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Protein

Kremen protein 1

Gene

KREMEN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).By similarity

GO - Biological processi

  • cell communication Source: UniProtKB
  • regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201681. TCF dependent signaling in response to WNT.
R-HSA-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.
R-HSA-5339717. Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling.
SignaLinkiQ96MU8.
SIGNORiQ96MU8.

Names & Taxonomyi

Protein namesi
Recommended name:
Kremen protein 1
Alternative name(s):
Dickkopf receptor
Kringle domain-containing transmembrane protein 1
Kringle-containing protein marking the eye and the nose
Gene namesi
Name:KREMEN1
Synonyms:KREMEN, KRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:17550. KREMEN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 392ExtracellularSequence analysisAdd BLAST372
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 473CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83999.
OpenTargetsiENSG00000183762.
PharmGKBiPA38241.

Polymorphism and mutation databases

BioMutaiKREMEN1.
DMDMi212287927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002156420 – 473Kremen protein 1Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 114By similarity
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi55 ↔ 95By similarity
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi84 ↔ 109By similarity
Disulfide bondi214 ↔ 240By similarity
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96MU8.
PeptideAtlasiQ96MU8.
PRIDEiQ96MU8.

PTM databases

iPTMnetiQ96MU8.
PhosphoSitePlusiQ96MU8.

Expressioni

Gene expression databases

BgeeiENSG00000183762.
ExpressionAtlasiQ96MU8. baseline and differential.
GenevisibleiQ96MU8. HS.

Organism-specific databases

HPAiHPA055946.
HPA058513.

Interactioni

Protein-protein interaction databases

DIPiDIP-46462N.
STRINGi9606.ENSP00000331242.

Structurei

Secondary structure

1473
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Beta strandi46 – 48Combined sources3
Turni49 – 51Combined sources3
Turni58 – 60Combined sources3
Beta strandi63 – 65Combined sources3
Turni68 – 70Combined sources3
Helixi72 – 77Combined sources6
Beta strandi79 – 81Combined sources3
Beta strandi94 – 96Combined sources3
Beta strandi101 – 103Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi119 – 124Combined sources6
Beta strandi127 – 129Combined sources3
Beta strandi134 – 138Combined sources5
Helixi144 – 153Combined sources10
Beta strandi157 – 162Combined sources6
Turni163 – 165Combined sources3
Beta strandi166 – 170Combined sources5
Turni173 – 178Combined sources6
Helixi183 – 186Combined sources4
Beta strandi193 – 197Combined sources5
Beta strandi203 – 208Combined sources6
Turni209 – 212Combined sources4
Beta strandi216 – 218Combined sources3
Beta strandi220 – 226Combined sources7
Turni228 – 231Combined sources4
Beta strandi239 – 245Combined sources7
Beta strandi250 – 260Combined sources11
Beta strandi266 – 272Combined sources7
Turni273 – 275Combined sources3
Beta strandi278 – 283Combined sources6
Beta strandi290 – 294Combined sources5
Beta strandi297 – 304Combined sources8
Beta strandi313 – 321Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FWSX-ray1.90A29-373[»]
5FWTX-ray2.10A29-373[»]
5FWUX-ray2.80A29-373[»]
5FWVX-ray3.20A29-373[»]
5FWWX-ray3.50B30-322[»]
ProteinModelPortaliQ96MU8.
SMRiQ96MU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 114KringlePROSITE-ProRule annotationAdd BLAST84
Domaini116 – 210WSCPROSITE-ProRule annotationAdd BLAST95
Domaini214 – 321CUBPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 WSC domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR07. Eukaryota.
ENOG41112QM. LUCA.
GeneTreeiENSGT00730000110973.
HOVERGENiHBG052290.
InParanoidiQ96MU8.
OMAiPECFTAN.
OrthoDBiEOG091G053O.
PhylomeDBiQ96MU8.
TreeFamiTF331319.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PIRSFiPIRSF036961. Kremen. 1 hit.
SMARTiSM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
SM00321. WSC. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPAARLAL LSAAALTLAA RPAPSPGLGP ECFTANGADY RGTQNWTALQ
60 70 80 90 100
GGKPCLFWNE TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH
110 120 130 140 150
EDGVYWKYCE IPACQMPGNL GCYKDHGNPP PLTGTSKTSN KLTIQTCISF
160 170 180 190 200
CRSQRFKFAG MESGYACFCG NNPDYWKYGE AASTECNSVC FGDHTQPCGG
210 220 230 240 250
DGRIILFDTL VGACGGNYSA MSSVVYSPDF PDTYATGRVC YWTIRVPGAS
260 270 280 290 300
HIHFSFPLFD IRDSADMVEL LDGYTHRVLA RFHGRSRPPL SFNVSLDFVI
310 320 330 340 350
LYFFSDRINQ AQGFAVLYQA VKEELPQERP AVNQTVAEVI TEQANLSVSA
360 370 380 390 400
ARSSKVLYVI TTSPSHPPQT VPGSNSWAPP MGAGSHRVEG WTVYGLATLL
410 420 430 440 450
ILTVTAIVAK ILLHVTFKSH RVPASGDLRD CHQPGTSGEI WSIFYKPSTS
460 470
ISIFKKKLKG QSQQDDRNPL VSD
Note: No experimental confirmation available. Exon 1 splicing donor site is not canonical.
Length:473
Mass (Da):51,744
Last modified:July 22, 2008 - v3
Checksum:iF6D30DDE708C186B
GO
Isoform 2 (identifier: Q96MU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: E → GPE
     471-473: VSD → AIQDSEVTSLIWSQGQPRSI

Note: No experimental confirmation available.
Show »
Length:492
Mass (Da):53,795
Checksum:iBCCDBC62C07AFF56
GO
Isoform 3 (identifier: Q96MU8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: E → GPE
     373-389: Missing.

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):50,177
Checksum:i8A56506A033E1D4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204I → V in BAB71180 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03491431E → GPE in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_015698373 – 389Missing in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_003900471 – 473VSD → AIQDSEVTSLIWSQGQPRSI in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059618 mRNA. Translation: BAB40969.1.
AK056425 mRNA. Translation: BAB71180.1.
AL021393, Z95116 Genomic DNA. Translation: CAM25378.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07689.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07690.1.
Z95116, AL021393 Genomic DNA. Translation: CAM25375.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08609.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08610.1.
CH471095 Genomic DNA. Translation: EAW59774.1.
BC063787 mRNA. Translation: AAH63787.1.
CCDSiCCDS13849.1. [Q96MU8-2]
CCDS43000.2. [Q96MU8-3]
RefSeqiNP_001034659.2. NM_001039570.2. [Q96MU8-3]
NP_114434.3. NM_032045.4. [Q96MU8-2]
UniGeneiHs.229335.

Genome annotation databases

EnsembliENST00000327813; ENSP00000331242; ENSG00000183762. [Q96MU8-2]
ENST00000400335; ENSP00000383189; ENSG00000183762. [Q96MU8-3]
ENST00000407188; ENSP00000385431; ENSG00000183762. [Q96MU8-1]
GeneIDi83999.
KEGGihsa:83999.
UCSCiuc003ael.3. human. [Q96MU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059618 mRNA. Translation: BAB40969.1.
AK056425 mRNA. Translation: BAB71180.1.
AL021393, Z95116 Genomic DNA. Translation: CAM25378.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07689.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07690.1.
Z95116, AL021393 Genomic DNA. Translation: CAM25375.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08609.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08610.1.
CH471095 Genomic DNA. Translation: EAW59774.1.
BC063787 mRNA. Translation: AAH63787.1.
CCDSiCCDS13849.1. [Q96MU8-2]
CCDS43000.2. [Q96MU8-3]
RefSeqiNP_001034659.2. NM_001039570.2. [Q96MU8-3]
NP_114434.3. NM_032045.4. [Q96MU8-2]
UniGeneiHs.229335.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FWSX-ray1.90A29-373[»]
5FWTX-ray2.10A29-373[»]
5FWUX-ray2.80A29-373[»]
5FWVX-ray3.20A29-373[»]
5FWWX-ray3.50B30-322[»]
ProteinModelPortaliQ96MU8.
SMRiQ96MU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46462N.
STRINGi9606.ENSP00000331242.

PTM databases

iPTMnetiQ96MU8.
PhosphoSitePlusiQ96MU8.

Polymorphism and mutation databases

BioMutaiKREMEN1.
DMDMi212287927.

Proteomic databases

PaxDbiQ96MU8.
PeptideAtlasiQ96MU8.
PRIDEiQ96MU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327813; ENSP00000331242; ENSG00000183762. [Q96MU8-2]
ENST00000400335; ENSP00000383189; ENSG00000183762. [Q96MU8-3]
ENST00000407188; ENSP00000385431; ENSG00000183762. [Q96MU8-1]
GeneIDi83999.
KEGGihsa:83999.
UCSCiuc003ael.3. human. [Q96MU8-1]

Organism-specific databases

CTDi83999.
DisGeNETi83999.
GeneCardsiKREMEN1.
HGNCiHGNC:17550. KREMEN1.
HPAiHPA055946.
HPA058513.
MIMi609898. gene.
neXtProtiNX_Q96MU8.
OpenTargetsiENSG00000183762.
PharmGKBiPA38241.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR07. Eukaryota.
ENOG41112QM. LUCA.
GeneTreeiENSGT00730000110973.
HOVERGENiHBG052290.
InParanoidiQ96MU8.
OMAiPECFTAN.
OrthoDBiEOG091G053O.
PhylomeDBiQ96MU8.
TreeFamiTF331319.

Enzyme and pathway databases

ReactomeiR-HSA-201681. TCF dependent signaling in response to WNT.
R-HSA-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.
R-HSA-5339717. Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling.
SignaLinkiQ96MU8.
SIGNORiQ96MU8.

Miscellaneous databases

ChiTaRSiKREMEN1. human.
GeneWikiiKREMEN1.
GenomeRNAii83999.
PROiQ96MU8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183762.
ExpressionAtlasiQ96MU8. baseline and differential.
GenevisibleiQ96MU8. HS.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PIRSFiPIRSF036961. Kremen. 1 hit.
SMARTiSM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
SM00321. WSC. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKREM1_HUMAN
AccessioniPrimary (citable) accession number: Q96MU8
Secondary accession number(s): B0QY46
, B0QY47, B1AJR5, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.