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Protein

Zinc finger protein 512

Gene

ZNF512

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 22024C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 31024C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 43025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 512
Gene namesi
Name:ZNF512
Synonyms:KIAA1805
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29380. ZNF512.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896861.

Polymorphism and mutation databases

DMDMi229462786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Zinc finger protein 512PRO_0000047630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki333 – 333Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96ME7.
MaxQBiQ96ME7.
PaxDbiQ96ME7.
PRIDEiQ96ME7.

PTM databases

iPTMnetiQ96ME7.

Expressioni

Gene expression databases

BgeeiQ96ME7.
CleanExiHS_ZNF512.
ExpressionAtlasiQ96ME7. baseline and differential.
GenevisibleiQ96ME7. HS.

Organism-specific databases

HPAiHPA031430.

Interactioni

Protein-protein interaction databases

BioGridi124088. 82 interactions.
IntActiQ96ME7. 2 interactions.
STRINGi9606.ENSP00000347648.

Structurei

Secondary structure

1
567
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi155 – 16511Combined sources
Turni172 – 1743Combined sources
Beta strandi178 – 1814Combined sources
Helixi182 – 19211Combined sources
Beta strandi200 – 2023Combined sources
Helixi209 – 21911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CTDNMR-A142-224[»]
ProteinModelPortaliQ96ME7.
SMRiQ96ME7. Positions 142-224, 280-318, 403-471.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96ME7.

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 22024C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 31024C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 43025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00490000043365.
HOGENOMiHOG000070082.
HOVERGENiHBG054123.
InParanoidiQ96ME7.
OMAiGPTSFKQ.
PhylomeDBiQ96ME7.
TreeFamiTF331185.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96ME7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSRLGAVPA TSGPTTFKQQ RSTRIVGAKN SRTQCSIKDN SFQYTIPHDD
60 70 80 90 100
SLSGSSSASS CEPVSDFPAS FRKSTYWMKM RRIKPAATSH VEGSGGVSAK
110 120 130 140 150
GKRKPRQEED EDYREFPQKK HKLYGRKQRP KTQPNPKSQA RRIRKEPPVY
160 170 180 190 200
AAGSLEEQWY LEIVDKGSVS CPTCQAVGRK TIEGLKKHME NCKQEMFTCH
210 220 230 240 250
HCGKQLRSLA GMKYHVMANH NSLPILKAGD EIDEPSERER LRTVLKRLGK
260 270 280 290 300
LRCMRESCSS SFTSIMGYLY HVRKCGKGAA ELEKMTLKCH HCGKPYRSKA
310 320 330 340 350
GLAYHLRSEH GPISFFPESG QPECLKEMNL ESKSGGRVQR RSAKIAVYHL
360 370 380 390 400
QELASAELAK EWPKRKVLQD LVPDDRKLKY TRPGLPTFSQ EVLHKWKTDI
410 420 430 440 450
KKYHRIQCPN QGCEAVYSSV SGLKAHLGSC TLGNFVAGKY KCLLCQKEFV
460 470 480 490 500
SESGVKYHIN SVHAEDWFVV NPTTTKSFEK LMKIKQRQQE EEKRRQQHRS
510 520 530 540 550
RRSLRRRQQP GIELPETELS LRVGKDQRRN NEELVVSASC KEPEQEPVPA
560
QFQKVKPPKT NHKRGRK
Length:567
Mass (Da):64,682
Last modified:May 5, 2009 - v2
Checksum:i0837E9DB4ED46E75
GO
Isoform 2 (identifier: Q96ME7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:490
Mass (Da):56,362
Checksum:iE4222A04C8AD1411
GO
Isoform 3 (identifier: Q96ME7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: Missing.
     126-153: Missing.

Show »
Length:538
Mass (Da):61,354
Checksum:i334EE2910BDB1E5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241R → S in BAB71348 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 2. 2 PublicationsVSP_046933Add
BLAST
Alternative sequencei31 – 311Missing in isoform 3. CuratedVSP_046934
Alternative sequencei126 – 15328Missing in isoform 3. CuratedVSP_046935Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057028 mRNA. Translation: BAB71348.1.
AK294055 mRNA. Translation: BAH11661.1.
AK299818 mRNA. Translation: BAG61687.1.
AK316299 mRNA. Translation: BAH14670.1.
AC074091 Genomic DNA. Translation: AAX93199.1.
CH471053 Genomic DNA. Translation: EAX00562.1.
CH471053 Genomic DNA. Translation: EAX00564.1.
CH471053 Genomic DNA. Translation: EAX00565.1.
AB058708 mRNA. Translation: BAB47434.1.
BC043221 mRNA. Translation: AAH43221.1.
BC093041 mRNA. Translation: AAH93041.1.
CCDSiCCDS1758.1. [Q96ME7-1]
CCDS59428.1. [Q96ME7-3]
CCDS59429.1. [Q96ME7-2]
RefSeqiNP_001258215.1. NM_001271286.1. [Q96ME7-3]
NP_001258216.1. NM_001271287.1. [Q96ME7-2]
NP_001258217.1. NM_001271288.1. [Q96ME7-2]
NP_001258218.1. NM_001271289.1.
NP_001258247.1. NM_001271318.1. [Q96ME7-2]
NP_115810.2. NM_032434.3. [Q96ME7-1]
UniGeneiHs.529178.

Genome annotation databases

EnsembliENST00000355467; ENSP00000347648; ENSG00000243943. [Q96ME7-1]
ENST00000413371; ENSP00000395660; ENSG00000243943. [Q96ME7-2]
ENST00000416005; ENSP00000407038; ENSG00000243943. [Q96ME7-3]
ENST00000556601; ENSP00000451572; ENSG00000243943. [Q96ME7-2]
GeneIDi84450.
KEGGihsa:84450.
UCSCiuc002rla.5. human. [Q96ME7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057028 mRNA. Translation: BAB71348.1.
AK294055 mRNA. Translation: BAH11661.1.
AK299818 mRNA. Translation: BAG61687.1.
AK316299 mRNA. Translation: BAH14670.1.
AC074091 Genomic DNA. Translation: AAX93199.1.
CH471053 Genomic DNA. Translation: EAX00562.1.
CH471053 Genomic DNA. Translation: EAX00564.1.
CH471053 Genomic DNA. Translation: EAX00565.1.
AB058708 mRNA. Translation: BAB47434.1.
BC043221 mRNA. Translation: AAH43221.1.
BC093041 mRNA. Translation: AAH93041.1.
CCDSiCCDS1758.1. [Q96ME7-1]
CCDS59428.1. [Q96ME7-3]
CCDS59429.1. [Q96ME7-2]
RefSeqiNP_001258215.1. NM_001271286.1. [Q96ME7-3]
NP_001258216.1. NM_001271287.1. [Q96ME7-2]
NP_001258217.1. NM_001271288.1. [Q96ME7-2]
NP_001258218.1. NM_001271289.1.
NP_001258247.1. NM_001271318.1. [Q96ME7-2]
NP_115810.2. NM_032434.3. [Q96ME7-1]
UniGeneiHs.529178.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CTDNMR-A142-224[»]
ProteinModelPortaliQ96ME7.
SMRiQ96ME7. Positions 142-224, 280-318, 403-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124088. 82 interactions.
IntActiQ96ME7. 2 interactions.
STRINGi9606.ENSP00000347648.

PTM databases

iPTMnetiQ96ME7.

Polymorphism and mutation databases

DMDMi229462786.

Proteomic databases

EPDiQ96ME7.
MaxQBiQ96ME7.
PaxDbiQ96ME7.
PRIDEiQ96ME7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355467; ENSP00000347648; ENSG00000243943. [Q96ME7-1]
ENST00000413371; ENSP00000395660; ENSG00000243943. [Q96ME7-2]
ENST00000416005; ENSP00000407038; ENSG00000243943. [Q96ME7-3]
ENST00000556601; ENSP00000451572; ENSG00000243943. [Q96ME7-2]
GeneIDi84450.
KEGGihsa:84450.
UCSCiuc002rla.5. human. [Q96ME7-1]

Organism-specific databases

CTDi84450.
GeneCardsiZNF512.
HGNCiHGNC:29380. ZNF512.
HPAiHPA031430.
neXtProtiNX_Q96ME7.
PharmGKBiPA134896861.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00490000043365.
HOGENOMiHOG000070082.
HOVERGENiHBG054123.
InParanoidiQ96ME7.
OMAiGPTSFKQ.
PhylomeDBiQ96ME7.
TreeFamiTF331185.

Miscellaneous databases

ChiTaRSiZNF512. human.
EvolutionaryTraceiQ96ME7.
GenomeRNAii84450.
NextBioi35474708.
PROiQ96ME7.

Gene expression databases

BgeeiQ96ME7.
CleanExiHS_ZNF512.
ExpressionAtlasiQ96ME7. baseline and differential.
GenevisibleiQ96ME7. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Cerebellum and Neuroepithelioma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis and Uterus.
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-567 (ISOFORM 1).
    Tissue: Brain.
  6. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Solution structure of two ZF-C2H2 domains from human zinc finger protein 512."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 142-224.

Entry informationi

Entry nameiZN512_HUMAN
AccessioniPrimary (citable) accession number: Q96ME7
Secondary accession number(s): B4DSM5
, Q53RZ7, Q86XK6, Q96JM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 5, 2009
Last modified: April 13, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.