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Protein

Zinc finger protein 560

Gene

ZNF560

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 314C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri712 – 734C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 560
Gene namesi
Name:ZNF560
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198028.3
HGNCiHGNC:26484 ZNF560
neXtProtiNX_Q96MR9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198028
PharmGKBiPA134992071

Polymorphism and mutation databases

BioMutaiZNF560
DMDMi97219157

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345891 – 790Zinc finger protein 560Add BLAST790

Proteomic databases

EPDiQ96MR9
PaxDbiQ96MR9
PeptideAtlasiQ96MR9
PRIDEiQ96MR9

PTM databases

iPTMnetiQ96MR9
PhosphoSitePlusiQ96MR9

Expressioni

Gene expression databases

BgeeiENSG00000198028
CleanExiHS_ZNF560
GenevisibleiQ96MR9 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301480

Structurei

3D structure databases

ProteinModelPortaliQ96MR9
SMRiQ96MR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini110 – 181KRAB 2PROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 314C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri712 – 734C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144146
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96MR9
KOiK09228
OMAiSVGYQLF
OrthoDBiEOG091G02KC
PhylomeDBiQ96MR9
TreeFamiTF342172

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequencei

Sequence statusi: Complete.

Q96MR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYCLTNCYQ YSVTFEDTAV DFTQEEWILL DPVQRNLYRD VMLENYENVA
60 70 80 90 100
KVGFQLFKPS VISWLEEEEL RTLQQGVLQD WAIKHQTSVS ALQQEFWKIQ
110 120 130 140 150
TSNGIQMDLV TFDSVAVEFT QEEWTLLDPA QRNLYSDVML ENYKNLSSVG
160 170 180 190 200
YQLFKPSLIS WLEEEEELST LPRVLQEWKM CLKTKGPALW QDNFCLKTLN
210 220 230 240 250
GIQLARNQNG EELYDCKQCE DVFCKHPCLK TNMSTQNRGN TSECIQYAKD
260 270 280 290 300
LLSLYNKTST IRKVSVFSKH GKSFRLILNV QVQRKCTQDK SFEGTDYGKA
310 320 330 340 350
FIYQSYLEAH RKTQSGEKLN EWKQCGEAFT HSTSHAVNVE THIIKNPYEC
360 370 380 390 400
KECGKDFRYP THLNNHMQTH IGIKPYKCKH CGKTFTVPSG FLEHVRTHTG
410 420 430 440 450
EKPYGCKECG KAFGTSAGLI EHIRCHAREK TFKCDHCGKA FISYPSLFGH
460 470 480 490 500
LRVHNGEKPY EHKEYGKAFG TSSGVIEDRR SNTGQKRFDC DQCGKVFVSF
510 520 530 540 550
SSLFAHLRTH TGEKPFKCYK CGKPFTSSAC LRIHMRTHTE ERLYQCKKCG
560 570 580 590 600
KAFTKCSYLT KHLRTHAGEK PYECMKCGKA FTERSYLTKH LRRHSGEKPY
610 620 630 640 650
ECKKCGKAFT ERSDLTKHLR RHTGDKPYEY KDCGKAFVVS SSLVDHLRTH
660 670 680 690 700
TGYKPYKCNA CEKAYSRSCV LTQHLKTHAA EKTSECNACG NSFRNSMCFH
710 720 730 740 750
DRLKTLTKIK PYKCKDCGKA FTCHSDLTNH VRIHTGEKPY KCKECGKAFR
760 770 780 790
TSSGRIQHLR THMGEKPFEC DQCGKAFASF SARIAHLKTH
Length:790
Mass (Da):91,121
Last modified:May 16, 2006 - v2
Checksum:i9434B9F290621036
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti475V → I in BAB71213 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035588186G → E in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_052866630Y → C. Corresponds to variant dbSNP:rs10416098Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056548 mRNA Translation: BAB71213.1
BC101040 mRNA Translation: AAI01041.1
BC101041 mRNA Translation: AAI01042.1
BC101042 mRNA Translation: AAI01043.1
CCDSiCCDS12214.1
RefSeqiNP_689689.2, NM_152476.2
XP_011525998.1, XM_011527696.2
XP_011525999.1, XM_011527697.2
XP_016881816.1, XM_017026327.1
XP_016881817.1, XM_017026328.1
XP_016881818.1, XM_017026329.1
UniGeneiHs.631613

Genome annotation databases

EnsembliENST00000301480; ENSP00000301480; ENSG00000198028
GeneIDi147741
KEGGihsa:147741
UCSCiuc002mlp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN560_HUMAN
AccessioniPrimary (citable) accession number: Q96MR9
Secondary accession number(s): Q495S9, Q495T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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