ID FXL18_HUMAN STANDARD; PRT; 805 AA. AC Q96ME1; Q9BR90; Q9BTC7; Q9HAK7; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 15-MAR-2005, sequence version 2. DT 27-JUN-2006, entry version 26. DE F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein DE 18). GN Name=FBXL18; Synonyms=FBL18; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 424-805 (ISOFORM 1). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 476-805 (ISOFORM 4). RC TISSUE=Skin; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F- CC box protein)-type E3 ubiquitin ligase complex (By similarity). CC -!- SUBUNIT: Directly interacts with SKP1A and CUL1 (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q96ME1-1; Sequence=Displayed; CC Note=No experimental confirmation available; CC Name=2; CC IsoId=Q96ME1-2; Sequence=VSP_013012, VSP_013013; CC Note=No experimental confirmation available; CC Name=3; CC IsoId=Q96ME1-3; Sequence=VSP_013009, VSP_013010; CC Note=No experimental confirmation available; CC Name=4; CC IsoId=Q96ME1-4; Sequence=VSP_013011, VSP_013014; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Contains 1 F-box domain. CC -!- SIMILARITY: Contains 3 LRR (leucine-rich) repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK021529; BAB13838.1; ALT_INIT; mRNA. DR EMBL; AK057042; BAB71354.1; -; mRNA. DR EMBL; BC004228; AAH04228.1; -; mRNA. DR EMBL; BC006426; AAH06426.2; -; mRNA. DR EMBL; BC024256; AAH24256.1; -; mRNA. DR Ensembl; ENSG00000155034; Homo sapiens. DR HGNC; HGNC:21874; FBXL18. DR MIM; 609084; gene. DR GO; GO:0005737; C:cytoplasm; ISS. DR GO; GO:0005515; F:protein binding; ISS. DR GO; GO:0004842; F:ubiquitin-protein ligase activity; ISS. DR GO; GO:0006464; P:protein modification; ISS. DR GO; GO:0006508; P:proteolysis; ISS. DR InterPro; IPR001810; F-box. DR Pfam; PF00646; F-box; 1. DR PROSITE; PS50181; FBOX; 1. KW Alternative splicing; Leucine-rich repeat; Repeat; KW Ubl conjugation pathway. FT CHAIN 1 805 F-box/LRR-repeat protein 18. FT /FTId=PRO_0000119867. FT DOMAIN 25 72 F-box. FT REPEAT 120 147 LRR 1. FT REPEAT 344 379 LRR 2. FT REPEAT 484 514 LRR 3. FT VAR_SEQ 364 365 RK -> CR (in isoform 3). FT /FTId=VSP_013009. FT VAR_SEQ 366 805 Missing (in isoform 3). FT /FTId=VSP_013010. FT VAR_SEQ 667 718 RWGEVTGRRPQLFTELREEPSARTSRATGRRQPCLPDSGVV FT CCPCGRPLAVS -> SFQAERPALNVVIFPLLHEGLTDVIR FT DVPLVHLDEITLFKSRVAEEPPNLWW (in isoform FT 4). FT /FTId=VSP_013011. FT VAR_SEQ 667 668 RW -> SR (in isoform 2). FT /FTId=VSP_013012. FT VAR_SEQ 669 805 Missing (in isoform 2). FT /FTId=VSP_013013. FT VAR_SEQ 719 805 Missing (in isoform 4). FT /FTId=VSP_013014. FT CONFLICT 555 555 L -> P (in Ref. 1; BAB13838). SQ SEQUENCE 805 AA; 88341 MW; 823FDC403787809C CRC64; MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL NVRRTCRKLA ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS MAGCYWLPGS TVEHVARCRS LVKVNLSGCH LTSLRLSKML SALQHLRSLA IDVSPGFDAS QLSSECKATL SRVRELKQTL FTPSYGVVPC CTSLEKLLLY FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG YINQEVVRLY LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL SGCVHCLSPD SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG LGRHLCQLLA RLRHLRSLSL PVCSVADSAP RADRAPAQPA MHAVPRGFGK KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK NLPFLEHLEL IGSNFSSAMP RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ LPSVLTGSGL VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT GESLATCKSL QQSLLRRWGE VTGRRPQLFT ELREEPSART SRATGRRQPC LPDSGVVCCP CGRPLAVSGI ILVGVSPSLV VKTTCVYRVL FKNLDYASIF FLVCLFETES HSVVQAGVQW RDLSSLQPLL SGLQPQPPEQ LENELEIGFS YCFVI //