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Protein

Palmitoyltransferase ZDHHC15

Gene

ZDHHC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131Zinc 1By similarity1
Metal bindingi134Zinc 1By similarity1
Metal bindingi144Zinc 1By similarity1
Metal bindingi145Zinc 2By similarity1
Metal bindingi148Zinc 2By similarity1
Metal bindingi151Zinc 1By similarity1
Metal bindingi158Zinc 2By similarity1
Active sitei159S-palmitoyl cysteine intermediatePROSITE-ProRule annotation1
Metal bindingi165Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC15 (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 15
Short name:
DHHC-15
Gene namesi
Name:ZDHHC15
ORF Names:UNQ1969/PRO4501
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102383.13
HGNCiHGNC:20342 ZDHHC15
MIMi300576 gene
neXtProtiNX_Q96MV8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20LumenalBy similarityAdd BLAST20
Transmembranei21 – 41HelicalBy similarityAdd BLAST21
Topological domaini42 – 56CytoplasmicBy similarityAdd BLAST15
Transmembranei57 – 77HelicalBy similarityAdd BLAST21
Topological domaini78 – 172LumenalBy similarityAdd BLAST95
Transmembranei173 – 193HelicalBy similarityAdd BLAST21
Topological domaini194 – 210CytoplasmicBy similarityAdd BLAST17
Transmembranei211 – 234HelicalBy similarityAdd BLAST24
Topological domaini235 – 337LumenalBy similarityAdd BLAST103

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 91 (MRX91)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
See also OMIM:300577

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi158866
MIMi300577 phenotype
OpenTargetsiENSG00000102383
PharmGKBiPA134945089

Polymorphism and mutation databases

BioMutaiZDHHC15
DMDMi37999855

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128931 – 337Palmitoyltransferase ZDHHC15Add BLAST337

Post-translational modificationi

Autopalmitoylated (in vitro).By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ96MV8
PeptideAtlasiQ96MV8
PRIDEiQ96MV8

PTM databases

iPTMnetiQ96MV8
PhosphoSitePlusiQ96MV8

Expressioni

Tissue specificityi

Expressed in placenta, liver, lung, kidney, heart and brain.1 Publication

Gene expression databases

BgeeiENSG00000102383
CleanExiHS_ZDHHC15
GenevisibleiQ96MV8 HS

Organism-specific databases

HPAiHPA003618

Interactioni

Protein-protein interaction databases

BioGridi127719, 1 interactor
IntActiQ96MV8, 5 interactors
STRINGi9606.ENSP00000362465

Structurei

3D structure databases

ProteinModelPortaliQ96MV8
SMRiQ96MV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 179DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000234777
HOVERGENiHBG055108
InParanoidiQ96MV8
KOiK20028
OMAiGLRCCQR
OrthoDBiEOG091G0AXR
PhylomeDBiQ96MV8
TreeFamiTF316044

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRGWKMALS GGLRCCRRVL SWVPVLVIVL VVLWSYYAYV FELCLVTVLS
60 70 80 90 100
PAEKVIYLIL YHAIFVFFTW TYWKSIFTLP QQPNQKFHLS YTDKERYENE
110 120 130 140 150
ERPEVQKQML VDMAKKLPVY TRTGSGAVRF CDRCHLIKPD RCHHCSVCAM
160 170 180 190 200
CVLKMDHHCP WVNNCIGFSN YKFFLQFLAY SVLYCLYIAT TVFSYFIKYW
210 220 230 240 250
RGELPSVRSK FHVLFLLFVA CMFFVSLVIL FGYHCWLVSR NKTTLEAFCT
260 270 280 290 300
PVFTSGPEKN GFNLGFIKNI QQVFGDKKKF WLIPIGSSPG DGHSFPMRSM
310 320 330
NESQNPLLAN EETWEDNEDD NQDYPEGSSS LAVETET
Length:337
Mass (Da):39,331
Last modified:December 1, 2001 - v1
Checksum:i6D7F920921E5D124
GO
Isoform 2 (identifier: Q96MV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-54: Missing.
     127-152: AVRFCDRCHLIKPDRCHHCSVCAMCV → GQFIQRQLERQLSKYLRKAKSYMFSN
     153-337: Missing.

Note: No experimental confirmation available.
Show »
Length:143
Mass (Da):17,255
Checksum:i3B7A9A07E0690619
GO
Isoform 3 (identifier: Q96MV8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-54: Missing.

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):38,406
Checksum:iAA13351DA5587183
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01320646 – 54Missing in isoform 2 and isoform 3. 2 Publications9
Alternative sequenceiVSP_013207127 – 152AVRFC…CAMCV → GQFIQRQLERQLSKYLRKAK SYMFSN in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_013208153 – 337Missing in isoform 2. 1 PublicationAdd BLAST185

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358786 mRNA Translation: AAQ89146.1
AK056374 mRNA Translation: BAB71168.1
AK122885 mRNA Translation: BAG53779.1
AC020717 Genomic DNA No translation available.
AL137013 Genomic DNA No translation available.
AL391055 Genomic DNA No translation available.
BC103980 mRNA Translation: AAI03981.1
BC103981 mRNA Translation: AAI03982.1
BC103982 mRNA Translation: AAI03983.1
CCDSiCCDS14430.1 [Q96MV8-1]
CCDS55454.1 [Q96MV8-3]
RefSeqiNP_001139728.1, NM_001146256.1 [Q96MV8-3]
NP_001139729.1, NM_001146257.1 [Q96MV8-2]
NP_659406.1, NM_144969.2 [Q96MV8-1]
XP_006724687.1, XM_006724624.3 [Q96MV8-1]
UniGeneiHs.253211

Genome annotation databases

EnsembliENST00000373367; ENSP00000362465; ENSG00000102383 [Q96MV8-1]
ENST00000541184; ENSP00000445420; ENSG00000102383 [Q96MV8-3]
GeneIDi158866
KEGGihsa:158866
UCSCiuc004ecg.4 human [Q96MV8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZDH15_HUMAN
AccessioniPrimary (citable) accession number: Q96MV8
Secondary accession number(s): B3KVG7, Q3SY30, Q6UWH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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