Q96MG2 (JSPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Junctional sarcoplasmic reticulum protein 1

Alternative name(s):
Junctional-face membrane protein of 45 kDa homolog
Short name=JP-45

Gene names

Name:	JSRP1
Synonyms:	JP45

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as a regulator of the voltage-sensitive calcium channel CACNA1S. May regulate CACNA1S membrane targeting and activity. May function in excitation/contraction coupling in muscle cells By similarity.
Subunit structure	Interacts with CACNA1S, CACNB1 and calsequestrin By similarity.
Subcellular location	Sarcoplasmic reticulum membrane By similarity. Endoplasmic reticulum membrane By similarity. Note: Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes By similarity.
Caution	It is uncertain whether Met-1 or Met-3 is the initiator.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Sarcoplasmic reticulum
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	sarcoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Junctional sarcoplasmic reticulum protein 1		PRO_0000314025
Regions
	Region	3 – 76	74	Mediates interaction with CACNA1S By similarity
	Compositional bias	102 – 202	101	Pro-rich
	Compositional bias	224 – 330	107	Arg-rich
Natural variations
	Natural variant	92	1	V → A. Corresponds to variant rs10426549 [ dbSNP | Ensembl ].		VAR_037838
	Natural variant	233	1	R → Q. Corresponds to variant rs35356610 [ dbSNP | Ensembl ].		VAR_037839

Sequences

	Sequence		Length	Mass (Da)
	Q96MG2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: BAB121BBB38EFB31	FASTA	331	36,319
	10 20 30 40 50 60 MSMTTRAWEE LDGGLGSCQA LEDHSALAET QEDRASATPR LADSGSVPHD SQVAEGPSVD 70 80 90 100 110 120 TRPKKMEKEP AARGTPGTGK ERLKAGASPR SVPARKKAQT APPLQPPPPP PALSEELPWG 130 140 150 160 170 180 DLSLNKCLVL ASLVALLGSA FQLCRDAVPG EAALQARVPE PWVPPSSAPR EPSSPLPKFE 190 200 210 220 230 240 AQAPPSAPPA PRAEAEVRPK IPGSREAAEN DEEEPGEATG EAVREDRVTL ADRGPKERPR 250 260 270 280 290 300 REGKPRKEKP RKEERPKKER PRKEERPRAA REPREALPQR WESREGGHRP WARDSRDAEP 310 320 330 RKKQAWVSPR RPDEEQRPGS RQKLRAGKGR D

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056978 mRNA. Translation: BAB71330.1. BC021201 mRNA. Translation: AAH21201.1.
IPI	IPI00065501.
RefSeq	NP_653217.1. NM_144616.3.
UniGene	Hs.712901.
3D structure databases
ProteinModelPortal	Q96MG2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96MG2.
PTM databases
PhosphoSite	Q96MG2.
Polymorphism databases
DMDM	74732368.
Proteomic databases
PRIDE	Q96MG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300961; ENSP00000300961; ENSG00000167476.
GeneID	126306.
KEGG	hsa:126306.
UCSC	uc002lvi.1. human.
Organism-specific databases
CTD	126306.
GeneCards	GC19M002252.
HGNC	HGNC:24963. JSRP1.
HPA	HPA044741.
MIM	608743. gene.
neXtProt	NX_Q96MG2.
PharmGKB	PA143485511.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16203.
GeneTree	ENSGT00390000012911.
HOGENOM	HBG125039.
HOVERGEN	HBG108014.
InParanoid	Q96MG2.
OMA	SCQAGED.
OrthoDB	EOG4JQ3ZT.
PhylomeDB	Q96MG2.
Gene expression databases
Bgee	Q96MG2.
CleanEx	HS_JSRP1.
Genevestigator	Q96MG2.
Family and domain databases
ProtoNet	Search...
Other
NextBio	81765.
SOURCE	Search...

Entry information

Entry name

JSPR1_HUMAN

Accession

Primary (citable) accession number: Q96MG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.