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Protein

WD repeat-containing protein 92

Gene

WDR92

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a modulator of apoptosis.1 Publication

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • histone lysine methylation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiQ96MX6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 92
Alternative name(s):
WD repeat-containing protein Monad
Gene namesi
Name:WDR92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25176. WDR92.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409167.

Polymorphism and mutation databases

BioMutaiWDR92.
DMDMi74760987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357WD repeat-containing protein 92PRO_0000301671Add
BLAST

Proteomic databases

MaxQBiQ96MX6.
PRIDEiQ96MX6.

PTM databases

PhosphoSiteiQ96MX6.

Expressioni

Tissue specificityi

Widely expressed with the highest expression in testis.1 Publication

Gene expression databases

BgeeiQ96MX6.
CleanExiHS_WDR92.
ExpressionAtlasiQ96MX6. baseline.
GenevestigatoriQ96MX6.

Organism-specific databases

HPAiHPA035335.
HPA035336.

Interactioni

Subunit structurei

Interacts with PIH1D1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPAP3Q9H6T35EBI-2434101,EBI-356928

Protein-protein interaction databases

BioGridi125479. 22 interactions.
IntActiQ96MX6. 5 interactions.
MINTiMINT-3056106.
STRINGi9606.ENSP00000295121.

Structurei

Secondary structure

1
357
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 168Combined sources
Beta strandi18 – 269Combined sources
Beta strandi30 – 389Combined sources
Beta strandi44 – 518Combined sources
Beta strandi53 – 6614Combined sources
Beta strandi68 – 725Combined sources
Turni78 – 803Combined sources
Beta strandi83 – 875Combined sources
Beta strandi92 – 954Combined sources
Beta strandi104 – 1074Combined sources
Beta strandi114 – 1218Combined sources
Helixi122 – 1243Combined sources
Beta strandi131 – 1366Combined sources
Beta strandi141 – 1444Combined sources
Beta strandi153 – 1564Combined sources
Beta strandi167 – 1737Combined sources
Beta strandi182 – 1876Combined sources
Beta strandi190 – 1967Combined sources
Turni197 – 2004Combined sources
Beta strandi201 – 2077Combined sources
Beta strandi212 – 2187Combined sources
Beta strandi220 – 2234Combined sources
Beta strandi226 – 2327Combined sources
Beta strandi235 – 2406Combined sources
Turni246 – 2483Combined sources
Beta strandi252 – 2565Combined sources
Beta strandi262 – 2687Combined sources
Beta strandi271 – 2799Combined sources
Beta strandi282 – 2909Combined sources
Beta strandi310 – 3189Combined sources
Beta strandi324 – 3296Combined sources
Beta strandi331 – 3333Combined sources
Beta strandi336 – 3416Combined sources
Beta strandi344 – 3518Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I2NX-ray1.95A1-357[»]
ProteinModelPortaliQ96MX6.
SMRiQ96MX6. Positions 5-353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96MX6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati63 – 10543WD 1Add
BLAST
Repeati115 – 15440WD 2Add
BLAST
Repeati162 – 20544WD 3Add
BLAST
Repeati207 – 24943WD 4Add
BLAST
Repeati257 – 29741WD 5Add
BLAST
Repeati319 – 35739WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00760000119179.
HOGENOMiHOG000256919.
HOVERGENiHBG055572.
InParanoidiQ96MX6.
OMAiPQNREIF.
OrthoDBiEOG75QR5D.
PhylomeDBiQ96MX6.
TreeFamiTF351064.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFEKPQII AHIQKGFNYT VFDCKWVPCS AKFVTMGNFA RGTGVIQLYE
60 70 80 90 100
IQHGDLKLLR EIEKAKPIKC GTFGATSLQQ RYLATGDFGG NLHIWNLEAP
110 120 130 140 150
EMPVYSVKGH KEIINAIDGI GGLGIGEGAP EIVTGSRDGT VKVWDPRQKD
160 170 180 190 200
DPVANMEPVQ GENKRDCWTV AFGNAYNQEE RVVCAGYDNG DIKLFDLRNM
210 220 230 240 250
ALRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD MRTQHPTKGF
260 270 280 290 300
ASVSEKAHKS TVWQVRHLPQ NRELFLTAGG AGGLHLWKYE YPIQRSKKDS
310 320 330 340 350
EGIEMGVAGS VSLLQNVTLS TQPISSLDWS PDKRGLCVCS SFDQTVRVLI

VTKLNKI
Length:357
Mass (Da):39,740
Last modified:December 1, 2001 - v1
Checksum:iCD48E8A09D8A8F95
GO
Isoform 2 (identifier: Q96MX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-357: Missing.

Show »
Length:288
Mass (Da):32,128
Checksum:i5C4798B25D1E54D1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411M → V.
Corresponds to variant rs13009282 [ dbSNP | Ensembl ].
VAR_053438

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei289 – 35769Missing in isoform 2. CuratedVSP_045123Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056303 mRNA. Translation: BAB71143.1.
AC017083 Genomic DNA. Translation: AAY14713.1.
BC014022 mRNA. Translation: AAH14022.2.
BC066657 mRNA. Translation: AAH66657.1.
CCDSiCCDS1884.1. [Q96MX6-1]
CCDS58712.1. [Q96MX6-2]
RefSeqiNP_001243405.1. NM_001256476.1. [Q96MX6-2]
NP_612467.1. NM_138458.3. [Q96MX6-1]
UniGeneiHs.631877.

Genome annotation databases

EnsembliENST00000295121; ENSP00000295121; ENSG00000243667. [Q96MX6-1]
ENST00000409164; ENSP00000386746; ENSG00000243667. [Q96MX6-2]
GeneIDi116143.
KEGGihsa:116143.
UCSCiuc002see.2. human. [Q96MX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056303 mRNA. Translation: BAB71143.1.
AC017083 Genomic DNA. Translation: AAY14713.1.
BC014022 mRNA. Translation: AAH14022.2.
BC066657 mRNA. Translation: AAH66657.1.
CCDSiCCDS1884.1. [Q96MX6-1]
CCDS58712.1. [Q96MX6-2]
RefSeqiNP_001243405.1. NM_001256476.1. [Q96MX6-2]
NP_612467.1. NM_138458.3. [Q96MX6-1]
UniGeneiHs.631877.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I2NX-ray1.95A1-357[»]
ProteinModelPortaliQ96MX6.
SMRiQ96MX6. Positions 5-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125479. 22 interactions.
IntActiQ96MX6. 5 interactions.
MINTiMINT-3056106.
STRINGi9606.ENSP00000295121.

PTM databases

PhosphoSiteiQ96MX6.

Polymorphism and mutation databases

BioMutaiWDR92.
DMDMi74760987.

Proteomic databases

MaxQBiQ96MX6.
PRIDEiQ96MX6.

Protocols and materials databases

DNASUi116143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295121; ENSP00000295121; ENSG00000243667. [Q96MX6-1]
ENST00000409164; ENSP00000386746; ENSG00000243667. [Q96MX6-2]
GeneIDi116143.
KEGGihsa:116143.
UCSCiuc002see.2. human. [Q96MX6-1]

Organism-specific databases

CTDi116143.
GeneCardsiGC02M068350.
HGNCiHGNC:25176. WDR92.
HPAiHPA035335.
HPA035336.
MIMi610729. gene.
neXtProtiNX_Q96MX6.
PharmGKBiPA162409167.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119179.
HOGENOMiHOG000256919.
HOVERGENiHBG055572.
InParanoidiQ96MX6.
OMAiPQNREIF.
OrthoDBiEOG75QR5D.
PhylomeDBiQ96MX6.
TreeFamiTF351064.

Enzyme and pathway databases

SignaLinkiQ96MX6.

Miscellaneous databases

EvolutionaryTraceiQ96MX6.
GenomeRNAii116143.
NextBioi79788.
PROiQ96MX6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MX6.
CleanExiHS_WDR92.
ExpressionAtlasiQ96MX6. baseline.
GenevestigatoriQ96MX6.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell and Skin.
  4. "Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha."
    Saeki M., Irie Y., Ni L., Yoshida M., Itsuki Y., Kamisaki Y.
    Biochem. Biophys. Res. Commun. 342:568-572(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis."
    Inoue M., Saeki M., Egusa H., Niwa H., Kamisaki Y.
    Biochem. Biophys. Res. Commun. 403:340-344(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIH1D1.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Structure and function of WD40 domain proteins."
    Xu C., Min J.
    Protein Cell 2:202-214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

Entry informationi

Entry nameiWDR92_HUMAN
AccessioniPrimary (citable) accession number: Q96MX6
Secondary accession number(s): Q96CR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.