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Protein

Tigger transposable element-derived protein 1

Gene

TIGD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5321H-T-H motifBy similarityAdd
BLAST
DNA bindingi103 – 14240H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 1
Gene namesi
Name:TIGD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14523. TIGD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38382.

Polymorphism and mutation databases

BioMutaiTIGD1.
DMDMi74762678.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Tigger transposable element-derived protein 1PRO_0000272615Add
BLAST

Proteomic databases

EPDiQ96MW7.
MaxQBiQ96MW7.
PaxDbiQ96MW7.
PRIDEiQ96MW7.

PTM databases

iPTMnetiQ96MW7.
PhosphoSiteiQ96MW7.

Expressioni

Gene expression databases

BgeeiQ96MW7.
CleanExiHS_TIGD1.
GenevisibleiQ96MW7. HS.

Organism-specific databases

HPAiHPA041717.

Interactioni

Protein-protein interaction databases

BioGridi128345. 2 interactions.
DIPiDIP-61581N.
IntActiQ96MW7. 1 interaction.
STRINGi9606.ENSP00000386186.

Structurei

3D structure databases

ProteinModelPortaliQ96MW7.
SMRiQ96MW7. Positions 5-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 5752HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini70 – 14980HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini178 – 403226DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154578.
HOVERGENiHBG053836.
InParanoidiQ96MW7.
OMAiMNTRMIR.
OrthoDBiEOG7KQ24B.
PhylomeDBiQ96MW7.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCSSERK SRTSLTLNQK LEMIKLSEEG MSKAEIGRRL GLLRQTVSQV
60 70 80 90 100
VNAKEKFLKE VKSATPMNTR MIRKRNSLIA DMEKVLVVWI EDQTSRNIPL
110 120 130 140 150
SQSLIQNKAL TLFNSMKAER GVEAAEEKFE ASRGWFMRFK ERSHFHNIKA
160 170 180 190 200
QGEAASADVE AAASYPEALA KIIDEGGYTK QQIFNVDETA FYWKKMPSRT
210 220 230 240 250
FIAREEKSVP GFKASKDRLT LLLGANAAGD FKLKPMLIYH SENPRALKNY
260 270 280 290 300
TKSTLPVLYK WNSKARMTAH LFTAWFTEYF KPTVETYCSE KKIPFKILLL
310 320 330 340 350
IDNAPSHPRA LMEIYEEINV IFMPANTTSI LQPMDQGVIS TFKSYYLRNT
360 370 380 390 400
FHKALAAMDS DVSDGSGQSK LKTFWKGFTI LDAIKNIRDS WEEVKLSTLT
410 420 430 440 450
GVWKKLIPTL IDDYEGFKTS VEEVSADVVE IAKELELEVE PEDVTELLQS
460 470 480 490 500
HDKTLTDEEL FLMDAQRKWF LEMESTPGED AVNIVEMTTK DLEYYINLVD
510 520 530 540 550
KAAAGFERID SNFERSSTVG KMLSNSIACY REIFHERKSQ LMRKASPMSY
560 570 580 590
FRKLPQPPQP SAATTLTSQQ PSTSRQDPPP AKRVRLTEGS D
Length:591
Mass (Da):67,299
Last modified:December 1, 2001 - v1
Checksum:i920CA1F0CF2805C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491N → S in AAH35143 (PubMed:15489334).Curated
Sequence conflicti302 – 3021D → G in AAH35143 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056329 mRNA. Translation: BAB71153.1.
AC092165 Genomic DNA. Translation: AAY24104.1.
BC035143 mRNA. Translation: AAH35143.2.
BC063500 mRNA. Translation: AAH63500.2.
CCDSiCCDS2495.1.
RefSeqiNP_663748.1. NM_145702.2.
UniGeneiHs.211823.

Genome annotation databases

EnsembliENST00000408957; ENSP00000386186; ENSG00000221944.
GeneIDi200765.
KEGGihsa:200765.
UCSCiuc002vsy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056329 mRNA. Translation: BAB71153.1.
AC092165 Genomic DNA. Translation: AAY24104.1.
BC035143 mRNA. Translation: AAH35143.2.
BC063500 mRNA. Translation: AAH63500.2.
CCDSiCCDS2495.1.
RefSeqiNP_663748.1. NM_145702.2.
UniGeneiHs.211823.

3D structure databases

ProteinModelPortaliQ96MW7.
SMRiQ96MW7. Positions 5-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128345. 2 interactions.
DIPiDIP-61581N.
IntActiQ96MW7. 1 interaction.
STRINGi9606.ENSP00000386186.

PTM databases

iPTMnetiQ96MW7.
PhosphoSiteiQ96MW7.

Polymorphism and mutation databases

BioMutaiTIGD1.
DMDMi74762678.

Proteomic databases

EPDiQ96MW7.
MaxQBiQ96MW7.
PaxDbiQ96MW7.
PRIDEiQ96MW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408957; ENSP00000386186; ENSG00000221944.
GeneIDi200765.
KEGGihsa:200765.
UCSCiuc002vsy.3. human.

Organism-specific databases

CTDi200765.
GeneCardsiTIGD1.
HGNCiHGNC:14523. TIGD1.
HPAiHPA041717.
MIMi612972. gene.
neXtProtiNX_Q96MW7.
PharmGKBiPA38382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154578.
HOVERGENiHBG053836.
InParanoidiQ96MW7.
OMAiMNTRMIR.
OrthoDBiEOG7KQ24B.
PhylomeDBiQ96MW7.
TreeFamiTF101131.

Miscellaneous databases

GenomeRNAii200765.
PROiQ96MW7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MW7.
CleanExiHS_TIGD1.
GenevisibleiQ96MW7. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTIGD1_HUMAN
AccessioniPrimary (citable) accession number: Q96MW7
Secondary accession number(s): Q6P4D2, Q6PIF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.