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Protein

Protein HEXIM2

Gene

HEXIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.2 Publications

GO - Molecular functioni

  • 7SK snRNA binding Source: UniProtKB
  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: HGNC
  • identical protein binding Source: IntAct
  • snRNA binding Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HEXIM2
Alternative name(s):
Hexamethylene bis-acetamide-inducible protein 2
Gene namesi
Name:HEXIM2
ORF Names:L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000168517.10
HGNCiHGNC:28591 HEXIM2
MIMi615695 gene
neXtProtiNX_Q96MH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi143T → A: Loss of interaction with P-TEFb. 1 Publication1
Mutagenesisi143T → D: Loss of interaction with P-TEFb. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000168517
PharmGKBiPA142671695

Polymorphism and mutation databases

BioMutaiHEXIM2
DMDMi74732374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052671 – 286Protein HEXIM2Add BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei32PhosphothreonineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei46PhosphothreonineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96MH2
MaxQBiQ96MH2
PaxDbiQ96MH2
PeptideAtlasiQ96MH2
PRIDEiQ96MH2

PTM databases

iPTMnetiQ96MH2
PhosphoSitePlusiQ96MH2

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.1 Publication

Inductioni

Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000168517
CleanExiHS_HEXIM2
ExpressionAtlasiQ96MH2 baseline and differential
GenevisibleiQ96MH2 HS

Organism-specific databases

HPAiHPA023323
HPA028455

Interactioni

Subunit structurei

Homooligomer and heterooligomer with HEXIM1; probably dimeric (PubMed:15713661, PubMed:15994294). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:15713661, PubMed:15713662, PubMed:15994294). Interacts with CCNT2 (PubMed:19883659).4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi125888, 37 interactors
IntActiQ96MH2, 44 interactors
MINTiQ96MH2
STRINGi9606.ENSP00000302276

Structurei

3D structure databases

ProteinModelPortaliQ96MH2
SMRiQ96MH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 143Interaction with P-TEFb4
Regioni226 – 286Interaction with CCNT1, HEXIM1 and HEXIM22 PublicationsAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili207 – 277Sequence analysisAdd BLAST71

Domaini

The coiled-coil domain mediates oligomerization.

Sequence similaritiesi

Belongs to the HEXIM family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH8I Eukaryota
ENOG4111K9Z LUCA
GeneTreeiENSGT00390000002808
HOGENOMiHOG000060338
HOVERGENiHBG107976
InParanoidiQ96MH2
KOiK15189
OMAiPCRQVEE
OrthoDBiEOG091G0Y9A
PhylomeDBiQ96MH2
TreeFamiTF336851

Family and domain databases

InterProiView protein in InterPro
IPR024872 HEXIM
IPR024876 HEXIM2
PANTHERiPTHR13469 PTHR13469, 1 hit
PTHR13469:SF3 PTHR13469:SF3, 1 hit
PfamiView protein in Pfam
PF15313 HEXIM, 1 hit
PRINTSiPR02094 HEXIMFAMILY

Sequencei

Sequence statusi: Complete.

Q96MH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMATPNQTAC NAESPVALEE AKTSGAPGSP QTPPERHDSG GSLPLTPRME
60 70 80 90 100
SHSEDEDLAG AVGGLGWNSR SPRTQSPGGC SAEAVLARKK HRRRPSKRKR
110 120 130 140 150
HWRPYLELSW AEKQQRDERQ SQRASRVREE MFAKGQPVAP YNTTQFLMND
160 170 180 190 200
RDPEEPNLDV PHGISHPGSS GESEAGDSDG RGRAHGEFQR KDFSETYERF
210 220 230 240 250
HTESLQGRSK QELVRDYLEL EKRLSQAEEE TRRLQQLQAC TGQQSCRQVE
260 270 280
ELAAEVQRLR TENQRLRQEN QMWNREGCRC DEEPGT
Length:286
Mass (Da):32,419
Last modified:December 1, 2001 - v1
Checksum:i58576D72096A8A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598322 mRNA Translation: AAT06733.1
AK056946 mRNA Translation: BAB71319.1
CH471178 Genomic DNA Translation: EAW51541.1
CH471178 Genomic DNA Translation: EAW51542.1
BC003531 mRNA Translation: AAH03531.1
BC012474 mRNA Translation: AAH12474.1
BC025970 mRNA Translation: AAH25970.1
CCDSiCCDS11496.1
RefSeqiNP_001290365.1, NM_001303436.1
NP_001290366.1, NM_001303437.1
NP_001290367.1, NM_001303438.1
NP_001290368.1, NM_001303439.1
NP_001290369.1, NM_001303440.1
NP_001290370.1, NM_001303441.1
NP_001290371.1, NM_001303442.1
NP_001290372.1, NM_001303443.1
NP_001290373.1, NM_001303444.1
NP_653209.1, NM_144608.2
XP_011522608.1, XM_011524306.2
XP_016879656.1, XM_017024167.1
XP_016879657.1, XM_017024168.1
XP_016879658.1, XM_017024169.1
XP_016879659.1, XM_017024170.1
UniGeneiHs.56382
Hs.594840

Genome annotation databases

EnsembliENST00000307275; ENSP00000302276; ENSG00000168517
ENST00000591576; ENSP00000465727; ENSG00000168517
ENST00000592695; ENSP00000467517; ENSG00000168517
GeneIDi124790
KEGGihsa:124790
UCSCiuc002iih.2 human

Similar proteinsi

Entry informationi

Entry nameiHEXI2_HUMAN
AccessioniPrimary (citable) accession number: Q96MH2
Secondary accession number(s): D3DX66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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