Reviewed,
UniProtKB/Swiss-Prot Q96MG7 (MAGG1_HUMAN)
Last modified
June 16, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Melanoma-associated antigen G1 Alternative name(s): MAGE-G1 antigen Necdin-like protein 2 Hepatocellular carcinoma-associated protein 4 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 304 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Growth suppressor that facilitates the entry of the cell into cell cycle arrest By similarity. |
| Subunit structure | Binds the C-terminus of E2F1 and NGFR By similarity. |
| Subcellular location | |
| Tissue specificity | Ubiquitous. Ref.6 |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7 Ref.8 |
| Sequence similarities | Contains 1 MAGE domain. |
| Sequence caution | The sequence BAB84964.1 differs from that shown. Reason: Frameshift at position 290. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Growth regulation |
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Tumor antigen |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 304 | 304 | Melanoma-associated antigen G1 | PRO_0000156733 | |||||
Regions | |||||||||
| Domain | 85 – 285 | 201 | MAGE | ||||||
Amino acid modifications | |||||||||
| Modified residue | 57 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||
| Modified residue | 60 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 64 | 1 | Phosphoserine Ref.8 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of genes in the chromosome X that are differentially expressed in hepatocellular carcinoma." Dong X.-Y., Chen W.-F. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lung, Spleen and Testis. |
| [4] | "The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-304. Tissue: Spleen. |
| [5] | "Identification of new genes of the MAGE family." Lucas S., Boon T. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 189-288. Tissue: Testis. |
| [6] | "A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues." Chibuk T.K., Bischof J.M., Wevrick R. BMC Genet. 2:22-22(2001) [PubMed: 11782285] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [7] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57 AND SER-60, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57 AND SER-64, MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF490510 mRNA. Translation: AAM08357.1. AK056957 mRNA. Translation: BAB71325.1. BC041166 mRNA. Translation: AAH41166.2. Different initiation. BC053999 mRNA. Translation: AAH53999.1. AK074138 mRNA. Translation: BAB84964.1. Frameshift. AF320911 Genomic DNA. Translation: AAG38607.1. | |
| IPI | IPI00217104. |
| RefSeq | NP_619649.1. |
| UniGene | Hs.656412 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q96MG7. |
Proteomic databases | |
| PRIDE | Q96MG7. |
Genome annotation databases | |
| Ensembl | ENSG00000185115. Homo sapiens. [Contig view] |
| GeneID | 56160. |
| KEGG | hsa:56160. |
Organism-specific databases | |
| GeneCards | GC15M027347. |
| H-InvDB | HIX0012059. |
| HGNC | HGNC:7677. NDNL2. |
| MIM | 608243. gene. |
| PharmGKB | PA31480. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q96MG7. |
| HOVERGEN | Q96MG7. |
| OMA | Q96MG7. IKETEVW. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | p75ntrpathway. p75(NTR)-mediated signaling. |
Gene expression databases | |
| ArrayExpress | Q96MG7. |
| Bgee | Q96MG7. |
| CleanEx | HS_NDNL2. |
| GermOnline | ENSG00000185115. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002190. MAGE. [Graphical view] |
| PANTHER | PTHR11736. MAGE. 1 hit. |
| Pfam | PF01454. MAGE. 1 hit. [Graphical view] |
| PROSITE | PS50838. MAGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 61786. |
| PMAP-CutDB | Q96MG7. |
| SOURCE | Search... |
Entry information
| Entry name | MAGG1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96MG7 Secondary accession number(s): Q8IW16, Q8TEI6, Q9H214 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


