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Q96MM6

- HS12B_HUMAN

UniProt

Q96MM6 - HS12B_HUMAN

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Protein

Heat shock 70 kDa protein 12B

Gene
HSPA12B, C20orf60
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 12B
Gene namesi
Name:HSPA12B
Synonyms:C20orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16193. HSPA12B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Heat shock 70 kDa protein 12BPRO_0000078294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96MM6.
PRIDEiQ96MM6.

PTM databases

PhosphoSiteiQ96MM6.

Expressioni

Tissue specificityi

Highest expression in muscle and heart. Lower levels in liver and kidney.1 Publication

Gene expression databases

ArrayExpressiQ96MM6.
BgeeiQ96MM6.
CleanExiHS_HSPA12B.
GenevestigatoriQ96MM6.

Organism-specific databases

HPAiHPA013659.
HPA015639.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000254963.

Structurei

3D structure databases

ProteinModelPortaliQ96MM6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG132277.
HOGENOMiHOG000231707.
HOVERGENiHBG051928.
OMAiAGRHPPD.
OrthoDBiEOG74J97G.
PhylomeDBiQ96MM6.
TreeFamiTF329492.

Family and domain databases

InterProiIPR029509. HSPA12B.
[Graphical view]
PANTHERiPTHR14187:SF39. PTHR14187:SF39. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96MM6-1 [UniParc]FASTAAdd to Basket

« Hide

MLAVPEMGLQ GLYIGSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE    50
VRAPQQASFS VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH 100
QKTPTCLLLT PEGAFHSFGY TARDYYHDLD PEEARDWLYF EKFKMKIHSA 150
TDLTLKTQLE AVNGKTMPAL EVFAHALRFF REHALQELRE QSPSLPEKDT 200
VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS RENAEQLLIA LEPEAASVYC 250
RKLRLHQLLD LSGRAPGGGR LGERRSIDSS FRQAREQLRR SRHSRTFLVE 300
SGVGELWAEM QAGDRYVVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP 350
YGAVGVDLAF EQLLCRIFGE DFIATFKRQR PAAWVDLTIA FEARKRTAGP 400
HRAGALNISL PFSFIDFYRK QRGHNVETAL RRSSVNFVKW SSQGMLRMSC 450
EAMNELFQPT VSGIIQHIEA LLARPEVQGV KLLFLVGGFA ESAVLQHAVQ 500
AALGARGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP LTYGVGVLNR 550
FVPGRHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG 600
QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPADCG QDTAGAPPGR 650
REIRAAMQFG DTEIKVTAVD VSTNRSVRAS IDFLSN 686
Length:686
Mass (Da):75,688
Last modified:January 10, 2003 - v2
Checksum:i5F873AE97E366606
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231V → L.
Corresponds to variant rs34414870 [ dbSNP | Ensembl ].
VAR_049621
Natural varianti270 – 2701R → H.
Corresponds to variant rs6139194 [ dbSNP | Ensembl ].
VAR_059362

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001E → D in BAB71261. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056712 mRNA. Translation: BAB71261.1.
AL109804 Genomic DNA. Translation: CAC17544.3.
CH471133 Genomic DNA. Translation: EAX10516.1.
BC110881 mRNA. Translation: AAI10882.1.
BC117284 mRNA. Translation: AAI17285.1.
BC126263 mRNA. Translation: AAI26264.1.
CCDSiCCDS13061.1.
RefSeqiNP_001184256.1. NM_001197327.1.
NP_443202.3. NM_052970.4.
UniGeneiHs.516854.

Genome annotation databases

EnsembliENST00000254963; ENSP00000254963; ENSG00000132622.
GeneIDi116835.
KEGGihsa:116835.
UCSCiuc002wjd.3. human.

Polymorphism databases

DMDMi27734244.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056712 mRNA. Translation: BAB71261.1 .
AL109804 Genomic DNA. Translation: CAC17544.3 .
CH471133 Genomic DNA. Translation: EAX10516.1 .
BC110881 mRNA. Translation: AAI10882.1 .
BC117284 mRNA. Translation: AAI17285.1 .
BC126263 mRNA. Translation: AAI26264.1 .
CCDSi CCDS13061.1.
RefSeqi NP_001184256.1. NM_001197327.1.
NP_443202.3. NM_052970.4.
UniGenei Hs.516854.

3D structure databases

ProteinModelPortali Q96MM6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000254963.

PTM databases

PhosphoSitei Q96MM6.

Polymorphism databases

DMDMi 27734244.

Proteomic databases

PaxDbi Q96MM6.
PRIDEi Q96MM6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254963 ; ENSP00000254963 ; ENSG00000132622 .
GeneIDi 116835.
KEGGi hsa:116835.
UCSCi uc002wjd.3. human.

Organism-specific databases

CTDi 116835.
GeneCardsi GC20P003708.
HGNCi HGNC:16193. HSPA12B.
HPAi HPA013659.
HPA015639.
MIMi 610702. gene.
neXtProti NX_Q96MM6.
PharmGKBi PA25771.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG132277.
HOGENOMi HOG000231707.
HOVERGENi HBG051928.
OMAi AGRHPPD.
OrthoDBi EOG74J97G.
PhylomeDBi Q96MM6.
TreeFami TF329492.

Miscellaneous databases

GenomeRNAii 116835.
NextBioi 79998.
PROi Q96MM6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96MM6.
Bgeei Q96MM6.
CleanExi HS_HSPA12B.
Genevestigatori Q96MM6.

Family and domain databases

InterProi IPR029509. HSPA12B.
[Graphical view ]
PANTHERi PTHR14187:SF39. PTHR14187:SF39. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  5. "Two Hsp70 family members expressed in atherosclerotic lesions."
    Han Z., Truong Q.A., Park S., Breslow J.L.
    Proc. Natl. Acad. Sci. U.S.A. 100:1256-1261(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHS12B_HUMAN
AccessioniPrimary (citable) accession number: Q96MM6
Secondary accession number(s): D3DVX7, Q2TAK3, Q9BR52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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