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Q96MU8

- KREM1_HUMAN

UniProt

Q96MU8 - KREM1_HUMAN

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Protein

Kremen protein 1

Gene

KREMEN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).By similarity

GO - Biological processi

  1. cell communication Source: UniProtKB
  2. regulation of canonical Wnt signaling pathway Source: BHF-UCL
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_200777. TCF dependent signaling in response to WNT.
SignaLinkiQ96MU8.

Names & Taxonomyi

Protein namesi
Recommended name:
Kremen protein 1
Alternative name(s):
Dickkopf receptor
Kringle domain-containing transmembrane protein 1
Kringle-containing protein marking the eye and the nose
Gene namesi
Name:KREMEN1
Synonyms:KREMEN, KRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:17550. KREMEN1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 473454Kremen protein 1PRO_0000021564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 114By similarity
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi55 ↔ 95By similarity
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi84 ↔ 109By similarity
Disulfide bondi214 ↔ 240By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96MU8.
PRIDEiQ96MU8.

PTM databases

PhosphoSiteiQ96MU8.

Expressioni

Gene expression databases

BgeeiQ96MU8.
GenevestigatoriQ96MU8.

Organism-specific databases

HPAiHPA055946.

Interactioni

Protein-protein interaction databases

DIPiDIP-46462N.

Structurei

3D structure databases

ProteinModelPortaliQ96MU8.
SMRiQ96MU8. Positions 4-183, 214-321.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 392372ExtracellularSequence AnalysisAdd
BLAST
Topological domaini414 – 47360CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 11484KringlePROSITE-ProRule annotationAdd
BLAST
Domaini116 – 21095WSCPROSITE-ProRule annotationAdd
BLAST
Domaini214 – 321108CUBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 WSC domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262750.
GeneTreeiENSGT00730000110973.
HOVERGENiHBG052290.
InParanoidiQ96MU8.
OMAiYQAVKEE.
OrthoDBiEOG7T1RB2.
PhylomeDBiQ96MU8.
TreeFamiTF331319.

Family and domain databases

Gene3Di2.40.20.10. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PIRSFiPIRSF036961. Kremen. 1 hit.
SMARTiSM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96MU8) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPAARLAL LSAAALTLAA RPAPSPGLGP ECFTANGADY RGTQNWTALQ
60 70 80 90 100
GGKPCLFWNE TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH
110 120 130 140 150
EDGVYWKYCE IPACQMPGNL GCYKDHGNPP PLTGTSKTSN KLTIQTCISF
160 170 180 190 200
CRSQRFKFAG MESGYACFCG NNPDYWKYGE AASTECNSVC FGDHTQPCGG
210 220 230 240 250
DGRIILFDTL VGACGGNYSA MSSVVYSPDF PDTYATGRVC YWTIRVPGAS
260 270 280 290 300
HIHFSFPLFD IRDSADMVEL LDGYTHRVLA RFHGRSRPPL SFNVSLDFVI
310 320 330 340 350
LYFFSDRINQ AQGFAVLYQA VKEELPQERP AVNQTVAEVI TEQANLSVSA
360 370 380 390 400
ARSSKVLYVI TTSPSHPPQT VPGSNSWAPP MGAGSHRVEG WTVYGLATLL
410 420 430 440 450
ILTVTAIVAK ILLHVTFKSH RVPASGDLRD CHQPGTSGEI WSIFYKPSTS
460 470
ISIFKKKLKG QSQQDDRNPL VSD

Note: No experimental confirmation available. Exon 1 splicing donor site is not canonical.

Length:473
Mass (Da):51,744
Last modified:July 22, 2008 - v3
Checksum:iF6D30DDE708C186B
GO
Isoform 2 (identifier: Q96MU8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: E → GPE
     471-473: VSD → AIQDSEVTSLIWSQGQPRSI

Note: No experimental confirmation available.

Show »
Length:492
Mass (Da):53,795
Checksum:iBCCDBC62C07AFF56
GO
Isoform 3 (identifier: Q96MU8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: E → GPE
     373-389: Missing.

Note: No experimental confirmation available.

Show »
Length:458
Mass (Da):50,177
Checksum:i8A56506A033E1D4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041I → V in BAB71180. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei31 – 311E → GPE in isoform 2 and isoform 3. 2 PublicationsVSP_034914
Alternative sequencei373 – 38917Missing in isoform 3. 1 PublicationVSP_015698Add
BLAST
Alternative sequencei471 – 4733VSD → AIQDSEVTSLIWSQGQPRSI in isoform 2. 1 PublicationVSP_003900

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB059618 mRNA. Translation: BAB40969.1.
AK056425 mRNA. Translation: BAB71180.1.
AL021393, Z95116 Genomic DNA. Translation: CAM25378.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07689.1.
AL021393, Z95116 Genomic DNA. Translation: CAQ07690.1.
Z95116, AL021393 Genomic DNA. Translation: CAM25375.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08609.1.
Z95116, AL021393 Genomic DNA. Translation: CAQ08610.1.
CH471095 Genomic DNA. Translation: EAW59774.1.
BC063787 mRNA. Translation: AAH63787.1.
CCDSiCCDS13849.1. [Q96MU8-2]
CCDS43000.2. [Q96MU8-3]
RefSeqiNP_001034659.2. NM_001039570.2. [Q96MU8-3]
NP_114434.3. NM_032045.4. [Q96MU8-2]
UniGeneiHs.229335.

Genome annotation databases

EnsembliENST00000327813; ENSP00000331242; ENSG00000183762. [Q96MU8-2]
ENST00000400335; ENSP00000383189; ENSG00000183762. [Q96MU8-3]
ENST00000407188; ENSP00000385431; ENSG00000183762. [Q96MU8-1]
GeneIDi83999.
KEGGihsa:83999.
UCSCiuc003ael.3. human. [Q96MU8-3]
uc011akm.1. human. [Q96MU8-2]
uc011akn.2. human. [Q96MU8-1]

Polymorphism databases

DMDMi212287927.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB059618 mRNA. Translation: BAB40969.1 .
AK056425 mRNA. Translation: BAB71180.1 .
AL021393 , Z95116 Genomic DNA. Translation: CAM25378.1 .
AL021393 , Z95116 Genomic DNA. Translation: CAQ07689.1 .
AL021393 , Z95116 Genomic DNA. Translation: CAQ07690.1 .
Z95116 , AL021393 Genomic DNA. Translation: CAM25375.1 .
Z95116 , AL021393 Genomic DNA. Translation: CAQ08609.1 .
Z95116 , AL021393 Genomic DNA. Translation: CAQ08610.1 .
CH471095 Genomic DNA. Translation: EAW59774.1 .
BC063787 mRNA. Translation: AAH63787.1 .
CCDSi CCDS13849.1. [Q96MU8-2 ]
CCDS43000.2. [Q96MU8-3 ]
RefSeqi NP_001034659.2. NM_001039570.2. [Q96MU8-3 ]
NP_114434.3. NM_032045.4. [Q96MU8-2 ]
UniGenei Hs.229335.

3D structure databases

ProteinModelPortali Q96MU8.
SMRi Q96MU8. Positions 4-183, 214-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46462N.

PTM databases

PhosphoSitei Q96MU8.

Polymorphism databases

DMDMi 212287927.

Proteomic databases

PaxDbi Q96MU8.
PRIDEi Q96MU8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327813 ; ENSP00000331242 ; ENSG00000183762 . [Q96MU8-2 ]
ENST00000400335 ; ENSP00000383189 ; ENSG00000183762 . [Q96MU8-3 ]
ENST00000407188 ; ENSP00000385431 ; ENSG00000183762 . [Q96MU8-1 ]
GeneIDi 83999.
KEGGi hsa:83999.
UCSCi uc003ael.3. human. [Q96MU8-3 ]
uc011akm.1. human. [Q96MU8-2 ]
uc011akn.2. human. [Q96MU8-1 ]

Organism-specific databases

CTDi 83999.
GeneCardsi GC22P029469.
HGNCi HGNC:17550. KREMEN1.
HPAi HPA055946.
MIMi 609898. gene.
neXtProti NX_Q96MU8.
PharmGKBi PA38241.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262750.
GeneTreei ENSGT00730000110973.
HOVERGENi HBG052290.
InParanoidi Q96MU8.
OMAi YQAVKEE.
OrthoDBi EOG7T1RB2.
PhylomeDBi Q96MU8.
TreeFami TF331319.

Enzyme and pathway databases

Reactomei REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_200777. TCF dependent signaling in response to WNT.
SignaLinki Q96MU8.

Miscellaneous databases

ChiTaRSi KREMEN1. human.
GeneWikii KREMEN1.
GenomeRNAii 83999.
NextBioi 73160.
PROi Q96MU8.
SOURCEi Search...

Gene expression databases

Bgeei Q96MU8.
Genevestigatori Q96MU8.

Family and domain databases

Gene3Di 2.40.20.10. 1 hit.
2.60.120.290. 1 hit.
InterProi IPR000859. CUB_dom.
IPR017076. Kremen.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR002889. WSC_carb-bd.
[Graphical view ]
Pfami PF00431. CUB. 1 hit.
PF00051. Kringle. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036961. Kremen. 1 hit.
SMARTi SM00042. CUB. 1 hit.
SM00130. KR. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEi PS01180. CUB. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Nakamura T., Nakamura T.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Eye.

Entry informationi

Entry nameiKREM1_HUMAN
AccessioniPrimary (citable) accession number: Q96MU8
Secondary accession number(s): B0QY46
, B0QY47, B1AJR5, Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3