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Protein

CKLF-like MARVEL transmembrane domain-containing protein 3

Gene

CMTM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 3
Alternative name(s):
Chemokine-like factor superfamily member 3
Gene namesi
Name:CMTM3
Synonyms:CKLFSF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19174. CMTM3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421HelicalSequence analysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38813.

Polymorphism and mutation databases

BioMutaiCMTM3.
DMDMi34922036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182CKLF-like MARVEL transmembrane domain-containing protein 3PRO_0000186101Add
BLAST

Proteomic databases

EPDiQ96MX0.
MaxQBiQ96MX0.
PaxDbiQ96MX0.
PRIDEiQ96MX0.

PTM databases

SwissPalmiQ96MX0.

Expressioni

Tissue specificityi

Expressed in the leukocytes, placenta and testis.1 Publication

Gene expression databases

BgeeiQ96MX0.
CleanExiHS_CMTM3.
ExpressionAtlasiQ96MX0. baseline and differential.
GenevisibleiQ96MX0. HS.

Organism-specific databases

HPAiHPA013870.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MOB1AQ9H8S93EBI-7247651,EBI-748229
MOB3CQ70IA83EBI-7247651,EBI-9679267

Protein-protein interaction databases

BioGridi125844. 6 interactions.
IntActiQ96MX0. 4 interactions.
MINTiMINT-8247569.
STRINGi9606.ENSP00000354579.

Structurei

3D structure databases

ProteinModelPortaliQ96MX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 155120MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063326.
HOVERGENiHBG053619.
InParanoidiQ96MX0.
OMAiTVPLLEF.
PhylomeDBiQ96MX0.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPPDPDPDP DPEPAGGSRP GPAVPGLRAL LPARAFLCSL KGRLLLAESG
60 70 80 90 100
LSFITFICYV ASSASAFLTA PLLEFLLALY FLFADAMQLN DKWQGLCWPM
110 120 130 140 150
MDFLRCVTAA LIYFAISITA IAKYSDGASK AAGVFGFFAT IVFATDFYLI
160 170 180
FNDVAKFLKQ GDSADETTAH KTEEENSDSD SD
Length:182
Mass (Da):19,714
Last modified:December 1, 2001 - v1
Checksum:iC56C7B93E7E638E1
GO
Isoform 2 (identifier: Q96MX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-59: RLLLAESGLSFITFICY → PGGFVCTWCSCPHQPLW
     60-182: Missing.

Show »
Length:59
Mass (Da):6,220
Checksum:iA5ADABE4E66AC83B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 5917RLLLA…TFICY → PGGFVCTWCSCPHQPLW in isoform 2. 1 PublicationVSP_008256Add
BLAST
Alternative sequencei60 – 182123Missing in isoform 2. 1 PublicationVSP_008257Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479813 mRNA. Translation: AAN73435.1.
AY166714 mRNA. Translation: AAN75573.1.
AK056324 mRNA. Translation: BAB71150.1.
AC018557 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83031.1.
BC023509 mRNA. Translation: AAH23509.2.
BC023591 mRNA. Translation: AAH23591.2.
BC036042 mRNA. Translation: AAH36042.2.
BC040227 mRNA. Translation: AAH40227.2.
BC047701 mRNA. Translation: AAH47701.1.
CCDSiCCDS10815.1. [Q96MX0-1]
RefSeqiNP_653202.1. NM_144601.3. [Q96MX0-1]
NP_853531.1. NM_181553.2. [Q96MX0-1]
XP_006721194.1. XM_006721131.1. [Q96MX0-1]
UniGeneiHs.298198.

Genome annotation databases

EnsembliENST00000361909; ENSP00000354579; ENSG00000140931. [Q96MX0-1]
ENST00000424011; ENSP00000400482; ENSG00000140931. [Q96MX0-1]
ENST00000562707; ENSP00000455758; ENSG00000140931. [Q96MX0-1]
ENST00000565922; ENSP00000456426; ENSG00000140931. [Q96MX0-2]
ENST00000567572; ENSP00000455851; ENSG00000140931. [Q96MX0-1]
GeneIDi123920.
KEGGihsa:123920.
UCSCiuc002epu.5. human. [Q96MX0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479813 mRNA. Translation: AAN73435.1.
AY166714 mRNA. Translation: AAN75573.1.
AK056324 mRNA. Translation: BAB71150.1.
AC018557 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83031.1.
BC023509 mRNA. Translation: AAH23509.2.
BC023591 mRNA. Translation: AAH23591.2.
BC036042 mRNA. Translation: AAH36042.2.
BC040227 mRNA. Translation: AAH40227.2.
BC047701 mRNA. Translation: AAH47701.1.
CCDSiCCDS10815.1. [Q96MX0-1]
RefSeqiNP_653202.1. NM_144601.3. [Q96MX0-1]
NP_853531.1. NM_181553.2. [Q96MX0-1]
XP_006721194.1. XM_006721131.1. [Q96MX0-1]
UniGeneiHs.298198.

3D structure databases

ProteinModelPortaliQ96MX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125844. 6 interactions.
IntActiQ96MX0. 4 interactions.
MINTiMINT-8247569.
STRINGi9606.ENSP00000354579.

PTM databases

SwissPalmiQ96MX0.

Polymorphism and mutation databases

BioMutaiCMTM3.
DMDMi34922036.

Proteomic databases

EPDiQ96MX0.
MaxQBiQ96MX0.
PaxDbiQ96MX0.
PRIDEiQ96MX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361909; ENSP00000354579; ENSG00000140931. [Q96MX0-1]
ENST00000424011; ENSP00000400482; ENSG00000140931. [Q96MX0-1]
ENST00000562707; ENSP00000455758; ENSG00000140931. [Q96MX0-1]
ENST00000565922; ENSP00000456426; ENSG00000140931. [Q96MX0-2]
ENST00000567572; ENSP00000455851; ENSG00000140931. [Q96MX0-1]
GeneIDi123920.
KEGGihsa:123920.
UCSCiuc002epu.5. human. [Q96MX0-1]

Organism-specific databases

CTDi123920.
GeneCardsiCMTM3.
HGNCiHGNC:19174. CMTM3.
HPAiHPA013870.
MIMi607886. gene.
neXtProtiNX_Q96MX0.
PharmGKBiPA38813.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063326.
HOVERGENiHBG053619.
InParanoidiQ96MX0.
OMAiTVPLLEF.
PhylomeDBiQ96MX0.
TreeFamiTF317387.

Miscellaneous databases

ChiTaRSiCMTM3. human.
GenomeRNAii123920.
PROiQ96MX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MX0.
CleanExiHS_CMTM3.
ExpressionAtlasiQ96MX0. baseline and differential.
GenevisibleiQ96MX0. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
    Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
    Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. Liu Y., Han W., Shi S., Xia D., Song Q., Zhang Y., Ma D.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Lung and Placenta.

Entry informationi

Entry nameiCKLF3_HUMAN
AccessioniPrimary (citable) accession number: Q96MX0
Secondary accession number(s): A6NCL9
, Q8IUU8, Q8IWQ6, Q8IYE2, Q8IZ39, Q8IZ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.