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Protein

Transmembrane protein 56

Gene

TMEM56

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 56
Gene namesi
Name:TMEM56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26477. TMEM56.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Transmembrane protein 56PRO_0000286701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96MV1.
PaxDbiQ96MV1.
PRIDEiQ96MV1.

PTM databases

PhosphoSiteiQ96MV1.

Expressioni

Gene expression databases

BgeeiQ96MV1.
CleanExiHS_TMEM56.
ExpressionAtlasiQ96MV1. baseline and differential.
GenevestigatoriQ96MV1.

Organism-specific databases

HPAiHPA046762.

Interactioni

Protein-protein interaction databases

BioGridi127154. 3 interactions.
STRINGi9606.ENSP00000359222.

Structurei

3D structure databases

ProteinModelPortaliQ96MV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 246203TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM56 family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327998.
GeneTreeiENSGT00510000047701.
HOGENOMiHOG000007105.
HOVERGENiHBG100306.
InParanoidiQ96MV1.
OMAiYGFMYSV.
OrthoDBiEOG7K9K46.
PhylomeDBiQ96MV1.
TreeFamiTF324847.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN
60 70 80 90 100
SRVVSTCHSL VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI
110 120 130 140 150
SDLSIIILYW KVIGDKFFIM HHCASLYAYY LVLKNGVLAY IGNFRLLAEL
160 170 180 190 200
SSPFVNQRWF FEALKYPKFS KAIVINGILM TVVFFIVRIA SMLPHYGFMY
210 220 230 240 250
SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG CIKVISHIRQ
260
EKAKNSLQNG KLD
Length:263
Mass (Da):30,041
Last modified:November 30, 2001 - v1
Checksum:i51480330FACC8ABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056404 mRNA. Translation: BAB71177.1.
CH471097 Genomic DNA. Translation: EAW73024.1.
CH471097 Genomic DNA. Translation: EAW73025.1.
BC137457 mRNA. Translation: AAI37458.1.
BC137458 mRNA. Translation: AAI37459.1.
BC139737 mRNA. Translation: AAI39738.1.
CCDSiCCDS753.1.
RefSeqiNP_001186608.1. NM_001199679.1.
NP_689700.1. NM_152487.2.
UniGeneiHs.483512.

Genome annotation databases

EnsembliENST00000370203; ENSP00000359222; ENSG00000152078.
GeneIDi148534.
KEGGihsa:148534.
UCSCiuc001drb.3. human.

Polymorphism databases

DMDMi74732443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056404 mRNA. Translation: BAB71177.1.
CH471097 Genomic DNA. Translation: EAW73024.1.
CH471097 Genomic DNA. Translation: EAW73025.1.
BC137457 mRNA. Translation: AAI37458.1.
BC137458 mRNA. Translation: AAI37459.1.
BC139737 mRNA. Translation: AAI39738.1.
CCDSiCCDS753.1.
RefSeqiNP_001186608.1. NM_001199679.1.
NP_689700.1. NM_152487.2.
UniGeneiHs.483512.

3D structure databases

ProteinModelPortaliQ96MV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127154. 3 interactions.
STRINGi9606.ENSP00000359222.

PTM databases

PhosphoSiteiQ96MV1.

Polymorphism databases

DMDMi74732443.

Proteomic databases

MaxQBiQ96MV1.
PaxDbiQ96MV1.
PRIDEiQ96MV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370203; ENSP00000359222; ENSG00000152078.
GeneIDi148534.
KEGGihsa:148534.
UCSCiuc001drb.3. human.

Organism-specific databases

CTDi148534.
GeneCardsiGC01P095582.
HGNCiHGNC:26477. TMEM56.
HPAiHPA046762.
neXtProtiNX_Q96MV1.
PharmGKBiPA142670772.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327998.
GeneTreeiENSGT00510000047701.
HOGENOMiHOG000007105.
HOVERGENiHBG100306.
InParanoidiQ96MV1.
OMAiYGFMYSV.
OrthoDBiEOG7K9K46.
PhylomeDBiQ96MV1.
TreeFamiTF324847.

Miscellaneous databases

ChiTaRSiTMEM56. human.
GenomeRNAii148534.
NextBioi85947.
PROiQ96MV1.

Gene expression databases

BgeeiQ96MV1.
CleanExiHS_TMEM56.
ExpressionAtlasiQ96MV1. baseline and differential.
GenevestigatoriQ96MV1.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMM56_HUMAN
AccessioniPrimary (citable) accession number: Q96MV1
Secondary accession number(s): B2RPI2, D3DT48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 14, 2007
Last sequence update: November 30, 2001
Last modified: January 6, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.