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Q96MT3

- PRIC1_HUMAN

UniProt

Q96MT3 - PRIC1_HUMAN

Protein

Prickle-like protein 1

Gene

PRICKLE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    2. negative regulation of cardiac muscle cell myoblast differentiation Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: BHF-UCL
    4. neural tube closure Source: UniProtKB
    5. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    6. positive regulation of protein ubiquitination Source: BHF-UCL
    7. protein import into nucleus Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_172638. Asymmetric localization of PCP proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prickle-like protein 1
    Alternative name(s):
    REST/NRSF-interacting LIM domain protein 1
    Gene namesi
    Name:PRICKLE1
    Synonyms:RILP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17019. PRICKLE1.

    Subcellular locationi

    Nucleus membrane 1 Publication. Cytoplasmcytosol 1 Publication
    Note: A smaller amount is detected in the cytosol.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. nuclear membrane Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Epilepsy, progressive myoclonic 1B (EPM1B) [MIM:612437]: An autosomal recessive disorder characterized by myoclonus that progressed in severity over time, tonic-clonic seizures and ataxia.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti104 – 1041R → Q in EPM1B; affects interaction with REST. 2 Publications
    VAR_054663
    Natural varianti144 – 1441R → H in EPM1B. 1 Publication
    VAR_065580
    Natural varianti472 – 4721Y → H in EPM1B. 1 Publication
    VAR_065581
    Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti69 – 691I → T May be associated with NTD. 1 Publication
    Corresponds to variant rs141795695 [ dbSNP | Ensembl ].
    VAR_066850
    Natural varianti81 – 811N → H May be associated with NTD. 1 Publication
    VAR_066851
    Natural varianti121 – 1211V → I May be associated with NTD. 1 Publication
    VAR_066852
    Natural varianti275 – 2751T → M May be associated with NTD. 1 Publication
    VAR_066854
    Natural varianti682 – 6821R → C May be associated with NTD. 1 Publication
    VAR_066855
    Natural varianti739 – 7391S → F May be associated with NTD. 1 Publication
    Corresponds to variant rs138452760 [ dbSNP | Ensembl ].
    VAR_066856
    Natural varianti771 – 7711D → N May be associated with NTD. 1 Publication
    VAR_066857
    Natural varianti799 – 7991S → C May be associated with NTD. 1 Publication
    VAR_066858

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi828 – 8314Missing: Abolishes localization to the nuclear membrane. 1 Publication

    Keywords - Diseasei

    Disease mutation, Epilepsy

    Organism-specific databases

    MIMi182940. phenotype.
    612437. phenotype.
    Orphaneti308. Unverricht-Lundborg disease.
    PharmGKBiPA134906946.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 828828Prickle-like protein 1PRO_0000075889Add
    BLAST
    Propeptidei829 – 8313Removed in mature formCuratedPRO_0000396712

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei828 – 8281Cysteine methyl esterCurated
    Lipidationi828 – 8281S-farnesyl cysteine2 Publications

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ96MT3.
    PaxDbiQ96MT3.
    PRIDEiQ96MT3.

    PTM databases

    PhosphoSiteiQ96MT3.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).3 Publications

    Gene expression databases

    ArrayExpressiQ96MT3.
    BgeeiQ96MT3.
    CleanExiHS_PRICKLE1.
    HS_RILP.
    GenevestigatoriQ96MT3.

    Organism-specific databases

    HPAiHPA001379.
    HPA050037.

    Interactioni

    Subunit structurei

    Interacts with REST.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DVL3Q929973EBI-2348662,EBI-739789

    Protein-protein interaction databases

    BioGridi126835. 2 interactions.
    IntActiQ96MT3. 5 interactions.
    STRINGi9606.ENSP00000345064.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96MT3.
    SMRiQ96MT3. Positions 120-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 122109PETPROSITE-ProRule annotationAdd
    BLAST
    Domaini124 – 18966LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini189 – 24961LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini249 – 31365LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi655 – 68228Arg/His-richAdd
    BLAST
    Compositional biasi761 – 77212Ser-richAdd
    BLAST
    Compositional biasi816 – 8216Poly-Lys

    Sequence similaritiesi

    Belongs to the prickle / espinas / testin family.Curated
    Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation
    Contains 1 PET domain.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG314122.
    HOGENOMiHOG000290649.
    HOVERGENiHBG053679.
    InParanoidiQ96MT3.
    KOiK04511.
    OMAiCCLECET.
    OrthoDBiEOG7P8P7M.
    PhylomeDBiQ96MT3.
    TreeFamiTF313265.

    Family and domain databases

    Gene3Di2.10.110.10. 3 hits.
    InterProiIPR010442. PET_domain.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 3 hits.
    PF06297. PET. 1 hit.
    [Graphical view]
    SMARTiSM00132. LIM. 3 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96MT3-1 [UniParc]FASTAAdd to Basket

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    MPLEMEPKMS KLAFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA    50
    CLPEEKVPYV NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF 100
    SAQRKKEALG RGTIKLLSRA VMHAVCEQCG LKINGGEVAV FASRAGPGVC 150
    WHPSCFVCFT CNELLVDLIY FYQDGKIHCG RHHAELLKPR CSACDEIIFA 200
    DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC GCFESLYAEY 250
    CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI 300
    YCSKTCSLGE DVHASDSSDS AFQSARSRDS RRSVRMGKSS RSADQCRQSL 350
    LLSPALNYKF PGLSGNADDT LSRKLDDLSL SRQGTSFASE EFWKGRVEQE 400
    TPEDPEEWAD HEDYMTQLLL KFGDKSLFQP QPNEMDIRAS EHWISDNMVK 450
    SKTELKQNNQ SLASKKYQSD MYWAQSQDGL GDSAYGSHPG PASSRRLQEL 500
    ELDHGASGYN HDETQWYEDS LECLSDLKPE QSVRDSMDSL ALSNITGASV 550
    DGENKPRPSL YSLQNFEEME TEDCEKMSNM GTLNSSMLHR SAESLKSLSS 600
    ELCPEKILPE EKPVHLPVLR RSKSQSRPQQ VKFSDDVIDN GNYDIEIRQP 650
    PMSERTRRRV YNFEERGSRS HHHRRRRSRK SRSDNALNLV TERKYSPKDR 700
    LRLYTPDNYE KFIQNKSARE IQAYIQNADL YGQYAHATSD YGLQNPGMNR 750
    FLGLYGEDDD SWCSSSSSSS DSEEEGYFLG QPIPQPRPQR FAYYTDDLSS 800
    PPSALPTPQF GQRTTKSKKK KGHKGKNCII S 831
    Length:831
    Mass (Da):94,300
    Last modified:February 1, 2005 - v2
    Checksum:i753D68BD5A4D0935
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti739 – 7391S → P in BAB71198. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti69 – 691I → T May be associated with NTD. 1 Publication
    Corresponds to variant rs141795695 [ dbSNP | Ensembl ].
    VAR_066850
    Natural varianti81 – 811N → H May be associated with NTD. 1 Publication
    VAR_066851
    Natural varianti104 – 1041R → Q in EPM1B; affects interaction with REST. 2 Publications
    VAR_054663
    Natural varianti121 – 1211V → I May be associated with NTD. 1 Publication
    VAR_066852
    Natural varianti124 – 1241A → T.1 Publication
    Corresponds to variant rs79087668 [ dbSNP | Ensembl ].
    VAR_066853
    Natural varianti144 – 1441R → H in EPM1B. 1 Publication
    VAR_065580
    Natural varianti275 – 2751T → M May be associated with NTD. 1 Publication
    VAR_066854
    Natural varianti472 – 4721Y → H in EPM1B. 1 Publication
    VAR_065581
    Natural varianti682 – 6821R → C May be associated with NTD. 1 Publication
    VAR_066855
    Natural varianti739 – 7391S → F May be associated with NTD. 1 Publication
    Corresponds to variant rs138452760 [ dbSNP | Ensembl ].
    VAR_066856
    Natural varianti746 – 7461P → S.
    Corresponds to variant rs3827522 [ dbSNP | Ensembl ].
    VAR_056164
    Natural varianti771 – 7711D → N May be associated with NTD. 1 Publication
    VAR_066857
    Natural varianti799 – 7991S → C May be associated with NTD. 1 Publication
    VAR_066858

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF399844 mRNA. Translation: AAQ03035.1.
    AK056189 mRNA. Translation: BAB71116.1.
    AK056499 mRNA. Translation: BAB71198.1.
    BC114939 mRNA. Translation: AAI14940.1.
    BC114940 mRNA. Translation: AAI14941.1.
    CCDSiCCDS8742.1.
    RefSeqiNP_001138353.1. NM_001144881.1.
    NP_001138354.1. NM_001144882.1.
    NP_001138355.1. NM_001144883.1.
    NP_694571.2. NM_153026.2.
    UniGeneiHs.524348.
    Hs.720221.

    Genome annotation databases

    EnsembliENST00000345127; ENSP00000345064; ENSG00000139174.
    ENST00000445766; ENSP00000398947; ENSG00000139174.
    ENST00000455697; ENSP00000401060; ENSG00000139174.
    ENST00000548696; ENSP00000448359; ENSG00000139174.
    ENST00000552240; ENSP00000449819; ENSG00000139174.
    GeneIDi144165.
    KEGGihsa:144165.
    UCSCiuc001rnl.3. human.

    Polymorphism databases

    DMDMi59800163.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF399844 mRNA. Translation: AAQ03035.1 .
    AK056189 mRNA. Translation: BAB71116.1 .
    AK056499 mRNA. Translation: BAB71198.1 .
    BC114939 mRNA. Translation: AAI14940.1 .
    BC114940 mRNA. Translation: AAI14941.1 .
    CCDSi CCDS8742.1.
    RefSeqi NP_001138353.1. NM_001144881.1.
    NP_001138354.1. NM_001144882.1.
    NP_001138355.1. NM_001144883.1.
    NP_694571.2. NM_153026.2.
    UniGenei Hs.524348.
    Hs.720221.

    3D structure databases

    ProteinModelPortali Q96MT3.
    SMRi Q96MT3. Positions 120-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126835. 2 interactions.
    IntActi Q96MT3. 5 interactions.
    STRINGi 9606.ENSP00000345064.

    PTM databases

    PhosphoSitei Q96MT3.

    Polymorphism databases

    DMDMi 59800163.

    Proteomic databases

    MaxQBi Q96MT3.
    PaxDbi Q96MT3.
    PRIDEi Q96MT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345127 ; ENSP00000345064 ; ENSG00000139174 .
    ENST00000445766 ; ENSP00000398947 ; ENSG00000139174 .
    ENST00000455697 ; ENSP00000401060 ; ENSG00000139174 .
    ENST00000548696 ; ENSP00000448359 ; ENSG00000139174 .
    ENST00000552240 ; ENSP00000449819 ; ENSG00000139174 .
    GeneIDi 144165.
    KEGGi hsa:144165.
    UCSCi uc001rnl.3. human.

    Organism-specific databases

    CTDi 144165.
    GeneCardsi GC12M042852.
    GeneReviewsi PRICKLE1.
    HGNCi HGNC:17019. PRICKLE1.
    HPAi HPA001379.
    HPA050037.
    MIMi 182940. phenotype.
    608500. gene.
    612437. phenotype.
    neXtProti NX_Q96MT3.
    Orphaneti 308. Unverricht-Lundborg disease.
    PharmGKBi PA134906946.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314122.
    HOGENOMi HOG000290649.
    HOVERGENi HBG053679.
    InParanoidi Q96MT3.
    KOi K04511.
    OMAi CCLECET.
    OrthoDBi EOG7P8P7M.
    PhylomeDBi Q96MT3.
    TreeFami TF313265.

    Enzyme and pathway databases

    Reactomei REACT_172638. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    GenomeRNAii 144165.
    NextBioi 84850.
    PROi Q96MT3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96MT3.
    Bgeei Q96MT3.
    CleanExi HS_PRICKLE1.
    HS_RILP.
    Genevestigatori Q96MT3.

    Family and domain databases

    Gene3Di 2.10.110.10. 3 hits.
    InterProi IPR010442. PET_domain.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 3 hits.
    PF06297. PET. 1 hit.
    [Graphical view ]
    SMARTi SM00132. LIM. 3 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor."
      Shimojo M., Hersh L.B.
      Mol. Cell. Biol. 23:9025-9031(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-828, MUTAGENESIS OF 828-CYS--SER-831, SUBCELLULAR LOCATION, INTERACTION WITH REST.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle."
      Katoh M., Katoh M.
      Int. J. Mol. Med. 11:249-256(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    5. "Towards complete sets of farnesylated and geranylgeranylated proteins."
      Maurer-Stroh S., Koranda M., Benetka W., Schneider G., Sirota F.L., Eisenhaber F.
      PLoS Comput. Biol. 3:634-648(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOPRENYLATION AT CYS-828.
    6. Cited for: TISSUE SPECIFICITY, VARIANT EPM1B GLN-104, CHARACTERIZATION OF VARIANT EPM1B GLN-104.
    7. "Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects."
      Bosoi C.M., Capra V., Allache R., Trinh V.Q., De Marco P., Merello E., Drapeau P., Bassuk A.G., Kibar Z.
      Hum. Mutat. 32:1371-1375(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, POSSIBLE INVOLVEMENT IN NTD, VARIANTS THR-69; HIS-81; ILE-121; THR-124; MET-275; CYS-682; PHE-739; ASN-771 AND CYS-799.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: VARIANTS EPM1B GLN-104; HIS-144 AND HIS-472.

    Entry informationi

    Entry nameiPRIC1_HUMAN
    AccessioniPrimary (citable) accession number: Q96MT3
    Secondary accession number(s): Q14C83, Q71QF8, Q96N00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3