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Protein

Coiled-coil domain-containing protein 43

Gene

CCDC43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 43
Gene namesi
Name:CCDC43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26472. CCDC43.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672160.

Polymorphism and mutation databases

BioMutaiCCDC43.
DMDMi296434426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Coiled-coil domain-containing protein 43PRO_0000234500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96MW1.
MaxQBiQ96MW1.
PaxDbiQ96MW1.
PRIDEiQ96MW1.

PTM databases

iPTMnetiQ96MW1.
PhosphoSiteiQ96MW1.

Expressioni

Gene expression databases

BgeeiQ96MW1.
CleanExiHS_CCDC43.
ExpressionAtlasiQ96MW1. baseline and differential.
GenevisibleiQ96MW1. HS.

Organism-specific databases

HPAiHPA023391.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KLHL2O951983EBI-9247198,EBI-746999
TINF2Q9BSI42EBI-9247198,EBI-717399

Protein-protein interaction databases

BioGridi125890. 7 interactions.
IntActiQ96MW1. 3 interactions.
STRINGi9606.ENSP00000323782.

Structurei

3D structure databases

ProteinModelPortaliQ96MW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili121 – 14525Sequence analysisAdd
BLAST
Coiled coili177 – 21842Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 2311Poly-GlyAdd
BLAST
Compositional biasi50 – 556Poly-Glu

Sequence similaritiesi

Belongs to the CCDC43 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXU7. Eukaryota.
ENOG4111JC7. LUCA.
GeneTreeiENSGT00390000015009.
HOGENOMiHOG000231398.
HOVERGENiHBG059861.
InParanoidiQ96MW1.
PhylomeDBiQ96MW1.
TreeFamiTF324859.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPSEVAAI APGEGDGGGG GFGSWLDGRL EALGVDRAVY GAYILGILQE
60 70 80 90 100
EEEEEKLDAL QGILSAFLEE DSLLNICKEI VERWSETQNV VTKVKKEDEV
110 120 130 140 150
QAIATLIEKQ AQIVVKPRMV SEEEKQRKAA LLAQYADVTD EEDEADEKDD
160 170 180 190 200
SGATTMNIGS DKLLFRNTNV EDVLNARKLE RDSLRDESQR KKEQDKLQRE
210 220
RDKLAKQERK EKEKKRTQRG ERKR
Length:224
Mass (Da):25,248
Last modified:May 18, 2010 - v2
Checksum:iED4E1CB196FEEFA7
GO
Isoform 2 (identifier: Q96MW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-224: EADEKDDSGA...KRTQRGERKR → SVPKHQCGRCP

Show »
Length:154
Mass (Da):16,758
Checksum:i63D2E9951F2BD360
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741L → F in BAB71162 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 22481EADEK…GERKR → SVPKHQCGRCP in isoform 2. 1 PublicationVSP_040750Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056357 mRNA. Translation: BAB71162.1.
BX648868 mRNA. No translation available.
AC091152 Genomic DNA. No translation available.
CCDSiCCDS45704.1. [Q96MW1-1]
CCDS45705.1. [Q96MW1-2]
RefSeqiNP_001092695.1. NM_001099225.1. [Q96MW1-2]
NP_653210.2. NM_144609.2. [Q96MW1-1]
UniGeneiHs.579115.

Genome annotation databases

EnsembliENST00000315286; ENSP00000323782; ENSG00000180329. [Q96MW1-1]
ENST00000457422; ENSP00000400845; ENSG00000180329. [Q96MW1-2]
GeneIDi124808.
KEGGihsa:124808.
UCSCiuc002ihc.3. human. [Q96MW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056357 mRNA. Translation: BAB71162.1.
BX648868 mRNA. No translation available.
AC091152 Genomic DNA. No translation available.
CCDSiCCDS45704.1. [Q96MW1-1]
CCDS45705.1. [Q96MW1-2]
RefSeqiNP_001092695.1. NM_001099225.1. [Q96MW1-2]
NP_653210.2. NM_144609.2. [Q96MW1-1]
UniGeneiHs.579115.

3D structure databases

ProteinModelPortaliQ96MW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125890. 7 interactions.
IntActiQ96MW1. 3 interactions.
STRINGi9606.ENSP00000323782.

PTM databases

iPTMnetiQ96MW1.
PhosphoSiteiQ96MW1.

Polymorphism and mutation databases

BioMutaiCCDC43.
DMDMi296434426.

Proteomic databases

EPDiQ96MW1.
MaxQBiQ96MW1.
PaxDbiQ96MW1.
PRIDEiQ96MW1.

Protocols and materials databases

DNASUi124808.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315286; ENSP00000323782; ENSG00000180329. [Q96MW1-1]
ENST00000457422; ENSP00000400845; ENSG00000180329. [Q96MW1-2]
GeneIDi124808.
KEGGihsa:124808.
UCSCiuc002ihc.3. human. [Q96MW1-1]

Organism-specific databases

CTDi124808.
GeneCardsiCCDC43.
H-InvDBHIX0039024.
HGNCiHGNC:26472. CCDC43.
HPAiHPA023391.
neXtProtiNX_Q96MW1.
PharmGKBiPA142672160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXU7. Eukaryota.
ENOG4111JC7. LUCA.
GeneTreeiENSGT00390000015009.
HOGENOMiHOG000231398.
HOVERGENiHBG059861.
InParanoidiQ96MW1.
PhylomeDBiQ96MW1.
TreeFamiTF324859.

Miscellaneous databases

ChiTaRSiCCDC43. human.
GenomeRNAii124808.
NextBioi81388.
PROiQ96MW1.

Gene expression databases

BgeeiQ96MW1.
CleanExiHS_CCDC43.
ExpressionAtlasiQ96MW1. baseline and differential.
GenevisibleiQ96MW1. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCD43_HUMAN
AccessioniPrimary (citable) accession number: Q96MW1
Secondary accession number(s): C9JVK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: April 13, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.