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Protein

Zinc finger protein 42 homolog

Gene

ZFP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri217 – 239C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 269C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • female gonad development Source: UniProtKB
  • male gonad development Source: UniProtKB
  • meiotic cell cycle Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96MM3.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 42 homolog
Short name:
Zfp-42
Alternative name(s):
Reduced expression protein 1
Short name:
REX-1
Short name:
hREX-1
Zinc finger protein 754
Gene namesi
Name:ZFP42
Synonyms:REX1, ZNF754
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30949. ZFP42.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi132625.
OpenTargetsiENSG00000179059.
PharmGKBiPA142670530.

Polymorphism and mutation databases

BioMutaiZFP42.
DMDMi296453032.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872891 – 310Zinc finger protein 42 homologAdd BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Polyubiquitinated by RNF12, leading to proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96MM3.
MaxQBiQ96MM3.
PaxDbiQ96MM3.
PeptideAtlasiQ96MM3.
PRIDEiQ96MM3.

PTM databases

iPTMnetiQ96MM3.
PhosphoSitePlusiQ96MM3.

Expressioni

Tissue specificityi

Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.4 Publications

Inductioni

Down-regulated upon retinoic acid addition to F9 stem cells.1 Publication

Gene expression databases

BgeeiENSG00000179059.
CleanExiHS_ZFP42.
GenevisibleiQ96MM3. HS.

Organism-specific databases

HPAiCAB025557.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126327. 5 interactors.
IntActiQ96MM3. 6 interactors.
STRINGi9606.ENSP00000317686.

Structurei

3D structure databases

ProteinModelPortaliQ96MM3.
SMRiQ96MM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri217 – 239C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 269C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000008232.
HOVERGENiHBG006823.
InParanoidiQ96MM3.
KOiK11516.
OMAiDCYIECI.
OrthoDBiEOG091G03FM.
PhylomeDBiQ96MM3.
TreeFamiTF106493.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q96MM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQLKKRAK TRHQKGLGGR APSGAKPRQG KSSQDLQAEI EPVSAVWALC
60 70 80 90 100
DGYVCYEPGP QALGGDDFSD CYIECVIRGE FSQPILEEDS LFESLEYLKK
110 120 130 140 150
GSEQQLSQKV FEASSLECSL EYMKKGVKKE LPQKIVGENS LEYSEYMTGK
160 170 180 190 200
KLPPGGIPGI DLSDPKQLAE FARKKPPINK EYDSLSAIAC PQSGCTRKLR
210 220 230 240 250
NRAALRKHLL IHGPRDHVCA ECGKAFVESS KLKRHFLVHT GEKPFRCTFE
260 270 280 290 300
GCGKRFSLDF NLRTHVRIHT GEKRFVCPFQ GCNRRFIQSN NLKAHILTHA
310
NTNKNEQEGK
Length:310
Mass (Da):34,802
Last modified:May 18, 2010 - v2
Checksum:iFBF4D7470DC37325
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88E → G in AAR07993 (Ref. 2) Curated1
Sequence conflicti88E → G in BAB71264 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450454 mRNA. Translation: AAL47167.1.
AY429593 mRNA. Translation: AAR07993.1.
AK056719 mRNA. Translation: BAB71264.1.
AC108073 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04610.1.
CH471056 Genomic DNA. Translation: EAX04611.1.
CH471056 Genomic DNA. Translation: EAX04612.1.
CCDSiCCDS3849.1.
RefSeqiNP_001291287.1. NM_001304358.1.
NP_777560.2. NM_174900.4.
XP_011529906.1. XM_011531604.2.
XP_011529907.1. XM_011531605.1.
XP_011529908.1. XM_011531606.1.
XP_011529909.1. XM_011531607.2.
UniGeneiHs.335787.

Genome annotation databases

EnsembliENST00000326866; ENSP00000317686; ENSG00000179059.
ENST00000509524; ENSP00000424662; ENSG00000179059.
ENST00000618147; ENSP00000483363; ENSG00000179059.
GeneIDi132625.
KEGGihsa:132625.
UCSCiuc003izh.2. human.

Similar proteinsi

Entry informationi

Entry nameiZFP42_HUMAN
AccessioniPrimary (citable) accession number: Q96MM3
Secondary accession number(s): D3DP65, Q8WXE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: August 30, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families