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Q96MV1

- TMM56_HUMAN

UniProt

Q96MV1 - TMM56_HUMAN

Protein

Transmembrane protein 56

Gene

TMEM56

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 56
    Gene namesi
    Name:TMEM56
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26477. TMEM56.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670772.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Transmembrane protein 56PRO_0000286701Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei165 – 1651N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96MV1.
    PaxDbiQ96MV1.
    PRIDEiQ96MV1.

    PTM databases

    PhosphoSiteiQ96MV1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96MV1.
    BgeeiQ96MV1.
    CleanExiHS_TMEM56.
    GenevestigatoriQ96MV1.

    Organism-specific databases

    HPAiHPA046762.

    Interactioni

    Protein-protein interaction databases

    BioGridi127154. 1 interaction.
    STRINGi9606.ENSP00000359222.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96MV1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 246203TLCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TMEM56 family.Curated
    Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG327998.
    HOGENOMiHOG000007105.
    HOVERGENiHBG100306.
    InParanoidiQ96MV1.
    OMAiYGFMYSV.
    OrthoDBiEOG7K9K46.
    PhylomeDBiQ96MV1.
    TreeFamiTF324847.

    Family and domain databases

    InterProiIPR006634. TLC-dom.
    [Graphical view]
    PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view]
    SMARTiSM00724. TLC. 1 hit.
    [Graphical view]
    PROSITEiPS50922. TLC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96MV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN    50
    SRVVSTCHSL VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI 100
    SDLSIIILYW KVIGDKFFIM HHCASLYAYY LVLKNGVLAY IGNFRLLAEL 150
    SSPFVNQRWF FEALKYPKFS KAIVINGILM TVVFFIVRIA SMLPHYGFMY 200
    SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG CIKVISHIRQ 250
    EKAKNSLQNG KLD 263
    Length:263
    Mass (Da):30,041
    Last modified:December 1, 2001 - v1
    Checksum:i51480330FACC8ABF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056404 mRNA. Translation: BAB71177.1.
    CH471097 Genomic DNA. Translation: EAW73024.1.
    CH471097 Genomic DNA. Translation: EAW73025.1.
    BC137457 mRNA. Translation: AAI37458.1.
    BC137458 mRNA. Translation: AAI37459.1.
    BC139737 mRNA. Translation: AAI39738.1.
    CCDSiCCDS753.1.
    RefSeqiNP_001186608.1. NM_001199679.1.
    NP_689700.1. NM_152487.2.
    UniGeneiHs.483512.

    Genome annotation databases

    EnsembliENST00000370203; ENSP00000359222; ENSG00000152078.
    GeneIDi148534.
    KEGGihsa:148534.
    UCSCiuc001drb.3. human.

    Polymorphism databases

    DMDMi74732443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056404 mRNA. Translation: BAB71177.1 .
    CH471097 Genomic DNA. Translation: EAW73024.1 .
    CH471097 Genomic DNA. Translation: EAW73025.1 .
    BC137457 mRNA. Translation: AAI37458.1 .
    BC137458 mRNA. Translation: AAI37459.1 .
    BC139737 mRNA. Translation: AAI39738.1 .
    CCDSi CCDS753.1.
    RefSeqi NP_001186608.1. NM_001199679.1.
    NP_689700.1. NM_152487.2.
    UniGenei Hs.483512.

    3D structure databases

    ProteinModelPortali Q96MV1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127154. 1 interaction.
    STRINGi 9606.ENSP00000359222.

    PTM databases

    PhosphoSitei Q96MV1.

    Polymorphism databases

    DMDMi 74732443.

    Proteomic databases

    MaxQBi Q96MV1.
    PaxDbi Q96MV1.
    PRIDEi Q96MV1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370203 ; ENSP00000359222 ; ENSG00000152078 .
    GeneIDi 148534.
    KEGGi hsa:148534.
    UCSCi uc001drb.3. human.

    Organism-specific databases

    CTDi 148534.
    GeneCardsi GC01P095582.
    HGNCi HGNC:26477. TMEM56.
    HPAi HPA046762.
    neXtProti NX_Q96MV1.
    PharmGKBi PA142670772.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327998.
    HOGENOMi HOG000007105.
    HOVERGENi HBG100306.
    InParanoidi Q96MV1.
    OMAi YGFMYSV.
    OrthoDBi EOG7K9K46.
    PhylomeDBi Q96MV1.
    TreeFami TF324847.

    Miscellaneous databases

    GenomeRNAii 148534.
    NextBioi 85947.
    PROi Q96MV1.

    Gene expression databases

    ArrayExpressi Q96MV1.
    Bgeei Q96MV1.
    CleanExi HS_TMEM56.
    Genevestigatori Q96MV1.

    Family and domain databases

    InterProi IPR006634. TLC-dom.
    [Graphical view ]
    Pfami PF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view ]
    SMARTi SM00724. TLC. 1 hit.
    [Graphical view ]
    PROSITEi PS50922. TLC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTMM56_HUMAN
    AccessioniPrimary (citable) accession number: Q96MV1
    Secondary accession number(s): B2RPI2, D3DT48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3