Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycosyltransferase 1 domain-containing protein 1

Gene

GLT1D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyltransferase 1 domain-containing protein 1 (EC:2.4.-.-)
Gene namesi
Name:GLT1D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26483. GLT1D1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394758.

Polymorphism and mutation databases

BioMutaiGLT1D1.
DMDMi162416226.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 346330Glycosyltransferase 1 domain-containing protein 1PRO_0000312203Add
BLAST

Proteomic databases

EPDiQ96MS3.
PaxDbiQ96MS3.
PRIDEiQ96MS3.

Expressioni

Gene expression databases

BgeeiQ96MS3.
CleanExiHS_GLT1D1.
ExpressionAtlasiQ96MS3. baseline and differential.
GenevisibleiQ96MS3. HS.

Organism-specific databases

HPAiHPA039051.
HPA039052.

Interactioni

Protein-protein interaction databases

BioGridi126851. 3 interactions.
STRINGi9606.ENSP00000281703.

Structurei

3D structure databases

ProteinModelPortaliQ96MS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIPB. Eukaryota.
ENOG410YAR9. LUCA.
GeneTreeiENSGT00390000016790.
HOGENOMiHOG000007568.
HOVERGENiHBG057333.
InParanoidiQ96MS3.
OrthoDBiEOG76DTSV.
PhylomeDBiQ96MS3.
TreeFamiTF331382.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLFLAVLR PHTGNAVTAQ RVRAHLEAAG HVCVLKDAFD FESRSEIANL
60 70 80 90 100
ILAENCEAAL ALHLYRGGRL LQGHRIPFGV IFGGTDVNED ANQAEKNTVM
110 120 130 140 150
GRVLEEARFA VAFTESMKEM AQAQWPHAKG KVYVQSQGIA TTPNAAFNWN
160 170 180 190 200
TFLQRSEINQ SADNLHIFLL ICGLRQVKDP LYLVDAFSAW HQEEPNVHLV
210 220 230 240 250
IVGPEVDPVF TREVKAKVKR AAGVRLIGEM PQEDLHAVVK NCFAVVNSSV
260 270 280 290 300
SEGMSAAILE AMDLEVPVLA RNIPGNAAVV KHEVTGLLFS NPQEFVHLAK
310 320 330 340
RLVSDPALEK EIVVNGREYV RMYHSWQVER DTYQQLIRKL EGSTED
Length:346
Mass (Da):38,507
Last modified:December 4, 2007 - v2
Checksum:i4CD1EE05FD72C5B5
GO
Isoform 2 (identifier: Q96MS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-205: Missing.

Show »
Length:266
Mass (Da):29,528
Checksum:iF2942AE9685B6342
GO
Isoform 3 (identifier: Q96MS3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-152: RFAVAFTESM...PNAAFNWNTF → SRMLRVRSMS...KVLIICTYFF
     153-346: Missing.

Show »
Length:152
Mass (Da):17,043
Checksum:iA964FAB7A777DEC8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei108 – 15245RFAVA…NWNTF → SRMLRVRSMSRVKELQQHQT PLLTGIPFFNALRLTKVLII CTYFF in isoform 3. 1 PublicationVSP_029732Add
BLAST
Alternative sequencei126 – 20580Missing in isoform 2. 1 PublicationVSP_029731Add
BLAST
Alternative sequencei153 – 346194Missing in isoform 3. 1 PublicationVSP_029733Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056540 mRNA. Translation: BAB71209.1.
AC069262 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98497.1.
CH471054 Genomic DNA. Translation: EAW98498.1.
BC043528 mRNA. Translation: AAH43528.1.
CCDSiCCDS9265.1. [Q96MS3-2]
RefSeqiNP_653270.1. NM_144669.2. [Q96MS3-2]
XP_005253610.1. XM_005253553.3. [Q96MS3-1]
UniGeneiHs.655668.

Genome annotation databases

EnsembliENST00000281703; ENSP00000281703; ENSG00000151948. [Q96MS3-2]
ENST00000441390; ENSP00000411992; ENSG00000151948. [Q96MS3-3]
ENST00000442111; ENSP00000394692; ENSG00000151948. [Q96MS3-1]
ENST00000539044; ENSP00000445064; ENSG00000151948. [Q96MS3-3]
GeneIDi144423.
KEGGihsa:144423.
UCSCiuc001uhx.2. human. [Q96MS3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056540 mRNA. Translation: BAB71209.1.
AC069262 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98497.1.
CH471054 Genomic DNA. Translation: EAW98498.1.
BC043528 mRNA. Translation: AAH43528.1.
CCDSiCCDS9265.1. [Q96MS3-2]
RefSeqiNP_653270.1. NM_144669.2. [Q96MS3-2]
XP_005253610.1. XM_005253553.3. [Q96MS3-1]
UniGeneiHs.655668.

3D structure databases

ProteinModelPortaliQ96MS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126851. 3 interactions.
STRINGi9606.ENSP00000281703.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Polymorphism and mutation databases

BioMutaiGLT1D1.
DMDMi162416226.

Proteomic databases

EPDiQ96MS3.
PaxDbiQ96MS3.
PRIDEiQ96MS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281703; ENSP00000281703; ENSG00000151948. [Q96MS3-2]
ENST00000441390; ENSP00000411992; ENSG00000151948. [Q96MS3-3]
ENST00000442111; ENSP00000394692; ENSG00000151948. [Q96MS3-1]
ENST00000539044; ENSP00000445064; ENSG00000151948. [Q96MS3-3]
GeneIDi144423.
KEGGihsa:144423.
UCSCiuc001uhx.2. human. [Q96MS3-1]

Organism-specific databases

CTDi144423.
GeneCardsiGLT1D1.
HGNCiHGNC:26483. GLT1D1.
HPAiHPA039051.
HPA039052.
neXtProtiNX_Q96MS3.
PharmGKBiPA128394758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPB. Eukaryota.
ENOG410YAR9. LUCA.
GeneTreeiENSGT00390000016790.
HOGENOMiHOG000007568.
HOVERGENiHBG057333.
InParanoidiQ96MS3.
OrthoDBiEOG76DTSV.
PhylomeDBiQ96MS3.
TreeFamiTF331382.

Miscellaneous databases

ChiTaRSiGLT1D1. human.
GenomeRNAii144423.
PROiQ96MS3.

Gene expression databases

BgeeiQ96MS3.
CleanExiHS_GLT1D1.
ExpressionAtlasiQ96MS3. baseline and differential.
GenevisibleiQ96MS3. HS.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Teratocarcinoma.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiGL1D1_HUMAN
AccessioniPrimary (citable) accession number: Q96MS3
Secondary accession number(s): Q86XG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.