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Protein

Janus kinase and microtubule-interacting protein 1

Gene

JAKMIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.3 Publications

GO - Molecular functioni

  • GABA receptor binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

  • cognition Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 1
Alternative name(s):
GABA-B receptor-binding protein
Multiple alpha-helices and RNA-linker protein 1
Short name:
Marlin-1
Gene namesi
Name:JAKMIP1
Synonyms:GABABRBP, JAMIP1, MARLIN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26460. JAKMIP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • extrinsic component of membrane Source: MGI
  • microtubule Source: UniProtKB-KW
  • ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485508.

Polymorphism and mutation databases

BioMutaiJAKMIP1.
DMDMi74732477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Janus kinase and microtubule-interacting protein 1PRO_0000323008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei382 – 3821Phosphoserine1 Publication
Modified residuei470 – 4701Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96N16.
PaxDbiQ96N16.
PRIDEiQ96N16.

PTM databases

PhosphoSiteiQ96N16.

Miscellaneous databases

PMAP-CutDBQ96N16.

Expressioni

Tissue specificityi

Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.2 Publications

Gene expression databases

BgeeiQ96N16.
CleanExiHS_JAKMIP1.
ExpressionAtlasiQ96N16. baseline and differential.
GenevisibleiQ96N16. HS.

Organism-specific databases

HPAiHPA044570.

Interactioni

Subunit structurei

Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428584EBI-2680803,EBI-466029

Protein-protein interaction databases

BioGridi127465. 1 interaction.
IntActiQ96N16. 3 interactions.
STRINGi9606.ENSP00000386711.

Structurei

3D structure databases

ProteinModelPortaliQ96N16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 365365Mediates association with microtubulesAdd
BLAST
Regioni365 – 626262Mediates interaction with TYK2 and GABBR1Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili19 – 255237Sequence AnalysisAdd
BLAST
Coiled coili284 – 413130Sequence AnalysisAdd
BLAST
Coiled coili490 – 604115Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG147883.
GeneTreeiENSGT00390000002812.
HOGENOMiHOG000060161.
HOVERGENiHBG054249.
InParanoidiQ96N16.
OMAiPAFNLHI.
OrthoDBiEOG7HHWRJ.
PhylomeDBiQ96N16.
TreeFamiTF331900.

Family and domain databases

InterProiIPR024836. JAKMIP.
[Graphical view]
PANTHERiPTHR18935. PTHR18935. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N16-1) [UniParc]FASTAAdd to basket

Also known as: Jakmip1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER
60 70 80 90 100
LQEAKLEREQ EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA
110 120 130 140 150
RTAKIKEGEL QRLQATLNVL RDGAADKVKT ALLTEAREEA RRAFDGERLR
160 170 180 190 200
LQQEILELKA ARKQAEEALS NCMQADKTKA ADLRAAYQAH QDEVHRIKRE
210 220 230 240 250
CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK EALDEQLVQV
260 270 280 290 300
KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
310 320 330 340 350
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI
360 370 380 390 400
QRMEEKIKNL TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL
410 420 430 440 450
QVLEQQHVID DLSLERERLL RSKRHRGKSL KPPKKHVVET FFGFDEESVD
460 470 480 490 500
SETLSETSYN TDRTDRTPAT PEEDLDDATA REEADLRFCQ LTREYQALQR
510 520 530 540 550
AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE KLLVEKGQDS
560 570 580 590 600
KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
610 620
LEVRDSICCK LSNGADILFE PKLKFM
Length:626
Mass (Da):73,209
Last modified:December 1, 2001 - v1
Checksum:i6A8E164E8A2A7EFB
GO
Isoform 2 (identifier: Q96N16-2) [UniParc]FASTAAdd to basket

Also known as: Jakmip1B

The sequence of this isoform differs from the canonical sequence as follows:
     603-626: VRDSICCKLSNGADILFEPKLKFM → ERERRSPAFN...FFSLAFILWP

Show »
Length:831
Mass (Da):97,436
Checksum:i331CB5500A662634
GO
Isoform 3 (identifier: Q96N16-3) [UniParc]FASTAAdd to basket

Also known as: Jakmip1C

The sequence of this isoform differs from the canonical sequence as follows:
     374-431: QASLKRHTSL...SKRHRGKSLK → HGAAAAGPAE...MTSVSQELGL
     432-626: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:431
Mass (Da):49,323
Checksum:i13C02CC36809B13C
GO
Isoform 4 (identifier: Q96N16-4) [UniParc]FASTAAdd to basket

Also known as: Jakmip1D

The sequence of this isoform differs from the canonical sequence as follows:
     495-569: YQALQRAYAL...IRTNQDLLEK → DLQAAVEKVR...FFSLAFILWP
     570-626: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:569
Mass (Da):67,000
Checksum:i3592DB24973B29D2
GO
Isoform 5 (identifier: Q96N16-5) [UniParc]FASTAAdd to basket

Also known as: Jakmip1E

The sequence of this isoform differs from the canonical sequence as follows:
     44-208: Missing.
     415-434: Missing.
     603-626: VRDSICCKLSNGADILFEPKLKFM → ERERRSPAFN...FFSLAFILWP

Show »
Length:646
Mass (Da):75,746
Checksum:iE0F39B9913C749C8
GO
Isoform 6 (identifier: Q96N16-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.
     494-520: Missing.

Note: No experimental confirmation available.
Show »
Length:391
Mass (Da):45,989
Checksum:i799EBF218498F2B0
GO
Isoform 7 (identifier: Q96N16-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-208: Missing.

Note: No experimental confirmation available.
Show »
Length:461
Mass (Da):53,973
Checksum:i6E1F8C344865C8B2
GO

Sequence cautioni

The sequence BAC05325.1 differs from that shown. Reason: Erroneous termination at position 285. Translated as Arg.Curated
The sequence BAC05325.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631K → N in AAH47075 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511K → R.1 Publication
VAR_039471
Natural varianti375 – 3751A → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_039472

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 208208Missing in isoform 6. 1 PublicationVSP_031989Add
BLAST
Alternative sequencei44 – 208165Missing in isoform 5 and isoform 7. 2 PublicationsVSP_031990Add
BLAST
Alternative sequencei374 – 43158QASLK…GKSLK → HGAAAAGPAENPRTGGQTGV SEAAPERTGGKVFVPFFVFL TSIHSVALMTSVSQELGL in isoform 3. 1 PublicationVSP_031991Add
BLAST
Alternative sequencei415 – 43420Missing in isoform 5. 1 PublicationVSP_031992Add
BLAST
Alternative sequencei432 – 626195Missing in isoform 3. 1 PublicationVSP_031993Add
BLAST
Alternative sequencei494 – 52027Missing in isoform 6. 1 PublicationVSP_031994Add
BLAST
Alternative sequencei495 – 56975YQALQ…DLLEK → DLQAAVEKVRRQILRQSREF DSQILRERMELLQQAQQRIR ELEDKLEFQKRHLKELEEKF LFLFLFFSLAFILWP in isoform 4. 1 PublicationVSP_031995Add
BLAST
Alternative sequencei570 – 62657Missing in isoform 4. 1 PublicationVSP_031996Add
BLAST
Alternative sequencei603 – 62624VRDSI…KLKFM → ERERRSPAFNLQITTFPENH SSALQLFCHQEGVKDVNVSE LMKKLDILGDNGNLRNEEQV AIIQAGTVLALCEKWLKQIE GTEAALTQKMLDLEKEKDLF SRQKGYLEEELDYRKQALDQ AYLKIQDLEATLYTALQQEP GRRAGEALSEGQREDLQAAV EKVRRQILRQSREFDSQILR ERMELLQQAQQRIRELEDKL EFQKRHLKELEEKFLFLFLF FSLAFILWP in isoform 2 and isoform 5. 1 PublicationVSP_031997Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382340 mRNA. Translation: AAR26235.1.
AM412307 mRNA. Translation: CAL80778.1.
AM412308 mRNA. Translation: CAL80779.1.
AM412309 mRNA. Translation: CAL80780.1.
AM412310 mRNA. Translation: CAL80781.1.
AK056126 mRNA. Translation: BAB71098.1.
AK098536 mRNA. Translation: BAC05325.1. Sequence problems.
AK295339 mRNA. Translation: BAG58310.1.
AC092442 Genomic DNA. No translation available.
AC113615 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82401.1.
CH471131 Genomic DNA. Translation: EAW82402.1.
BC047075 mRNA. Translation: AAH47075.1.
CCDSiCCDS3385.1. [Q96N16-1]
CCDS47005.1. [Q96N16-2]
RefSeqiNP_001092903.1. NM_001099433.1. [Q96N16-2]
NP_653321.1. NM_144720.3. [Q96N16-1]
UniGeneiHs.479066.

Genome annotation databases

EnsembliENST00000282924; ENSP00000282924; ENSG00000152969. [Q96N16-1]
ENST00000409021; ENSP00000386711; ENSG00000152969. [Q96N16-2]
ENST00000409371; ENSP00000387042; ENSG00000152969. [Q96N16-5]
ENST00000409831; ENSP00000386925; ENSG00000152969. [Q96N16-1]
ENST00000410077; ENSP00000386745; ENSG00000152969. [Q96N16-7]
GeneIDi152789.
KEGGihsa:152789.
UCSCiuc003giu.4. human. [Q96N16-1]
uc010idb.1. human. [Q96N16-2]
uc010idc.1. human. [Q96N16-5]
uc011bwc.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382340 mRNA. Translation: AAR26235.1.
AM412307 mRNA. Translation: CAL80778.1.
AM412308 mRNA. Translation: CAL80779.1.
AM412309 mRNA. Translation: CAL80780.1.
AM412310 mRNA. Translation: CAL80781.1.
AK056126 mRNA. Translation: BAB71098.1.
AK098536 mRNA. Translation: BAC05325.1. Sequence problems.
AK295339 mRNA. Translation: BAG58310.1.
AC092442 Genomic DNA. No translation available.
AC113615 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82401.1.
CH471131 Genomic DNA. Translation: EAW82402.1.
BC047075 mRNA. Translation: AAH47075.1.
CCDSiCCDS3385.1. [Q96N16-1]
CCDS47005.1. [Q96N16-2]
RefSeqiNP_001092903.1. NM_001099433.1. [Q96N16-2]
NP_653321.1. NM_144720.3. [Q96N16-1]
UniGeneiHs.479066.

3D structure databases

ProteinModelPortaliQ96N16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127465. 1 interaction.
IntActiQ96N16. 3 interactions.
STRINGi9606.ENSP00000386711.

PTM databases

PhosphoSiteiQ96N16.

Polymorphism and mutation databases

BioMutaiJAKMIP1.
DMDMi74732477.

Proteomic databases

MaxQBiQ96N16.
PaxDbiQ96N16.
PRIDEiQ96N16.

Protocols and materials databases

DNASUi152789.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282924; ENSP00000282924; ENSG00000152969. [Q96N16-1]
ENST00000409021; ENSP00000386711; ENSG00000152969. [Q96N16-2]
ENST00000409371; ENSP00000387042; ENSG00000152969. [Q96N16-5]
ENST00000409831; ENSP00000386925; ENSG00000152969. [Q96N16-1]
ENST00000410077; ENSP00000386745; ENSG00000152969. [Q96N16-7]
GeneIDi152789.
KEGGihsa:152789.
UCSCiuc003giu.4. human. [Q96N16-1]
uc010idb.1. human. [Q96N16-2]
uc010idc.1. human. [Q96N16-5]
uc011bwc.2. human.

Organism-specific databases

CTDi152789.
GeneCardsiGC04M005962.
HGNCiHGNC:26460. JAKMIP1.
HPAiHPA044570.
MIMi611195. gene.
neXtProtiNX_Q96N16.
PharmGKBiPA143485508.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147883.
GeneTreeiENSGT00390000002812.
HOGENOMiHOG000060161.
HOVERGENiHBG054249.
InParanoidiQ96N16.
OMAiPAFNLHI.
OrthoDBiEOG7HHWRJ.
PhylomeDBiQ96N16.
TreeFamiTF331900.

Miscellaneous databases

GenomeRNAii152789.
NextBioi35472147.
PMAP-CutDBQ96N16.
PROiQ96N16.
SOURCEiSearch...

Gene expression databases

BgeeiQ96N16.
CleanExiHS_JAKMIP1.
ExpressionAtlasiQ96N16. baseline and differential.
GenevisibleiQ96N16. HS.

Family and domain databases

InterProiIPR024836. JAKMIP.
[Graphical view]
PANTHERiPTHR18935. PTHR18935. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH GABBR1, SUBCELLULAR LOCATION.
    Tissue: Brain.
  2. "Identification and expression analysis of novel Jakmip1 transcripts."
    Costa V., Conte I., Ziviello C., Casamassimi A., Alfano G., Banfi S., Ciccodicola A.
    Gene 402:1-8(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), TISSUE SPECIFICITY, VARIANT ARG-251.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 6 AND 7).
    Tissue: Caudate nucleus, Teratocarcinoma and Testis.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules."
    Steindler C., Li Z., Algarte M., Alcover A., Libri V., Ragimbeau J., Pellegrini S.
    J. Biol. Chem. 279:43168-43177(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH JAK1 AND TYK2, OLIGOMERIZATION, SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
  8. "Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport."
    Vidal R.L., Ramirez O.A., Sandoval L., Koenig-Robert R., Haertel S., Couve A.
    Mol. Cell. Neurosci. 35:501-512(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH GABBR1 AND KIF5B.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND THR-470, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-375.

Entry informationi

Entry nameiJKIP1_HUMAN
AccessioniPrimary (citable) accession number: Q96N16
Secondary accession number(s): A6H2J2
, A6H2J3, A6H2J4, A6H2J5, A8MTK6, B4DHZ8, B8ZZR7, D3DVT0, Q86Y69, Q8N7G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to bind single-stranded RNA molecules and regulate GABA-B receptor expression.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.