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Protein

Zinc finger protein 488

Gene

ZNF488

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 30228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 488
Gene namesi
Name:ZNF488
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23535. ZNF488.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917840.

Polymorphism and mutation databases

BioMutaiZNF488.
DMDMi68566223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Zinc finger protein 488PRO_0000047612Add
BLAST

Proteomic databases

PaxDbiQ96MN9.
PRIDEiQ96MN9.

PTM databases

iPTMnetiQ96MN9.
PhosphoSiteiQ96MN9.

Expressioni

Gene expression databases

BgeeiQ96MN9.
CleanExiHS_ZNF488.
GenevisibleiQ96MN9. HS.

Organism-specific databases

HPAiHPA035957.
HPA044867.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542533EBI-948288,EBI-930964
BANPQ8N9N53EBI-948288,EBI-744695
DAB1O755533EBI-948288,EBI-7875264
GOLGA2Q083793EBI-948288,EBI-618309
KRT40Q6A1623EBI-948288,EBI-10171697
MAGED1Q9Y5V33EBI-948288,EBI-716006
PRR20CP864793EBI-948288,EBI-10172814
RBPMSQ930623EBI-948288,EBI-740322
RIMBP3Q9UFD93EBI-948288,EBI-10182375
TRAF2Q129333EBI-948288,EBI-355744

Protein-protein interaction databases

BioGridi125620. 15 interactions.
IntActiQ96MN9. 10 interactions.
MINTiMINT-2878369.
STRINGi9606.ENSP00000379054.

Structurei

3D structure databases

ProteinModelPortaliQ96MN9.
SMRiQ96MN9. Positions 276-306, 314-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 30228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00520000055673.
HOGENOMiHOG000155798.
HOVERGENiHBG055998.
InParanoidiQ96MN9.
OMAiPQNAPLC.
PhylomeDBiQ96MN9.
TreeFamiTF327090.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEWPPCLSV APALVITMAA GKGAPLSPSA ENRWRLSEPE LGRGCKPVLL
60 70 80 90 100
EKTNRLGPEA AVGRAGRDVG SAELALLVAP GKPRPGKPLP PKTRGEQRQS
110 120 130 140 150
AFTELPRMKD RQVDAQAQER EHDDPTGQPG APQLTQNIPR GPAGSKVFSV
160 170 180 190 200
WPSGARSEQR SAFSKPTKRP AERPELTSVF PAGESADALG ELSGLLNTTD
210 220 230 240 250
LACWGRLSTP KLLVGDLWNL QALPQNAPLC STFLGAPTLW LEHTQAQVPP
260 270 280 290 300
PSSSSTTSWA LLPPTLTSLG LSTQNWCAKC NLSFRLTSDL VFHMRSHHKK
310 320 330 340
EHAGPDPHSQ KRREEALACP VCQEHFRERH HLSRHMTSHS
Length:340
Mass (Da):36,962
Last modified:December 1, 2001 - v1
Checksum:i0584ABA6A8F36CBF
GO
Isoform 2 (identifier: Q96MN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):25,670
Checksum:iB161BC2AAD577CE0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721A → V.
Corresponds to variant rs35618062 [ dbSNP | Ensembl ].
VAR_033571
Natural varianti106 – 1061P → L.
Corresponds to variant rs12251609 [ dbSNP | Ensembl ].
VAR_033572
Natural varianti249 – 2491P → S.
Corresponds to variant rs3814160 [ dbSNP | Ensembl ].
VAR_033573

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_055961Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056666 mRNA. Translation: BAB71246.1.
AL731561 Genomic DNA. Translation: CAH74044.1.
BC026895 mRNA. Translation: AAH26895.1.
BC051323 mRNA. Translation: AAH51323.1.
CCDSiCCDS73120.1. [Q96MN9-1]
RefSeqiNP_694579.1. NM_153034.2. [Q96MN9-1]
XP_005270370.1. XM_005270313.1. [Q96MN9-1]
XP_006717680.1. XM_006717617.2. [Q96MN9-1]
XP_011537546.1. XM_011539244.1. [Q96MN9-1]
XP_011537547.1. XM_011539245.1. [Q96MN9-1]
XP_011537548.1. XM_011539246.1. [Q96MN9-1]
XP_011537549.1. XM_011539247.1. [Q96MN9-1]
UniGeneiHs.27788.

Genome annotation databases

EnsembliENST00000585316; ENSP00000462269; ENSG00000265763. [Q96MN9-1]
ENST00000591025; ENSP00000468133; ENSG00000265763. [Q96MN9-2]
GeneIDi118738.
KEGGihsa:118738.
UCSCiuc001jex.3. human. [Q96MN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056666 mRNA. Translation: BAB71246.1.
AL731561 Genomic DNA. Translation: CAH74044.1.
BC026895 mRNA. Translation: AAH26895.1.
BC051323 mRNA. Translation: AAH51323.1.
CCDSiCCDS73120.1. [Q96MN9-1]
RefSeqiNP_694579.1. NM_153034.2. [Q96MN9-1]
XP_005270370.1. XM_005270313.1. [Q96MN9-1]
XP_006717680.1. XM_006717617.2. [Q96MN9-1]
XP_011537546.1. XM_011539244.1. [Q96MN9-1]
XP_011537547.1. XM_011539245.1. [Q96MN9-1]
XP_011537548.1. XM_011539246.1. [Q96MN9-1]
XP_011537549.1. XM_011539247.1. [Q96MN9-1]
UniGeneiHs.27788.

3D structure databases

ProteinModelPortaliQ96MN9.
SMRiQ96MN9. Positions 276-306, 314-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125620. 15 interactions.
IntActiQ96MN9. 10 interactions.
MINTiMINT-2878369.
STRINGi9606.ENSP00000379054.

PTM databases

iPTMnetiQ96MN9.
PhosphoSiteiQ96MN9.

Polymorphism and mutation databases

BioMutaiZNF488.
DMDMi68566223.

Proteomic databases

PaxDbiQ96MN9.
PRIDEiQ96MN9.

Protocols and materials databases

DNASUi118738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585316; ENSP00000462269; ENSG00000265763. [Q96MN9-1]
ENST00000591025; ENSP00000468133; ENSG00000265763. [Q96MN9-2]
GeneIDi118738.
KEGGihsa:118738.
UCSCiuc001jex.3. human. [Q96MN9-1]

Organism-specific databases

CTDi118738.
GeneCardsiZNF488.
HGNCiHGNC:23535. ZNF488.
HPAiHPA035957.
HPA044867.
neXtProtiNX_Q96MN9.
PharmGKBiPA134917840.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00520000055673.
HOGENOMiHOG000155798.
HOVERGENiHBG055998.
InParanoidiQ96MN9.
OMAiPQNAPLC.
PhylomeDBiQ96MN9.
TreeFamiTF327090.

Miscellaneous databases

GenomeRNAii118738.
PROiQ96MN9.

Gene expression databases

BgeeiQ96MN9.
CleanExiHS_ZNF488.
GenevisibleiQ96MN9. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Pancreas.

Entry informationi

Entry nameiZN488_HUMAN
AccessioniPrimary (citable) accession number: Q96MN9
Secondary accession number(s): Q05CE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.