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Protein

Zinc finger protein 560

Gene

ZNF560

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 31431C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri712 – 73423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri740 – 76223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 560
Gene namesi
Name:ZNF560
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26484. ZNF560.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992071.

Polymorphism and mutation databases

BioMutaiZNF560.
DMDMi97219157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Zinc finger protein 560PRO_0000234589Add
BLAST

Proteomic databases

EPDiQ96MR9.
PaxDbiQ96MR9.
PeptideAtlasiQ96MR9.
PRIDEiQ96MR9.

PTM databases

iPTMnetiQ96MR9.
PhosphoSiteiQ96MR9.

Expressioni

Gene expression databases

BgeeiQ96MR9.
CleanExiHS_ZNF560.
GenevisibleiQ96MR9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301480.

Structurei

3D structure databases

ProteinModelPortaliQ96MR9.
SMRiQ96MR9. Positions 13-54, 110-151, 290-790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 8472KRAB 1PROSITE-ProRule annotationAdd
BLAST
Domaini110 – 18172KRAB 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 2 KRAB domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 31431C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri712 – 73423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri740 – 76223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96MR9.
KOiK09228.
OMAiSVGYQLF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96MR9.
TreeFamiTF342172.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 2 hits.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 2 hits.
PROSITEiPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYCLTNCYQ YSVTFEDTAV DFTQEEWILL DPVQRNLYRD VMLENYENVA
60 70 80 90 100
KVGFQLFKPS VISWLEEEEL RTLQQGVLQD WAIKHQTSVS ALQQEFWKIQ
110 120 130 140 150
TSNGIQMDLV TFDSVAVEFT QEEWTLLDPA QRNLYSDVML ENYKNLSSVG
160 170 180 190 200
YQLFKPSLIS WLEEEEELST LPRVLQEWKM CLKTKGPALW QDNFCLKTLN
210 220 230 240 250
GIQLARNQNG EELYDCKQCE DVFCKHPCLK TNMSTQNRGN TSECIQYAKD
260 270 280 290 300
LLSLYNKTST IRKVSVFSKH GKSFRLILNV QVQRKCTQDK SFEGTDYGKA
310 320 330 340 350
FIYQSYLEAH RKTQSGEKLN EWKQCGEAFT HSTSHAVNVE THIIKNPYEC
360 370 380 390 400
KECGKDFRYP THLNNHMQTH IGIKPYKCKH CGKTFTVPSG FLEHVRTHTG
410 420 430 440 450
EKPYGCKECG KAFGTSAGLI EHIRCHAREK TFKCDHCGKA FISYPSLFGH
460 470 480 490 500
LRVHNGEKPY EHKEYGKAFG TSSGVIEDRR SNTGQKRFDC DQCGKVFVSF
510 520 530 540 550
SSLFAHLRTH TGEKPFKCYK CGKPFTSSAC LRIHMRTHTE ERLYQCKKCG
560 570 580 590 600
KAFTKCSYLT KHLRTHAGEK PYECMKCGKA FTERSYLTKH LRRHSGEKPY
610 620 630 640 650
ECKKCGKAFT ERSDLTKHLR RHTGDKPYEY KDCGKAFVVS SSLVDHLRTH
660 670 680 690 700
TGYKPYKCNA CEKAYSRSCV LTQHLKTHAA EKTSECNACG NSFRNSMCFH
710 720 730 740 750
DRLKTLTKIK PYKCKDCGKA FTCHSDLTNH VRIHTGEKPY KCKECGKAFR
760 770 780 790
TSSGRIQHLR THMGEKPFEC DQCGKAFASF SARIAHLKTH
Length:790
Mass (Da):91,121
Last modified:May 16, 2006 - v2
Checksum:i9434B9F290621036
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti475 – 4751V → I in BAB71213 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861G → E in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035588
Natural varianti630 – 6301Y → C.
Corresponds to variant rs10416098 [ dbSNP | Ensembl ].
VAR_052866

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056548 mRNA. Translation: BAB71213.1.
BC101040 mRNA. Translation: AAI01041.1.
BC101041 mRNA. Translation: AAI01042.1.
BC101042 mRNA. Translation: AAI01043.1.
CCDSiCCDS12214.1.
RefSeqiNP_689689.2. NM_152476.2.
XP_011525998.1. XM_011527696.1.
XP_011525999.1. XM_011527697.1.
UniGeneiHs.631613.

Genome annotation databases

EnsembliENST00000301480; ENSP00000301480; ENSG00000198028.
GeneIDi147741.
KEGGihsa:147741.
UCSCiuc002mlp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056548 mRNA. Translation: BAB71213.1.
BC101040 mRNA. Translation: AAI01041.1.
BC101041 mRNA. Translation: AAI01042.1.
BC101042 mRNA. Translation: AAI01043.1.
CCDSiCCDS12214.1.
RefSeqiNP_689689.2. NM_152476.2.
XP_011525998.1. XM_011527696.1.
XP_011525999.1. XM_011527697.1.
UniGeneiHs.631613.

3D structure databases

ProteinModelPortaliQ96MR9.
SMRiQ96MR9. Positions 13-54, 110-151, 290-790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301480.

PTM databases

iPTMnetiQ96MR9.
PhosphoSiteiQ96MR9.

Polymorphism and mutation databases

BioMutaiZNF560.
DMDMi97219157.

Proteomic databases

EPDiQ96MR9.
PaxDbiQ96MR9.
PeptideAtlasiQ96MR9.
PRIDEiQ96MR9.

Protocols and materials databases

DNASUi147741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301480; ENSP00000301480; ENSG00000198028.
GeneIDi147741.
KEGGihsa:147741.
UCSCiuc002mlp.2. human.

Organism-specific databases

CTDi147741.
GeneCardsiZNF560.
HGNCiHGNC:26484. ZNF560.
neXtProtiNX_Q96MR9.
PharmGKBiPA134992071.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96MR9.
KOiK09228.
OMAiSVGYQLF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96MR9.
TreeFamiTF342172.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii147741.
PROiQ96MR9.

Gene expression databases

BgeeiQ96MR9.
CleanExiHS_ZNF560.
GenevisibleiQ96MR9. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 2 hits.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 2 hits.
PROSITEiPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-186.

Entry informationi

Entry nameiZN560_HUMAN
AccessioniPrimary (citable) accession number: Q96MR9
Secondary accession number(s): Q495S9, Q495T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.