Q96N19 (G137A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integral membrane protein GPR137

Alternative name(s):
Transmembrane 7 superfamily member 1-like 1 protein

Gene names

Name:	GPR137
Synonyms:	C11orf4, GPR137A, TM7SF1L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the GPR137 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96N19-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96N19-2)

The sequence of this isoform differs from the canonical sequence as follows:
     344-417: RCQDQAATTT...SCHSELVPSP → SMSGSLGSGS...HHSLYSTPQT

Isoform 3 (identifier: Q96N19-3)

The sequence of this isoform differs from the canonical sequence as follows:
     212-261: Missing.
     344-417: RCQDQAATTT...SCHSELVPSP → SMSGSLGSGS...HHSLYSTPQT

Isoform 4 (identifier: Q96N19-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLWAVRTRCYVVKAQLGPTVALEGRAPRAPGPSCLGNGNCQRPGPITSRNVTRASLPDM

Note: No experimental confirmation available.

Isoform 5 (identifier: Q96N19-5)

The sequence of this isoform differs from the canonical sequence as follows:
     305-320: STSHILNGQVFASRSY → YVGQSRLWELVWCHRA
     321-417: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Integral membrane protein GPR137		PRO_0000269996
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Topological domain	53 – 60	8	Cytoplasmic Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Topological domain	82 – 89	8	Extracellular Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Topological domain	111 – 140	30	Cytoplasmic Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Topological domain	162 – 175	14	Extracellular Potential
	Transmembrane	176 – 196	21	Helical; Potential
	Topological domain	197 – 218	22	Cytoplasmic Potential
	Transmembrane	219 – 241	23	Helical; Potential
	Topological domain	242 – 274	33	Extracellular Potential
	Transmembrane	275 – 295	21	Helical; Potential
	Topological domain	296 – 417	122	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1	1	M → MLWAVRTRCYVVKAQLGPTV ALEGRAPRAPGPSCLGNGNC QRPGPITSRNVTRASLPDM in isoform 4.		VSP_043278
	Alternative sequence	212 – 261	50	Missing in isoform 3.		VSP_022121
	Alternative sequence	305 – 320	16	STSHI…ASRSY → YVGQSRLWELVWCHRA in isoform 5.		VSP_043592
	Alternative sequence	321 – 417	97	Missing in isoform 5.		VSP_043593
	Alternative sequence	344 – 417	74	RCQDQ…LVPSP → SMSGSLGSGSWYGAIGREPG WYGGSQTKTTPLLFSQVPGP GGHHHSLYSTPQT in isoform 2 and isoform 3.		VSP_022122
Experimental info
	Sequence conflict	254	1	D → G in BAB71093. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 4059610F4B822FCA	FASTA	417	46,059
	10 20 30 40 50 60 MESNLSGLVP AAGLVPALPP AVTLGLTAAY TTLYALLFFS VYAQLWLVLL YGHKRLSYQT 70 80 90 100 110 120 VFLALCLLWA ALRTTLFSFY FRDTPRANRL GPLPFWLLYC CPVCLQFFTL TLMNLYFAQV 130 140 150 160 170 180 VFKAKVKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAVL SHRRRAQPWA LLLVRVLVSD 190 200 210 220 230 240 SLFVICALSL AACLCLVARR APSTSIYLEA KGTSVCQAAA MGGAMVLLYA SRACYNLTAL 250 260 270 280 290 300 ALAPQSRLDT FDYDWYNVSD QADLVNDLGN KGYLVFGLIL FVWELLPTTL LVGFFRVHRP 310 320 330 340 350 360 PQDLSTSHIL NGQVFASRSY FFDRAGHCED EGCSWEHSRG ESTRCQDQAA TTTVSTPPHR 370 380 390 400 410 RDPPPSPTEY PGPSPPHPRP LCQVCLPLLA QDPGGRGYPL LWPAPCCSCH SELVPSP
	Isoform 2 [UniParc]. Checksum: F95C30010101995F	FASTA	396	43,632
	10 20 30 40 50 60 MESNLSGLVP AAGLVPALPP AVTLGLTAAY TTLYALLFFS VYAQLWLVLL YGHKRLSYQT 70 80 90 100 110 120 VFLALCLLWA ALRTTLFSFY FRDTPRANRL GPLPFWLLYC CPVCLQFFTL TLMNLYFAQV 130 140 150 160 170 180 VFKAKVKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAVL SHRRRAQPWA LLLVRVLVSD 190 200 210 220 230 240 SLFVICALSL AACLCLVARR APSTSIYLEA KGTSVCQAAA MGGAMVLLYA SRACYNLTAL 250 260 270 280 290 300 ALAPQSRLDT FDYDWYNVSD QADLVNDLGN KGYLVFGLIL FVWELLPTTL LVGFFRVHRP 310 320 330 340 350 360 PQDLSTSHIL NGQVFASRSY FFDRAGHCED EGCSWEHSRG ESTSMSGSLG SGSWYGAIGR 370 380 390 EPGWYGGSQT KTTPLLFSQV PGPGGHHHSL YSTPQT
	Isoform 3 [UniParc]. Checksum: 597CE021C5309BD0	FASTA	346	38,256
	10 20 30 40 50 60 MESNLSGLVP AAGLVPALPP AVTLGLTAAY TTLYALLFFS VYAQLWLVLL YGHKRLSYQT 70 80 90 100 110 120 VFLALCLLWA ALRTTLFSFY FRDTPRANRL GPLPFWLLYC CPVCLQFFTL TLMNLYFAQV 130 140 150 160 170 180 VFKAKVKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAVL SHRRRAQPWA LLLVRVLVSD 190 200 210 220 230 240 SLFVICALSL AACLCLVARR APSTSIYLEA KADLVNDLGN KGYLVFGLIL FVWELLPTTL 250 260 270 280 290 300 LVGFFRVHRP PQDLSTSHIL NGQVFASRSY FFDRAGHCED EGCSWEHSRG ESTSMSGSLG 310 320 330 340 SGSWYGAIGR EPGWYGGSQT KTTPLLFSQV PGPGGHHHSL YSTPQT
	Isoform 4 [UniParc]. Checksum: F2A08B174069042B	FASTA	475	52,202
	10 20 30 40 50 60 MLWAVRTRCY VVKAQLGPTV ALEGRAPRAP GPSCLGNGNC QRPGPITSRN VTRASLPDME 70 80 90 100 110 120 SNLSGLVPAA GLVPALPPAV TLGLTAAYTT LYALLFFSVY AQLWLVLLYG HKRLSYQTVF 130 140 150 160 170 180 LALCLLWAAL RTTLFSFYFR DTPRANRLGP LPFWLLYCCP VCLQFFTLTL MNLYFAQVVF 190 200 210 220 230 240 KAKVKRRPEM SRGLLAVRGA FVGASLLFLL VNVLCAVLSH RRRAQPWALL LVRVLVSDSL 250 260 270 280 290 300 FVICALSLAA CLCLVARRAP STSIYLEAKG TSVCQAAAMG GAMVLLYASR ACYNLTALAL 310 320 330 340 350 360 APQSRLDTFD YDWYNVSDQA DLVNDLGNKG YLVFGLILFV WELLPTTLLV GFFRVHRPPQ 370 380 390 400 410 420 DLSTSHILNG QVFASRSYFF DRAGHCEDEG CSWEHSRGES TRCQDQAATT TVSTPPHRRD 430 440 450 460 470 PPPSPTEYPG PSPPHPRPLC QVCLPLLAQD PGGRGYPLLW PAPCCSCHSE LVPSP
	Isoform 5 [UniParc]. Checksum: 6829135D1AEAF215	FASTA	320	35,756
	10 20 30 40 50 60 MESNLSGLVP AAGLVPALPP AVTLGLTAAY TTLYALLFFS VYAQLWLVLL YGHKRLSYQT 70 80 90 100 110 120 VFLALCLLWA ALRTTLFSFY FRDTPRANRL GPLPFWLLYC CPVCLQFFTL TLMNLYFAQV 130 140 150 160 170 180 VFKAKVKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAVL SHRRRAQPWA LLLVRVLVSD 190 200 210 220 230 240 SLFVICALSL AACLCLVARR APSTSIYLEA KGTSVCQAAA MGGAMVLLYA SRACYNLTAL 250 260 270 280 290 300 ALAPQSRLDT FDYDWYNVSD QADLVNDLGN KGYLVFGLIL FVWELLPTTL LVGFFRVHRP 310 320 PQDLYVGQSR LWELVWCHRA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5). Tissue: Placenta and Testis.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Pancreas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056094 mRNA. Translation: BAB71093.1. AK300209 mRNA. Translation: BAG61979.1. AK302256 mRNA. Translation: BAH13657.1. AP001453 Genomic DNA. No translation available. BC033920 mRNA. Translation: AAH33920.1. BC035002 mRNA. Translation: AAH35002.1.
IPI	IPI00140138. IPI00645236. IPI00815937. IPI00941884. IPI00956520.
RefSeq	NP_001164197.1. NM_001170726.1. NP_001164351.1. NM_001170880.1. NP_001164352.1. NM_001170881.1. NP_001170829.1. NM_001177358.1. NP_064540.3. NM_020155.3.
UniGene	Hs.523763.
3D structure databases
ProteinModelPortal	Q96N19.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000321698.
PTM databases
PhosphoSite	Q96N19.
Polymorphism databases
DMDM	126302549.
Proteomic databases
PaxDb	Q96N19.
PRIDE	Q96N19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313074; ENSP00000321698; ENSG00000173264. ENST00000377702; ENSP00000366931; ENSG00000173264. ENST00000411458; ENSP00000411827; ENSG00000173264. ENST00000438980; ENSP00000415698; ENSG00000173264. ENST00000539851; ENSP00000442792; ENSG00000173264.
GeneID	56834.
KEGG	hsa:56834.
UCSC	uc001nze.2. human. uc001nzf.3. human. uc001nzi.3. human.
Organism-specific databases
CTD	56834.
GeneCards	GC11P064051.
HGNC	HGNC:24300. GPR137.
neXtProt	NX_Q96N19.
PharmGKB	PA143485482.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74980.
HOGENOM	HOG000286020.
HOVERGEN	HBG058911.
InParanoid	Q96N19.
OMA	REPGWCG.
OrthoDB	EOG44QT19.
PhylomeDB	Q96N19.
Gene expression databases
ArrayExpress	Q96N19.
Bgee	Q96N19.
CleanEx	HS_GPR137.
Genevestigator	Q96N19.
Family and domain databases
InterPro	IPR027209. GPR137. [Graphical view]
PANTHER	PTHR32550. PTHR32550. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	56834.
NextBio	62240.

Entry information

Entry name

G137A_HUMAN

Accession

Primary (citable) accession number: Q96N19
Secondary accession number(s): B4DTG7 , B7Z7M1, Q4G0Y9, Q8N4K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.