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Q96MU8 (KREM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kremen protein 1
Alternative name(s):
Dickkopf receptor
Kringle domain-containing transmembrane protein 1
Kringle-containing protein marking the eye and the nose
Gene names
Name:KREMEN1
Synonyms:KREMEN, KRM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Contains 1 CUB domain.

Contains 1 kringle domain.

Contains 1 WSC domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96MU8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available. Exon 1 splicing donor site is not canonical.
Isoform 2 (identifier: Q96MU8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: E → GPE
     471-473: VSD → AIQDSEVTSLIWSQGQPRSI
Note: No experimental confirmation available.
Isoform 3 (identifier: Q96MU8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: E → GPE
     373-389: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 473454Kremen protein 1
PRO_0000021564

Regions

Topological domain21 – 392372Extracellular Potential
Transmembrane393 – 41321Helical; Potential
Topological domain414 – 47360Cytoplasmic Potential
Domain31 – 11484Kringle
Domain116 – 21095WSC
Domain214 – 321108CUB

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation2171N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation3451N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 114 By similarity
Disulfide bond55 ↔ 95 By similarity
Disulfide bond84 ↔ 109 By similarity
Disulfide bond214 ↔ 240 By similarity

Natural variations

Alternative sequence311E → GPE in isoform 2 and isoform 3.
VSP_034914
Alternative sequence373 – 38917Missing in isoform 3.
VSP_015698
Alternative sequence471 – 4733VSD → AIQDSEVTSLIWSQGQPRSI in isoform 2.
VSP_003900

Experimental info

Sequence conflict2041I → V in BAB71180. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 22, 2008. Version 3.
Checksum: F6D30DDE708C186B

FASTA47351,744
        10         20         30         40         50         60 
MAPPAARLAL LSAAALTLAA RPAPSPGLGP ECFTANGADY RGTQNWTALQ GGKPCLFWNE 

        70         80         90        100        110        120 
TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH EDGVYWKYCE IPACQMPGNL 

       130        140        150        160        170        180 
GCYKDHGNPP PLTGTSKTSN KLTIQTCISF CRSQRFKFAG MESGYACFCG NNPDYWKYGE 

       190        200        210        220        230        240 
AASTECNSVC FGDHTQPCGG DGRIILFDTL VGACGGNYSA MSSVVYSPDF PDTYATGRVC 

       250        260        270        280        290        300 
YWTIRVPGAS HIHFSFPLFD IRDSADMVEL LDGYTHRVLA RFHGRSRPPL SFNVSLDFVI 

       310        320        330        340        350        360 
LYFFSDRINQ AQGFAVLYQA VKEELPQERP AVNQTVAEVI TEQANLSVSA ARSSKVLYVI 

       370        380        390        400        410        420 
TTSPSHPPQT VPGSNSWAPP MGAGSHRVEG WTVYGLATLL ILTVTAIVAK ILLHVTFKSH 

       430        440        450        460        470 
RVPASGDLRD CHQPGTSGEI WSIFYKPSTS ISIFKKKLKG QSQQDDRNPL VSD 

« Hide

Isoform 2 [UniParc].

Checksum: BCCDBC62C07AFF56
Show »

FASTA49253,795
Isoform 3 [UniParc].

Checksum: 8A56506A033E1D4C
Show »

FASTA45850,177

References

« Hide 'large scale' references
[1]Nakamura T., Nakamura T.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Eye.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB059618 mRNA. Translation: BAB40969.1.
AK056425 mRNA. Translation: BAB71180.1.
AL021393, Z95116 Genomic DNA. Translation: CAM25378.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07689.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07690.1.
Z95116, AL021393 Genomic DNA. Translation: CAM25375.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08609.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08610.1.
CH471095 Genomic DNA. Translation: EAW59774.1.
BC063787 mRNA. Translation: AAH63787.1.
RefSeqNP_001034659.2. NM_001039570.2.
NP_114434.3. NM_032045.4.
UniGeneHs.229335.

3D structure databases

ProteinModelPortalQ96MU8.
SMRQ96MU8. Positions 4-321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-46462N.

PTM databases

PhosphoSiteQ96MU8.

Polymorphism databases

DMDM212287927.

Proteomic databases

PaxDbQ96MU8.
PRIDEQ96MU8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327813; ENSP00000331242; ENSG00000183762. [Q96MU8-2]
ENST00000400335; ENSP00000383189; ENSG00000183762. [Q96MU8-3]
ENST00000407188; ENSP00000385431; ENSG00000183762. [Q96MU8-1]
GeneID83999.
KEGGhsa:83999.
UCSCuc003ael.3. human. [Q96MU8-3]
uc011akm.1. human. [Q96MU8-2]
uc011akn.2. human. [Q96MU8-1]

Organism-specific databases

CTD83999.
GeneCardsGC22P029469.
HGNCHGNC:17550. KREMEN1.
HPAHPA055946.
MIM609898. gene.
neXtProtNX_Q96MU8.
PharmGKBPA38241.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG262750.
HOVERGENHBG052290.
OMAYQAVKEE.
OrthoDBEOG7T1RB2.
PhylomeDBQ96MU8.
TreeFamTF331319.

Enzyme and pathway databases

SignaLinkQ96MU8.

Gene expression databases

ArrayExpressQ96MU8.
BgeeQ96MU8.
GenevestigatorQ96MU8.

Family and domain databases

Gene3D2.40.20.10. 1 hit.
2.60.120.290. 1 hit.
InterProIPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamPF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PIRSFPIRSF036961. Kremen. 1 hit.
SMARTSM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
[Graphical view]
SUPFAMSSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEPS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKREMEN1. human.
GeneWikiKREMEN1.
GenomeRNAi83999.
NextBio73160.
PROQ96MU8.
SOURCESearch...

Entry information

Entry nameKREM1_HUMAN
AccessionPrimary (citable) accession number: Q96MU8
Secondary accession number(s): B0QY46 expand/collapse secondary AC list , B0QY47, B1AJR5, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: July 22, 2008
Last modified: April 16, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM