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Q96MY1

- NOL4L_HUMAN

UniProt

Q96MY1 - NOL4L_HUMAN

Protein

Nucleolar protein 4-like

Gene

NOL4L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Feb 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar protein 4-like
    Gene namesi
    Name:NOL4L
    Synonyms:C20orf112, C20orf113
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16106. NOL4L.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25652.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Nucleolar protein 4-likePRO_0000079456Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96MY1.
    PaxDbiQ96MY1.
    PRIDEiQ96MY1.

    PTM databases

    PhosphoSiteiQ96MY1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96MY1.
    BgeeiQ96MY1.
    CleanExiHS_C20orf112.
    GenevestigatoriQ96MY1.

    Organism-specific databases

    HPAiHPA041768.
    HPA043600.

    Interactioni

    Protein-protein interaction databases

    BioGridi126651. 1 interaction.
    IntActiQ96MY1. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96MY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi161 – 1699Poly-Asp

    Phylogenomic databases

    eggNOGiNOG76509.
    HOGENOMiHOG000220856.
    HOVERGENiHBG031438.
    InParanoidiQ96MY1.
    OMAiMNDSTWI.
    PhylomeDBiQ96MY1.
    TreeFamiTF325594.

    Family and domain databases

    InterProiIPR026746. UPF_C20orf112.
    [Graphical view]
    PANTHERiPTHR12449:SF16. PTHR12449:SF16. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96MY1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDSTWMSAD PHLASSLSPS QDERMRSPQN LHSQEDDDSS SESGSGNGSS    50
    TLNPSTSSST QGDPAFPEMN GNGAVAPMDF TTAAEDQPIN LCDKLPPATA 100
    LGTASYPSDG CGADGLRSRV KYGVKTTPES PPYSSGSYDS IKTEVSGCPE 150
    DLTVGRAPTA DDDDDDHDDH EDNDKMNDSE GMDPERLKAF NMFVRLFVDE 200
    NLDRMVPISK QPKEKIQAII ESCSRQFPEF QERARKRIRT YLKSCRRMKK 250
    NGMEMTRPTP PHLTSAMAEN ILAAACESET RKAAKRMRLE IYQSSQDEPI 300
    ALDKQHSRDS AAITHSTYSL PASSYSQDPV YANGGLNYSY RGYGALSSNL 350
    QPPASLQTGN HSNGPTDLSM KGGASTTSTT PTPTPSSTST SRPVPTAQLS 400
    PTEISAVRQL IAGYRESAAF LLRSADELEN LILQQN 436
    Length:436
    Mass (Da):47,215
    Last modified:February 1, 2003 - v2
    Checksum:i139A07537D875DF8
    GO
    Isoform 2 (identifier: Q96MY1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         382-398: TPTPSSTSTSRPVPTAQ → SALSGEPPTRRWGCSSV
         399-436: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:398
    Mass (Da):43,077
    Checksum:i1819B33D042BC9B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti215 – 2151K → E in BAB71138. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei382 – 39817TPTPS…VPTAQ → SALSGEPPTRRWGCSSV in isoform 2. 1 PublicationVSP_014667Add
    BLAST
    Alternative sequencei399 – 43638Missing in isoform 2. 1 PublicationVSP_014668Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056286 mRNA. Translation: BAB71138.1.
    AL034550 Genomic DNA. Translation: CAI42261.1.
    BC065370 mRNA. Translation: AAH65370.1.
    CCDSiCCDS13202.1. [Q96MY1-1]
    RefSeqiNP_001243727.1. NM_001256798.1.
    NP_542183.2. NM_080616.4. [Q96MY1-1]
    XP_005260345.1. XM_005260288.1. [Q96MY1-1]
    XP_005260346.1. XM_005260289.2. [Q96MY1-1]
    XP_005260347.1. XM_005260290.1. [Q96MY1-1]
    UniGeneiHs.516978.
    Hs.729596.

    Genome annotation databases

    EnsembliENST00000359676; ENSP00000352704; ENSG00000197183. [Q96MY1-1]
    GeneIDi140688.
    KEGGihsa:140688.
    UCSCiuc002wxu.5. human. [Q96MY1-1]

    Polymorphism databases

    DMDMi28212212.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056286 mRNA. Translation: BAB71138.1 .
    AL034550 Genomic DNA. Translation: CAI42261.1 .
    BC065370 mRNA. Translation: AAH65370.1 .
    CCDSi CCDS13202.1. [Q96MY1-1 ]
    RefSeqi NP_001243727.1. NM_001256798.1.
    NP_542183.2. NM_080616.4. [Q96MY1-1 ]
    XP_005260345.1. XM_005260288.1. [Q96MY1-1 ]
    XP_005260346.1. XM_005260289.2. [Q96MY1-1 ]
    XP_005260347.1. XM_005260290.1. [Q96MY1-1 ]
    UniGenei Hs.516978.
    Hs.729596.

    3D structure databases

    ProteinModelPortali Q96MY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126651. 1 interaction.
    IntActi Q96MY1. 1 interaction.

    PTM databases

    PhosphoSitei Q96MY1.

    Polymorphism databases

    DMDMi 28212212.

    Proteomic databases

    MaxQBi Q96MY1.
    PaxDbi Q96MY1.
    PRIDEi Q96MY1.

    Protocols and materials databases

    DNASUi 140688.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359676 ; ENSP00000352704 ; ENSG00000197183 . [Q96MY1-1 ]
    GeneIDi 140688.
    KEGGi hsa:140688.
    UCSCi uc002wxu.5. human. [Q96MY1-1 ]

    Organism-specific databases

    CTDi 140688.
    GeneCardsi GC20M031030.
    H-InvDB HIX0015727.
    HIX0015728.
    HGNCi HGNC:16106. NOL4L.
    HPAi HPA041768.
    HPA043600.
    neXtProti NX_Q96MY1.
    PharmGKBi PA25652.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76509.
    HOGENOMi HOG000220856.
    HOVERGENi HBG031438.
    InParanoidi Q96MY1.
    OMAi MNDSTWI.
    PhylomeDBi Q96MY1.
    TreeFami TF325594.

    Miscellaneous databases

    GenomeRNAii 140688.
    NextBioi 84231.

    Gene expression databases

    ArrayExpressi Q96MY1.
    Bgeei Q96MY1.
    CleanExi HS_C20orf112.
    Genevestigatori Q96MY1.

    Family and domain databases

    InterProi IPR026746. UPF_C20orf112.
    [Graphical view ]
    PANTHERi PTHR12449:SF16. PTHR12449:SF16. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Neuron.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiNOL4L_HUMAN
    AccessioniPrimary (citable) accession number: Q96MY1
    Secondary accession number(s): Q5JYB7
    , Q6P0Y4, Q9BR34, Q9NQF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: February 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM

    External Data

    Dasty 3