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Protein

RIPOR family member 3

Gene

RIPOR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RIPOR family member 3Imported
Gene namesi
Name:RIPOR3Imported
Synonyms:C20orf175Imported, C20orf176Imported, FAM65CImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000042062.11.
HGNCiHGNC:16168. RIPOR3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000042062.
PharmGKBiPA162387710.

Polymorphism and mutation databases

BioMutaiFAM65C.
DMDMi152031578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794841 – 946RIPOR family member 3Add BLAST946

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei345PhosphothreonineCombined sources1
Modified residuei351PhosphoserineBy similarity1
Modified residuei384PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96MK2.
PeptideAtlasiQ96MK2.
PRIDEiQ96MK2.

PTM databases

iPTMnetiQ96MK2.
PhosphoSitePlusiQ96MK2.

Expressioni

Gene expression databases

BgeeiENSG00000042062.
CleanExiHS_FAM65C.
GenevisibleiQ96MK2. HS.

Organism-specific databases

HPAiHPA051823.
HPA054759.

Interactioni

Protein-protein interaction databases

IntActiQ96MK2. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96MK2.
SMRiQ96MK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RIPOR family.Curated

Phylogenomic databases

eggNOGiENOG410IEF5. Eukaryota.
ENOG410Y99I. LUCA.
GeneTreeiENSGT00490000043360.
HOVERGENiHBG053834.
InParanoidiQ96MK2.
OMAiEQPGWRN.
OrthoDBiEOG091G018M.
PhylomeDBiQ96MK2.
TreeFamiTF329332.

Family and domain databases

InterProiView protein in InterPro
IPR031780. FAM65_N.
IPR026136. RIPOR3.
PANTHERiPTHR15829. PTHR15829. 1 hit.
PfamiView protein in Pfam
PF15903. PL48. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVRLRFLSP GDTGAVGVVG RSASFAGFSS AQSRRIAKSI NRNSVRSRMP
60 70 80 90 100
AKSSKMYGTL RKGSVCADPK PQQVKKIFEA LKRGLKEYLC VQQAELDHLS
110 120 130 140 150
GRHKDTRRNS RLAFYYDLDK QTRCVERHIR KMEFHISKVD ELYEDYCIQC
160 170 180 190 200
RLRDGASSMQ RAFARCPPSR AARESLQELG RSLHECAEDM WLIEGALEVH
210 220 230 240 250
LGEFHIRMKG LVGYARLCPG DHYEVLMRLG RQRWKLKGRI ESDDSQTWDE
260 270 280 290 300
EEKAFIPTLH ENLDIKVTEL RGLGSLAVGA VTCDIADFFT TRPQVIVVDI
310 320 330 340 350
TELGTIKLQL EVQWNPFDTE SFLVSPSPTG KFSMGSRKGS LYNWTPPSTP
360 370 380 390 400
SFRERYYLSV LQQPTQQALL LGGPRATSIL SYLSDSDLRG PSLRSQSQEL
410 420 430 440 450
PEMDSFSSED PRDTETSTSA STSDVGFLPL TFGPHASIEE EAREDPLPPG
460 470 480 490 500
LLPEMAHLSG GPFAEQPGWR NLGGESPSLP QGSLFHSGTA SSSQNGHEEG
510 520 530 540 550
ATGDREDGPG VALEGPLQEV LELLRPTDST QPQLRELEYQ VLGFRDRLKP
560 570 580 590 600
CRARQEHTSA ESLMECILES FAFLNADFAL DELSLFGGSQ GLRKDRPLPP
610 620 630 640 650
PSSLKASSRE LTAGAPELDV LLMVHLQVCK ALLQKLASPN LSRLVQECLL
660 670 680 690 700
EEVAQQKHVL ETLSVLDFEK VGKATSIEEI IPQASRTKGC LKLWRGCTGP
710 720 730 740 750
GRVLSCPATT LLNQLKKTFQ HRVRGKYPGQ LEIACRRLLE QVVSCGGLLP
760 770 780 790 800
GAGLPEEQII TWFQFHSYLQ RQSVSDLEKH FTQLTKEVTL IEELHCAGQA
810 820 830 840 850
KVVRKLQGKR LGQLQPLPQT LRAWALLQLD GTPRVCRAAS ARLAGAVRNR
860 870 880 890 900
SFREKALLFY TNALAENDAR LQQAACLALK HLKGIESIDQ TASLCQSDLE
910 920 930 940
AVRAAARETT LSFGEKGRLA FEKMDKLCSE QREVFCQEAD VEITIF
Note: No experimental confirmation available.
Length:946
Mass (Da):105,290
Last modified:July 10, 2007 - v4
Checksum:i4130C51B865B01F4
GO
Isoform 2 (identifier: Q96MK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     594-946: Missing.

Note: No experimental confirmation available.
Show »
Length:593
Mass (Da):66,096
Checksum:i0C7121D1B4550961
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti557H → L in BAB71286 (PubMed:14702039).Curated1
Sequence conflicti564M → I in BAB71286 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062194566C → S. Corresponds to variant dbSNP:rs35965508Ensembl.1
Natural variantiVAR_053914580L → P1 PublicationCorresponds to variant dbSNP:rs6020624Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026496594 – 946Missing in isoform 2. 1 PublicationAdd BLAST353

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056792 mRNA. Translation: BAB71286.1.
AL133230 Genomic DNA. Translation: CAI21688.2.
CCDSiCCDS13431.2. [Q96MK2-1]
RefSeqiNP_543019.2. NM_080829.3. [Q96MK2-1]
XP_011526881.1. XM_011528579.2. [Q96MK2-1]
XP_011526882.1. XM_011528580.2. [Q96MK2-1]
XP_011526883.1. XM_011528581.2. [Q96MK2-1]
UniGeneiHs.372578.

Genome annotation databases

EnsembliENST00000045083; ENSP00000045083; ENSG00000042062. [Q96MK2-1]
ENST00000327979; ENSP00000332663; ENSG00000042062. [Q96MK2-1]
GeneIDi140876.
KEGGihsa:140876.
UCSCiuc002xvm.4. human. [Q96MK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRIPR3_HUMAN
AccessioniPrimary (citable) accession number: Q96MK2
Secondary accession number(s): Q5QPB6, Q9NQQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 118 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families