Q96MG7 (MAGG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 81.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Melanoma-associated antigen G1 Alternative name(s): Hepatocellular carcinoma-associated protein 4 MAGE-G1 antigen Necdin-like protein 2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 304 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Growth suppressor that facilitates the entry of the cell into cell cycle arrest By similarity. |
| Subunit structure | Binds the C-terminus of E2F1 and NGFR By similarity. |
| Subcellular location | |
| Tissue specificity | Ubiquitous. Ref.6 |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7 Ref.8 Ref.9 |
| Sequence similarities | Contains 1 MAGE domain. |
| Sequence caution | The sequence AAH41166.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB84964.1 differs from that shown. Reason: Frameshift at position 290. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Growth regulation |
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Tumor antigen |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 304 | 304 | Melanoma-associated antigen G1 | PRO_0000156733 | |||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||
| Domain | 85 – 285 | 201 | MAGE | ||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||
| Modified residue | 57 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||||||||||||||||||||||||||||
| Modified residue | 60 | 1 | Phosphoserine Ref.7 | ||||||||||||||||||||||||||||||||
| Modified residue | 64 | 1 | Phosphoserine Ref.8 Ref.9 | ||||||||||||||||||||||||||||||||
| Modified residue | 304 | 1 | Phosphoserine Ref.9 | ||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||
| Helix | 82 – 102 | 21 | |||||||||||||||||||||||||||||||||
| Helix | 108 – 114 | 7 | |||||||||||||||||||||||||||||||||
| Helix | 119 – 122 | 4 | |||||||||||||||||||||||||||||||||
| Helix | 123 – 138 | 16 | |||||||||||||||||||||||||||||||||
| Beta strand | 141 – 146 | 6 | |||||||||||||||||||||||||||||||||
| Beta strand | 150 – 155 | 6 | |||||||||||||||||||||||||||||||||
| Helix | 179 – 182 | 4 | |||||||||||||||||||||||||||||||||
| Turn | 186 – 188 | 3 | |||||||||||||||||||||||||||||||||
| Helix | 195 – 204 | 10 | |||||||||||||||||||||||||||||||||
| Helix | 220 – 230 | 11 | |||||||||||||||||||||||||||||||||
| Helix | 254 – 256 | 3 | |||||||||||||||||||||||||||||||||
| Helix | 260 – 271 | 12 | |||||||||||||||||||||||||||||||||
| Beta strand | 275 – 277 | 3 | |||||||||||||||||||||||||||||||||
| Helix | 278 – 293 | 16 | |||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of genes in the chromosome X that are differentially expressed in hepatocellular carcinoma." Dong X.-Y., Chen W.-F. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lung, Spleen and Testis. |
| [4] | "The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-304. Tissue: Spleen. |
| [5] | "Identification of new genes of the MAGE family." Lucas S., Boon T. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 189-288. Tissue: Testis. |
| [6] | "A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues." Chibuk T.K., Bischof J.M., Wevrick R. BMC Genet. 2:22-22(2001) [PubMed: 11782285] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [7] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57 AND SER-60, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57 AND SER-64, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [9] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64 AND SER-304, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [10] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF490510 mRNA. Translation: AAM08357.1. AK056957 mRNA. Translation: BAB71325.1. BC041166 mRNA. Translation: AAH41166.2. Different initiation. BC053999 mRNA. Translation: AAH53999.1. AK074138 mRNA. Translation: BAB84964.1. Frameshift. AF320911 Genomic DNA. Translation: AAG38607.1. | ||||||||||||
| IPI | IPI00217104. | ||||||||||||
| RefSeq | NP_619649.1. NM_138704.3. | ||||||||||||
| UniGene | Hs.728271. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q96MG7. | ||||||||||||
| SMR | Q96MG7. Positions 78-294. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q96MG7. 1 interaction. | ||||||||||||
| STRING | Q96MG7. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q96MG7. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 46396494. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q96MG7. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000332303; ENSP00000330694; ENSG00000185115. | ||||||||||||
| GeneID | 56160. | ||||||||||||
| KEGG | hsa:56160. | ||||||||||||
| UCSC | uc001zco.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 56160. | ||||||||||||
| GeneCards | GC15M029560. | ||||||||||||
| H-InvDB | HIX0012059. | ||||||||||||
| HGNC | HGNC:7677. NDNL2. | ||||||||||||
| MIM | 608243. gene. | ||||||||||||
| neXtProt | NX_Q96MG7. | ||||||||||||
| PharmGKB | PA31480. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG08818. | ||||||||||||
| GeneTree | ENSGT00560000076930. | ||||||||||||
| HOGENOM | HBG507249. | ||||||||||||
| HOVERGEN | HBG006315. | ||||||||||||
| InParanoid | Q96MG7. | ||||||||||||
| OMA | IKETEVW. | ||||||||||||
| OrthoDB | EOG44J2JT. | ||||||||||||
| PhylomeDB | Q96MG7. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | p75ntrpathway. p75(NTR)-mediated signaling. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q96MG7. | ||||||||||||
| Bgee | Q96MG7. | ||||||||||||
| CleanEx | HS_NDNL2. | ||||||||||||
| Genevestigator | Q96MG7. | ||||||||||||
| GermOnline | ENSG00000185115. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002190. MAGE. [Graphical view] | ||||||||||||
| PANTHER | PTHR11736. MAGE. 1 hit. | ||||||||||||
| Pfam | PF01454. MAGE. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS50838. MAGE. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 61786. | ||||||||||||
| PMAP-CutDB | Q96MG7. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | MAGG1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96MG7 Secondary accession number(s): Q8IW16, Q8TEI6, Q9H214 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with