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Q96MX6

- WDR92_HUMAN

UniProt

Q96MX6 - WDR92_HUMAN

Protein

WD repeat-containing protein 92

Gene

WDR92

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Seems to act as a modulator of apoptosis.1 Publication

    GO - Molecular functioni

    1. methylated histone binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. histone lysine methylation Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    SignaLinkiQ96MX6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 92
    Alternative name(s):
    WD repeat-containing protein Monad
    Gene namesi
    Name:WDR92
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25176. WDR92.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409167.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357WD repeat-containing protein 92PRO_0000301671Add
    BLAST

    Proteomic databases

    MaxQBiQ96MX6.
    PRIDEiQ96MX6.

    PTM databases

    PhosphoSiteiQ96MX6.

    Expressioni

    Tissue specificityi

    Widely expressed with the highest expression in testis.1 Publication

    Gene expression databases

    BgeeiQ96MX6.
    CleanExiHS_WDR92.
    GenevestigatoriQ96MX6.

    Organism-specific databases

    HPAiHPA035335.
    HPA035336.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RPAP3Q9H6T35EBI-2434101,EBI-356928

    Protein-protein interaction databases

    BioGridi125479. 15 interactions.
    IntActiQ96MX6. 5 interactions.
    MINTiMINT-3056106.
    STRINGi9606.ENSP00000295121.

    Structurei

    Secondary structure

    1
    357
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 168
    Beta strandi18 – 269
    Beta strandi30 – 389
    Beta strandi44 – 518
    Beta strandi53 – 6614
    Beta strandi68 – 725
    Turni78 – 803
    Beta strandi83 – 875
    Beta strandi92 – 954
    Beta strandi104 – 1074
    Beta strandi114 – 1218
    Helixi122 – 1243
    Beta strandi131 – 1366
    Beta strandi141 – 1444
    Beta strandi153 – 1564
    Beta strandi167 – 1737
    Beta strandi182 – 1876
    Beta strandi190 – 1967
    Turni197 – 2004
    Beta strandi201 – 2077
    Beta strandi212 – 2187
    Beta strandi220 – 2234
    Beta strandi226 – 2327
    Beta strandi235 – 2406
    Turni246 – 2483
    Beta strandi252 – 2565
    Beta strandi262 – 2687
    Beta strandi271 – 2799
    Beta strandi282 – 2909
    Beta strandi310 – 3189
    Beta strandi324 – 3296
    Beta strandi331 – 3333
    Beta strandi336 – 3416
    Beta strandi344 – 3518

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3I2NX-ray1.95A1-357[»]
    ProteinModelPortaliQ96MX6.
    SMRiQ96MX6. Positions 5-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96MX6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati63 – 10543WD 1Add
    BLAST
    Repeati115 – 15440WD 2Add
    BLAST
    Repeati162 – 20544WD 3Add
    BLAST
    Repeati207 – 24943WD 4Add
    BLAST
    Repeati257 – 29741WD 5Add
    BLAST
    Repeati319 – 35739WD 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    HOVERGENiHBG055572.
    InParanoidiQ96MX6.
    OMAiDIPMNKL.
    OrthoDBiEOG75QR5D.
    PhylomeDBiQ96MX6.
    TreeFamiTF351064.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96MX6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAFEKPQII AHIQKGFNYT VFDCKWVPCS AKFVTMGNFA RGTGVIQLYE    50
    IQHGDLKLLR EIEKAKPIKC GTFGATSLQQ RYLATGDFGG NLHIWNLEAP 100
    EMPVYSVKGH KEIINAIDGI GGLGIGEGAP EIVTGSRDGT VKVWDPRQKD 150
    DPVANMEPVQ GENKRDCWTV AFGNAYNQEE RVVCAGYDNG DIKLFDLRNM 200
    ALRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD MRTQHPTKGF 250
    ASVSEKAHKS TVWQVRHLPQ NRELFLTAGG AGGLHLWKYE YPIQRSKKDS 300
    EGIEMGVAGS VSLLQNVTLS TQPISSLDWS PDKRGLCVCS SFDQTVRVLI 350
    VTKLNKI 357
    Length:357
    Mass (Da):39,740
    Last modified:December 1, 2001 - v1
    Checksum:iCD48E8A09D8A8F95
    GO
    Isoform 2 (identifier: Q96MX6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         289-357: Missing.

    Show »
    Length:288
    Mass (Da):32,128
    Checksum:i5C4798B25D1E54D1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti241 – 2411M → V.
    Corresponds to variant rs13009282 [ dbSNP | Ensembl ].
    VAR_053438

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei289 – 35769Missing in isoform 2. CuratedVSP_045123Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056303 mRNA. Translation: BAB71143.1.
    AC017083 Genomic DNA. Translation: AAY14713.1.
    BC014022 mRNA. Translation: AAH14022.2.
    BC066657 mRNA. Translation: AAH66657.1.
    CCDSiCCDS1884.1. [Q96MX6-1]
    CCDS58712.1. [Q96MX6-2]
    RefSeqiNP_001243405.1. NM_001256476.1. [Q96MX6-2]
    NP_612467.1. NM_138458.3. [Q96MX6-1]
    UniGeneiHs.631877.

    Genome annotation databases

    EnsembliENST00000295121; ENSP00000295121; ENSG00000243667. [Q96MX6-1]
    ENST00000409164; ENSP00000386746; ENSG00000243667. [Q96MX6-2]
    GeneIDi116143.
    KEGGihsa:116143.
    UCSCiuc002see.2. human. [Q96MX6-1]

    Polymorphism databases

    DMDMi74760987.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056303 mRNA. Translation: BAB71143.1 .
    AC017083 Genomic DNA. Translation: AAY14713.1 .
    BC014022 mRNA. Translation: AAH14022.2 .
    BC066657 mRNA. Translation: AAH66657.1 .
    CCDSi CCDS1884.1. [Q96MX6-1 ]
    CCDS58712.1. [Q96MX6-2 ]
    RefSeqi NP_001243405.1. NM_001256476.1. [Q96MX6-2 ]
    NP_612467.1. NM_138458.3. [Q96MX6-1 ]
    UniGenei Hs.631877.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3I2N X-ray 1.95 A 1-357 [» ]
    ProteinModelPortali Q96MX6.
    SMRi Q96MX6. Positions 5-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125479. 15 interactions.
    IntActi Q96MX6. 5 interactions.
    MINTi MINT-3056106.
    STRINGi 9606.ENSP00000295121.

    PTM databases

    PhosphoSitei Q96MX6.

    Polymorphism databases

    DMDMi 74760987.

    Proteomic databases

    MaxQBi Q96MX6.
    PRIDEi Q96MX6.

    Protocols and materials databases

    DNASUi 116143.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295121 ; ENSP00000295121 ; ENSG00000243667 . [Q96MX6-1 ]
    ENST00000409164 ; ENSP00000386746 ; ENSG00000243667 . [Q96MX6-2 ]
    GeneIDi 116143.
    KEGGi hsa:116143.
    UCSCi uc002see.2. human. [Q96MX6-1 ]

    Organism-specific databases

    CTDi 116143.
    GeneCardsi GC02M068350.
    HGNCi HGNC:25176. WDR92.
    HPAi HPA035335.
    HPA035336.
    MIMi 610729. gene.
    neXtProti NX_Q96MX6.
    PharmGKBi PA162409167.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG055572.
    InParanoidi Q96MX6.
    OMAi DIPMNKL.
    OrthoDBi EOG75QR5D.
    PhylomeDBi Q96MX6.
    TreeFami TF351064.

    Enzyme and pathway databases

    SignaLinki Q96MX6.

    Miscellaneous databases

    EvolutionaryTracei Q96MX6.
    GenomeRNAii 116143.
    NextBioi 79788.
    PROi Q96MX6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96MX6.
    CleanExi HS_WDR92.
    Genevestigatori Q96MX6.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell and Skin.
    4. "Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha."
      Saeki M., Irie Y., Ni L., Yoshida M., Itsuki Y., Kamisaki Y.
      Biochem. Biophys. Res. Commun. 342:568-572(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Structure and function of WD40 domain proteins."
      Xu C., Min J.
      Protein Cell 2:202-214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

    Entry informationi

    Entry nameiWDR92_HUMAN
    AccessioniPrimary (citable) accession number: Q96MX6
    Secondary accession number(s): Q96CR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3