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Protein

Protein HEXIM2

Gene

HEXIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.2 Publications

GO - Molecular functioni

  • 7SK snRNA binding Source: UniProtKB
  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: HGNC
  • snRNA binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168517-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HEXIM2
Alternative name(s):
Hexamethylene bis-acetamide-inducible protein 2
Gene namesi
Name:HEXIM2
ORF Names:L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28591. HEXIM2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi143T → A: Loss of interaction with P-TEFb. 1 Publication1
Mutagenesisi143T → D: Loss of interaction with P-TEFb. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000168517.
PharmGKBiPA142671695.

Polymorphism and mutation databases

BioMutaiHEXIM2.
DMDMi74732374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052671 – 286Protein HEXIM2Add BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei32PhosphothreonineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei46PhosphothreonineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96MH2.
MaxQBiQ96MH2.
PaxDbiQ96MH2.
PeptideAtlasiQ96MH2.
PRIDEiQ96MH2.

PTM databases

iPTMnetiQ96MH2.
PhosphoSitePlusiQ96MH2.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.1 Publication

Inductioni

Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000168517.
CleanExiHS_HEXIM2.
ExpressionAtlasiQ96MH2. baseline and differential.
GenevisibleiQ96MH2. HS.

Organism-specific databases

HPAiHPA023323.
HPA028455.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with HEXIM1; probably dimeric (PubMed:15713661, PubMed:15994294). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:15713661, PubMed:15713662, PubMed:15994294). Interacts with CCNT2 (PubMed:19883659).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-5460660,EBI-5460660
CCDC36Q8IYA83EBI-5460660,EBI-8638439
GATA1P159763EBI-5460660,EBI-3909284
MEOX2A4D1275EBI-5460660,EBI-10172134
PIM1P113093EBI-5460660,EBI-696621
PIN1Q135263EBI-5460660,EBI-714158
PRDM14Q9GZV84EBI-5460660,EBI-3957793
RNPS1D3DU923EBI-5460660,EBI-10176640
SPRY1O436093EBI-5460660,EBI-3866665
SPRY2O435973EBI-5460660,EBI-742487
TADA3O755283EBI-5460660,EBI-473249
TCF12Q990814EBI-5460660,EBI-722877
TERF1P542742EBI-5460660,EBI-710997

Protein-protein interaction databases

BioGridi125888. 36 interactors.
IntActiQ96MH2. 30 interactors.
STRINGi9606.ENSP00000302276.

Structurei

3D structure databases

ProteinModelPortaliQ96MH2.
SMRiQ96MH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 143Interaction with P-TEFb4
Regioni226 – 286Interaction with CCNT1, HEXIM1 and HEXIM22 PublicationsAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili207 – 277Sequence analysisAdd BLAST71

Domaini

The coiled-coil domain mediates oligomerization.

Sequence similaritiesi

Belongs to the HEXIM family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH8I. Eukaryota.
ENOG4111K9Z. LUCA.
GeneTreeiENSGT00390000002808.
HOGENOMiHOG000060338.
HOVERGENiHBG107976.
InParanoidiQ96MH2.
KOiK15189.
OMAiPCRQVEE.
OrthoDBiEOG091G0Y9A.
PhylomeDBiQ96MH2.
TreeFamiTF336851.

Family and domain databases

InterProiIPR024872. HEXIM.
IPR024876. HEXIM2.
[Graphical view]
PANTHERiPTHR13469. PTHR13469. 1 hit.
PTHR13469:SF3. PTHR13469:SF3. 1 hit.
PfamiPF15313. HEXIM. 1 hit.
[Graphical view]
PRINTSiPR02094. HEXIMFAMILY.

Sequencei

Sequence statusi: Complete.

Q96MH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMATPNQTAC NAESPVALEE AKTSGAPGSP QTPPERHDSG GSLPLTPRME
60 70 80 90 100
SHSEDEDLAG AVGGLGWNSR SPRTQSPGGC SAEAVLARKK HRRRPSKRKR
110 120 130 140 150
HWRPYLELSW AEKQQRDERQ SQRASRVREE MFAKGQPVAP YNTTQFLMND
160 170 180 190 200
RDPEEPNLDV PHGISHPGSS GESEAGDSDG RGRAHGEFQR KDFSETYERF
210 220 230 240 250
HTESLQGRSK QELVRDYLEL EKRLSQAEEE TRRLQQLQAC TGQQSCRQVE
260 270 280
ELAAEVQRLR TENQRLRQEN QMWNREGCRC DEEPGT
Length:286
Mass (Da):32,419
Last modified:December 1, 2001 - v1
Checksum:i58576D72096A8A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598322 mRNA. Translation: AAT06733.1.
AK056946 mRNA. Translation: BAB71319.1.
CH471178 Genomic DNA. Translation: EAW51541.1.
CH471178 Genomic DNA. Translation: EAW51542.1.
BC003531 mRNA. Translation: AAH03531.1.
BC012474 mRNA. Translation: AAH12474.1.
BC025970 mRNA. Translation: AAH25970.1.
CCDSiCCDS11496.1.
RefSeqiNP_001290365.1. NM_001303436.1.
NP_001290366.1. NM_001303437.1.
NP_001290367.1. NM_001303438.1.
NP_001290368.1. NM_001303439.1.
NP_001290369.1. NM_001303440.1.
NP_001290370.1. NM_001303441.1.
NP_001290371.1. NM_001303442.1.
NP_001290372.1. NM_001303443.1.
NP_001290373.1. NM_001303444.1.
NP_653209.1. NM_144608.2.
XP_011522608.1. XM_011524306.2.
XP_016879656.1. XM_017024167.1.
XP_016879657.1. XM_017024168.1.
XP_016879658.1. XM_017024169.1.
XP_016879659.1. XM_017024170.1.
UniGeneiHs.56382.
Hs.594840.

Genome annotation databases

EnsembliENST00000307275; ENSP00000302276; ENSG00000168517.
ENST00000591576; ENSP00000465727; ENSG00000168517.
ENST00000592695; ENSP00000467517; ENSG00000168517.
GeneIDi124790.
KEGGihsa:124790.
UCSCiuc002iih.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598322 mRNA. Translation: AAT06733.1.
AK056946 mRNA. Translation: BAB71319.1.
CH471178 Genomic DNA. Translation: EAW51541.1.
CH471178 Genomic DNA. Translation: EAW51542.1.
BC003531 mRNA. Translation: AAH03531.1.
BC012474 mRNA. Translation: AAH12474.1.
BC025970 mRNA. Translation: AAH25970.1.
CCDSiCCDS11496.1.
RefSeqiNP_001290365.1. NM_001303436.1.
NP_001290366.1. NM_001303437.1.
NP_001290367.1. NM_001303438.1.
NP_001290368.1. NM_001303439.1.
NP_001290369.1. NM_001303440.1.
NP_001290370.1. NM_001303441.1.
NP_001290371.1. NM_001303442.1.
NP_001290372.1. NM_001303443.1.
NP_001290373.1. NM_001303444.1.
NP_653209.1. NM_144608.2.
XP_011522608.1. XM_011524306.2.
XP_016879656.1. XM_017024167.1.
XP_016879657.1. XM_017024168.1.
XP_016879658.1. XM_017024169.1.
XP_016879659.1. XM_017024170.1.
UniGeneiHs.56382.
Hs.594840.

3D structure databases

ProteinModelPortaliQ96MH2.
SMRiQ96MH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125888. 36 interactors.
IntActiQ96MH2. 30 interactors.
STRINGi9606.ENSP00000302276.

PTM databases

iPTMnetiQ96MH2.
PhosphoSitePlusiQ96MH2.

Polymorphism and mutation databases

BioMutaiHEXIM2.
DMDMi74732374.

Proteomic databases

EPDiQ96MH2.
MaxQBiQ96MH2.
PaxDbiQ96MH2.
PeptideAtlasiQ96MH2.
PRIDEiQ96MH2.

Protocols and materials databases

DNASUi124790.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307275; ENSP00000302276; ENSG00000168517.
ENST00000591576; ENSP00000465727; ENSG00000168517.
ENST00000592695; ENSP00000467517; ENSG00000168517.
GeneIDi124790.
KEGGihsa:124790.
UCSCiuc002iih.2. human.

Organism-specific databases

CTDi124790.
GeneCardsiHEXIM2.
HGNCiHGNC:28591. HEXIM2.
HPAiHPA023323.
HPA028455.
MIMi615695. gene.
neXtProtiNX_Q96MH2.
OpenTargetsiENSG00000168517.
PharmGKBiPA142671695.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH8I. Eukaryota.
ENOG4111K9Z. LUCA.
GeneTreeiENSGT00390000002808.
HOGENOMiHOG000060338.
HOVERGENiHBG107976.
InParanoidiQ96MH2.
KOiK15189.
OMAiPCRQVEE.
OrthoDBiEOG091G0Y9A.
PhylomeDBiQ96MH2.
TreeFamiTF336851.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168517-MONOMER.

Miscellaneous databases

ChiTaRSiHEXIM2. human.
GeneWikiiHEXIM2.
GenomeRNAii124790.
PROiQ96MH2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168517.
CleanExiHS_HEXIM2.
ExpressionAtlasiQ96MH2. baseline and differential.
GenevisibleiQ96MH2. HS.

Family and domain databases

InterProiIPR024872. HEXIM.
IPR024876. HEXIM2.
[Graphical view]
PANTHERiPTHR13469. PTHR13469. 1 hit.
PTHR13469:SF3. PTHR13469:SF3. 1 hit.
PfamiPF15313. HEXIM. 1 hit.
[Graphical view]
PRINTSiPR02094. HEXIMFAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiHEXI2_HUMAN
AccessioniPrimary (citable) accession number: Q96MH2
Secondary accession number(s): D3DX66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.