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Protein

Conserved oligomeric Golgi complex subunit 8

Gene

COG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 8
Short name:
COG complex subunit 8
Alternative name(s):
Component of oligomeric Golgi complex 8
Gene namesi
Name:COG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18623. COG8.

Subcellular locationi

  • Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  • Golgi membrane Source: Reactome
  • Golgi transport complex Source: UniProtKB
  • membrane Source: UniProtKB
  • trans-Golgi network membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2H (CDG2H)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:611182

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

MalaCardsiCOG8.
MIMi611182. phenotype.
Orphaneti95428. COG8-CDG.
PharmGKBiPA38606.

Polymorphism and mutation databases

BioMutaiCOG8.
DMDMi215273958.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Conserved oligomeric Golgi complex subunit 8PRO_0000213521Add
BLAST

Proteomic databases

EPDiQ96MW5.
MaxQBiQ96MW5.
PaxDbiQ96MW5.
PeptideAtlasiQ96MW5.
PRIDEiQ96MW5.

PTM databases

iPTMnetiQ96MW5.
PhosphoSiteiQ96MW5.

Expressioni

Gene expression databases

BgeeiQ96MW5.
CleanExiHS_COG8.
ExpressionAtlasiQ96MW5. baseline and differential.
GenevisibleiQ96MW5. HS.

Organism-specific databases

HPAiHPA041406.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

Binary interactionsi

WithEntry#Exp.IntActNotes
GEMP550403EBI-720875,EBI-744104
MYEF2Q9P2K5-23EBI-720875,EBI-10318831

Protein-protein interaction databases

BioGridi124063. 19 interactions.
IntActiQ96MW5. 16 interactions.
MINTiMINT-3056080.
STRINGi9606.ENSP00000305459.

Structurei

3D structure databases

ProteinModelPortaliQ96MW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG8 family.Curated

Phylogenomic databases

eggNOGiKOG2069. Eukaryota.
ENOG410XNZ7. LUCA.
GeneTreeiENSGT00390000015893.
HOVERGENiHBG028357.
InParanoidiQ96MW5.
OMAiMGEHTVN.
PhylomeDBiQ96MW5.
TreeFamiTF315000.

Family and domain databases

InterProiIPR007255. COG8.
IPR016632. COG8_Metazoal_Plant.
IPR016159. Cullin_repeat-like_dom.
[Graphical view]
PANTHERiPTHR21311. PTHR21311. 1 hit.
PfamiPF04124. Dor1. 1 hit.
[Graphical view]
PIRSFiPIRSF015415. COG8. 1 hit.
SUPFAMiSSF74788. SSF74788. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96MW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAATIPSV ATATAAALGE VEDEGLLASL FRDRFPEAQW RERPDVGRYL
60 70 80 90 100
RELSGSGLER LRREPERLAE ERAQLLQQTR DLAFANYKTF IRGAECTERI
110 120 130 140 150
HRLFGDVEAS LGRLLDRLPS FQQSCRNFVK EAEEISSNRR MNSLTLNRHT
160 170 180 190 200
EILEILEIPQ LMDTCVRNSY YEEALELAAY VRRLERKYSS IPVIQGIVNE
210 220 230 240 250
VRQSMQLMLS QLIQQLRTNI QLPACLRVIG YLRRMDVFTE AELRVKFLQA
260 270 280 290 300
RDAWLRSILT AIPNDDPYFH ITKTIEASRV HLFDIITQYR AIFSDEDPLL
310 320 330 340 350
PPAMGEHTVN ESAIFHGWVL QKVSQFLQVL ETDLYRGIGG HLDSLLGQCM
360 370 380 390 400
YFGLSFSRVG ADFRGQLAPV FQRVAISTFQ KAIQETVEKF QEEMNSYMLI
410 420 430 440 450
SAPAILGTSN MPAAVPATQP GTLQPPMVLL DFPPLACFLN NILVAFNDLR
460 470 480 490 500
LCCPVALAQD VTGALEDALA KVTKIILAFH RAEEAAFSSG EQELFVQFCT
510 520 530 540 550
VFLEDLVPYL NRCLQVLFPP AQIAQTLGIP PTQLSKYGNL GHVNIGAIQE
560 570 580 590 600
PLAFILPKRE TLFTLDDQAL GPELTAPAPE PPAEEPRLEP AGPACPEGGR
610
AETQAEPPSV GP
Length:612
Mass (Da):68,424
Last modified:November 25, 2008 - v2
Checksum:i2780349A5B037E55
GO

Sequence cautioni

The sequence AAH17492.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15301.1 differs from that shown. Reason: Frameshift at position 371. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3481Q → R in BAB71157 (PubMed:14702039).Curated
Sequence conflicti399 – 3991L → H in BAB15301 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti517 – 5171L → R.
Corresponds to variant rs3027 [ dbSNP | Ensembl ].
VAR_047655

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056344 mRNA. Translation: BAB71157.1.
AK025968 mRNA. Translation: BAB15301.1. Frameshift.
CH471092 Genomic DNA. Translation: EAW83266.1.
BC017492 mRNA. Translation: AAH17492.1. Different initiation.
BC121022 mRNA. Translation: AAI21023.1.
BC121023 mRNA. Translation: AAI21024.1.
CCDSiCCDS10876.1.
RefSeqiNP_115758.3. NM_032382.4.
UniGeneiHs.130849.

Genome annotation databases

EnsembliENST00000306875; ENSP00000305459; ENSG00000213380.
GeneIDi84342.
KEGGihsa:84342.
UCSCiuc002ewy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056344 mRNA. Translation: BAB71157.1.
AK025968 mRNA. Translation: BAB15301.1. Frameshift.
CH471092 Genomic DNA. Translation: EAW83266.1.
BC017492 mRNA. Translation: AAH17492.1. Different initiation.
BC121022 mRNA. Translation: AAI21023.1.
BC121023 mRNA. Translation: AAI21024.1.
CCDSiCCDS10876.1.
RefSeqiNP_115758.3. NM_032382.4.
UniGeneiHs.130849.

3D structure databases

ProteinModelPortaliQ96MW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124063. 19 interactions.
IntActiQ96MW5. 16 interactions.
MINTiMINT-3056080.
STRINGi9606.ENSP00000305459.

PTM databases

iPTMnetiQ96MW5.
PhosphoSiteiQ96MW5.

Polymorphism and mutation databases

BioMutaiCOG8.
DMDMi215273958.

Proteomic databases

EPDiQ96MW5.
MaxQBiQ96MW5.
PaxDbiQ96MW5.
PeptideAtlasiQ96MW5.
PRIDEiQ96MW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306875; ENSP00000305459; ENSG00000213380.
GeneIDi84342.
KEGGihsa:84342.
UCSCiuc002ewy.3. human.

Organism-specific databases

CTDi84342.
GeneCardsiCOG8.
GeneReviewsiCOG8.
HGNCiHGNC:18623. COG8.
HPAiHPA041406.
MalaCardsiCOG8.
MIMi606979. gene.
611182. phenotype.
neXtProtiNX_Q96MW5.
Orphaneti95428. COG8-CDG.
PharmGKBiPA38606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2069. Eukaryota.
ENOG410XNZ7. LUCA.
GeneTreeiENSGT00390000015893.
HOVERGENiHBG028357.
InParanoidiQ96MW5.
OMAiMGEHTVN.
PhylomeDBiQ96MW5.
TreeFamiTF315000.

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

GeneWikiiCOG8.
GenomeRNAii84342.
PROiQ96MW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MW5.
CleanExiHS_COG8.
ExpressionAtlasiQ96MW5. baseline and differential.
GenevisibleiQ96MW5. HS.

Family and domain databases

InterProiIPR007255. COG8.
IPR016632. COG8_Metazoal_Plant.
IPR016159. Cullin_repeat-like_dom.
[Graphical view]
PANTHERiPTHR21311. PTHR21311. 1 hit.
PfamiPF04124. Dor1. 1 hit.
[Graphical view]
PIRSFiPIRSF015415. COG8. 1 hit.
SUPFAMiSSF74788. SSF74788. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
    Whyte J.R., Munro S.
    Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: INVOLVEMENT IN CDG2H.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOG8_HUMAN
AccessioniPrimary (citable) accession number: Q96MW5
Secondary accession number(s): Q0VAK2, Q8WVV6, Q9H6F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.