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Protein

Heat shock 70 kDa protein 12B

Gene

HSPA12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 12B
Gene namesi
Name:HSPA12B
Synonyms:C20orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132622.10
HGNCiHGNC:16193 HSPA12B
MIMi610702 gene
neXtProtiNX_Q96MM6

Pathology & Biotechi

Organism-specific databases

DisGeNETi116835
OpenTargetsiENSG00000132622
PharmGKBiPA25771

Polymorphism and mutation databases

BioMutaiHSPA12B
DMDMi27734244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782941 – 686Heat shock 70 kDa protein 12BAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei42PhosphothreonineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei276PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96MM6
PaxDbiQ96MM6
PeptideAtlasiQ96MM6
PRIDEiQ96MM6
ProteomicsDBi77374

PTM databases

iPTMnetiQ96MM6
PhosphoSitePlusiQ96MM6

Expressioni

Tissue specificityi

Highest expression in muscle and heart. Lower levels in liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000132622
CleanExiHS_HSPA12B
ExpressionAtlasiQ96MM6 baseline and differential
GenevisibleiQ96MM6 HS

Organism-specific databases

HPAiHPA013659
HPA015639

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125532, 6 interactors
IntActiQ96MM6, 9 interactors
STRINGi9606.ENSP00000254963

Structurei

3D structure databases

ProteinModelPortaliQ96MM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000014360
HOGENOMiHOG000231707
HOVERGENiHBG051928
InParanoidiQ96MM6
OMAiKIHSATD
OrthoDBiEOG091G03BF
PhylomeDBiQ96MM6
TreeFamiTF329492

Family and domain databases

InterProiView protein in InterPro
IPR029509 HSPA12B
PANTHERiPTHR14187:SF39 PTHR14187:SF39, 1 hit

Sequencei

Sequence statusi: Complete.

Q96MM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVPEMGLQ GLYIGSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE
60 70 80 90 100
VRAPQQASFS VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH
110 120 130 140 150
QKTPTCLLLT PEGAFHSFGY TARDYYHDLD PEEARDWLYF EKFKMKIHSA
160 170 180 190 200
TDLTLKTQLE AVNGKTMPAL EVFAHALRFF REHALQELRE QSPSLPEKDT
210 220 230 240 250
VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS RENAEQLLIA LEPEAASVYC
260 270 280 290 300
RKLRLHQLLD LSGRAPGGGR LGERRSIDSS FRQAREQLRR SRHSRTFLVE
310 320 330 340 350
SGVGELWAEM QAGDRYVVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP
360 370 380 390 400
YGAVGVDLAF EQLLCRIFGE DFIATFKRQR PAAWVDLTIA FEARKRTAGP
410 420 430 440 450
HRAGALNISL PFSFIDFYRK QRGHNVETAL RRSSVNFVKW SSQGMLRMSC
460 470 480 490 500
EAMNELFQPT VSGIIQHIEA LLARPEVQGV KLLFLVGGFA ESAVLQHAVQ
510 520 530 540 550
AALGARGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP LTYGVGVLNR
560 570 580 590 600
FVPGRHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG
610 620 630 640 650
QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPADCG QDTAGAPPGR
660 670 680
REIRAAMQFG DTEIKVTAVD VSTNRSVRAS IDFLSN
Length:686
Mass (Da):75,688
Last modified:January 10, 2003 - v2
Checksum:i5F873AE97E366606
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300E → D in BAB71261 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04962123V → L. Corresponds to variant dbSNP:rs34414870Ensembl.1
Natural variantiVAR_059362270R → H. Corresponds to variant dbSNP:rs6139194Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056712 mRNA Translation: BAB71261.1
AL109804 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10516.1
BC110881 mRNA Translation: AAI10882.1
BC117284 mRNA Translation: AAI17285.1
BC126263 mRNA Translation: AAI26264.1
CCDSiCCDS13061.1
RefSeqiNP_001184256.1, NM_001197327.1
NP_443202.3, NM_052970.4
XP_016883121.1, XM_017027632.1
UniGeneiHs.516854

Genome annotation databases

EnsembliENST00000254963; ENSP00000254963; ENSG00000132622
GeneIDi116835
KEGGihsa:116835
UCSCiuc002wjd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHS12B_HUMAN
AccessioniPrimary (citable) accession number: Q96MM6
Secondary accession number(s): D3DVX7, Q2TAK3, Q9BR52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: June 20, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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