Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 43

Gene

CCDC43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180329-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 43
Gene namesi
Name:CCDC43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26472. CCDC43.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180329.
PharmGKBiPA142672160.

Polymorphism and mutation databases

BioMutaiCCDC43.
DMDMi296434426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345001 – 224Coiled-coil domain-containing protein 43Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei139PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96MW1.
MaxQBiQ96MW1.
PaxDbiQ96MW1.
PeptideAtlasiQ96MW1.
PRIDEiQ96MW1.

PTM databases

iPTMnetiQ96MW1.
PhosphoSitePlusiQ96MW1.

Expressioni

Gene expression databases

BgeeiENSG00000180329.
CleanExiHS_CCDC43.
ExpressionAtlasiQ96MW1. baseline and differential.
GenevisibleiQ96MW1. HS.

Organism-specific databases

HPAiHPA023391.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KLHL2O951983EBI-9247198,EBI-746999
TINF2Q9BSI42EBI-9247198,EBI-717399

Protein-protein interaction databases

BioGridi125890. 7 interactors.
IntActiQ96MW1. 3 interactors.
STRINGi9606.ENSP00000323782.

Structurei

3D structure databases

ProteinModelPortaliQ96MW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili121 – 145Sequence analysisAdd BLAST25
Coiled coili177 – 218Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 23Poly-GlyAdd BLAST11
Compositional biasi50 – 55Poly-Glu6

Sequence similaritiesi

Belongs to the CCDC43 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXU7. Eukaryota.
ENOG4111JC7. LUCA.
GeneTreeiENSGT00390000015009.
HOGENOMiHOG000231398.
HOVERGENiHBG059861.
InParanoidiQ96MW1.
PhylomeDBiQ96MW1.
TreeFamiTF324859.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPSEVAAI APGEGDGGGG GFGSWLDGRL EALGVDRAVY GAYILGILQE
60 70 80 90 100
EEEEEKLDAL QGILSAFLEE DSLLNICKEI VERWSETQNV VTKVKKEDEV
110 120 130 140 150
QAIATLIEKQ AQIVVKPRMV SEEEKQRKAA LLAQYADVTD EEDEADEKDD
160 170 180 190 200
SGATTMNIGS DKLLFRNTNV EDVLNARKLE RDSLRDESQR KKEQDKLQRE
210 220
RDKLAKQERK EKEKKRTQRG ERKR
Length:224
Mass (Da):25,248
Last modified:May 18, 2010 - v2
Checksum:iED4E1CB196FEEFA7
GO
Isoform 2 (identifier: Q96MW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-224: EADEKDDSGA...KRTQRGERKR → SVPKHQCGRCP

Show »
Length:154
Mass (Da):16,758
Checksum:i63D2E9951F2BD360
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174L → F in BAB71162 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040750144 – 224EADEK…GERKR → SVPKHQCGRCP in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056357 mRNA. Translation: BAB71162.1.
BX648868 mRNA. No translation available.
AC091152 Genomic DNA. No translation available.
CCDSiCCDS45704.1. [Q96MW1-1]
CCDS45705.1. [Q96MW1-2]
RefSeqiNP_001092695.1. NM_001099225.1. [Q96MW1-2]
NP_653210.2. NM_144609.2. [Q96MW1-1]
UniGeneiHs.579115.

Genome annotation databases

EnsembliENST00000315286; ENSP00000323782; ENSG00000180329. [Q96MW1-1]
ENST00000457422; ENSP00000400845; ENSG00000180329. [Q96MW1-2]
GeneIDi124808.
KEGGihsa:124808.
UCSCiuc002ihc.3. human. [Q96MW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056357 mRNA. Translation: BAB71162.1.
BX648868 mRNA. No translation available.
AC091152 Genomic DNA. No translation available.
CCDSiCCDS45704.1. [Q96MW1-1]
CCDS45705.1. [Q96MW1-2]
RefSeqiNP_001092695.1. NM_001099225.1. [Q96MW1-2]
NP_653210.2. NM_144609.2. [Q96MW1-1]
UniGeneiHs.579115.

3D structure databases

ProteinModelPortaliQ96MW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125890. 7 interactors.
IntActiQ96MW1. 3 interactors.
STRINGi9606.ENSP00000323782.

PTM databases

iPTMnetiQ96MW1.
PhosphoSitePlusiQ96MW1.

Polymorphism and mutation databases

BioMutaiCCDC43.
DMDMi296434426.

Proteomic databases

EPDiQ96MW1.
MaxQBiQ96MW1.
PaxDbiQ96MW1.
PeptideAtlasiQ96MW1.
PRIDEiQ96MW1.

Protocols and materials databases

DNASUi124808.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315286; ENSP00000323782; ENSG00000180329. [Q96MW1-1]
ENST00000457422; ENSP00000400845; ENSG00000180329. [Q96MW1-2]
GeneIDi124808.
KEGGihsa:124808.
UCSCiuc002ihc.3. human. [Q96MW1-1]

Organism-specific databases

CTDi124808.
GeneCardsiCCDC43.
H-InvDBHIX0039024.
HGNCiHGNC:26472. CCDC43.
HPAiHPA023391.
neXtProtiNX_Q96MW1.
OpenTargetsiENSG00000180329.
PharmGKBiPA142672160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXU7. Eukaryota.
ENOG4111JC7. LUCA.
GeneTreeiENSGT00390000015009.
HOGENOMiHOG000231398.
HOVERGENiHBG059861.
InParanoidiQ96MW1.
PhylomeDBiQ96MW1.
TreeFamiTF324859.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180329-MONOMER.

Miscellaneous databases

ChiTaRSiCCDC43. human.
GenomeRNAii124808.
PROiQ96MW1.

Gene expression databases

BgeeiENSG00000180329.
CleanExiHS_CCDC43.
ExpressionAtlasiQ96MW1. baseline and differential.
GenevisibleiQ96MW1. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD43_HUMAN
AccessioniPrimary (citable) accession number: Q96MW1
Secondary accession number(s): C9JVK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.