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Q96MM6

- HS12B_HUMAN

UniProt

Q96MM6 - HS12B_HUMAN

Protein

Heat shock 70 kDa protein 12B

Gene

HSPA12B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock 70 kDa protein 12B
    Gene namesi
    Name:HSPA12B
    Synonyms:C20orf60
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16193. HSPA12B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25771.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 686686Heat shock 70 kDa protein 12BPRO_0000078294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei42 – 421PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ96MM6.
    PRIDEiQ96MM6.

    PTM databases

    PhosphoSiteiQ96MM6.

    Expressioni

    Tissue specificityi

    Highest expression in muscle and heart. Lower levels in liver and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ96MM6.
    BgeeiQ96MM6.
    CleanExiHS_HSPA12B.
    GenevestigatoriQ96MM6.

    Organism-specific databases

    HPAiHPA013659.
    HPA015639.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000254963.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96MM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Phylogenomic databases

    eggNOGiNOG132277.
    HOGENOMiHOG000231707.
    HOVERGENiHBG051928.
    OMAiAGRHPPD.
    OrthoDBiEOG74J97G.
    PhylomeDBiQ96MM6.
    TreeFamiTF329492.

    Family and domain databases

    InterProiIPR029509. HSPA12B.
    [Graphical view]
    PANTHERiPTHR14187:SF39. PTHR14187:SF39. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96MM6-1 [UniParc]FASTAAdd to Basket

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    MLAVPEMGLQ GLYIGSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE    50
    VRAPQQASFS VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH 100
    QKTPTCLLLT PEGAFHSFGY TARDYYHDLD PEEARDWLYF EKFKMKIHSA 150
    TDLTLKTQLE AVNGKTMPAL EVFAHALRFF REHALQELRE QSPSLPEKDT 200
    VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS RENAEQLLIA LEPEAASVYC 250
    RKLRLHQLLD LSGRAPGGGR LGERRSIDSS FRQAREQLRR SRHSRTFLVE 300
    SGVGELWAEM QAGDRYVVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP 350
    YGAVGVDLAF EQLLCRIFGE DFIATFKRQR PAAWVDLTIA FEARKRTAGP 400
    HRAGALNISL PFSFIDFYRK QRGHNVETAL RRSSVNFVKW SSQGMLRMSC 450
    EAMNELFQPT VSGIIQHIEA LLARPEVQGV KLLFLVGGFA ESAVLQHAVQ 500
    AALGARGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP LTYGVGVLNR 550
    FVPGRHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG 600
    QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPADCG QDTAGAPPGR 650
    REIRAAMQFG DTEIKVTAVD VSTNRSVRAS IDFLSN 686
    Length:686
    Mass (Da):75,688
    Last modified:January 10, 2003 - v2
    Checksum:i5F873AE97E366606
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti300 – 3001E → D in BAB71261. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231V → L.
    Corresponds to variant rs34414870 [ dbSNP | Ensembl ].
    VAR_049621
    Natural varianti270 – 2701R → H.
    Corresponds to variant rs6139194 [ dbSNP | Ensembl ].
    VAR_059362

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056712 mRNA. Translation: BAB71261.1.
    AL109804 Genomic DNA. Translation: CAC17544.3.
    CH471133 Genomic DNA. Translation: EAX10516.1.
    BC110881 mRNA. Translation: AAI10882.1.
    BC117284 mRNA. Translation: AAI17285.1.
    BC126263 mRNA. Translation: AAI26264.1.
    CCDSiCCDS13061.1.
    RefSeqiNP_001184256.1. NM_001197327.1.
    NP_443202.3. NM_052970.4.
    UniGeneiHs.516854.

    Genome annotation databases

    EnsembliENST00000254963; ENSP00000254963; ENSG00000132622.
    GeneIDi116835.
    KEGGihsa:116835.
    UCSCiuc002wjd.3. human.

    Polymorphism databases

    DMDMi27734244.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056712 mRNA. Translation: BAB71261.1 .
    AL109804 Genomic DNA. Translation: CAC17544.3 .
    CH471133 Genomic DNA. Translation: EAX10516.1 .
    BC110881 mRNA. Translation: AAI10882.1 .
    BC117284 mRNA. Translation: AAI17285.1 .
    BC126263 mRNA. Translation: AAI26264.1 .
    CCDSi CCDS13061.1.
    RefSeqi NP_001184256.1. NM_001197327.1.
    NP_443202.3. NM_052970.4.
    UniGenei Hs.516854.

    3D structure databases

    ProteinModelPortali Q96MM6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000254963.

    PTM databases

    PhosphoSitei Q96MM6.

    Polymorphism databases

    DMDMi 27734244.

    Proteomic databases

    PaxDbi Q96MM6.
    PRIDEi Q96MM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254963 ; ENSP00000254963 ; ENSG00000132622 .
    GeneIDi 116835.
    KEGGi hsa:116835.
    UCSCi uc002wjd.3. human.

    Organism-specific databases

    CTDi 116835.
    GeneCardsi GC20P003708.
    HGNCi HGNC:16193. HSPA12B.
    HPAi HPA013659.
    HPA015639.
    MIMi 610702. gene.
    neXtProti NX_Q96MM6.
    PharmGKBi PA25771.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG132277.
    HOGENOMi HOG000231707.
    HOVERGENi HBG051928.
    OMAi AGRHPPD.
    OrthoDBi EOG74J97G.
    PhylomeDBi Q96MM6.
    TreeFami TF329492.

    Miscellaneous databases

    GenomeRNAii 116835.
    NextBioi 79998.
    PROi Q96MM6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96MM6.
    Bgeei Q96MM6.
    CleanExi HS_HSPA12B.
    Genevestigatori Q96MM6.

    Family and domain databases

    InterProi IPR029509. HSPA12B.
    [Graphical view ]
    PANTHERi PTHR14187:SF39. PTHR14187:SF39. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Ovary.
    5. "Two Hsp70 family members expressed in atherosclerotic lesions."
      Han Z., Truong Q.A., Park S., Breslow J.L.
      Proc. Natl. Acad. Sci. U.S.A. 100:1256-1261(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHS12B_HUMAN
    AccessioniPrimary (citable) accession number: Q96MM6
    Secondary accession number(s): D3DVX7, Q2TAK3, Q9BR52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3