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Protein

Zinc finger protein 488

Gene

ZNF488

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 302C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri317 – 339C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 488
Gene namesi
Name:ZNF488
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000265763.3.
HGNCiHGNC:23535. ZNF488.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000265763.
PharmGKBiPA134917840.

Polymorphism and mutation databases

BioMutaiZNF488.
DMDMi68566223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476121 – 340Zinc finger protein 488Add BLAST340

Proteomic databases

PaxDbiQ96MN9.
PRIDEiQ96MN9.

PTM databases

iPTMnetiQ96MN9.
PhosphoSitePlusiQ96MN9.

Expressioni

Gene expression databases

BgeeiENSG00000265763.
CleanExiHS_ZNF488.
GenevisibleiQ96MN9. HS.

Organism-specific databases

HPAiHPA035957.
HPA035958.
HPA044867.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125620. 15 interactors.
IntActiQ96MN9. 10 interactors.
MINTiMINT-2878369.
STRINGi9606.ENSP00000379054.

Structurei

3D structure databases

ProteinModelPortaliQ96MN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 302C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri317 – 339C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139463.
HOGENOMiHOG000155798.
HOVERGENiHBG055998.
InParanoidiQ96MN9.
OMAiQNAPLCS.
OrthoDBiEOG091G089W.
PhylomeDBiQ96MN9.
TreeFamiTF327090.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 2 hits.
SUPFAMiSSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEWPPCLSV APALVITMAA GKGAPLSPSA ENRWRLSEPE LGRGCKPVLL
60 70 80 90 100
EKTNRLGPEA AVGRAGRDVG SAELALLVAP GKPRPGKPLP PKTRGEQRQS
110 120 130 140 150
AFTELPRMKD RQVDAQAQER EHDDPTGQPG APQLTQNIPR GPAGSKVFSV
160 170 180 190 200
WPSGARSEQR SAFSKPTKRP AERPELTSVF PAGESADALG ELSGLLNTTD
210 220 230 240 250
LACWGRLSTP KLLVGDLWNL QALPQNAPLC STFLGAPTLW LEHTQAQVPP
260 270 280 290 300
PSSSSTTSWA LLPPTLTSLG LSTQNWCAKC NLSFRLTSDL VFHMRSHHKK
310 320 330 340
EHAGPDPHSQ KRREEALACP VCQEHFRERH HLSRHMTSHS
Length:340
Mass (Da):36,962
Last modified:December 1, 2001 - v1
Checksum:i0584ABA6A8F36CBF
GO
Isoform 2 (identifier: Q96MN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):25,670
Checksum:iB161BC2AAD577CE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03357172A → V. Corresponds to variant dbSNP:rs35618062Ensembl.1
Natural variantiVAR_033572106P → L. Corresponds to variant dbSNP:rs12251609Ensembl.1
Natural variantiVAR_033573249P → S. Corresponds to variant dbSNP:rs3814160Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559611 – 107Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056666 mRNA. Translation: BAB71246.1.
AL731561 Genomic DNA. No translation available.
BC026895 mRNA. Translation: AAH26895.1.
BC051323 mRNA. Translation: AAH51323.1.
CCDSiCCDS73120.1. [Q96MN9-1]
RefSeqiNP_001333861.1. NM_001346932.1. [Q96MN9-1]
NP_001333862.1. NM_001346933.1. [Q96MN9-1]
NP_001333863.1. NM_001346934.1. [Q96MN9-1]
NP_001333864.1. NM_001346935.1. [Q96MN9-1]
NP_001333865.1. NM_001346936.1. [Q96MN9-1]
NP_694579.1. NM_153034.3. [Q96MN9-1]
XP_006717680.1. XM_006717617.3. [Q96MN9-1]
XP_011537546.1. XM_011539244.2. [Q96MN9-1]
XP_016871132.1. XM_017015643.1. [Q96MN9-1]
UniGeneiHs.27788.

Genome annotation databases

EnsembliENST00000585316; ENSP00000462269; ENSG00000265763. [Q96MN9-1]
ENST00000591025; ENSP00000468133; ENSG00000265763. [Q96MN9-2]
GeneIDi118738.
KEGGihsa:118738.
UCSCiuc001jex.3. human. [Q96MN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN488_HUMAN
AccessioniPrimary (citable) accession number: Q96MN9
Secondary accession number(s): Q05CE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families