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Q96MY1

- NOL4L_HUMAN

UniProt

Q96MY1 - NOL4L_HUMAN

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Protein
Nucleolar protein 4-like
Gene
NOL4L, C20orf112, C20orf113
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 4-like
Gene namesi
Name:NOL4L
Synonyms:C20orf112, C20orf113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16106. NOL4L.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Nucleolar protein 4-like
PRO_0000079456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96MY1.
PaxDbiQ96MY1.
PRIDEiQ96MY1.

PTM databases

PhosphoSiteiQ96MY1.

Expressioni

Gene expression databases

ArrayExpressiQ96MY1.
BgeeiQ96MY1.
CleanExiHS_C20orf112.
GenevestigatoriQ96MY1.

Organism-specific databases

HPAiHPA041768.
HPA043600.

Interactioni

Protein-protein interaction databases

BioGridi126651. 1 interaction.
IntActiQ96MY1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96MY1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi161 – 1699Poly-Asp

Phylogenomic databases

eggNOGiNOG76509.
HOGENOMiHOG000220856.
HOVERGENiHBG031438.
InParanoidiQ96MY1.
OMAiMNDSTWI.
PhylomeDBiQ96MY1.
TreeFamiTF325594.

Family and domain databases

InterProiIPR026746. UPF_C20orf112.
[Graphical view]
PANTHERiPTHR12449:SF16. PTHR12449:SF16. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96MY1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDSTWMSAD PHLASSLSPS QDERMRSPQN LHSQEDDDSS SESGSGNGSS    50
TLNPSTSSST QGDPAFPEMN GNGAVAPMDF TTAAEDQPIN LCDKLPPATA 100
LGTASYPSDG CGADGLRSRV KYGVKTTPES PPYSSGSYDS IKTEVSGCPE 150
DLTVGRAPTA DDDDDDHDDH EDNDKMNDSE GMDPERLKAF NMFVRLFVDE 200
NLDRMVPISK QPKEKIQAII ESCSRQFPEF QERARKRIRT YLKSCRRMKK 250
NGMEMTRPTP PHLTSAMAEN ILAAACESET RKAAKRMRLE IYQSSQDEPI 300
ALDKQHSRDS AAITHSTYSL PASSYSQDPV YANGGLNYSY RGYGALSSNL 350
QPPASLQTGN HSNGPTDLSM KGGASTTSTT PTPTPSSTST SRPVPTAQLS 400
PTEISAVRQL IAGYRESAAF LLRSADELEN LILQQN 436
Length:436
Mass (Da):47,215
Last modified:February 1, 2003 - v2
Checksum:i139A07537D875DF8
GO
Isoform 2 (identifier: Q96MY1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-398: TPTPSSTSTSRPVPTAQ → SALSGEPPTRRWGCSSV
     399-436: Missing.

Note: No experimental confirmation available.

Show »
Length:398
Mass (Da):43,077
Checksum:i1819B33D042BC9B8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei382 – 39817TPTPS…VPTAQ → SALSGEPPTRRWGCSSV in isoform 2.
VSP_014667Add
BLAST
Alternative sequencei399 – 43638Missing in isoform 2.
VSP_014668Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2151K → E in BAB71138. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056286 mRNA. Translation: BAB71138.1.
AL034550 Genomic DNA. Translation: CAI42261.1.
BC065370 mRNA. Translation: AAH65370.1.
CCDSiCCDS13202.1. [Q96MY1-1]
RefSeqiNP_001243727.1. NM_001256798.1.
NP_542183.2. NM_080616.4. [Q96MY1-1]
XP_005260345.1. XM_005260288.1. [Q96MY1-1]
XP_005260346.1. XM_005260289.2. [Q96MY1-1]
XP_005260347.1. XM_005260290.1. [Q96MY1-1]
UniGeneiHs.516978.
Hs.729596.

Genome annotation databases

EnsembliENST00000359676; ENSP00000352704; ENSG00000197183. [Q96MY1-1]
GeneIDi140688.
KEGGihsa:140688.
UCSCiuc002wxu.5. human. [Q96MY1-1]

Polymorphism databases

DMDMi28212212.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056286 mRNA. Translation: BAB71138.1 .
AL034550 Genomic DNA. Translation: CAI42261.1 .
BC065370 mRNA. Translation: AAH65370.1 .
CCDSi CCDS13202.1. [Q96MY1-1 ]
RefSeqi NP_001243727.1. NM_001256798.1.
NP_542183.2. NM_080616.4. [Q96MY1-1 ]
XP_005260345.1. XM_005260288.1. [Q96MY1-1 ]
XP_005260346.1. XM_005260289.2. [Q96MY1-1 ]
XP_005260347.1. XM_005260290.1. [Q96MY1-1 ]
UniGenei Hs.516978.
Hs.729596.

3D structure databases

ProteinModelPortali Q96MY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126651. 1 interaction.
IntActi Q96MY1. 1 interaction.

PTM databases

PhosphoSitei Q96MY1.

Polymorphism databases

DMDMi 28212212.

Proteomic databases

MaxQBi Q96MY1.
PaxDbi Q96MY1.
PRIDEi Q96MY1.

Protocols and materials databases

DNASUi 140688.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359676 ; ENSP00000352704 ; ENSG00000197183 . [Q96MY1-1 ]
GeneIDi 140688.
KEGGi hsa:140688.
UCSCi uc002wxu.5. human. [Q96MY1-1 ]

Organism-specific databases

CTDi 140688.
GeneCardsi GC20M031030.
H-InvDB HIX0015727.
HIX0015728.
HGNCi HGNC:16106. NOL4L.
HPAi HPA041768.
HPA043600.
neXtProti NX_Q96MY1.
PharmGKBi PA25652.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76509.
HOGENOMi HOG000220856.
HOVERGENi HBG031438.
InParanoidi Q96MY1.
OMAi MNDSTWI.
PhylomeDBi Q96MY1.
TreeFami TF325594.

Miscellaneous databases

GenomeRNAii 140688.
NextBioi 84231.

Gene expression databases

ArrayExpressi Q96MY1.
Bgeei Q96MY1.
CleanExi HS_C20orf112.
Genevestigatori Q96MY1.

Family and domain databases

InterProi IPR026746. UPF_C20orf112.
[Graphical view ]
PANTHERi PTHR12449:SF16. PTHR12449:SF16. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Neuron.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNOL4L_HUMAN
AccessioniPrimary (citable) accession number: Q96MY1
Secondary accession number(s): Q5JYB7
, Q6P0Y4, Q9BR34, Q9NQF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: September 3, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

External Data

Dasty 3

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