652 mRNA. Translation: AAI19653.1.
BC119653 mRNA. Translation: AAI19654.1.
X91826 Genomic DNA. Translation: CAA62935.1.
CCDSiCCDS10501.1.
RefSeqiNP_694573.1. NM_153028.2.
UniGeneiHs.513292.

Genome annotation databases

EnsembliENST00000574298; ENSP00000459566; ENSG00000162086.
GeneIDi7627.
KEGGihsa:7627.
UCSCiuc002cut.4. human.

Polymorphism databases

DMDMi68566224.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056091 mRNA. Translation: BAB71092.1 .
BC119652 mRNA. Translation: AAI19653.1 .
BC119653 mRNA. Translation: AAI19654.1 .
X91826 Genomic DNA. Translation: CAA62935.1 .
CCDSi CCDS10501.1.
RefSeqi NP_694573.1. NM_153028.2.
UniGenei Hs.513292.

3D structure databases

ProteinModelPortali Q96N20.
SMRi Q96N20. Positions 129-295.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113446. 1 interaction.
STRINGi 9606.ENSP00000293995.

Polymorphism databases

DMDMi 68566224.

Proteomic databases

PaxDbi Q96N20.
PRIDEi Q96N20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000574298 ; ENSP00000459566 ; ENSG00000162086 .
GeneIDi 7627.
KEGGi hsa:7627.
UCSCi uc002cut.4. human.

Organism-specific databases

CTDi 7627.
GeneCardsi GC16P003355.
HGNCi HGNC:13146. ZNF75A.
HPAi HPA001665.
MIMi 601473. gene.
neXtProti NX_Q96N20.
PharmGKBi PA37720.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q96N20.
KOi K09229.
OMAi DMHRVGK.
OrthoDBi EOG73NG31.
PhylomeDBi Q96N20.
TreeFami TF340832.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF75A. human.
GenomeRNAii 7627.
NextBioi 29726.
PROi Q96N20.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96N20.
Bgeei Q96N20.
CleanExi HS_ZNF75A.
Genevestigatori Q96N20.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes."
    Villa A., Strina D., Frattini A., Faranda S., Macchi P., Finelli P., Bozzi F., Susani L., Archidiacono N., Rocchi M., Vezzoni P.
    Genomics 35:312-320(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-291.
    Tissue: Peripheral blood.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-228.

Entry informationi

Entry nameiZN75A_HUMAN
AccessioniPrimary (citable) accession number: Q96N20
Secondary accession number(s): Q0VDI8, Q92669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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