Q96N16 (JKIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Janus kinase and microtubule-interacting protein 1

Alternative name(s):
GABA-B receptor-binding protein
Multiple alpha-helices and RNA-linker protein 1
Short name=Marlin-1

Gene names

Name:	JAKMIP1
Synonyms:	GABABRBP, JAMIP1, MARLIN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. Ref.1 Ref.7 Ref.8
Subunit structure	Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2. Ref.1 Ref.7 Ref.8
Subcellular location	Cytoplasm › cytoskeleton. Membrane; Peripheral membrane protein. Note: Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells. Ref.1 Ref.7
Tissue specificity	Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine. Ref.2 Ref.7
Sequence similarities	Belongs to the JAKMIP family.
Caution	Was originally (Ref.1) thought to bind single-stranded RNA molecules and regulate GABA-B receptor expression.
Sequence caution	The sequence BAC05325.1 differs from that shown. Reason: Erroneous termination at position 285. Translated as Arg. The sequence BAC05325.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Membrane Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from direct assay Ref.1. Source: MGI microtubule Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoprotein complex Inferred from direct assay Ref.1. Source: MGI
Molecular_function	GABA receptor binding Inferred from direct assay Ref.1. Source: MGI RNA binding Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96N16-1)

Also known as: Jakmip1A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96N16-2)

Also known as: Jakmip1B;

The sequence of this isoform differs from the canonical sequence as follows:
     603-626: VRDSICCKLSNGADILFEPKLKFM → ERERRSPAFN...FFSLAFILWP

Isoform 3 (identifier: Q96N16-3)

Also known as: Jakmip1C;

The sequence of this isoform differs from the canonical sequence as follows:
     374-431: QASLKRHTSL...SKRHRGKSLK → HGAAAAGPAE...MTSVSQELGL
     432-626: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Isoform 4 (identifier: Q96N16-4)

Also known as: Jakmip1D;

The sequence of this isoform differs from the canonical sequence as follows:
     495-569: YQALQRAYAL...IRTNQDLLEK → DLQAAVEKVR...FFSLAFILWP
     570-626: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Isoform 5 (identifier: Q96N16-5)

Also known as: Jakmip1E;

The sequence of this isoform differs from the canonical sequence as follows:
     44-208: Missing.
     415-434: Missing.
     603-626: VRDSICCKLSNGADILFEPKLKFM → ERERRSPAFN...FFSLAFILWP

Isoform 6 (identifier: Q96N16-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.
     494-520: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	Janus kinase and microtubule-interacting protein 1		PRO_0000323008
Regions
	Region	1 – 365	365	Mediates association with microtubules
	Region	365 – 626	262	Mediates interaction with TYK2 and GABBR1
	Coiled coil	19 – 255	237	Potential
	Coiled coil	284 – 413	130	Potential
	Coiled coil	490 – 604	115	Potential
Amino acid modifications
	Modified residue	382	1	Phosphoserine Ref.9
	Modified residue	470	1	Phosphothreonine Ref.9
Natural variations
	Alternative sequence	1 – 208	208	Missing in isoform 6.		VSP_031989
	Alternative sequence	44 – 208	165	Missing in isoform 5.		VSP_031990
	Alternative sequence	374 – 431	58	QASLK…GKSLK → HGAAAAGPAENPRTGGQTGV SEAAPERTGGKVFVPFFVFL TSIHSVALMTSVSQELGL in isoform 3.		VSP_031991
	Alternative sequence	415 – 434	20	Missing in isoform 5.		VSP_031992
	Alternative sequence	432 – 626	195	Missing in isoform 3.		VSP_031993
	Alternative sequence	494 – 520	27	Missing in isoform 6.		VSP_031994
	Alternative sequence	495 – 569	75	YQALQ…DLLEK → DLQAAVEKVRRQILRQSREF DSQILRERMELLQQAQQRIR ELEDKLEFQKRHLKELEEKF LFLFLFFSLAFILWP in isoform 4.		VSP_031995
	Alternative sequence	570 – 626	57	Missing in isoform 4.		VSP_031996
	Alternative sequence	603 – 626	24	VRDSI…KLKFM → ERERRSPAFNLQITTFPENH SSALQLFCHQEGVKDVNVSE LMKKLDILGDNGNLRNEEQV AIIQAGTVLALCEKWLKQIE GTEAALTQKMLDLEKEKDLF SRQKGYLEEELDYRKQALDQ AYLKIQDLEATLYTALQQEP GRRAGEALSEGQREDLQAAV EKVRRQILRQSREFDSQILR ERMELLQQAQQRIRELEDKL EFQKRHLKELEEKFLFLFLF FSLAFILWP in isoform 2 and isoform 5.		VSP_031997
	Natural variant	251	1	K → R. Ref.2		VAR_039471
	Natural variant	375	1	A → V in a colorectal cancer sample; somatic mutation. Ref.10		VAR_039472
Experimental info
	Sequence conflict	163	1	K → N in AAH47075. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Jakmip1A) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 6A8E164E8A2A7EFB	FASTA	626	73,209
	10 20 30 40 50 60 MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ 70 80 90 100 110 120 EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL 130 140 150 160 170 180 RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA 190 200 210 220 230 240 ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK 250 260 270 280 290 300 EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV 310 320 330 340 350 360 IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL 370 380 390 400 410 420 TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL 430 440 450 460 470 480 RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA 490 500 510 520 530 540 REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE 550 560 570 580 590 600 KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE 610 620 LEVRDSICCK LSNGADILFE PKLKFM
	Isoform 2 (Jakmip1B) [UniParc]. Checksum: 331CB5500A662634	FASTA	831	97,436
	10 20 30 40 50 60 MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ 70 80 90 100 110 120 EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL 130 140 150 160 170 180 RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA 190 200 210 220 230 240 ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK 250 260 270 280 290 300 EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV 310 320 330 340 350 360 IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL 370 380 390 400 410 420 TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL 430 440 450 460 470 480 RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA 490 500 510 520 530 540 REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE 550 560 570 580 590 600 KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE 610 620 630 640 650 660 LEERERRSPA FNLQITTFPE NHSSALQLFC HQEGVKDVNV SELMKKLDIL GDNGNLRNEE 670 680 690 700 710 720 QVAIIQAGTV LALCEKWLKQ IEGTEAALTQ KMLDLEKEKD LFSRQKGYLE EELDYRKQAL 730 740 750 760 770 780 DQAYLKIQDL EATLYTALQQ EPGRRAGEAL SEGQREDLQA AVEKVRRQIL RQSREFDSQI 790 800 810 820 830 LRERMELLQQ AQQRIRELED KLEFQKRHLK ELEEKFLFLF LFFSLAFILW P
	Isoform 3 (Jakmip1C) [UniParc]. Checksum: 13C02CC36809B13C	FASTA	431	49,323
	10 20 30 40 50 60 MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ 70 80 90 100 110 120 EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL 130 140 150 160 170 180 RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA 190 200 210 220 230 240 ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK 250 260 270 280 290 300 EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV 310 320 330 340 350 360 IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL 370 380 390 400 410 420 TRENVEMKEK LSAHGAAAAG PAENPRTGGQ TGVSEAAPER TGGKVFVPFF VFLTSIHSVA 430 LMTSVSQELG L
	Isoform 4 (Jakmip1D) [UniParc]. Checksum: 3592DB24973B29D2	FASTA	569	67,000
	10 20 30 40 50 60 MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ 70 80 90 100 110 120 EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL 130 140 150 160 170 180 RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA 190 200 210 220 230 240 ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK 250 260 270 280 290 300 EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV 310 320 330 340 350 360 IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL 370 380 390 400 410 420 TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL 430 440 450 460 470 480 RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA 490 500 510 520 530 540 REEADLRFCQ LTREDLQAAV EKVRRQILRQ SREFDSQILR ERMELLQQAQ QRIRELEDKL 550 560 EFQKRHLKEL EEKFLFLFLF FSLAFILWP
	Isoform 5 (Jakmip1E) [UniParc]. Checksum: E0F39B9913C749C8	FASTA	646	75,746
	10 20 30 40 50 60 MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKMDEIKGK DRVILALEKE 70 80 90 100 110 120 LGVQAGQTQK LLLQKEALDE QLVQVKEAER HHSSPKRELP PGIGDMVELM GVQDQHMDER 130 140 150 160 170 180 DVRRFQLKIA ELNSVIRKLE DRNTLLADER NELLKRSRET EVQLKPLVEK NKRMNKKNED 190 200 210 220 230 240 LLQSIQRMEE KIKNLTRENV EMKEKLSAQA SLKRHTSLND LSLTRDEQEI EFLRLQVLEQ 250 260 270 280 290 300 QHVIDDLSLK HVVETFFGFD EESVDSETLS ETSYNTDRTD RTPATPEEDL DDATAREEAD 310 320 330 340 350 360 LRFCQLTREY QALQRAYALL QEQVGGTLDA EREARTREQL QADLLRCQAK IEDLEKLLVE 370 380 390 400 410 420 KGQDSKWVEE KQLLIRTNQD LLEKIYRLEM EENQLKNEMQ DAKDQNELLE FRVLELEERE 430 440 450 460 470 480 RRSPAFNLQI TTFPENHSSA LQLFCHQEGV KDVNVSELMK KLDILGDNGN LRNEEQVAII 490 500 510 520 530 540 QAGTVLALCE KWLKQIEGTE AALTQKMLDL EKEKDLFSRQ KGYLEEELDY RKQALDQAYL 550 560 570 580 590 600 KIQDLEATLY TALQQEPGRR AGEALSEGQR EDLQAAVEKV RRQILRQSRE FDSQILRERM 610 620 630 640 ELLQQAQQRI RELEDKLEFQ KRHLKELEEK FLFLFLFFSL AFILWP
	Isoform 6 [UniParc]. Checksum: 799EBF218498F2B0	FASTA	391	45,989
	10 20 30 40 50 60 MDEIKGKDRV ILALEKELGV QAGQTQKLLL QKEALDEQLV QVKEAERHHS SPKRELPPGI 70 80 90 100 110 120 GDMVELMGVQ DQHMDERDVR RFQLKIAELN SVIRKLEDRN TLLADERNEL LKRSRETEVQ 130 140 150 160 170 180 LKPLVEKNKR MNKKNEDLLQ SIQRMEEKIK NLTRENVEMK EKLSAQASLK RHTSLNDLSL 190 200 210 220 230 240 TRDEQEIEFL RLQVLEQQHV IDDLSLERER LLRSKRHRGK SLKPPKKHVV ETFFGFDEES 250 260 270 280 290 300 VDSETLSETS YNTDRTDRTP ATPEEDLDDA TAREEADLRF CQLTRTREQL QADLLRCQAK 310 320 330 340 350 360 IEDLEKLLVE KGQDSKWVEE KQLLIRTNQD LLEKIYRLEM EENQLKNEMQ DAKDQNELLE 370 380 390 FRVLELEVRD SICCKLSNGA DILFEPKLKF M

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Marlin-1, a novel RNA-binding protein associates with GABA receptors." Couve A., Restituito S., Brandon J.M., Charles K.J., Bawagan H., Freeman K.B., Pangalos M.N., Calver A.R., Moss S.J. J. Biol. Chem. 279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH GABBR1, SUBCELLULAR LOCATION. Tissue: Brain.
[2]	"Identification and expression analysis of novel Jakmip1 transcripts." Costa V., Conte I., Ziviello C., Casamassimi A., Alfano G., Banfi S., Ciccodicola A. Gene 402:1-8(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), TISSUE SPECIFICITY, VARIANT ARG-251. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6). Tissue: Teratocarcinoma and Testis.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules." Steindler C., Li Z., Algarte M., Alcover A., Libri V., Ragimbeau J., Pellegrini S. J. Biol. Chem. 279:43168-43177(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH JAK1 AND TYK2, OLIGOMERIZATION, SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
[8]	"Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport." Vidal R.L., Ramirez O.A., Sandoval L., Koenig-Robert R., Haertel S., Couve A. Mol. Cell. Neurosci. 35:501-512(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH GABBR1 AND KIF5B.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND THR-470, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-375.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY382340 mRNA. Translation: AAR26235.1. AM412307 mRNA. Translation: CAL80778.1. AM412308 mRNA. Translation: CAL80779.1. AM412309 mRNA. Translation: CAL80780.1. AM412310 mRNA. Translation: CAL80781.1. AK056126 mRNA. Translation: BAB71098.1. AK098536 mRNA. Translation: BAC05325.1. Sequence problems. AC092442 Genomic DNA. No translation available. AC113615 Genomic DNA. No translation available. CH471131 Genomic DNA. Translation: EAW82401.1. CH471131 Genomic DNA. Translation: EAW82402.1. BC047075 mRNA. Translation: AAH47075.1.
IPI	IPI00410321. IPI00853270. IPI00854585. IPI00854781. IPI00887997. IPI00888736.
RefSeq	NP_001092903.1. NM_001099433.1. NP_653321.1. NM_144720.3.
UniGene	Hs.479066.
3D structure databases
HSSP	HSSP built from PDB template 1GU4 based on UniProtKB P17676.
ProteinModelPortal	Q96N16.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96N16. 2 interactions.
PTM databases
PhosphoSite	Q96N16.
Polymorphism databases
DMDM	74732477.
Proteomic databases
PaxDb	Q96N16.
PRIDE	Q96N16.
Protocols and materials databases
DNASU	152789.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282924; ENSP00000282924; ENSG00000152969. ENST00000409021; ENSP00000386711; ENSG00000152969. ENST00000409371; ENSP00000387042; ENSG00000152969. ENST00000409831; ENSP00000386925; ENSG00000152969.
GeneID	152789.
KEGG	hsa:152789.
UCSC	uc003giu.4. human. uc010idb.1. human. uc010idc.1. human.
Organism-specific databases
CTD	152789.
GeneCards	GC04M005962.
HGNC	HGNC:26460. JAKMIP1.
HPA	HPA044570.
MIM	611195. gene.
neXtProt	NX_Q96N16.
PharmGKB	PA143485508.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147883.
HOVERGEN	HBG054249.
OMA	MVELMGV.
PhylomeDB	Q96N16.
Gene expression databases
ArrayExpress	Q96N16.
Bgee	Q96N16.
CleanEx	HS_JAKMIP1.
Genevestigator	Q96N16.
Family and domain databases
InterPro	IPR024836. JAKMIP. [Graphical view]
PANTHER	PTHR18935. PTHR18935. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	152789.
NextBio	87027.
PMAP-CutDB	Q96N16.
SOURCE	Search...

Entry information

Entry name

JKIP1_HUMAN

Accession

Primary (citable) accession number: Q96N16
Secondary accession number(s): A6H2J2 , A6H2J3, A6H2J4, A6H2J5, A8MTK6, B8ZZR7, D3DVT0, Q86Y69, Q8N7G3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.