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Protein

WD repeat-containing protein 92

Gene

WDR92

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a modulator of apoptosis.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163004-MONOMER.
SignaLinkiQ96MX6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 92
Alternative name(s):
WD repeat-containing protein Monad
Gene namesi
Name:WDR92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25176. WDR92.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000243667.
PharmGKBiPA162409167.

Polymorphism and mutation databases

BioMutaiWDR92.
DMDMi74760987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003016711 – 357WD repeat-containing protein 92Add BLAST357

Proteomic databases

EPDiQ96MX6.
MaxQBiQ96MX6.
PaxDbiQ96MX6.
PeptideAtlasiQ96MX6.
PRIDEiQ96MX6.

PTM databases

iPTMnetiQ96MX6.
PhosphoSitePlusiQ96MX6.

Expressioni

Tissue specificityi

Widely expressed with the highest expression in testis.1 Publication

Gene expression databases

BgeeiENSG00000243667.
CleanExiHS_WDR92.
ExpressionAtlasiQ96MX6. baseline and differential.
GenevisibleiQ96MX6. HS.

Organism-specific databases

HPAiHPA035335.
HPA035336.

Interactioni

Subunit structurei

Interacts with PIH1D1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPAP3Q9H6T35EBI-2434101,EBI-356928

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125479. 43 interactors.
IntActiQ96MX6. 25 interactors.
MINTiMINT-3056106.
STRINGi9606.ENSP00000295121.

Structurei

Secondary structure

1357
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 16Combined sources8
Beta strandi18 – 26Combined sources9
Beta strandi30 – 38Combined sources9
Beta strandi44 – 51Combined sources8
Beta strandi53 – 66Combined sources14
Beta strandi68 – 72Combined sources5
Turni78 – 80Combined sources3
Beta strandi83 – 87Combined sources5
Beta strandi92 – 95Combined sources4
Beta strandi104 – 107Combined sources4
Beta strandi114 – 121Combined sources8
Helixi122 – 124Combined sources3
Beta strandi131 – 136Combined sources6
Beta strandi141 – 144Combined sources4
Beta strandi153 – 156Combined sources4
Beta strandi167 – 173Combined sources7
Beta strandi182 – 187Combined sources6
Beta strandi190 – 196Combined sources7
Turni197 – 200Combined sources4
Beta strandi201 – 207Combined sources7
Beta strandi212 – 218Combined sources7
Beta strandi220 – 223Combined sources4
Beta strandi226 – 232Combined sources7
Beta strandi235 – 240Combined sources6
Turni246 – 248Combined sources3
Beta strandi252 – 256Combined sources5
Beta strandi262 – 268Combined sources7
Beta strandi271 – 279Combined sources9
Beta strandi282 – 290Combined sources9
Beta strandi310 – 318Combined sources9
Beta strandi324 – 329Combined sources6
Beta strandi331 – 333Combined sources3
Beta strandi336 – 341Combined sources6
Beta strandi344 – 351Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I2NX-ray1.95A1-357[»]
ProteinModelPortaliQ96MX6.
SMRiQ96MX6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96MX6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 105WD 1Add BLAST43
Repeati115 – 154WD 2Add BLAST40
Repeati162 – 205WD 3Add BLAST44
Repeati207 – 249WD 4Add BLAST43
Repeati257 – 297WD 5Add BLAST41
Repeati319 – 357WD 6Add BLAST39

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IFWY. Eukaryota.
ENOG410XPW4. LUCA.
GeneTreeiENSGT00860000133870.
HOGENOMiHOG000256919.
HOVERGENiHBG055572.
InParanoidiQ96MX6.
OrthoDBiEOG091G0R0W.
PhylomeDBiQ96MX6.
TreeFamiTF351064.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFEKPQII AHIQKGFNYT VFDCKWVPCS AKFVTMGNFA RGTGVIQLYE
60 70 80 90 100
IQHGDLKLLR EIEKAKPIKC GTFGATSLQQ RYLATGDFGG NLHIWNLEAP
110 120 130 140 150
EMPVYSVKGH KEIINAIDGI GGLGIGEGAP EIVTGSRDGT VKVWDPRQKD
160 170 180 190 200
DPVANMEPVQ GENKRDCWTV AFGNAYNQEE RVVCAGYDNG DIKLFDLRNM
210 220 230 240 250
ALRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD MRTQHPTKGF
260 270 280 290 300
ASVSEKAHKS TVWQVRHLPQ NRELFLTAGG AGGLHLWKYE YPIQRSKKDS
310 320 330 340 350
EGIEMGVAGS VSLLQNVTLS TQPISSLDWS PDKRGLCVCS SFDQTVRVLI

VTKLNKI
Length:357
Mass (Da):39,740
Last modified:December 1, 2001 - v1
Checksum:iCD48E8A09D8A8F95
GO
Isoform 2 (identifier: Q96MX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-357: Missing.

Show »
Length:288
Mass (Da):32,128
Checksum:i5C4798B25D1E54D1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053438241M → V.Corresponds to variant rs13009282dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045123289 – 357Missing in isoform 2. CuratedAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056303 mRNA. Translation: BAB71143.1.
AC017083 Genomic DNA. Translation: AAY14713.1.
BC014022 mRNA. Translation: AAH14022.2.
BC066657 mRNA. Translation: AAH66657.1.
CCDSiCCDS1884.1. [Q96MX6-1]
CCDS58712.1. [Q96MX6-2]
RefSeqiNP_001243405.1. NM_001256476.1. [Q96MX6-2]
NP_612467.1. NM_138458.3. [Q96MX6-1]
UniGeneiHs.631877.

Genome annotation databases

EnsembliENST00000295121; ENSP00000295121; ENSG00000243667. [Q96MX6-1]
ENST00000409164; ENSP00000386746; ENSG00000243667. [Q96MX6-2]
GeneIDi116143.
KEGGihsa:116143.
UCSCiuc002see.3. human. [Q96MX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056303 mRNA. Translation: BAB71143.1.
AC017083 Genomic DNA. Translation: AAY14713.1.
BC014022 mRNA. Translation: AAH14022.2.
BC066657 mRNA. Translation: AAH66657.1.
CCDSiCCDS1884.1. [Q96MX6-1]
CCDS58712.1. [Q96MX6-2]
RefSeqiNP_001243405.1. NM_001256476.1. [Q96MX6-2]
NP_612467.1. NM_138458.3. [Q96MX6-1]
UniGeneiHs.631877.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I2NX-ray1.95A1-357[»]
ProteinModelPortaliQ96MX6.
SMRiQ96MX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125479. 43 interactors.
IntActiQ96MX6. 25 interactors.
MINTiMINT-3056106.
STRINGi9606.ENSP00000295121.

PTM databases

iPTMnetiQ96MX6.
PhosphoSitePlusiQ96MX6.

Polymorphism and mutation databases

BioMutaiWDR92.
DMDMi74760987.

Proteomic databases

EPDiQ96MX6.
MaxQBiQ96MX6.
PaxDbiQ96MX6.
PeptideAtlasiQ96MX6.
PRIDEiQ96MX6.

Protocols and materials databases

DNASUi116143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295121; ENSP00000295121; ENSG00000243667. [Q96MX6-1]
ENST00000409164; ENSP00000386746; ENSG00000243667. [Q96MX6-2]
GeneIDi116143.
KEGGihsa:116143.
UCSCiuc002see.3. human. [Q96MX6-1]

Organism-specific databases

CTDi116143.
GeneCardsiWDR92.
HGNCiHGNC:25176. WDR92.
HPAiHPA035335.
HPA035336.
MIMi610729. gene.
neXtProtiNX_Q96MX6.
OpenTargetsiENSG00000243667.
PharmGKBiPA162409167.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFWY. Eukaryota.
ENOG410XPW4. LUCA.
GeneTreeiENSGT00860000133870.
HOGENOMiHOG000256919.
HOVERGENiHBG055572.
InParanoidiQ96MX6.
OrthoDBiEOG091G0R0W.
PhylomeDBiQ96MX6.
TreeFamiTF351064.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163004-MONOMER.
SignaLinkiQ96MX6.

Miscellaneous databases

EvolutionaryTraceiQ96MX6.
GenomeRNAii116143.
PROiQ96MX6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243667.
CleanExiHS_WDR92.
ExpressionAtlasiQ96MX6. baseline and differential.
GenevisibleiQ96MX6. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR92_HUMAN
AccessioniPrimary (citable) accession number: Q96MX6
Secondary accession number(s): Q96CR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.