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Protein

Heat shock 70 kDa protein 12B

Gene

HSPA12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_264487. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 12B
Gene namesi
Name:HSPA12B
Synonyms:C20orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16193. HSPA12B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25771.

Polymorphism and mutation databases

BioMutaiHSPA12B.
DMDMi27734244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Heat shock 70 kDa protein 12BPRO_0000078294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei29 – 291Phosphoserine1 Publication
Modified residuei42 – 421PhosphothreonineBy similarity
Modified residuei276 – 2761Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96MM6.
PRIDEiQ96MM6.

PTM databases

PhosphoSiteiQ96MM6.

Expressioni

Tissue specificityi

Highest expression in muscle and heart. Lower levels in liver and kidney.1 Publication

Gene expression databases

BgeeiQ96MM6.
CleanExiHS_HSPA12B.
ExpressionAtlasiQ96MM6. baseline and differential.
GenevisibleiQ96MM6. HS.

Organism-specific databases

HPAiHPA013659.
HPA015639.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-10291310,EBI-948001
KRT40Q6A1623EBI-10291310,EBI-10171697
NOTCH2NLQ7Z3S93EBI-10291310,EBI-945833

Protein-protein interaction databases

BioGridi125532. 6 interactions.
IntActiQ96MM6. 3 interactions.
STRINGi9606.ENSP00000254963.

Structurei

3D structure databases

ProteinModelPortaliQ96MM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiNOG132277.
GeneTreeiENSGT00390000014360.
HOGENOMiHOG000231707.
HOVERGENiHBG051928.
InParanoidiQ96MM6.
OMAiQAGDRYM.
OrthoDBiEOG74J97G.
PhylomeDBiQ96MM6.
TreeFamiTF329492.

Family and domain databases

InterProiIPR029509. HSPA12B.
[Graphical view]
PANTHERiPTHR14187:SF39. PTHR14187:SF39. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96MM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVPEMGLQ GLYIGSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE
60 70 80 90 100
VRAPQQASFS VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH
110 120 130 140 150
QKTPTCLLLT PEGAFHSFGY TARDYYHDLD PEEARDWLYF EKFKMKIHSA
160 170 180 190 200
TDLTLKTQLE AVNGKTMPAL EVFAHALRFF REHALQELRE QSPSLPEKDT
210 220 230 240 250
VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS RENAEQLLIA LEPEAASVYC
260 270 280 290 300
RKLRLHQLLD LSGRAPGGGR LGERRSIDSS FRQAREQLRR SRHSRTFLVE
310 320 330 340 350
SGVGELWAEM QAGDRYVVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP
360 370 380 390 400
YGAVGVDLAF EQLLCRIFGE DFIATFKRQR PAAWVDLTIA FEARKRTAGP
410 420 430 440 450
HRAGALNISL PFSFIDFYRK QRGHNVETAL RRSSVNFVKW SSQGMLRMSC
460 470 480 490 500
EAMNELFQPT VSGIIQHIEA LLARPEVQGV KLLFLVGGFA ESAVLQHAVQ
510 520 530 540 550
AALGARGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP LTYGVGVLNR
560 570 580 590 600
FVPGRHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG
610 620 630 640 650
QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPADCG QDTAGAPPGR
660 670 680
REIRAAMQFG DTEIKVTAVD VSTNRSVRAS IDFLSN
Length:686
Mass (Da):75,688
Last modified:January 10, 2003 - v2
Checksum:i5F873AE97E366606
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001E → D in BAB71261 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231V → L.
Corresponds to variant rs34414870 [ dbSNP | Ensembl ].
VAR_049621
Natural varianti270 – 2701R → H.
Corresponds to variant rs6139194 [ dbSNP | Ensembl ].
VAR_059362

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056712 mRNA. Translation: BAB71261.1.
AL109804 Genomic DNA. Translation: CAC17544.3.
CH471133 Genomic DNA. Translation: EAX10516.1.
BC110881 mRNA. Translation: AAI10882.1.
BC117284 mRNA. Translation: AAI17285.1.
BC126263 mRNA. Translation: AAI26264.1.
CCDSiCCDS13061.1.
RefSeqiNP_001184256.1. NM_001197327.1.
NP_443202.3. NM_052970.4.
UniGeneiHs.516854.

Genome annotation databases

EnsembliENST00000254963; ENSP00000254963; ENSG00000132622.
GeneIDi116835.
KEGGihsa:116835.
UCSCiuc002wjd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056712 mRNA. Translation: BAB71261.1.
AL109804 Genomic DNA. Translation: CAC17544.3.
CH471133 Genomic DNA. Translation: EAX10516.1.
BC110881 mRNA. Translation: AAI10882.1.
BC117284 mRNA. Translation: AAI17285.1.
BC126263 mRNA. Translation: AAI26264.1.
CCDSiCCDS13061.1.
RefSeqiNP_001184256.1. NM_001197327.1.
NP_443202.3. NM_052970.4.
UniGeneiHs.516854.

3D structure databases

ProteinModelPortaliQ96MM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125532. 6 interactions.
IntActiQ96MM6. 3 interactions.
STRINGi9606.ENSP00000254963.

PTM databases

PhosphoSiteiQ96MM6.

Polymorphism and mutation databases

BioMutaiHSPA12B.
DMDMi27734244.

Proteomic databases

PaxDbiQ96MM6.
PRIDEiQ96MM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254963; ENSP00000254963; ENSG00000132622.
GeneIDi116835.
KEGGihsa:116835.
UCSCiuc002wjd.3. human.

Organism-specific databases

CTDi116835.
GeneCardsiGC20P003708.
HGNCiHGNC:16193. HSPA12B.
HPAiHPA013659.
HPA015639.
MIMi610702. gene.
neXtProtiNX_Q96MM6.
PharmGKBiPA25771.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG132277.
GeneTreeiENSGT00390000014360.
HOGENOMiHOG000231707.
HOVERGENiHBG051928.
InParanoidiQ96MM6.
OMAiQAGDRYM.
OrthoDBiEOG74J97G.
PhylomeDBiQ96MM6.
TreeFamiTF329492.

Enzyme and pathway databases

ReactomeiREACT_264487. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSiHSPA12B. human.
GenomeRNAii116835.
NextBioi79998.
PROiQ96MM6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MM6.
CleanExiHS_HSPA12B.
ExpressionAtlasiQ96MM6. baseline and differential.
GenevisibleiQ96MM6. HS.

Family and domain databases

InterProiIPR029509. HSPA12B.
[Graphical view]
PANTHERiPTHR14187:SF39. PTHR14187:SF39. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  5. "Two Hsp70 family members expressed in atherosclerotic lesions."
    Han Z., Truong Q.A., Park S., Breslow J.L.
    Proc. Natl. Acad. Sci. U.S.A. 100:1256-1261(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-29 AND SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHS12B_HUMAN
AccessioniPrimary (citable) accession number: Q96MM6
Secondary accession number(s): D3DVX7, Q2TAK3, Q9BR52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: July 22, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.