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Q96N03 (VTM2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-set and transmembrane domain-containing protein 2-like protein
Gene names
Name:VSTM2L
Synonyms:C20orf102
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin domain
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ATXN1P542533EBI-948213,EBI-930964

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96N03-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96N03-2)

The sequence of this isoform differs from the canonical sequence as follows:
     98-114: Missing.
     167-204: Missing.
Note: Gene prediction based on EST data.
Isoform 3 (identifier: Q96N03-3)

The sequence of this isoform differs from the canonical sequence as follows:
     41-132: ALFTETPHDM...ISHKLRLSRV → GGQGGGQQHL...GGPGGLQPLD
     133-204: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 204180V-set and transmembrane domain-containing protein 2-like protein
PRO_0000015164

Regions

Domain41 – 158118Ig-like

Amino acid modifications

Disulfide bond62 ↔ 142 Potential

Natural variations

Alternative sequence41 – 13292ALFTE…RLSRV → GGQGGGQQHLPQAAPVPGEA HGRRHLRVPRHRLQRRQGPA PQGQGLPAGAARGELRPASA RSPSRRARPAAPQARQGAEE ALGGPGGLQPLD in isoform 3.
VSP_026512
Alternative sequence98 – 11417Missing in isoform 2.
VSP_013380
Alternative sequence133 – 20472Missing in isoform 3.
VSP_026513
Alternative sequence167 – 20438Missing in isoform 2.
VSP_026514

Experimental info

Sequence conflict1391T → S in AAH33818. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 79917025B4C8425E

FASTA20422,349
        10         20         30         40         50         60 
MGAPLAVALG ALHYLALFLQ LGGATRPAGH APWDNHVSGH ALFTETPHDM TARTGEDVEM 

        70         80         90        100        110        120 
ACSFRGSGSP SYSLEIQWWY VRSHRDWTDK QAWASNQLKA SQQEDAGKEA TKISVVKVVG 

       130        140        150        160        170        180 
SNISHKLRLS RVKPTDEGTY ECRVIDFSDG KARHHKVKAY LRVQPGENSV LHLPEAPPAA 

       190        200 
PAPPPPKPGK ELRKRSVDQE ACSL

« Hide

Isoform 2 [UniParc].

Checksum: 26AB2723281561E6
Show »

FASTA14916,554
Isoform 3 [UniParc].

Checksum: 61891B30E4B179A9
Show »

FASTA13213,528

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK056177 mRNA. Translation: BAB71113.1.
AL834410 mRNA. Translation: CAD39072.2.
AL109964 Genomic DNA. Translation: CAI42205.1.
AL109964 Genomic DNA. Translation: CAI42206.2.
AL109964 Genomic DNA. Translation: CAI42207.1.
CH471077 Genomic DNA. Translation: EAW76051.1.
CH471077 Genomic DNA. Translation: EAW76053.1.
BC033818 mRNA. Translation: AAH33818.1.
IPIIPI00028685.
IPI00553123.
IPI00555977.
RefSeqNP_542174.1. NM_080607.2.
UniGeneHs.517029.

3D structure databases

ProteinModelPortalQ96N03.
ModBaseSearch...

Protein-protein interaction databases

IntActQ96N03. 1 interaction.
MINTMINT-2878612.
STRING9606.ENSP00000362560.

Polymorphism databases

DMDM27151481.

Proteomic databases

PaxDbQ96N03.
PRIDEQ96N03.

Protocols and materials databases

DNASU128434.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373459; ENSP00000362558; ENSG00000132821.
ENST00000373461; ENSP00000362560; ENSG00000132821.
ENST00000448944; ENSP00000406537; ENSG00000132821.
GeneID128434.
KEGGhsa:128434.
UCSCuc002xhk.4. human.

Organism-specific databases

CTD128434.
GeneCardsGC20P036531.
HGNCHGNC:16096. VSTM2L.
HPAHPA043832.
neXtProtNX_Q96N03.
PharmGKBPA162408904.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG18017.
HOGENOMHOG000231260.
HOVERGENHBG052093.
InParanoidQ96N03.
OMAQTWASNQ.
OrthoDBEOG4B5P66.
PhylomeDBQ96N03.

Gene expression databases

ArrayExpressQ96N03.
BgeeQ96N03.
CleanExHS_VSTM2L.
GenevestigatorQ96N03.
GermOnlineENSG00000132821. Homo sapiens.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR027115. VSTM2L.
[Graphical view]
PANTHERPTHR10075:SF7. PTHR10075:SF7. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi128434.
NextBio82349.

Entry information

Entry nameVTM2L_HUMAN
AccessionPrimary (citable) accession number: Q96N03
Secondary accession number(s): E1P5V7 expand/collapse secondary AC list , Q5JWZ4, Q5JWZ5, Q8ND45, Q9BR37
Entry history
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents