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Protein

SH3 and cysteine-rich domain-containing protein 3

Gene

STAC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In skeletal muscles contraction, may play a role in neuromuscular synaptic transmission.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri89 – 14052Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • neuromuscular synaptic transmission Source: UniProtKB
  • skeletal muscle contraction Source: UniProtKB
  • skeletal muscle fiber development Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein 3
Gene namesi
Name:STAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28423. STAC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Native American myopathy (NAM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by congenital weakness and arthrogryposis, cleft palate, ptosis, short stature, kyphoscoliosis, talipes deformities, and susceptibility to malignant hyperthermia provoked by anesthesia.
See also OMIM:255995
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti284 – 2841W → S in NAM. 1 Publication
VAR_071313

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiSTAC3.
MIMi255995. phenotype.
Orphaneti168572. Native American myopathy.
PharmGKBiPA134877600.

Polymorphism and mutation databases

DMDMi74732360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364SH3 and cysteine-rich domain-containing protein 3PRO_0000232582Add
BLAST

Proteomic databases

EPDiQ96MF2.
PaxDbiQ96MF2.
PRIDEiQ96MF2.

PTM databases

iPTMnetiQ96MF2.
PhosphoSiteiQ96MF2.

Expressioni

Gene expression databases

BgeeiQ96MF2.
CleanExiHS_STAC3.
ExpressionAtlasiQ96MF2. baseline and differential.
GenevisibleiQ96MF2. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-745680,EBI-745680
BAZ2BQ9UIF8-23EBI-745680,EBI-10321972
C11orf57Q6ZUT13EBI-745680,EBI-3920396
C11orf57Q6ZUT1-23EBI-745680,EBI-10180231
CSNK2A1P684003EBI-745680,EBI-347804
DIP2AQ14689-63EBI-745680,EBI-10233719
FAM124AQ86V423EBI-745680,EBI-744506
FAM133AQ8N9E03EBI-745680,EBI-10268158
FAM90A1Q86YD73EBI-745680,EBI-6658203
L3MBTL2Q969R53EBI-745680,EBI-739909
MAB21L3Q8N8X93EBI-745680,EBI-10268010
SREK1IP1Q8N9Q23EBI-745680,EBI-10268630
ZCCHC10Q8TBK64EBI-745680,EBI-597063
ZGPATQ8N5A53EBI-745680,EBI-3439227
ZGPATQ8N5A5-23EBI-745680,EBI-10183064

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi128899. 22 interactions.
IntActiQ96MF2. 15 interactions.
MINTiMINT-1456589.
STRINGi9606.ENSP00000329200.

Structurei

Secondary structure

1
364
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi87 – 893Combined sources
Beta strandi92 – 965Combined sources
Beta strandi104 – 1063Combined sources
Helixi112 – 1154Combined sources
Beta strandi116 – 1238Combined sources
Turni129 – 1324Combined sources
Helixi133 – 1353Combined sources
Beta strandi136 – 1394Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DB6NMR-A80-140[»]
ProteinModelPortaliQ96MF2.
SMRiQ96MF2. Positions 80-142, 252-304, 309-364.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96MF2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini247 – 30660SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini309 – 36456SH3 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 7612Poly-GluAdd
BLAST

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri89 – 14052Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFB4. Eukaryota.
ENOG410YWV2. LUCA.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiQ96MF2.
OMAiQEDDKNS.
OrthoDBiEOG7XM2ZF.
PhylomeDBiQ96MF2.
TreeFamiTF332878.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEKEVLESP KPSFPAETRQ SGLQRLKQLL RKGSTGTKEM ELPPEPQANG
60 70 80 90 100
EAVGAGGGPI YYIYEEEEEE EEEEEEPPPE PPKLVNDKPH KFKDHFFKKP
110 120 130 140 150
KFCDVCARMI VLNNKFGLRC KNCKTNIHEH CQSYVEMQRC FGKIPPGFHR
160 170 180 190 200
AYSSPLYSNQ QYACVKDLSA ANRNDPVFET LRTGVIMANK ERKKGQADKK
210 220 230 240 250
NPVAAMMEEE PESARPEEGK PQDGNPEGDK KAEKKTPDDK HKQPGFQQSH
260 270 280 290 300
YFVALYRFKA LEKDDLDFPP GEKITVIDDS NEEWWRGKIG EKVGFFPPNF
310 320 330 340 350
IIRVRAGERV HRVTRSFVGN REIGQITLKK DQIVVQKGDE AGGYVKVYTG
360
RKVGLFPTDF LEEI
Length:364
Mass (Da):41,507
Last modified:December 1, 2001 - v1
Checksum:i9464C4F035FEDB98
GO
Isoform 2 (identifier: Q96MF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:325
Mass (Da):37,138
Checksum:i89A5DB6F1CD2022F
GO
Isoform 3 (identifier: Q96MF2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,304
Checksum:i185FF8AD4BE8CB38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti284 – 2841W → S in NAM. 1 Publication
VAR_071313

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 186186Missing in isoform 3. 1 PublicationVSP_055272Add
BLAST
Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_017914Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057013 mRNA. Translation: BAB71343.1.
AK300688 mRNA. Translation: BAG62371.1.
AC137834 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97005.1.
BC008069 mRNA. Translation: AAH08069.1.
CCDSiCCDS66405.1. [Q96MF2-3]
CCDS66406.1. [Q96MF2-2]
CCDS8936.1. [Q96MF2-1]
RefSeqiNP_001273185.1. NM_001286256.1. [Q96MF2-2]
NP_001273186.1. NM_001286257.1. [Q96MF2-3]
NP_659501.1. NM_145064.2. [Q96MF2-1]
XP_011536428.1. XM_011538126.1. [Q96MF2-1]
UniGeneiHs.417595.

Genome annotation databases

EnsembliENST00000332782; ENSP00000329200; ENSG00000185482. [Q96MF2-1]
ENST00000546246; ENSP00000441515; ENSG00000185482. [Q96MF2-3]
ENST00000554578; ENSP00000452068; ENSG00000185482. [Q96MF2-2]
GeneIDi246329.
KEGGihsa:246329.
UCSCiuc001snp.4. human. [Q96MF2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057013 mRNA. Translation: BAB71343.1.
AK300688 mRNA. Translation: BAG62371.1.
AC137834 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97005.1.
BC008069 mRNA. Translation: AAH08069.1.
CCDSiCCDS66405.1. [Q96MF2-3]
CCDS66406.1. [Q96MF2-2]
CCDS8936.1. [Q96MF2-1]
RefSeqiNP_001273185.1. NM_001286256.1. [Q96MF2-2]
NP_001273186.1. NM_001286257.1. [Q96MF2-3]
NP_659501.1. NM_145064.2. [Q96MF2-1]
XP_011536428.1. XM_011538126.1. [Q96MF2-1]
UniGeneiHs.417595.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DB6NMR-A80-140[»]
ProteinModelPortaliQ96MF2.
SMRiQ96MF2. Positions 80-142, 252-304, 309-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128899. 22 interactions.
IntActiQ96MF2. 15 interactions.
MINTiMINT-1456589.
STRINGi9606.ENSP00000329200.

PTM databases

iPTMnetiQ96MF2.
PhosphoSiteiQ96MF2.

Polymorphism and mutation databases

DMDMi74732360.

Proteomic databases

EPDiQ96MF2.
PaxDbiQ96MF2.
PRIDEiQ96MF2.

Protocols and materials databases

DNASUi246329.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332782; ENSP00000329200; ENSG00000185482. [Q96MF2-1]
ENST00000546246; ENSP00000441515; ENSG00000185482. [Q96MF2-3]
ENST00000554578; ENSP00000452068; ENSG00000185482. [Q96MF2-2]
GeneIDi246329.
KEGGihsa:246329.
UCSCiuc001snp.4. human. [Q96MF2-1]

Organism-specific databases

CTDi246329.
GeneCardsiSTAC3.
HGNCiHGNC:28423. STAC3.
MalaCardsiSTAC3.
MIMi255995. phenotype.
615521. gene.
neXtProtiNX_Q96MF2.
Orphaneti168572. Native American myopathy.
PharmGKBiPA134877600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFB4. Eukaryota.
ENOG410YWV2. LUCA.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiQ96MF2.
OMAiQEDDKNS.
OrthoDBiEOG7XM2ZF.
PhylomeDBiQ96MF2.
TreeFamiTF332878.

Miscellaneous databases

EvolutionaryTraceiQ96MF2.
GenomeRNAii246329.
PROiQ96MF2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MF2.
CleanExiHS_STAC3.
ExpressionAtlasiQ96MF2. baseline and differential.
GenevisibleiQ96MF2. HS.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Skeletal muscle.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.
  5. Cited for: VARIANT NAM SER-284, CHARACTERIZATION OF VARIANT NAM SER-284, INVOLVEMENT IN NAM, FUNCTION.
  6. "Solution structure of RSGI RUH-051, a C1 domain of STAC3 from human cDNA."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 80-142.

Entry informationi

Entry nameiSTAC3_HUMAN
AccessioniPrimary (citable) accession number: Q96MF2
Secondary accession number(s): B4DUK9, Q96HU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.