Q96MY7 (F161B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM161B

Gene names

Name:	FAM161B
Synonyms:	C14orf44

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with FAM161A. Ref.4
Tissue specificity	Ubiquitously expressed. Ref.4
Sequence similarities	Belongs to the FAM161 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96MY7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96MY7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGENRPIGKRTLPPRAGWIGGCPGSQPDAKARKGWTLAPHSSRCHRCCHYRCHCRCCLCPAEM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 647	647	Protein FAM161B		PRO_0000089890
Regions
	Coiled coil	262 – 292	31	Potential
	Coiled coil	510 – 546	37	Potential
Natural variations
	Alternative sequence	1	1	M → MRGENRPIGKRTLPPRAGWI GGCPGSQPDAKARKGWTLAP HSSRCHRCCHYRCHCRCCLC PAEM in isoform 2.		VSP_046328
	Natural variant	11	1	G → A. Corresponds to variant rs11848954 [ dbSNP | Ensembl ].		VAR_027963
	Natural variant	487	1	K → R. Ref.1 Corresponds to variant rs28927675 [ dbSNP | Ensembl ].		VAR_069168
	Natural variant	622	1	L → P. Corresponds to variant rs17094077 [ dbSNP | Ensembl ].		VAR_027964
Experimental info
	Sequence conflict	57	1	I → M in BAB71131. Ref.1
	Sequence conflict	96	1	N → S in BAH13868. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 11EB0F73E24F2948	FASTA	647	73,647
	10 20 30 40 50 60 MTVGRPEGAP GGAEGSRQIF PPESFADTEA GEELSGDGLV LPRASKLDEF LSPEEEIDST 70 80 90 100 110 120 SDSTGSIYQN LQELKQKGRW CLLESLFQSD PESDENLSED EEDLESFFQD KDRGMVQVQC 130 140 150 160 170 180 PQALRCGSTR RCSSLNNLPS NIPRPQTQPP SGSRPPSQHR SVSSWASSIT VPRPFRMTLR 190 200 210 220 230 240 EARKKAEWLG SPASFEQERQ RAQRQGEEEA ECHRQFRAQP VPAHVYLPLY QEIMERSEAR 250 260 270 280 290 300 RQAGIQKRKE LLLSSLKPFS FLEKEEQLKE AARQRDLAAT AEAKISKQKA TRRIPKSILE 310 320 330 340 350 360 PALGDKLQEA ELFRKIRIQM RALDMLQMAS SPIASSSNRA NPQPRTATRT QQEKLGFLHT 370 380 390 400 410 420 NFRFQPRVNP VVPDYEGLYK AFQRRAAKRR ETQEATRNKP FLLRTANLRH PQRPCDAATT 430 440 450 460 470 480 GRRQDSPQPP ATPLPRSRSL SGLASLSANT LPVHITDATR KRESAVRSAL EKKNKADESI 490 500 510 520 530 540 QWLEIHKKKS QAMSKSVTLR AKAMDPHKSL EEVFKAKLKE NRNNDRKRAK EYKKELEEMK 550 560 570 580 590 600 QRIQTRPYLF EQVAKDLAKK EAEQWYLDTL KQAGLEEDFV RNKGQGTRAV QEKETKIKDF 610 620 630 640 PRFQETTKLS IRDPEQGLEG SLEQPASPRK VLEELSHQSP ENLVSLA
	Isoform 2 [UniParc]. Checksum: 4987BCB424E2E3C8	FASTA	710	80,660
	10 20 30 40 50 60 MRGENRPIGK RTLPPRAGWI GGCPGSQPDA KARKGWTLAP HSSRCHRCCH YRCHCRCCLC 70 80 90 100 110 120 PAEMTVGRPE GAPGGAEGSR QIFPPESFAD TEAGEELSGD GLVLPRASKL DEFLSPEEEI 130 140 150 160 170 180 DSTSDSTGSI YQNLQELKQK GRWCLLESLF QSDPESDENL SEDEEDLESF FQDKDRGMVQ 190 200 210 220 230 240 VQCPQALRCG STRRCSSLNN LPSNIPRPQT QPPSGSRPPS QHRSVSSWAS SITVPRPFRM 250 260 270 280 290 300 TLREARKKAE WLGSPASFEQ ERQRAQRQGE EEAECHRQFR AQPVPAHVYL PLYQEIMERS 310 320 330 340 350 360 EARRQAGIQK RKELLLSSLK PFSFLEKEEQ LKEAARQRDL AATAEAKISK QKATRRIPKS 370 380 390 400 410 420 ILEPALGDKL QEAELFRKIR IQMRALDMLQ MASSPIASSS NRANPQPRTA TRTQQEKLGF 430 440 450 460 470 480 LHTNFRFQPR VNPVVPDYEG LYKAFQRRAA KRRETQEATR NKPFLLRTAN LRHPQRPCDA 490 500 510 520 530 540 ATTGRRQDSP QPPATPLPRS RSLSGLASLS ANTLPVHITD ATRKRESAVR SALEKKNKAD 550 560 570 580 590 600 ESIQWLEIHK KKSQAMSKSV TLRAKAMDPH KSLEEVFKAK LKENRNNDRK RAKEYKKELE 610 620 630 640 650 660 EMKQRIQTRP YLFEQVAKDL AKKEAEQWYL DTLKQAGLEE DFVRNKGQGT RAVQEKETKI 670 680 690 700 710 KDFPRFQETT KLSIRDPEQG LEGSLEQPAS PRKVLEELSH QSPENLVSLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-487. Tissue: Neuron and Testis.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[4]	"The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association." Zach F., Grassmann F., Langmann T., Sorusch N., Wolfrum U., Stohr H. Hum. Mol. Genet. 21:4573-4586(2012) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH FAM161A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056259 mRNA. Translation: BAB71131.1. AK302982 mRNA. Translation: BAH13868.1. AC005480 Genomic DNA. No translation available. BC053909 mRNA. Translation: AAH53909.1.
IPI	IPI00043526. IPI01009729.
RefSeq	NP_689658.2. NM_152445.2.
UniGene	Hs.550547. Hs.660789.
3D structure databases
ProteinModelPortal	Q96MY7.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1195327.
PTM databases
PhosphoSite	Q96MY7.
Polymorphism databases
DMDM	116241303.
Proteomic databases
PaxDb	Q96MY7.
PRIDE	Q96MY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286544; ENSP00000286544; ENSG00000156050. ENST00000534936; ENSP00000445326; ENSG00000156050.
GeneID	145483.
KEGG	hsa:145483.
Organism-specific databases
CTD	145483.
GeneCards	GC14M074400.
HGNC	HGNC:19854. FAM161B.
HPA	HPA019125.
neXtProt	NX_Q96MY7.
PharmGKB	PA162386893.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80167.
HOVERGEN	HBG051009.
InParanoid	Q96MY7.
OrthoDB	EOG4W3SN9.
PhylomeDB	Q96MY7.
Gene expression databases
Bgee	Q96MY7.
CleanEx	HS_FAM161B.
Genevestigator	Q96MY7.
GermOnline	ENSG00000156050. Homo sapiens.
Family and domain databases
InterPro	IPR019579. UPF0564. [Graphical view]
Pfam	PF10595. UPF0564. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	145483.
NextBio	35534861.

Entry information

Entry name

F161B_HUMAN

Accession

Primary (citable) accession number: Q96MY7
Secondary accession number(s): B7Z882, J3KNA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.