ID FXL18_HUMAN Reviewed; 805 AA. AC Q96ME1; Q9BR90; Q9BTC7; Q9HAK7; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 15-MAR-2005, sequence version 2. DT 19-MAR-2014, entry version 94. DE RecName: Full=F-box/LRR-repeat protein 18; DE AltName: Full=F-box and leucine-rich repeat protein 18; GN Name=FBXL18; Synonyms=FBL18; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 424-805 (ISOFORM 1). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 476-805 (ISOFORM 4). RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F- CC box protein)-type E3 ubiquitin ligase complex (By similarity). CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1 (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q96ME1-1; Sequence=Displayed; CC Note=No experimental confirmation available; CC Name=2; CC IsoId=Q96ME1-2; Sequence=VSP_013012, VSP_013013; CC Note=No experimental confirmation available; CC Name=3; CC IsoId=Q96ME1-3; Sequence=VSP_013009, VSP_013010; CC Note=No experimental confirmation available; CC Name=4; CC IsoId=Q96ME1-4; Sequence=VSP_013011, VSP_013014; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Contains 1 F-box domain. CC -!- SIMILARITY: Contains 12 LRR (leucine-rich) repeats. CC -!- SEQUENCE CAUTION: CC Sequence=BAB13838.1; Type=Erroneous initiation; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK021529; BAB13838.1; ALT_INIT; mRNA. DR EMBL; AK057042; BAB71354.1; -; mRNA. DR EMBL; BC004228; AAH04228.1; -; mRNA. DR EMBL; BC006426; AAH06426.2; -; mRNA. DR EMBL; BC024256; AAH24256.1; -; mRNA. DR RefSeq; NP_079239.3; NM_024963.4. DR UniGene; Hs.623974; -. DR UniGene; Hs.706587; -. DR ProteinModelPortal; Q96ME1; -. DR SMR; Q96ME1; 25-153, 317-428, 525-622. DR BioGrid; 123080; 13. DR IntAct; Q96ME1; 1. DR STRING; 9606.ENSP00000371805; -. DR PhosphoSite; Q96ME1; -. DR DMDM; 61213731; -. DR PaxDb; Q96ME1; -. DR PRIDE; Q96ME1; -. DR Ensembl; ENST00000382368; ENSP00000371805; ENSG00000155034. [Q96ME1-4] DR Ensembl; ENST00000415009; ENSP00000415064; ENSG00000155034. [Q96ME1-2] DR GeneID; 80028; -. DR KEGG; hsa:80028; -. DR UCSC; uc003son.4; human. [Q96ME1-4] DR CTD; 80028; -. DR GeneCards; GC07M005470; -. DR HGNC; HGNC:21874; FBXL18. DR HPA; HPA036049; -. DR MIM; 609084; gene. DR neXtProt; NX_Q96ME1; -. DR PharmGKB; PA134949446; -. DR eggNOG; NOG72426; -. DR HOGENOM; HOG000112676; -. DR HOVERGEN; HBG051676; -. DR InParanoid; Q96ME1; -. DR KO; K10284; -. DR OrthoDB; EOG7X3QQJ; -. DR TreeFam; TF331865; -. DR GenomeRNAi; 80028; -. DR NextBio; 70186; -. DR PRO; PR:Q96ME1; -. DR ArrayExpress; Q96ME1; -. DR Bgee; Q96ME1; -. DR CleanEx; HS_FBXL18; -. DR Genevestigator; Q96ME1; -. DR InterPro; IPR001810; F-box_dom. DR SMART; SM00256; FBOX; 1. DR SUPFAM; SSF81383; SSF81383; 1. DR PROSITE; PS50181; FBOX; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Leucine-rich repeat; KW Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. FT CHAIN 1 805 F-box/LRR-repeat protein 18. FT /FTId=PRO_0000119867. FT DOMAIN 25 72 F-box. FT REPEAT 77 103 LRR 1. FT REPEAT 104 128 LRR 2. FT REPEAT 129 153 LRR 3. FT REPEAT 177 201 LRR 4. FT REPEAT 324 352 LRR 5. FT REPEAT 367 392 LRR 6. FT REPEAT 393 422 LRR 7. FT REPEAT 468 492 LRR 8. FT REPEAT 516 540 LRR 9. FT REPEAT 542 567 LRR 10. FT REPEAT 572 597 LRR 11. FT REPEAT 599 623 LRR 12. FT VAR_SEQ 364 365 RK -> CR (in isoform 3). FT /FTId=VSP_013009. FT VAR_SEQ 366 805 Missing (in isoform 3). FT /FTId=VSP_013010. FT VAR_SEQ 667 718 RWGEVTGRRPQLFTELREEPSARTSRATGRRQPCLPDSGVV FT CCPCGRPLAVS -> SFQAERPALNVVIFPLLHEGLTDVIR FT DVPLVHLDEITLFKSRVAEEPPNLWW (in isoform FT 4). FT /FTId=VSP_013011. FT VAR_SEQ 667 668 RW -> SR (in isoform 2). FT /FTId=VSP_013012. FT VAR_SEQ 669 805 Missing (in isoform 2). FT /FTId=VSP_013013. FT VAR_SEQ 719 805 Missing (in isoform 4). FT /FTId=VSP_013014. FT VARIANT 552 552 N -> K (in dbSNP:rs33941092). FT /FTId=VAR_055800. FT CONFLICT 555 555 L -> P (in Ref. 1; BAB13838). SQ SEQUENCE 805 AA; 88341 MW; 823FDC403787809C CRC64; MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL NVRRTCRKLA ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS MAGCYWLPGS TVEHVARCRS LVKVNLSGCH LTSLRLSKML SALQHLRSLA IDVSPGFDAS QLSSECKATL SRVRELKQTL FTPSYGVVPC CTSLEKLLLY FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG YINQEVVRLY LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL SGCVHCLSPD SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG LGRHLCQLLA RLRHLRSLSL PVCSVADSAP RADRAPAQPA MHAVPRGFGK KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK NLPFLEHLEL IGSNFSSAMP RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ LPSVLTGSGL VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT GESLATCKSL QQSLLRRWGE VTGRRPQLFT ELREEPSART SRATGRRQPC LPDSGVVCCP CGRPLAVSGI ILVGVSPSLV VKTTCVYRVL FKNLDYASIF FLVCLFETES HSVVQAGVQW RDLSSLQPLL SGLQPQPPEQ LENELEIGFS YCFVI //