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Q96N20

- ZN75A_HUMAN

UniProt

Q96N20 - ZN75A_HUMAN

Protein

Zinc finger protein 75A

Gene

ZNF75A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 75A
    Gene namesi
    Name:ZNF75A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:13146. ZNF75A.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37720.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Zinc finger protein 75APRO_0000047385Add
    BLAST

    Proteomic databases

    PaxDbiQ96N20.
    PRIDEiQ96N20.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96N20.
    BgeeiQ96N20.
    CleanExiHS_ZNF75A.
    GenevestigatoriQ96N20.

    Organism-specific databases

    HPAiHPA001665.

    Interactioni

    Protein-protein interaction databases

    BioGridi113446. 1 interaction.
    STRINGi9606.ENSP00000293995.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96N20.
    SMRiQ96N20. Positions 129-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6666KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96N20.
    KOiK09229.
    OMAiDMHRVGK.
    OrthoDBiEOG73NG31.
    PhylomeDBiQ96N20.
    TreeFamiTF340832.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96N20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYFSQEEWEL LDPTQKALYN DVMQENYETV ISLALFVLPK PKVISCLEQG    50
    EEPWVQVSPE FKDSAGKSPT GLKLKNDTEN HQPVSLSDLE IQASAGVISK 100
    KAKVKVPQKT AGKENHFDMH RVGKWHQDFP VKKRKKLSTW KQELLKLMDR 150
    HKKDCAREKP FKCQECGKTF RVSSDLIKHQ RIHTEEKPYK CQQCDKRFRW 200
    SSDLNKHLTT HQGIKPYKCS WCGKSFSQNT NLHTHQRTHT GEKPFTCHEC 250
    GKKFSQNSHL IKHRRTHTGE QPYTCSICRR NFSRRSSLLR HQKLHL 296
    Length:296
    Mass (Da):34,694
    Last modified:December 1, 2001 - v1
    Checksum:iD8EBD7023CA726AA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841V → A.
    Corresponds to variant rs17611866 [ dbSNP | Ensembl ].
    VAR_033545
    Natural varianti228 – 2281Q → E in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035570

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056091 mRNA. Translation: BAB71092.1.
    BC119652 mRNA. Translation: AAI19653.1.
    BC119653 mRNA. Translation: AAI19654.1.
    X91826 Genomic DNA. Translation: CAA62935.1.
    CCDSiCCDS10501.1.
    RefSeqiNP_694573.1. NM_153028.2.
    UniGeneiHs.513292.

    Genome annotation databases

    EnsembliENST00000574298; ENSP00000459566; ENSG00000162086.
    GeneIDi7627.
    KEGGihsa:7627.
    UCSCiuc002cut.4. human.

    Polymorphism databases

    DMDMi68566224.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056091 mRNA. Translation: BAB71092.1 .
    BC119652 mRNA. Translation: AAI19653.1 .
    BC119653 mRNA. Translation: AAI19654.1 .
    X91826 Genomic DNA. Translation: CAA62935.1 .
    CCDSi CCDS10501.1.
    RefSeqi NP_694573.1. NM_153028.2.
    UniGenei Hs.513292.

    3D structure databases

    ProteinModelPortali Q96N20.
    SMRi Q96N20. Positions 129-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113446. 1 interaction.
    STRINGi 9606.ENSP00000293995.

    Polymorphism databases

    DMDMi 68566224.

    Proteomic databases

    PaxDbi Q96N20.
    PRIDEi Q96N20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000574298 ; ENSP00000459566 ; ENSG00000162086 .
    GeneIDi 7627.
    KEGGi hsa:7627.
    UCSCi uc002cut.4. human.

    Organism-specific databases

    CTDi 7627.
    GeneCardsi GC16P003355.
    HGNCi HGNC:13146. ZNF75A.
    HPAi HPA001665.
    MIMi 601473. gene.
    neXtProti NX_Q96N20.
    PharmGKBi PA37720.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96N20.
    KOi K09229.
    OMAi DMHRVGK.
    OrthoDBi EOG73NG31.
    PhylomeDBi Q96N20.
    TreeFami TF340832.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF75A. human.
    GenomeRNAii 7627.
    NextBioi 29726.
    PROi Q96N20.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96N20.
    Bgeei Q96N20.
    CleanExi HS_ZNF75A.
    Genevestigatori Q96N20.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes."
      Villa A., Strina D., Frattini A., Faranda S., Macchi P., Finelli P., Bozzi F., Susani L., Archidiacono N., Rocchi M., Vezzoni P.
      Genomics 35:312-320(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-291.
      Tissue: Peripheral blood.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-228.

    Entry informationi

    Entry nameiZN75A_HUMAN
    AccessioniPrimary (citable) accession number: Q96N20
    Secondary accession number(s): Q0VDI8, Q92669
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3