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Protein

Zinc finger protein 512

Gene

ZNF512

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri287 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri406 – 430C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri440 – 463C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 512
Gene namesi
Name:ZNF512
Synonyms:KIAA1805
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000243943.9.
HGNCiHGNC:29380. ZNF512.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000243943.
PharmGKBiPA134896861.

Polymorphism and mutation databases

DMDMi229462786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476301 – 567Zinc finger protein 512Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki18Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki84Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki333Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96ME7.
MaxQBiQ96ME7.
PaxDbiQ96ME7.
PeptideAtlasiQ96ME7.
PRIDEiQ96ME7.

PTM databases

iPTMnetiQ96ME7.
PhosphoSitePlusiQ96ME7.

Expressioni

Gene expression databases

BgeeiENSG00000243943.
CleanExiHS_ZNF512.
ExpressionAtlasiQ96ME7. baseline and differential.
GenevisibleiQ96ME7. HS.

Organism-specific databases

HPAiHPA031430.

Interactioni

Protein-protein interaction databases

BioGridi124088. 103 interactors.
IntActiQ96ME7. 4 interactors.
STRINGi9606.ENSP00000347648.

Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi155 – 165Combined sources11
Turni172 – 174Combined sources3
Beta strandi178 – 181Combined sources4
Helixi182 – 192Combined sources11
Beta strandi200 – 202Combined sources3
Helixi209 – 219Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CTDNMR-A142-224[»]
ProteinModelPortaliQ96ME7.
SMRiQ96ME7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96ME7.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri287 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri406 – 430C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri440 – 463C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00490000043365.
HOGENOMiHOG000070082.
HOVERGENiHBG054123.
InParanoidiQ96ME7.
OMAiGPTSFKQ.
OrthoDBiEOG091G0WWW.
PhylomeDBiQ96ME7.
TreeFamiTF331185.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96ME7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSRLGAVPA TSGPTTFKQQ RSTRIVGAKN SRTQCSIKDN SFQYTIPHDD
60 70 80 90 100
SLSGSSSASS CEPVSDFPAS FRKSTYWMKM RRIKPAATSH VEGSGGVSAK
110 120 130 140 150
GKRKPRQEED EDYREFPQKK HKLYGRKQRP KTQPNPKSQA RRIRKEPPVY
160 170 180 190 200
AAGSLEEQWY LEIVDKGSVS CPTCQAVGRK TIEGLKKHME NCKQEMFTCH
210 220 230 240 250
HCGKQLRSLA GMKYHVMANH NSLPILKAGD EIDEPSERER LRTVLKRLGK
260 270 280 290 300
LRCMRESCSS SFTSIMGYLY HVRKCGKGAA ELEKMTLKCH HCGKPYRSKA
310 320 330 340 350
GLAYHLRSEH GPISFFPESG QPECLKEMNL ESKSGGRVQR RSAKIAVYHL
360 370 380 390 400
QELASAELAK EWPKRKVLQD LVPDDRKLKY TRPGLPTFSQ EVLHKWKTDI
410 420 430 440 450
KKYHRIQCPN QGCEAVYSSV SGLKAHLGSC TLGNFVAGKY KCLLCQKEFV
460 470 480 490 500
SESGVKYHIN SVHAEDWFVV NPTTTKSFEK LMKIKQRQQE EEKRRQQHRS
510 520 530 540 550
RRSLRRRQQP GIELPETELS LRVGKDQRRN NEELVVSASC KEPEQEPVPA
560
QFQKVKPPKT NHKRGRK
Length:567
Mass (Da):64,682
Last modified:May 5, 2009 - v2
Checksum:i0837E9DB4ED46E75
GO
Isoform 2 (identifier: Q96ME7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:490
Mass (Da):56,362
Checksum:iE4222A04C8AD1411
GO
Isoform 3 (identifier: Q96ME7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: Missing.
     126-153: Missing.

Show »
Length:538
Mass (Da):61,354
Checksum:i334EE2910BDB1E5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24R → S in BAB71348 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469331 – 77Missing in isoform 2. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_04693431Missing in isoform 3. Curated1
Alternative sequenceiVSP_046935126 – 153Missing in isoform 3. CuratedAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057028 mRNA. Translation: BAB71348.1.
AK294055 mRNA. Translation: BAH11661.1.
AK299818 mRNA. Translation: BAG61687.1.
AK316299 mRNA. Translation: BAH14670.1.
AC074091 Genomic DNA. Translation: AAX93199.1.
CH471053 Genomic DNA. Translation: EAX00562.1.
CH471053 Genomic DNA. Translation: EAX00564.1.
CH471053 Genomic DNA. Translation: EAX00565.1.
AB058708 mRNA. Translation: BAB47434.1.
BC043221 mRNA. Translation: AAH43221.1.
BC093041 mRNA. Translation: AAH93041.1.
CCDSiCCDS1758.1. [Q96ME7-1]
CCDS59428.1. [Q96ME7-3]
CCDS59429.1. [Q96ME7-2]
RefSeqiNP_001258215.1. NM_001271286.1. [Q96ME7-3]
NP_001258216.1. NM_001271287.1. [Q96ME7-2]
NP_001258217.1. NM_001271288.1. [Q96ME7-2]
NP_001258218.1. NM_001271289.1.
NP_001258247.1. NM_001271318.1. [Q96ME7-2]
NP_115810.2. NM_032434.3. [Q96ME7-1]
UniGeneiHs.529178.

Genome annotation databases

EnsembliENST00000355467; ENSP00000347648; ENSG00000243943. [Q96ME7-1]
ENST00000413371; ENSP00000395660; ENSG00000243943. [Q96ME7-2]
ENST00000416005; ENSP00000407038; ENSG00000243943. [Q96ME7-3]
ENST00000556601; ENSP00000451572; ENSG00000243943. [Q96ME7-2]
GeneIDi84450.
KEGGihsa:84450.
UCSCiuc002rla.5. human. [Q96ME7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN512_HUMAN
AccessioniPrimary (citable) accession number: Q96ME7
Secondary accession number(s): B4DSM5
, Q53RZ7, Q86XK6, Q96JM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families