Q96MP5 (ZSWM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger SWIM domain-containing protein 3

Gene names

Name:	ZSWIM3
Synonyms:	C20orf164

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SWIM-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 696	696	Zinc finger SWIM domain-containing protein 3		PRO_0000223099
Regions
	Zinc finger	531 – 572	42	SWIM-type
Natural variations
	Natural variant	259	1	V → A. Ref.1 Corresponds to variant rs2903808 [ dbSNP | Ensembl ].		VAR_053769
	Natural variant	291	1	R → W. Corresponds to variant rs35928298 [ dbSNP | Ensembl ].		VAR_062161
Experimental info
	Sequence conflict	329	1	R → S in BAB71239. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96MP5 [UniParc]. Last modified October 10, 2003. Version 2. Checksum: 30C91C23ACB1AF23	FASTA	696	79,454
	10 20 30 40 50 60 MELGSCFKTY EDFKECFSAY KRENRCSFIL RDCVSVRFHN LNHGTSIRED ILYVQVKFVC 70 80 90 100 110 120 IRTQSNRKRT READMCPAYL LLRYNERLDR LFISELNTQH IHGDSKVASP GGDTTGKSQK 130 140 150 160 170 180 TMCLQRLQPV QPTTKKDLDT AEKSLVEPSF CLDKVQVSSK PEQEGITPSD LAKIAKVMKN 190 200 210 220 230 240 FLKVDEGSMA SFSVGDSQHL DRLSFQSSKM TDLFIRFPEN LLLHRVENTQ GHILYAFLVE 250 260 270 280 290 300 NKERESRVVH FAVLKAETVT SVAKMLSIFT EFNSDWPKVK VVFVDPSFHY RAILQEIFPA 310 320 330 340 350 360 ARILLSIYHT TRLLEKKLHR SSANPSFKRL MKEALREAVF VTSEASLKNL CQMSQAVLDE 370 380 390 400 410 420 DLFNFLQAHW FTCELLWYMH VRKGLLACNT YMDSLDIVTS KVSSLFREQQ SLLDCILCFV 430 440 450 460 470 480 DYIDFFNTKG LKNLPTPPPK LKRARPASMP LKSKKAFGIC GESLTSLPAE ETKPDAQQVQ 490 500 510 520 530 540 VQQQSQVPPS QVGMLDTLHQ SGSELAYKLC HNEWEVVQNS THLVDMAGSS VDVQLLEDSH 550 560 570 580 590 600 QVSKDGCSCS CSFQQWYHLP CRHILALLHT SQQPVGEAMV CRRWQKKYQY LLGPNGELQD 610 620 630 640 650 660 RGMVPNTGQP EKQGRNDMIQ DLSRELANLL MQTEGPELEE RYSTLRKIVD IWAGPSQPSE 670 680 690 LFQQPGDFKD VGRLPFLWGK QEEGEGFPPA TAVMHY

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-259. Tissue: Fetal brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056641 mRNA. Translation: BAB71239.1. AL008726 Genomic DNA. Translation: CAC36014.1. BC027611 mRNA. Translation: AAH27611.1.
IPI	IPI00102268.
RefSeq	NP_542790.2. NM_080752.3.
UniGene	Hs.292135.
3D structure databases
ProteinModelPortal	Q96MP5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96MP5. 1 interaction.
PTM databases
PhosphoSite	Q96MP5.
Polymorphism databases
DMDM	41019518.
Proteomic databases
PaxDb	Q96MP5.
PRIDE	Q96MP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255152; ENSP00000255152; ENSG00000132801.
GeneID	140831.
KEGG	hsa:140831.
UCSC	uc002xqd.3. human.
Organism-specific databases
CTD	140831.
GeneCards	GC20P044486.
H-InvDB	HIX0015866.
HGNC	HGNC:16157. ZSWIM3.
neXtProt	NX_Q96MP5.
PharmGKB	PA25706.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40350.
HOGENOM	HOG000230974.
HOVERGEN	HBG079390.
InParanoid	Q96MP5.
OMA	MVCRRWQ.
OrthoDB	EOG4W0XCH.
PhylomeDB	Q96MP5.
Gene expression databases
ArrayExpress	Q96MP5.
Bgee	Q96MP5.
CleanEx	HS_ZSWIM3.
Genevestigator	Q96MP5.
GermOnline	ENSG00000132801. Homo sapiens.
Family and domain databases
InterPro	IPR018289. MULE_transposase_dom. IPR006564. Znf_PMZ. IPR007527. Znf_SWIM. [Graphical view]
Pfam	PF10551. MULE. 1 hit. PF04434. SWIM. 1 hit. [Graphical view]
SMART	SM00575. ZnF_PMZ. 1 hit. [Graphical view]
PROSITE	PS50966. ZF_SWIM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	140831.
NextBio	84438.

Entry information

Entry name

ZSWM3_HUMAN

Accession

Primary (citable) accession number: Q96MP5
Secondary accession number(s): Q9BR13

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.