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Protein

Zinc finger SWIM domain-containing protein 3

Gene

ZSWIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri531 – 572SWIM-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132801-MONOMER.
SignaLinkiQ96MP5.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 3
Gene namesi
Name:ZSWIM3
Synonyms:C20orf164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16157. ZSWIM3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132801.
PharmGKBiPA25706.

Polymorphism and mutation databases

BioMutaiZSWIM3.
DMDMi41019518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002230991 – 696Zinc finger SWIM domain-containing protein 3Add BLAST696

Proteomic databases

EPDiQ96MP5.
MaxQBiQ96MP5.
PaxDbiQ96MP5.
PeptideAtlasiQ96MP5.
PRIDEiQ96MP5.

PTM databases

iPTMnetiQ96MP5.
PhosphoSitePlusiQ96MP5.

Expressioni

Gene expression databases

BgeeiENSG00000132801.
CleanExiHS_ZSWIM3.
GenevisibleiQ96MP5. HS.

Organism-specific databases

HPAiHPA055692.

Interactioni

Protein-protein interaction databases

BioGridi126724. 1 interactor.
IntActiQ96MP5. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96MP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri531 – 572SWIM-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEGZ. Eukaryota.
ENOG4110N49. LUCA.
GeneTreeiENSGT00390000017273.
HOGENOMiHOG000230974.
HOVERGENiHBG079390.
InParanoidiQ96MP5.
KOiK17604.
OMAiCPAYLLL.
OrthoDBiEOG091G01A2.
PhylomeDBiQ96MP5.
TreeFamiTF335703.

Family and domain databases

InterProiIPR006564. Znf_PMZ.
IPR007527. Znf_SWIM.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
[Graphical view]
SMARTiSM00575. ZnF_PMZ. 1 hit.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGSCFKTY EDFKECFSAY KRENRCSFIL RDCVSVRFHN LNHGTSIRED
60 70 80 90 100
ILYVQVKFVC IRTQSNRKRT READMCPAYL LLRYNERLDR LFISELNTQH
110 120 130 140 150
IHGDSKVASP GGDTTGKSQK TMCLQRLQPV QPTTKKDLDT AEKSLVEPSF
160 170 180 190 200
CLDKVQVSSK PEQEGITPSD LAKIAKVMKN FLKVDEGSMA SFSVGDSQHL
210 220 230 240 250
DRLSFQSSKM TDLFIRFPEN LLLHRVENTQ GHILYAFLVE NKERESRVVH
260 270 280 290 300
FAVLKAETVT SVAKMLSIFT EFNSDWPKVK VVFVDPSFHY RAILQEIFPA
310 320 330 340 350
ARILLSIYHT TRLLEKKLHR SSANPSFKRL MKEALREAVF VTSEASLKNL
360 370 380 390 400
CQMSQAVLDE DLFNFLQAHW FTCELLWYMH VRKGLLACNT YMDSLDIVTS
410 420 430 440 450
KVSSLFREQQ SLLDCILCFV DYIDFFNTKG LKNLPTPPPK LKRARPASMP
460 470 480 490 500
LKSKKAFGIC GESLTSLPAE ETKPDAQQVQ VQQQSQVPPS QVGMLDTLHQ
510 520 530 540 550
SGSELAYKLC HNEWEVVQNS THLVDMAGSS VDVQLLEDSH QVSKDGCSCS
560 570 580 590 600
CSFQQWYHLP CRHILALLHT SQQPVGEAMV CRRWQKKYQY LLGPNGELQD
610 620 630 640 650
RGMVPNTGQP EKQGRNDMIQ DLSRELANLL MQTEGPELEE RYSTLRKIVD
660 670 680 690
IWAGPSQPSE LFQQPGDFKD VGRLPFLWGK QEEGEGFPPA TAVMHY
Length:696
Mass (Da):79,454
Last modified:October 10, 2003 - v2
Checksum:i30C91C23ACB1AF23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti329R → S in BAB71239 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053769259V → A.1 PublicationCorresponds to variant rs2903808dbSNPEnsembl.1
Natural variantiVAR_062161291R → W.Corresponds to variant rs35928298dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056641 mRNA. Translation: BAB71239.1.
AL008726 Genomic DNA. Translation: CAC36014.1.
BC027611 mRNA. Translation: AAH27611.1.
CCDSiCCDS13381.1.
RefSeqiNP_542790.2. NM_080752.3.
UniGeneiHs.292135.

Genome annotation databases

EnsembliENST00000255152; ENSP00000255152; ENSG00000132801.
GeneIDi140831.
KEGGihsa:140831.
UCSCiuc002xqd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056641 mRNA. Translation: BAB71239.1.
AL008726 Genomic DNA. Translation: CAC36014.1.
BC027611 mRNA. Translation: AAH27611.1.
CCDSiCCDS13381.1.
RefSeqiNP_542790.2. NM_080752.3.
UniGeneiHs.292135.

3D structure databases

ProteinModelPortaliQ96MP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126724. 1 interactor.
IntActiQ96MP5. 3 interactors.

PTM databases

iPTMnetiQ96MP5.
PhosphoSitePlusiQ96MP5.

Polymorphism and mutation databases

BioMutaiZSWIM3.
DMDMi41019518.

Proteomic databases

EPDiQ96MP5.
MaxQBiQ96MP5.
PaxDbiQ96MP5.
PeptideAtlasiQ96MP5.
PRIDEiQ96MP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255152; ENSP00000255152; ENSG00000132801.
GeneIDi140831.
KEGGihsa:140831.
UCSCiuc002xqd.4. human.

Organism-specific databases

CTDi140831.
GeneCardsiZSWIM3.
H-InvDBHIX0015866.
HGNCiHGNC:16157. ZSWIM3.
HPAiHPA055692.
neXtProtiNX_Q96MP5.
OpenTargetsiENSG00000132801.
PharmGKBiPA25706.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGZ. Eukaryota.
ENOG4110N49. LUCA.
GeneTreeiENSGT00390000017273.
HOGENOMiHOG000230974.
HOVERGENiHBG079390.
InParanoidiQ96MP5.
KOiK17604.
OMAiCPAYLLL.
OrthoDBiEOG091G01A2.
PhylomeDBiQ96MP5.
TreeFamiTF335703.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132801-MONOMER.
SignaLinkiQ96MP5.

Miscellaneous databases

GenomeRNAii140831.
PROiQ96MP5.

Gene expression databases

BgeeiENSG00000132801.
CleanExiHS_ZSWIM3.
GenevisibleiQ96MP5. HS.

Family and domain databases

InterProiIPR006564. Znf_PMZ.
IPR007527. Znf_SWIM.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
[Graphical view]
SMARTiSM00575. ZnF_PMZ. 1 hit.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSWM3_HUMAN
AccessioniPrimary (citable) accession number: Q96MP5
Secondary accession number(s): Q9BR13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.