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Q96MV1

- TMM56_HUMAN

UniProt

Q96MV1 - TMM56_HUMAN

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Protein

Transmembrane protein 56

Gene

TMEM56

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 56
Gene namesi
Name:TMEM56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26477. TMEM56.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Transmembrane protein 56PRO_0000286701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96MV1.
PaxDbiQ96MV1.
PRIDEiQ96MV1.

PTM databases

PhosphoSiteiQ96MV1.

Expressioni

Gene expression databases

BgeeiQ96MV1.
CleanExiHS_TMEM56.
ExpressionAtlasiQ96MV1. baseline and differential.
GenevestigatoriQ96MV1.

Organism-specific databases

HPAiHPA046762.

Interactioni

Protein-protein interaction databases

BioGridi127154. 3 interactions.
STRINGi9606.ENSP00000359222.

Structurei

3D structure databases

ProteinModelPortaliQ96MV1.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 246203TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM56 family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327998.
GeneTreeiENSGT00510000047701.
HOGENOMiHOG000007105.
HOVERGENiHBG100306.
InParanoidiQ96MV1.
OMAiYGFMYSV.
OrthoDBiEOG7K9K46.
PhylomeDBiQ96MV1.
TreeFamiTF324847.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN
60 70 80 90 100
SRVVSTCHSL VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI
110 120 130 140 150
SDLSIIILYW KVIGDKFFIM HHCASLYAYY LVLKNGVLAY IGNFRLLAEL
160 170 180 190 200
SSPFVNQRWF FEALKYPKFS KAIVINGILM TVVFFIVRIA SMLPHYGFMY
210 220 230 240 250
SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG CIKVISHIRQ
260
EKAKNSLQNG KLD
Length:263
Mass (Da):30,041
Last modified:December 1, 2001 - v1
Checksum:i51480330FACC8ABF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056404 mRNA. Translation: BAB71177.1.
CH471097 Genomic DNA. Translation: EAW73024.1.
CH471097 Genomic DNA. Translation: EAW73025.1.
BC137457 mRNA. Translation: AAI37458.1.
BC137458 mRNA. Translation: AAI37459.1.
BC139737 mRNA. Translation: AAI39738.1.
CCDSiCCDS753.1.
RefSeqiNP_001186608.1. NM_001199679.1.
NP_689700.1. NM_152487.2.
UniGeneiHs.483512.

Genome annotation databases

EnsembliENST00000370203; ENSP00000359222; ENSG00000152078.
GeneIDi148534.
KEGGihsa:148534.
UCSCiuc001drb.3. human.

Polymorphism databases

DMDMi74732443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056404 mRNA. Translation: BAB71177.1 .
CH471097 Genomic DNA. Translation: EAW73024.1 .
CH471097 Genomic DNA. Translation: EAW73025.1 .
BC137457 mRNA. Translation: AAI37458.1 .
BC137458 mRNA. Translation: AAI37459.1 .
BC139737 mRNA. Translation: AAI39738.1 .
CCDSi CCDS753.1.
RefSeqi NP_001186608.1. NM_001199679.1.
NP_689700.1. NM_152487.2.
UniGenei Hs.483512.

3D structure databases

ProteinModelPortali Q96MV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127154. 3 interactions.
STRINGi 9606.ENSP00000359222.

PTM databases

PhosphoSitei Q96MV1.

Polymorphism databases

DMDMi 74732443.

Proteomic databases

MaxQBi Q96MV1.
PaxDbi Q96MV1.
PRIDEi Q96MV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370203 ; ENSP00000359222 ; ENSG00000152078 .
GeneIDi 148534.
KEGGi hsa:148534.
UCSCi uc001drb.3. human.

Organism-specific databases

CTDi 148534.
GeneCardsi GC01P095582.
HGNCi HGNC:26477. TMEM56.
HPAi HPA046762.
neXtProti NX_Q96MV1.
PharmGKBi PA142670772.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327998.
GeneTreei ENSGT00510000047701.
HOGENOMi HOG000007105.
HOVERGENi HBG100306.
InParanoidi Q96MV1.
OMAi YGFMYSV.
OrthoDBi EOG7K9K46.
PhylomeDBi Q96MV1.
TreeFami TF324847.

Miscellaneous databases

GenomeRNAii 148534.
NextBioi 85947.
PROi Q96MV1.

Gene expression databases

Bgeei Q96MV1.
CleanExi HS_TMEM56.
ExpressionAtlasi Q96MV1. baseline and differential.
Genevestigatori Q96MV1.

Family and domain databases

InterProi IPR006634. TLC-dom.
[Graphical view ]
Pfami PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view ]
SMARTi SM00724. TLC. 1 hit.
[Graphical view ]
PROSITEi PS50922. TLC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMM56_HUMAN
AccessioniPrimary (citable) accession number: Q96MV1
Secondary accession number(s): B2RPI2, D3DT48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3