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Protein

Nucleolar protein 4-like

Gene

NOL4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 4-like
Gene namesi
Name:NOL4L
Synonyms:C20orf112, C20orf113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000197183.12
HGNCiHGNC:16106 NOL4L
neXtProtiNX_Q96MY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi140688
OpenTargetsiENSG00000197183
PharmGKBiPA25652

Polymorphism and mutation databases

BioMutaiC20orf112
DMDMi28212212

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794561 – 436Nucleolar protein 4-likeAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96MY1
MaxQBiQ96MY1
PaxDbiQ96MY1
PeptideAtlasiQ96MY1
PRIDEiQ96MY1

PTM databases

iPTMnetiQ96MY1
PhosphoSitePlusiQ96MY1

Expressioni

Gene expression databases

BgeeiENSG00000197183
CleanExiHS_C20orf112
ExpressionAtlasiQ96MY1 baseline and differential
GenevisibleiQ96MY1 HS

Organism-specific databases

HPAiHPA041768
HPA043600

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1266516 interactors.
IntActiQ96MY1 3 interactors.
STRINGi9606.ENSP00000352704

Structurei

3D structure databases

ProteinModelPortaliQ96MY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi161 – 169Poly-Asp9

Phylogenomic databases

eggNOGiENOG410IHZD Eukaryota
ENOG410YIBB LUCA
GeneTreeiENSGT00390000017363
HOGENOMiHOG000220856
HOVERGENiHBG031438
InParanoidiQ96MY1
PhylomeDBiQ96MY1
TreeFamiTF325594

Family and domain databases

InterProiView protein in InterPro
IPR026746 NOL4L
PANTHERiPTHR12449:SF19 PTHR12449:SF19, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSTWMSAD PHLASSLSPS QDERMRSPQN LHSQEDDDSS SESGSGNGSS
60 70 80 90 100
TLNPSTSSST QGDPAFPEMN GNGAVAPMDF TTAAEDQPIN LCDKLPPATA
110 120 130 140 150
LGTASYPSDG CGADGLRSRV KYGVKTTPES PPYSSGSYDS IKTEVSGCPE
160 170 180 190 200
DLTVGRAPTA DDDDDDHDDH EDNDKMNDSE GMDPERLKAF NMFVRLFVDE
210 220 230 240 250
NLDRMVPISK QPKEKIQAII ESCSRQFPEF QERARKRIRT YLKSCRRMKK
260 270 280 290 300
NGMEMTRPTP PHLTSAMAEN ILAAACESET RKAAKRMRLE IYQSSQDEPI
310 320 330 340 350
ALDKQHSRDS AAITHSTYSL PASSYSQDPV YANGGLNYSY RGYGALSSNL
360 370 380 390 400
QPPASLQTGN HSNGPTDLSM KGGASTTSTT PTPTPSSTST SRPVPTAQLS
410 420 430
PTEISAVRQL IAGYRESAAF LLRSADELEN LILQQN
Length:436
Mass (Da):47,215
Last modified:February 1, 2003 - v2
Checksum:i139A07537D875DF8
GO
Isoform 2 (identifier: Q96MY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-398: TPTPSSTSTSRPVPTAQ → SALSGEPPTRRWGCSSV
     399-436: Missing.

Note: No experimental confirmation available.
Show »
Length:398
Mass (Da):43,077
Checksum:i1819B33D042BC9B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215K → E in BAB71138 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014667382 – 398TPTPS…VPTAQ → SALSGEPPTRRWGCSSV in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_014668399 – 436Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056286 mRNA Translation: BAB71138.1
AL034550 Genomic DNA No translation available.
BC065370 mRNA Translation: AAH65370.1
CCDSiCCDS13202.1 [Q96MY1-1]
RefSeqiNP_001243727.1, NM_001256798.1
NP_542183.2, NM_080616.4 [Q96MY1-1]
XP_005260345.1, XM_005260288.2 [Q96MY1-1]
XP_005260346.1, XM_005260289.4 [Q96MY1-1]
XP_016883158.1, XM_017027669.1 [Q96MY1-1]
UniGeneiHs.516978
Hs.729596

Genome annotation databases

EnsembliENST00000359676; ENSP00000352704; ENSG00000197183 [Q96MY1-1]
GeneIDi140688
KEGGihsa:140688
UCSCiuc002wxu.6 human [Q96MY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNOL4L_HUMAN
AccessioniPrimary (citable) accession number: Q96MY1
Secondary accession number(s): Q5JYB7
, Q6P0Y4, Q9BR34, Q9NQF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: March 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome