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Protein

Zinc finger protein 42 homolog

Gene

ZFP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 21225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • female gonad development Source: UniProtKB
  • male gonad development Source: UniProtKB
  • meiotic nuclear division Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96MM3.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 42 homolog
Short name:
Zfp-42
Alternative name(s):
Reduced expression protein 1
Short name:
REX-1
Short name:
hREX-1
Zinc finger protein 754
Gene namesi
Name:ZFP42
Synonyms:REX1, ZNF754
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30949. ZFP42.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670530.

Polymorphism and mutation databases

BioMutaiZFP42.
DMDMi296453032.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Zinc finger protein 42 homologPRO_0000287289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki231 – 231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki233 – 233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Polyubiquitinated by RNF12, leading to proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96MM3.
MaxQBiQ96MM3.
PaxDbiQ96MM3.
PeptideAtlasiQ96MM3.
PRIDEiQ96MM3.

PTM databases

iPTMnetiQ96MM3.
PhosphoSiteiQ96MM3.

Expressioni

Tissue specificityi

Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.4 Publications

Inductioni

Down-regulated upon retinoic acid addition to F9 stem cells.1 Publication

Gene expression databases

BgeeiQ96MM3.
CleanExiHS_ZFP42.
GenevisibleiQ96MM3. HS.

Organism-specific databases

HPAiCAB025557.

Interactioni

Protein-protein interaction databases

BioGridi126327. 5 interactions.
STRINGi9606.ENSP00000317686.

Structurei

3D structure databases

ProteinModelPortaliQ96MM3.
SMRiQ96MM3. Positions 188-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 21225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000008232.
HOVERGENiHBG006823.
InParanoidiQ96MM3.
KOiK11516.
OMAiDCYIECI.
OrthoDBiEOG769ZJD.
PhylomeDBiQ96MM3.
TreeFamiTF106493.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQLKKRAK TRHQKGLGGR APSGAKPRQG KSSQDLQAEI EPVSAVWALC
60 70 80 90 100
DGYVCYEPGP QALGGDDFSD CYIECVIRGE FSQPILEEDS LFESLEYLKK
110 120 130 140 150
GSEQQLSQKV FEASSLECSL EYMKKGVKKE LPQKIVGENS LEYSEYMTGK
160 170 180 190 200
KLPPGGIPGI DLSDPKQLAE FARKKPPINK EYDSLSAIAC PQSGCTRKLR
210 220 230 240 250
NRAALRKHLL IHGPRDHVCA ECGKAFVESS KLKRHFLVHT GEKPFRCTFE
260 270 280 290 300
GCGKRFSLDF NLRTHVRIHT GEKRFVCPFQ GCNRRFIQSN NLKAHILTHA
310
NTNKNEQEGK
Length:310
Mass (Da):34,802
Last modified:May 18, 2010 - v2
Checksum:iFBF4D7470DC37325
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881E → G in AAR07993 (Ref. 2) Curated
Sequence conflicti88 – 881E → G in BAB71264 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450454 mRNA. Translation: AAL47167.1.
AY429593 mRNA. Translation: AAR07993.1.
AK056719 mRNA. Translation: BAB71264.1.
AC108073 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04610.1.
CH471056 Genomic DNA. Translation: EAX04611.1.
CH471056 Genomic DNA. Translation: EAX04612.1.
CCDSiCCDS3849.1.
RefSeqiNP_001291287.1. NM_001304358.1.
NP_777560.2. NM_174900.4.
XP_011529906.1. XM_011531604.1.
XP_011529907.1. XM_011531605.1.
XP_011529908.1. XM_011531606.1.
XP_011529909.1. XM_011531607.1.
UniGeneiHs.335787.

Genome annotation databases

EnsembliENST00000326866; ENSP00000317686; ENSG00000179059.
ENST00000509524; ENSP00000424662; ENSG00000179059.
ENST00000618147; ENSP00000483363; ENSG00000179059.
GeneIDi132625.
KEGGihsa:132625.
UCSCiuc003izh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450454 mRNA. Translation: AAL47167.1.
AY429593 mRNA. Translation: AAR07993.1.
AK056719 mRNA. Translation: BAB71264.1.
AC108073 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04610.1.
CH471056 Genomic DNA. Translation: EAX04611.1.
CH471056 Genomic DNA. Translation: EAX04612.1.
CCDSiCCDS3849.1.
RefSeqiNP_001291287.1. NM_001304358.1.
NP_777560.2. NM_174900.4.
XP_011529906.1. XM_011531604.1.
XP_011529907.1. XM_011531605.1.
XP_011529908.1. XM_011531606.1.
XP_011529909.1. XM_011531607.1.
UniGeneiHs.335787.

3D structure databases

ProteinModelPortaliQ96MM3.
SMRiQ96MM3. Positions 188-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126327. 5 interactions.
STRINGi9606.ENSP00000317686.

PTM databases

iPTMnetiQ96MM3.
PhosphoSiteiQ96MM3.

Polymorphism and mutation databases

BioMutaiZFP42.
DMDMi296453032.

Proteomic databases

EPDiQ96MM3.
MaxQBiQ96MM3.
PaxDbiQ96MM3.
PeptideAtlasiQ96MM3.
PRIDEiQ96MM3.

Protocols and materials databases

DNASUi132625.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326866; ENSP00000317686; ENSG00000179059.
ENST00000509524; ENSP00000424662; ENSG00000179059.
ENST00000618147; ENSP00000483363; ENSG00000179059.
GeneIDi132625.
KEGGihsa:132625.
UCSCiuc003izh.2. human.

Organism-specific databases

CTDi132625.
GeneCardsiZFP42.
HGNCiHGNC:30949. ZFP42.
HPAiCAB025557.
MIMi614572. gene.
neXtProtiNX_Q96MM3.
PharmGKBiPA142670530.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000008232.
HOVERGENiHBG006823.
InParanoidiQ96MM3.
KOiK11516.
OMAiDCYIECI.
OrthoDBiEOG769ZJD.
PhylomeDBiQ96MM3.
TreeFamiTF106493.

Enzyme and pathway databases

SignaLinkiQ96MM3.

Miscellaneous databases

GeneWikiiRex1.
GenomeRNAii132625.
PROiQ96MM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MM3.
CleanExiHS_ZFP42.
GenevisibleiQ96MM3. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens."
    Henderson J.K., Draper J.S., Baillie H.S., Fishel S., Thomson J.A., Moore H., Andrews P.W.
    Stem Cells 20:329-337(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "A survey of transcripts in the 4q35 FSHD region."
    Clapp J., Hewitt J.E.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors."
    Korkola J.E., Houldsworth J., Chadalavada R.S., Olshen A.B., Dobrzynski D., Reuter V.E., Bosl G.J., Chaganti R.S.
    Cancer Res. 66:820-827(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma."
    Raman J.D., Mongan N.P., Liu L., Tickoo S.K., Nanus D.M., Scherr D.S., Gudas L.J.
    Carcinogenesis 27:499-507(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.
  8. "The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures."
    Mongan N.P., Martin K.M., Gudas L.J.
    Mol. Carcinog. 45:887-900(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiZFP42_HUMAN
AccessioniPrimary (citable) accession number: Q96MM3
Secondary accession number(s): D3DP65, Q8WXE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.