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Protein

Palmitoyltransferase ZDHHC15

Gene

ZDHHC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase specific for GAP43 and DLG4/PSD95.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 17951DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC15 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 15
Short name:
DHHC-15
Gene namesi
Name:ZDHHC15
ORF Names:UNQ1969/PRO4501
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:20342. ZDHHC15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 91 (MRX91)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

See also OMIM:300577

Keywords - Diseasei

Mental retardation

Organism-specific databases

MIMi300577. phenotype.
PharmGKBiPA134945089.

Polymorphism and mutation databases

BioMutaiZDHHC15.
DMDMi37999855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Palmitoyltransferase ZDHHC15PRO_0000212893Add
BLAST

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ96MV8.
PRIDEiQ96MV8.

PTM databases

PhosphoSiteiQ96MV8.

Expressioni

Tissue specificityi

Expressed in placenta, liver, lung, kidney, heart and brain.1 Publication

Gene expression databases

BgeeiQ96MV8.
CleanExiHS_ZDHHC15.
GenevisibleiQ96MV8. HS.

Organism-specific databases

HPAiHPA003618.

Interactioni

Protein-protein interaction databases

BioGridi127719. 1 interaction.
STRINGi9606.ENSP00000362465.

Structurei

3D structure databases

ProteinModelPortaliQ96MV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 17951DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
GeneTreeiENSGT00790000122959.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ96MV8.
KOiK18932.
OMAiFCDRCQV.
OrthoDBiEOG71ZP21.
PhylomeDBiQ96MV8.
TreeFamiTF316044.

Family and domain databases

InterProiIPR030293. ZDHHC15.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR22883:SF6. PTHR22883:SF6. 1 hit.
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRGWKMALS GGLRCCRRVL SWVPVLVIVL VVLWSYYAYV FELCLVTVLS
60 70 80 90 100
PAEKVIYLIL YHAIFVFFTW TYWKSIFTLP QQPNQKFHLS YTDKERYENE
110 120 130 140 150
ERPEVQKQML VDMAKKLPVY TRTGSGAVRF CDRCHLIKPD RCHHCSVCAM
160 170 180 190 200
CVLKMDHHCP WVNNCIGFSN YKFFLQFLAY SVLYCLYIAT TVFSYFIKYW
210 220 230 240 250
RGELPSVRSK FHVLFLLFVA CMFFVSLVIL FGYHCWLVSR NKTTLEAFCT
260 270 280 290 300
PVFTSGPEKN GFNLGFIKNI QQVFGDKKKF WLIPIGSSPG DGHSFPMRSM
310 320 330
NESQNPLLAN EETWEDNEDD NQDYPEGSSS LAVETET
Length:337
Mass (Da):39,331
Last modified:December 1, 2001 - v1
Checksum:i6D7F920921E5D124
GO
Isoform 2 (identifier: Q96MV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-54: Missing.
     127-152: AVRFCDRCHLIKPDRCHHCSVCAMCV → GQFIQRQLERQLSKYLRKAKSYMFSN
     153-337: Missing.

Note: No experimental confirmation available.
Show »
Length:143
Mass (Da):17,255
Checksum:i3B7A9A07E0690619
GO
Isoform 3 (identifier: Q96MV8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-54: Missing.

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):38,406
Checksum:iAA13351DA5587183
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei46 – 549Missing in isoform 2 and isoform 3. 2 PublicationsVSP_013206
Alternative sequencei127 – 15226AVRFC…CAMCV → GQFIQRQLERQLSKYLRKAK SYMFSN in isoform 2. 1 PublicationVSP_013207Add
BLAST
Alternative sequencei153 – 337185Missing in isoform 2. 1 PublicationVSP_013208Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358786 mRNA. Translation: AAQ89146.1.
AK056374 mRNA. Translation: BAB71168.1.
AK122885 mRNA. Translation: BAG53779.1.
AL137013, AC020717 Genomic DNA. Translation: CAI40090.1.
AL391055 Genomic DNA. No translation available.
BC103980 mRNA. Translation: AAI03981.1.
BC103981 mRNA. Translation: AAI03982.1.
BC103982 mRNA. Translation: AAI03983.1.
CCDSiCCDS14430.1. [Q96MV8-1]
CCDS55454.1. [Q96MV8-3]
RefSeqiNP_001139728.1. NM_001146256.1. [Q96MV8-3]
NP_001139729.1. NM_001146257.1. [Q96MV8-2]
NP_659406.1. NM_144969.2. [Q96MV8-1]
XP_006724687.1. XM_006724624.2. [Q96MV8-1]
UniGeneiHs.253211.

Genome annotation databases

EnsembliENST00000373367; ENSP00000362465; ENSG00000102383. [Q96MV8-1]
ENST00000541184; ENSP00000445420; ENSG00000102383. [Q96MV8-3]
GeneIDi158866.
KEGGihsa:158866.
UCSCiuc004ecg.3. human. [Q96MV8-1]
uc004ech.3. human. [Q96MV8-3]
uc004eci.2. human. [Q96MV8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358786 mRNA. Translation: AAQ89146.1.
AK056374 mRNA. Translation: BAB71168.1.
AK122885 mRNA. Translation: BAG53779.1.
AL137013, AC020717 Genomic DNA. Translation: CAI40090.1.
AL391055 Genomic DNA. No translation available.
BC103980 mRNA. Translation: AAI03981.1.
BC103981 mRNA. Translation: AAI03982.1.
BC103982 mRNA. Translation: AAI03983.1.
CCDSiCCDS14430.1. [Q96MV8-1]
CCDS55454.1. [Q96MV8-3]
RefSeqiNP_001139728.1. NM_001146256.1. [Q96MV8-3]
NP_001139729.1. NM_001146257.1. [Q96MV8-2]
NP_659406.1. NM_144969.2. [Q96MV8-1]
XP_006724687.1. XM_006724624.2. [Q96MV8-1]
UniGeneiHs.253211.

3D structure databases

ProteinModelPortaliQ96MV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127719. 1 interaction.
STRINGi9606.ENSP00000362465.

PTM databases

PhosphoSiteiQ96MV8.

Polymorphism and mutation databases

BioMutaiZDHHC15.
DMDMi37999855.

Proteomic databases

PaxDbiQ96MV8.
PRIDEiQ96MV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373367; ENSP00000362465; ENSG00000102383. [Q96MV8-1]
ENST00000541184; ENSP00000445420; ENSG00000102383. [Q96MV8-3]
GeneIDi158866.
KEGGihsa:158866.
UCSCiuc004ecg.3. human. [Q96MV8-1]
uc004ech.3. human. [Q96MV8-3]
uc004eci.2. human. [Q96MV8-2]

Organism-specific databases

CTDi158866.
GeneCardsiGC0XM074588.
HGNCiHGNC:20342. ZDHHC15.
HPAiHPA003618.
MIMi300576. gene.
300577. phenotype.
neXtProtiNX_Q96MV8.
PharmGKBiPA134945089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5273.
GeneTreeiENSGT00790000122959.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ96MV8.
KOiK18932.
OMAiFCDRCQV.
OrthoDBiEOG71ZP21.
PhylomeDBiQ96MV8.
TreeFamiTF316044.

Miscellaneous databases

ChiTaRSiZDHHC15. human.
GenomeRNAii158866.
NextBioi87835.
PROiQ96MV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MV8.
CleanExiHS_ZDHHC15.
GenevisibleiQ96MV8. HS.

Family and domain databases

InterProiIPR030293. ZDHHC15.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR22883:SF6. PTHR22883:SF6. 1 hit.
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain and Teratocarcinoma.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation."
    Mansouri M.R., Marklund L., Gustavsson P., Davey E., Carlsson B., Larsson C., White I., Gustavson K.-H., Dahl N.
    Eur. J. Hum. Genet. 13:970-977(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DISEASE.

Entry informationi

Entry nameiZDH15_HUMAN
AccessioniPrimary (citable) accession number: Q96MV8
Secondary accession number(s): B3KVG7, Q3SY30, Q6UWH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.