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Protein

Zinc finger protein 778

Gene

ZNF778

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri115 – 14026C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri561 – 58323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri589 – 61123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri617 – 63923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri645 – 66723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri673 – 69523C2H2-type 17; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri701 – 72323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 778
Gene namesi
Name:ZNF778
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26479. ZNF778.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410400.

Polymorphism and mutation databases

BioMutaiZNF778.
DMDMi317373490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Zinc finger protein 778PRO_0000263109Add
BLAST

Proteomic databases

MaxQBiQ96MU6.
PaxDbiQ96MU6.
PeptideAtlasiQ96MU6.
PRIDEiQ96MU6.
TopDownProteomicsiQ96MU6-1. [Q96MU6-1]

PTM databases

iPTMnetiQ96MU6.
PhosphoSiteiQ96MU6.

Expressioni

Gene expression databases

BgeeiQ96MU6.
CleanExiHS_ZNF778.
ExpressionAtlasiQ96MU6. baseline and differential.
GenevisibleiQ96MU6. HS.

Organism-specific databases

HPAiHPA052057.
HPA057151.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10291463,EBI-10172290

Protein-protein interaction databases

BioGridi128247. 2 interactions.
IntActiQ96MU6. 2 interactions.
STRINGi9606.ENSP00000405289.

Structurei

3D structure databases

ProteinModelPortaliQ96MU6.
SMRiQ96MU6. Positions 41-91, 121-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11069KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri115 – 14026C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri561 – 58323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri589 – 61123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri617 – 63923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri645 – 66723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri673 – 69523C2H2-type 17; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri701 – 72323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96MU6.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96MU6.
TreeFamiTF342172.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPDLAHGG HVSRDSVCLH EEQTQAAGMV AGWLINCYQD AVTFDDVAVD
60 70 80 90 100
FTQEEWTLLD PSQRDLYRDV MLENYENLAS VEWRLKTKGP ALRQDRSWFR
110 120 130 140 150
ASNETQTARS HNGGQLCDRT QCGEAFSEHS GLSTHVRTQN TGDSCVSNHY
160 170 180 190 200
ERDFFIPCQK TLFKIGEQFS VLGQCGKAFS STPNVVSQQA CTRDRSLDYS
210 220 230 240 250
SCGEVFLNQS YLQARAGSHN GEETWKWKPC GKALTHSMGC ATPVEMHAVR
260 270 280 290 300
NPHVCRECGK AFRYTAYLTG RVQVHPGEKP CELEECGKAS PVSSSLTQHV
310 320 330 340 350
RIHAAEKPCE CKECGKAFTG LSGLSKHVQT DPGQKPYECK DCGKACGGFY
360 370 380 390 400
LLNEHGKTHT REKPFACVVC GKYFRNSSCL NNHVRIHTGI KPYTCSYCGK
410 420 430 440 450
AFTVRCGLTR HVRTHTGEKP YTCKDCGKAF CTSSGLTEHV RTHTGEKPYE
460 470 480 490 500
CKDCGKSFTV SSSLTEHARI HTGEKPYECK QCGKAFTGRS GLTKHMRTHT
510 520 530 540 550
GEKPYECKDC GKAYNRVYLL NEHVKTHTEE KPFICTVCRK SFRNSSCLNK
560 570 580 590 600
HIQIHTGIKP YECKDCGKTF TVSSSLTEHI RTHTGEKPYE CKVCGKAFTT
610 620 630 640 650
SSHLIVHIRT HTGEKPYICK ECGKAFASSS HLIEHRRTHT GEKPYICNEC
660 670 680 690 700
GKAFRASSHL HKHGRIHTGQ KPYKCKECGK AYNRFYLLKE HLKTYTEEQV
710 720
FVCKDCGKSF KNSSCLNHHT QIHTDEKPF
Length:729
Mass (Da):81,964
Last modified:January 11, 2011 - v3
Checksum:i86E9F02F0A19FC68
GO
Isoform 2 (identifier: Q96MU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     81-81: V → VGHHLFQPSVIYWLEQEEELRAGRRAVLQ

Show »
Length:687
Mass (Da):77,517
Checksum:i916FBCB1EB56AF1D
GO

Sequence cautioni

The sequence BAB71183.1 differs from that shown. Reason: Frameshift at position 393. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641K → T in BAB71183 (PubMed:14702039).Curated
Sequence conflicti393 – 3931Y → H in BAB71183 (PubMed:14702039).Curated
Sequence conflicti534 – 5341I → T in BAB71183 (PubMed:14702039).Curated
Sequence conflicti553 – 5531Q → H in BAB71183 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti683 – 6831N → D.
Corresponds to variant rs55974122 [ dbSNP | Ensembl ].
VAR_061966

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_040338Add
BLAST
Alternative sequencei81 – 811V → VGHHLFQPSVIYWLEQEEEL RAGRRAVLQ in isoform 2. 1 PublicationVSP_040339

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056437 mRNA. Translation: BAB71183.1. Frameshift.
AC009113 Genomic DNA. No translation available.
BC125192 mRNA. Translation: AAI25193.3.
CCDSiCCDS45550.1. [Q96MU6-1]
RefSeqiNP_872337.2. NM_182531.3. [Q96MU6-1]
UniGeneiHs.647385.

Genome annotation databases

EnsembliENST00000306502; ENSP00000305203; ENSG00000170100. [Q96MU6-2]
ENST00000620195; ENSP00000481538; ENSG00000170100. [Q96MU6-1]
GeneIDi197320.
KEGGihsa:197320.
UCSCiuc002fmv.4. human. [Q96MU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056437 mRNA. Translation: BAB71183.1. Frameshift.
AC009113 Genomic DNA. No translation available.
BC125192 mRNA. Translation: AAI25193.3.
CCDSiCCDS45550.1. [Q96MU6-1]
RefSeqiNP_872337.2. NM_182531.3. [Q96MU6-1]
UniGeneiHs.647385.

3D structure databases

ProteinModelPortaliQ96MU6.
SMRiQ96MU6. Positions 41-91, 121-729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128247. 2 interactions.
IntActiQ96MU6. 2 interactions.
STRINGi9606.ENSP00000405289.

PTM databases

iPTMnetiQ96MU6.
PhosphoSiteiQ96MU6.

Polymorphism and mutation databases

BioMutaiZNF778.
DMDMi317373490.

Proteomic databases

MaxQBiQ96MU6.
PaxDbiQ96MU6.
PeptideAtlasiQ96MU6.
PRIDEiQ96MU6.
TopDownProteomicsiQ96MU6-1. [Q96MU6-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306502; ENSP00000305203; ENSG00000170100. [Q96MU6-2]
ENST00000620195; ENSP00000481538; ENSG00000170100. [Q96MU6-1]
GeneIDi197320.
KEGGihsa:197320.
UCSCiuc002fmv.4. human. [Q96MU6-1]

Organism-specific databases

CTDi197320.
GeneCardsiZNF778.
HGNCiHGNC:26479. ZNF778.
HPAiHPA052057.
HPA057151.
neXtProtiNX_Q96MU6.
PharmGKBiPA162410400.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96MU6.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96MU6.
TreeFamiTF342172.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii197320.
PROiQ96MU6.

Gene expression databases

BgeeiQ96MU6.
CleanExiHS_ZNF778.
ExpressionAtlasiQ96MU6. baseline and differential.
GenevisibleiQ96MU6. HS.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiZN778_HUMAN
AccessioniPrimary (citable) accession number: Q96MU6
Secondary accession number(s): Q08AG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 11, 2011
Last modified: July 6, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.