Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-set and transmembrane domain-containing protein 2-like protein

Gene

VSTM2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of neuron apoptotic process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132821-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 2-like protein
Gene namesi
Name:VSTM2L
Synonyms:C20orf102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16096. VSTM2L.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132821.
PharmGKBiPA162408904.

Polymorphism and mutation databases

BioMutaiVSTM2L.
DMDMi27151481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001516425 – 204V-set and transmembrane domain-containing protein 2-like proteinAdd BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 142PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ96N03.
PaxDbiQ96N03.
PeptideAtlasiQ96N03.
PRIDEiQ96N03.

PTM databases

iPTMnetiQ96N03.
PhosphoSitePlusiQ96N03.

Expressioni

Gene expression databases

BgeeiENSG00000132821.
CleanExiHS_VSTM2L.
GenevisibleiQ96N03. HS.

Organism-specific databases

HPAiHPA043832.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542533EBI-948213,EBI-930964
CCM2Q9BSQ53EBI-948213,EBI-1573056

Protein-protein interaction databases

BioGridi126121. 3 interactors.
IntActiQ96N03. 2 interactors.
MINTiMINT-2878612.
STRINGi9606.ENSP00000362560.

Structurei

3D structure databases

ProteinModelPortaliQ96N03.
SMRiQ96N03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 158Ig-likeAdd BLAST118

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IIG5. Eukaryota.
ENOG4111M4F. LUCA.
GeneTreeiENSGT00510000046940.
HOGENOMiHOG000231260.
HOVERGENiHBG052093.
InParanoidiQ96N03.
OMAiQQEDTGK.
OrthoDBiEOG091G0ND0.
PhylomeDBiQ96N03.
TreeFamiTF331739.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96N03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAPLAVALG ALHYLALFLQ LGGATRPAGH APWDNHVSGH ALFTETPHDM
60 70 80 90 100
TARTGEDVEM ACSFRGSGSP SYSLEIQWWY VRSHRDWTDK QAWASNQLKA
110 120 130 140 150
SQQEDAGKEA TKISVVKVVG SNISHKLRLS RVKPTDEGTY ECRVIDFSDG
160 170 180 190 200
KARHHKVKAY LRVQPGENSV LHLPEAPPAA PAPPPPKPGK ELRKRSVDQE

ACSL
Length:204
Mass (Da):22,349
Last modified:December 1, 2001 - v1
Checksum:i79917025B4C8425E
GO
Isoform 2 (identifier: Q96N03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-114: Missing.
     167-204: Missing.

Note: Gene prediction based on EST data.
Show »
Length:149
Mass (Da):16,554
Checksum:i26AB2723281561E6
GO
Isoform 3 (identifier: Q96N03-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-132: ALFTETPHDM...ISHKLRLSRV → GGQGGGQQHL...GGPGGLQPLD
     133-204: Missing.

Note: Gene prediction based on EST data.
Show »
Length:132
Mass (Da):13,528
Checksum:i61891B30E4B179A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139T → S in AAH33818 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02651241 – 132ALFTE…RLSRV → GGQGGGQQHLPQAAPVPGEA HGRRHLRVPRHRLQRRQGPA PQGQGLPAGAARGELRPASA RSPSRRARPAAPQARQGAEE ALGGPGGLQPLD in isoform 3. CuratedAdd BLAST92
Alternative sequenceiVSP_01338098 – 114Missing in isoform 2. CuratedAdd BLAST17
Alternative sequenceiVSP_026513133 – 204Missing in isoform 3. CuratedAdd BLAST72
Alternative sequenceiVSP_026514167 – 204Missing in isoform 2. CuratedAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056177 mRNA. Translation: BAB71113.1.
AL834410 mRNA. Translation: CAD39072.2.
AL109964 Genomic DNA. Translation: CAI42205.1.
AL109964 Genomic DNA. Translation: CAI42206.2.
AL109964 Genomic DNA. Translation: CAI42207.1.
CH471077 Genomic DNA. Translation: EAW76051.1.
CH471077 Genomic DNA. Translation: EAW76053.1.
BC033818 mRNA. Translation: AAH33818.1.
CCDSiCCDS13299.1. [Q96N03-1]
RefSeqiNP_542174.1. NM_080607.2. [Q96N03-1]
UniGeneiHs.517029.

Genome annotation databases

EnsembliENST00000373459; ENSP00000362558; ENSG00000132821. [Q96N03-3]
ENST00000373461; ENSP00000362560; ENSG00000132821. [Q96N03-1]
ENST00000448944; ENSP00000406537; ENSG00000132821. [Q96N03-2]
GeneIDi128434.
KEGGihsa:128434.
UCSCiuc002xhk.5. human. [Q96N03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056177 mRNA. Translation: BAB71113.1.
AL834410 mRNA. Translation: CAD39072.2.
AL109964 Genomic DNA. Translation: CAI42205.1.
AL109964 Genomic DNA. Translation: CAI42206.2.
AL109964 Genomic DNA. Translation: CAI42207.1.
CH471077 Genomic DNA. Translation: EAW76051.1.
CH471077 Genomic DNA. Translation: EAW76053.1.
BC033818 mRNA. Translation: AAH33818.1.
CCDSiCCDS13299.1. [Q96N03-1]
RefSeqiNP_542174.1. NM_080607.2. [Q96N03-1]
UniGeneiHs.517029.

3D structure databases

ProteinModelPortaliQ96N03.
SMRiQ96N03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126121. 3 interactors.
IntActiQ96N03. 2 interactors.
MINTiMINT-2878612.
STRINGi9606.ENSP00000362560.

PTM databases

iPTMnetiQ96N03.
PhosphoSitePlusiQ96N03.

Polymorphism and mutation databases

BioMutaiVSTM2L.
DMDMi27151481.

Proteomic databases

MaxQBiQ96N03.
PaxDbiQ96N03.
PeptideAtlasiQ96N03.
PRIDEiQ96N03.

Protocols and materials databases

DNASUi128434.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373459; ENSP00000362558; ENSG00000132821. [Q96N03-3]
ENST00000373461; ENSP00000362560; ENSG00000132821. [Q96N03-1]
ENST00000448944; ENSP00000406537; ENSG00000132821. [Q96N03-2]
GeneIDi128434.
KEGGihsa:128434.
UCSCiuc002xhk.5. human. [Q96N03-1]

Organism-specific databases

CTDi128434.
GeneCardsiVSTM2L.
HGNCiHGNC:16096. VSTM2L.
HPAiHPA043832.
neXtProtiNX_Q96N03.
OpenTargetsiENSG00000132821.
PharmGKBiPA162408904.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIG5. Eukaryota.
ENOG4111M4F. LUCA.
GeneTreeiENSGT00510000046940.
HOGENOMiHOG000231260.
HOVERGENiHBG052093.
InParanoidiQ96N03.
OMAiQQEDTGK.
OrthoDBiEOG091G0ND0.
PhylomeDBiQ96N03.
TreeFamiTF331739.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132821-MONOMER.

Miscellaneous databases

ChiTaRSiVSTM2L. human.
GenomeRNAii128434.
PROiQ96N03.

Gene expression databases

BgeeiENSG00000132821.
CleanExiHS_VSTM2L.
GenevisibleiQ96N03. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVTM2L_HUMAN
AccessioniPrimary (citable) accession number: Q96N03
Secondary accession number(s): E1P5V7
, Q5JWZ4, Q5JWZ5, Q8ND45, Q9BR37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.