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Protein

Junctional sarcoplasmic reticulum protein 1

Gene

JSRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.1 Publication

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional sarcoplasmic reticulum protein 1
Alternative name(s):
Junctional-face membrane protein of 45 kDa homolog
Short name:
JP-45
Gene namesi
Name:JSRP1
Synonyms:JP45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167476.10
HGNCiHGNC:24963 JSRP1
MIMi608743 gene
neXtProtiNX_Q96MG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi126306
OpenTargetsiENSG00000167476
PharmGKBiPA143485511

Polymorphism and mutation databases

BioMutaiJSRP1
DMDMi74732368

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140251 – 331Junctional sarcoplasmic reticulum protein 1Add BLAST331

Proteomic databases

PaxDbiQ96MG2
PeptideAtlasiQ96MG2
PRIDEiQ96MG2

PTM databases

iPTMnetiQ96MG2
PhosphoSitePlusiQ96MG2

Expressioni

Gene expression databases

BgeeiENSG00000167476
CleanExiHS_JSRP1
GenevisibleiQ96MG2 HS

Organism-specific databases

HPAiHPA044741

Interactioni

Subunit structurei

Interacts with CACNA1S, CACNB1 and calsequestrin.By similarity

Protein-protein interaction databases

BioGridi1259779 interactors.
IntActiQ96MG2 9 interactors.
STRINGi9606.ENSP00000300961

Structurei

3D structure databases

ProteinModelPortaliQ96MG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 76Mediates interaction with CACNA1SBy similarityAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 202Pro-richAdd BLAST101
Compositional biasi224 – 330Arg-richAdd BLAST107

Phylogenomic databases

eggNOGiENOG410J9EZ Eukaryota
ENOG4111EBH LUCA
GeneTreeiENSGT00390000012911
HOGENOMiHOG000113137
HOVERGENiHBG108014
InParanoidiQ96MG2
OMAiKFEAQAP
OrthoDBiEOG091G0WAR
PhylomeDBiQ96MG2

Family and domain databases

InterProiView protein in InterPro
IPR026178 JSRP1
PANTHERiPTHR22397 PTHR22397, 1 hit
PfamiView protein in Pfam
PF15312 JSRP, 1 hit

Sequencei

Sequence statusi: Complete.

Q96MG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTTRAWEE LDGGLGSCQA LEDHSALAET QEDRASATPR LADSGSVPHD
60 70 80 90 100
SQVAEGPSVD TRPKKMEKEP AARGTPGTGK ERLKAGASPR SVPARKKAQT
110 120 130 140 150
APPLQPPPPP PALSEELPWG DLSLNKCLVL ASLVALLGSA FQLCRDAVPG
160 170 180 190 200
EAALQARVPE PWVPPSSAPR EPSSPLPKFE AQAPPSAPPA PRAEAEVRPK
210 220 230 240 250
IPGSREAAEN DEEEPGEATG EAVREDRVTL ADRGPKERPR REGKPRKEKP
260 270 280 290 300
RKEERPKKER PRKEERPRAA REPREALPQR WESREGGHRP WARDSRDAEP
310 320 330
RKKQAWVSPR RPDEEQRPGS RQKLRAGKGR D
Length:331
Mass (Da):36,319
Last modified:December 1, 2001 - v1
Checksum:iBAB121BBB38EFB31
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03783892V → A. Corresponds to variant dbSNP:rs10426549Ensembl.1
Natural variantiVAR_069019108P → L Polymorphism affecting excitation/contraction coupling in muscle fibers; the sensitivity of CACNA1S voltage sensor is shifted to higher depolarizing voltages in cells carrying this variant. 1 PublicationCorresponds to variant dbSNP:rs74521370Ensembl.1
Natural variantiVAR_069020150G → A Polymorphism affecting excitation/contraction coupling in muscle fibers; the sensitivity of CACNA1S voltage sensor is shifted to higher depolarizing voltages in cells carrying this variant. 1 PublicationCorresponds to variant dbSNP:rs80043033Ensembl.1
Natural variantiVAR_037839233R → Q. Corresponds to variant dbSNP:rs35356610Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056978 mRNA Translation: BAB71330.1
BC021201 mRNA Translation: AAH21201.1
CCDSiCCDS12086.1
RefSeqiNP_653217.1, NM_144616.3
UniGeneiHs.330742

Genome annotation databases

EnsembliENST00000300961; ENSP00000300961; ENSG00000167476
GeneIDi126306
KEGGihsa:126306
UCSCiuc002lvj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiJSPR1_HUMAN
AccessioniPrimary (citable) accession number: Q96MG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome