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Q96MX6 (WDR92_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 92
Alternative name(s):
WD repeat-containing protein Monad
Gene names
Name:WDR92
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to act as a modulator of apoptosis. Ref.4

Tissue specificity

Widely expressed with the highest expression in testis. Ref.4

Sequence similarities

Contains 6 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RPAP3Q9H6T34EBI-2434101,EBI-356928

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96MX6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96MX6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     289-357: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357WD repeat-containing protein 92
PRO_0000301671

Regions

Repeat63 – 10543WD 1
Repeat115 – 15440WD 2
Repeat162 – 20544WD 3
Repeat207 – 24943WD 4
Repeat257 – 29741WD 5
Repeat319 – 35739WD 6

Natural variations

Alternative sequence289 – 35769Missing in isoform 2.
VSP_045123
Natural variant2411M → V.
Corresponds to variant rs13009282 [ dbSNP | Ensembl ].
VAR_053438

Secondary structure

.................................................................. 357
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: CD48E8A09D8A8F95

FASTA35739,740
        10         20         30         40         50         60 
MSAFEKPQII AHIQKGFNYT VFDCKWVPCS AKFVTMGNFA RGTGVIQLYE IQHGDLKLLR 

        70         80         90        100        110        120 
EIEKAKPIKC GTFGATSLQQ RYLATGDFGG NLHIWNLEAP EMPVYSVKGH KEIINAIDGI 

       130        140        150        160        170        180 
GGLGIGEGAP EIVTGSRDGT VKVWDPRQKD DPVANMEPVQ GENKRDCWTV AFGNAYNQEE 

       190        200        210        220        230        240 
RVVCAGYDNG DIKLFDLRNM ALRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD 

       250        260        270        280        290        300 
MRTQHPTKGF ASVSEKAHKS TVWQVRHLPQ NRELFLTAGG AGGLHLWKYE YPIQRSKKDS 

       310        320        330        340        350 
EGIEMGVAGS VSLLQNVTLS TQPISSLDWS PDKRGLCVCS SFDQTVRVLI VTKLNKI 

« Hide

Isoform 2 [UniParc].

Checksum: 5C4798B25D1E54D1
Show »

FASTA28832,128

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: B-cell and Skin.
[4]"Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha."
Saeki M., Irie Y., Ni L., Yoshida M., Itsuki Y., Kamisaki Y.
Biochem. Biophys. Res. Commun. 342:568-572(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Structure and function of WD40 domain proteins."
Xu C., Min J.
Protein Cell 2:202-214(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056303 mRNA. Translation: BAB71143.1.
AC017083 Genomic DNA. Translation: AAY14713.1.
BC014022 mRNA. Translation: AAH14022.2.
BC066657 mRNA. Translation: AAH66657.1.
CCDSCCDS1884.1. [Q96MX6-1]
CCDS58712.1. [Q96MX6-2]
RefSeqNP_001243405.1. NM_001256476.1. [Q96MX6-2]
NP_612467.1. NM_138458.3. [Q96MX6-1]
UniGeneHs.631877.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3I2NX-ray1.95A1-357[»]
ProteinModelPortalQ96MX6.
SMRQ96MX6. Positions 5-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125479. 15 interactions.
IntActQ96MX6. 4 interactions.
MINTMINT-3056106.
STRING9606.ENSP00000295121.

PTM databases

PhosphoSiteQ96MX6.

Polymorphism databases

DMDM74760987.

Proteomic databases

MaxQBQ96MX6.
PRIDEQ96MX6.

Protocols and materials databases

DNASU116143.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295121; ENSP00000295121; ENSG00000243667. [Q96MX6-1]
ENST00000409164; ENSP00000386746; ENSG00000243667. [Q96MX6-2]
GeneID116143.
KEGGhsa:116143.
UCSCuc002see.2. human. [Q96MX6-1]

Organism-specific databases

CTD116143.
GeneCardsGC02M068350.
HGNCHGNC:25176. WDR92.
HPAHPA035335.
HPA035336.
MIM610729. gene.
neXtProtNX_Q96MX6.
PharmGKBPA162409167.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG055572.
InParanoidQ96MX6.
OMADIPMNKL.
OrthoDBEOG75QR5D.
PhylomeDBQ96MX6.
TreeFamTF351064.

Enzyme and pathway databases

SignaLinkQ96MX6.

Gene expression databases

BgeeQ96MX6.
CleanExHS_WDR92.
GenevestigatorQ96MX6.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 2 hits.
[Graphical view]
SMARTSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ96MX6.
GenomeRNAi116143.
NextBio79788.
PROQ96MX6.
SOURCESearch...

Entry information

Entry nameWDR92_HUMAN
AccessionPrimary (citable) accession number: Q96MX6
Secondary accession number(s): Q96CR6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM