ID TLCD4_HUMAN Reviewed; 263 AA. AC Q96MV1; B2RPI2; D3DT48; DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 27-MAR-2024, entry version 137. DE RecName: Full=TLC domain-containing protein 4 {ECO:0000305}; DE AltName: Full=Transmembrane protein 56; GN Name=TLCD4 {ECO:0000312|HGNC:HGNC:26477}; Synonyms=TMEM56; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Teratocarcinoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). CC -!- INTERACTION: CC Q96MV1; O60242: ADGRB3; NbExp=3; IntAct=EBI-12947623, EBI-2682765; CC Q96MV1; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-12947623, EBI-11277970; CC Q96MV1; Q9H2C2: ARV1; NbExp=3; IntAct=EBI-12947623, EBI-11724186; CC Q96MV1; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-12947623, EBI-12069500; CC Q96MV1; Q12983: BNIP3; NbExp=3; IntAct=EBI-12947623, EBI-749464; CC Q96MV1; Q06432: CACNG1; NbExp=3; IntAct=EBI-12947623, EBI-9686780; CC Q96MV1; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-12947623, EBI-9083477; CC Q96MV1; O14735: CDIPT; NbExp=3; IntAct=EBI-12947623, EBI-358858; CC Q96MV1; Q8WUD6: CHPT1; NbExp=3; IntAct=EBI-12947623, EBI-11337856; CC Q96MV1; P51798: CLCN7; NbExp=3; IntAct=EBI-12947623, EBI-4402346; CC Q96MV1; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-12947623, EBI-11989440; CC Q96MV1; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-12947623, EBI-11522780; CC Q96MV1; P21964: COMT; NbExp=3; IntAct=EBI-12947623, EBI-372265; CC Q96MV1; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-12947623, EBI-12019274; CC Q96MV1; P78329: CYP4F2; NbExp=3; IntAct=EBI-12947623, EBI-1752413; CC Q96MV1; Q6NT55: CYP4F22; NbExp=3; IntAct=EBI-12947623, EBI-17509525; CC Q96MV1; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-12947623, EBI-3923585; CC Q96MV1; Q15125: EBP; NbExp=3; IntAct=EBI-12947623, EBI-3915253; CC Q96MV1; Q9BV81: EMC6; NbExp=3; IntAct=EBI-12947623, EBI-2820492; CC Q96MV1; P54849: EMP1; NbExp=3; IntAct=EBI-12947623, EBI-4319440; CC Q96MV1; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-12947623, EBI-711490; CC Q96MV1; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-12947623, EBI-11337888; CC Q96MV1; P37268: FDFT1; NbExp=3; IntAct=EBI-12947623, EBI-714550; CC Q96MV1; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-12947623, EBI-713304; CC Q96MV1; P29033: GJB2; NbExp=3; IntAct=EBI-12947623, EBI-3905204; CC Q96MV1; O14653: GOSR2; NbExp=3; IntAct=EBI-12947623, EBI-4401517; CC Q96MV1; P02724: GYPA; NbExp=3; IntAct=EBI-12947623, EBI-702665; CC Q96MV1; P09601: HMOX1; NbExp=3; IntAct=EBI-12947623, EBI-2806151; CC Q96MV1; P24593: IGFBP5; NbExp=3; IntAct=EBI-12947623, EBI-720480; CC Q96MV1; P04264: KRT1; NbExp=3; IntAct=EBI-12947623, EBI-298429; CC Q96MV1; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-12947623, EBI-12133176; CC Q96MV1; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-12947623, EBI-12070086; CC Q96MV1; Q9HB07: MYG1; NbExp=3; IntAct=EBI-12947623, EBI-709754; CC Q96MV1; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-12947623, EBI-2863634; CC Q96MV1; O95167: NDUFA3; NbExp=3; IntAct=EBI-12947623, EBI-1246131; CC Q96MV1; Q92982: NINJ1; NbExp=3; IntAct=EBI-12947623, EBI-2802124; CC Q96MV1; Q16617: NKG7; NbExp=3; IntAct=EBI-12947623, EBI-3919611; CC Q96MV1; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-12947623, EBI-1054848; CC Q96MV1; Q01453: PMP22; NbExp=3; IntAct=EBI-12947623, EBI-2845982; CC Q96MV1; O60831: PRAF2; NbExp=3; IntAct=EBI-12947623, EBI-2506064; CC Q96MV1; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-12947623, EBI-722696; CC Q96MV1; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-12947623, EBI-14065960; CC Q96MV1; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-12947623, EBI-2695784; CC Q96MV1; O00767: SCD; NbExp=3; IntAct=EBI-12947623, EBI-2684237; CC Q96MV1; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-12947623, EBI-8652744; CC Q96MV1; O75396: SEC22B; NbExp=3; IntAct=EBI-12947623, EBI-1058865; CC Q96MV1; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-12947623, EBI-10329948; CC Q96MV1; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-12947623, EBI-355861; CC Q96MV1; Q9BWM7: SFXN3; NbExp=3; IntAct=EBI-12947623, EBI-1171999; CC Q96MV1; Q96BI1: SLC22A18; NbExp=3; IntAct=EBI-12947623, EBI-11721845; CC Q96MV1; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-12947623, EBI-12266234; CC Q96MV1; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-12947623, EBI-10226799; CC Q96MV1; P02808: STATH; NbExp=3; IntAct=EBI-12947623, EBI-738687; CC Q96MV1; Q86Y82: STX12; NbExp=3; IntAct=EBI-12947623, EBI-2691717; CC Q96MV1; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-12947623, EBI-726331; CC Q96MV1; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-12947623, EBI-1049004; CC Q96MV1; O14925: TIMM23; NbExp=3; IntAct=EBI-12947623, EBI-1047996; CC Q96MV1; Q12893: TMEM115; NbExp=3; IntAct=EBI-12947623, EBI-8633987; CC Q96MV1; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-12947623, EBI-10171534; CC Q96MV1; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-12947623, EBI-741829; CC Q96MV1; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-12947623, EBI-12195227; CC Q96MV1; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12947623, EBI-10982110; CC Q96MV1; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-12947623, EBI-2852148; CC Q96MV1; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-12947623, EBI-11343401; CC Q96MV1; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-12947623, EBI-988826; CC Q96MV1; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-12947623, EBI-7850136; CC Q96MV1; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-12947623, EBI-751253; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK056404; BAB71177.1; -; mRNA. DR EMBL; CH471097; EAW73024.1; -; Genomic_DNA. DR EMBL; CH471097; EAW73025.1; -; Genomic_DNA. DR EMBL; BC137457; AAI37458.1; -; mRNA. DR EMBL; BC137458; AAI37459.1; -; mRNA. DR EMBL; BC139737; AAI39738.1; -; mRNA. DR CCDS; CCDS753.1; -. DR RefSeq; NP_001186608.1; NM_001199679.1. DR RefSeq; NP_689700.1; NM_152487.2. DR AlphaFoldDB; Q96MV1; -. DR SMR; Q96MV1; -. DR BioGRID; 127154; 105. DR IntAct; Q96MV1; 83. DR MINT; Q96MV1; -. DR STRING; 9606.ENSP00000359222; -. DR CarbonylDB; Q96MV1; -. DR iPTMnet; Q96MV1; -. DR PhosphoSitePlus; Q96MV1; -. DR BioMuta; TMEM56; -. DR DMDM; 74732443; -. DR jPOST; Q96MV1; -. DR MassIVE; Q96MV1; -. DR MaxQB; Q96MV1; -. DR PaxDb; 9606-ENSP00000359222; -. DR PeptideAtlas; Q96MV1; -. DR ProteomicsDB; 77418; -. DR Pumba; Q96MV1; -. DR Antibodypedia; 71812; 54 antibodies from 9 providers. DR DNASU; 148534; -. DR Ensembl; ENST00000370203.9; ENSP00000359222.4; ENSG00000152078.10. DR GeneID; 148534; -. DR KEGG; hsa:148534; -. DR MANE-Select; ENST00000370203.9; ENSP00000359222.4; NM_152487.3; NP_689700.1. DR UCSC; uc001drb.4; human. DR AGR; HGNC:26477; -. DR CTD; 148534; -. DR DisGeNET; 148534; -. DR GeneCards; TLCD4; -. DR HGNC; HGNC:26477; TLCD4. DR HPA; ENSG00000152078; Tissue enriched (liver). DR neXtProt; NX_Q96MV1; -. DR OpenTargets; ENSG00000152078; -. DR VEuPathDB; HostDB:ENSG00000152078; -. DR eggNOG; KOG4561; Eukaryota. DR GeneTree; ENSGT01010000222313; -. DR HOGENOM; CLU_034597_2_0_1; -. DR InParanoid; Q96MV1; -. DR OMA; MPVYYSH; -. DR OrthoDB; 1066733at2759; -. DR PhylomeDB; Q96MV1; -. DR TreeFam; TF324847; -. DR PathwayCommons; Q96MV1; -. DR SignaLink; Q96MV1; -. DR BioGRID-ORCS; 148534; 11 hits in 1140 CRISPR screens. DR GenomeRNAi; 148534; -. DR Pharos; Q96MV1; Tdark. DR PRO; PR:Q96MV1; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q96MV1; Protein. DR Bgee; ENSG00000152078; Expressed in left ventricle myocardium and 172 other cell types or tissues. DR ExpressionAtlas; Q96MV1; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central. DR InterPro; IPR006634; TLC-dom. DR PANTHER; PTHR13439; CT120 PROTEIN; 1. DR PANTHER; PTHR13439:SF1; TLC DOMAIN-CONTAINING PROTEIN 4; 1. DR Pfam; PF03798; TRAM_LAG1_CLN8; 1. DR SMART; SM00724; TLC; 1. DR PROSITE; PS50922; TLC; 1. DR Genevisible; Q96MV1; HS. PE 1: Evidence at protein level; KW Acetylation; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..263 FT /note="TLC domain-containing protein 4" FT /id="PRO_0000286701" FT TRANSMEM 7..27 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 53..73 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 90..110 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 124..144 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 173..193 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 211..231 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 44..246 FT /note="TLC" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205" FT MOD_RES 165 FT /note="N6-acetyllysine" FT /evidence="ECO:0007744|PubMed:19608861" SQ SEQUENCE 263 AA; 30041 MW; 51480330FACC8ABF CRC64; MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN SRVVSTCHSL VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI SDLSIIILYW KVIGDKFFIM HHCASLYAYY LVLKNGVLAY IGNFRLLAEL SSPFVNQRWF FEALKYPKFS KAIVINGILM TVVFFIVRIA SMLPHYGFMY SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG CIKVISHIRQ EKAKNSLQNG KLD //