Q96MM6 (HS12B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock 70 kDa protein 12B

Gene names

Name:	HSPA12B
Synonyms:	C20orf60

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	686 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Highest expression in muscle and heart. Lower levels in liver and kidney. Ref.5
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 686	686	Heat shock 70 kDa protein 12B		PRO_0000078294
Amino acid modifications
	Modified residue	42	1	Phosphothreonine By similarity
Natural variations
	Natural variant	23	1	V → L. Corresponds to variant rs34414870 [ dbSNP | Ensembl ].		VAR_049621
	Natural variant	270	1	R → H. Corresponds to variant rs6139194 [ dbSNP | Ensembl ].		VAR_059362
Experimental info
	Sequence conflict	300	1	E → D in BAB71261. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96MM6 [UniParc]. Last modified January 10, 2003. Version 2. Checksum: 5F873AE97E366606	FASTA	686	75,688
	10 20 30 40 50 60 MLAVPEMGLQ GLYIGSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE VRAPQQASFS 70 80 90 100 110 120 VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH QKTPTCLLLT PEGAFHSFGY 130 140 150 160 170 180 TARDYYHDLD PEEARDWLYF EKFKMKIHSA TDLTLKTQLE AVNGKTMPAL EVFAHALRFF 190 200 210 220 230 240 REHALQELRE QSPSLPEKDT VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS RENAEQLLIA 250 260 270 280 290 300 LEPEAASVYC RKLRLHQLLD LSGRAPGGGR LGERRSIDSS FRQAREQLRR SRHSRTFLVE 310 320 330 340 350 360 SGVGELWAEM QAGDRYVVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP YGAVGVDLAF 370 380 390 400 410 420 EQLLCRIFGE DFIATFKRQR PAAWVDLTIA FEARKRTAGP HRAGALNISL PFSFIDFYRK 430 440 450 460 470 480 QRGHNVETAL RRSSVNFVKW SSQGMLRMSC EAMNELFQPT VSGIIQHIEA LLARPEVQGV 490 500 510 520 530 540 KLLFLVGGFA ESAVLQHAVQ AALGARGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP 550 560 570 580 590 600 LTYGVGVLNR FVPGRHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG 610 620 630 640 650 660 QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPADCG QDTAGAPPGR REIRAAMQFG 670 680 DTEIKVTAVD VSTNRSVRAS IDFLSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Ovary.
[5]	"Two Hsp70 family members expressed in atherosclerotic lesions." Han Z., Truong Q.A., Park S., Breslow J.L. Proc. Natl. Acad. Sci. U.S.A. 100:1256-1261(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056712 mRNA. Translation: BAB71261.1. AL109804 Genomic DNA. Translation: CAC17544.3. CH471133 Genomic DNA. Translation: EAX10516.1. BC110881 mRNA. Translation: AAI10882.1. BC117284 mRNA. Translation: AAI17285.1. BC126263 mRNA. Translation: AAI26264.1.
IPI	IPI00307820.
RefSeq	NP_001184256.1. NM_001197327.1. NP_443202.3. NM_052970.4.
UniGene	Hs.516854.
3D structure databases
ProteinModelPortal	Q96MM6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000254963.
PTM databases
PhosphoSite	Q96MM6.
Polymorphism databases
DMDM	27734244.
Proteomic databases
PaxDb	Q96MM6.
PRIDE	Q96MM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254963; ENSP00000254963; ENSG00000132622.
GeneID	116835.
KEGG	hsa:116835.
UCSC	uc002wjd.3. human.
Organism-specific databases
CTD	116835.
GeneCards	GC20P003708.
HGNC	HGNC:16193. HSPA12B.
HPA	HPA013659. HPA015639.
MIM	610702. gene.
neXtProt	NX_Q96MM6.
PharmGKB	PA25771.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG132277.
HOGENOM	HOG000231707.
HOVERGEN	HBG051928.
OMA	QKTPTCL.
OrthoDB	EOG4HX50H.
PhylomeDB	Q96MM6.
Gene expression databases
ArrayExpress	Q96MM6.
Bgee	Q96MM6.
CleanEx	HS_HSPA12B.
Genevestigator	Q96MM6.
GermOnline	ENSG00000132622. Homo sapiens.
Family and domain databases
InterPro	IPR026685. HSPA12. [Graphical view]
PANTHER	PTHR14187:SF5. PTHR14187:SF5. 1 hit.
PROSITE	PS00297. HSP70_1. False negative. PS00329. HSP70_2. False negative. PS01036. HSP70_3. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	116835.
NextBio	79998.
SOURCE	Search...

Entry information

Entry name

HS12B_HUMAN

Accession

Primary (citable) accession number: Q96MM6
Secondary accession number(s): D3DVX7, Q2TAK3, Q9BR52

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	January 10, 2003
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.