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Protein

F-box/LRR-repeat protein 18

Gene

FBXL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 18
Alternative name(s):
F-box and leucine-rich repeat protein 18
Gene namesi
Name:FBXL18
Synonyms:FBL18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21874. FBXL18.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949446.

Polymorphism and mutation databases

BioMutaiFBXL18.
DMDMi61213731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805F-box/LRR-repeat protein 18PRO_0000119867Add
BLAST

Proteomic databases

EPDiQ96ME1.
MaxQBiQ96ME1.
PaxDbiQ96ME1.
PeptideAtlasiQ96ME1.
PRIDEiQ96ME1.

PTM databases

iPTMnetiQ96ME1.
PhosphoSiteiQ96ME1.

Expressioni

Gene expression databases

BgeeiQ96ME1.
CleanExiHS_FBXL18.
ExpressionAtlasiQ96ME1. baseline and differential.
GenevisibleiQ96ME1. HS.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi123080. 40 interactions.
IntActiQ96ME1. 2 interactions.
STRINGi9606.ENSP00000371805.

Structurei

3D structure databases

ProteinModelPortaliQ96ME1.
SMRiQ96ME1. Positions 380-424, 529-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 7248F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati77 – 10327LRR 1Add
BLAST
Repeati104 – 12825LRR 2Add
BLAST
Repeati129 – 15325LRR 3Add
BLAST
Repeati177 – 20125LRR 4Add
BLAST
Repeati324 – 35229LRR 5Add
BLAST
Repeati367 – 39226LRR 6Add
BLAST
Repeati393 – 42230LRR 7Add
BLAST
Repeati468 – 49225LRR 8Add
BLAST
Repeati516 – 54025LRR 9Add
BLAST
Repeati542 – 56726LRR 10Add
BLAST
Repeati572 – 59726LRR 11Add
BLAST
Repeati599 – 62325LRR 12Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IEMD. Eukaryota.
ENOG410ZR0R. LUCA.
GeneTreeiENSGT00390000015109.
HOGENOMiHOG000112676.
HOVERGENiHBG051676.
InParanoidiQ96ME1.
KOiK10284.
OMAiMCHMFMG.
OrthoDBiEOG7X3QQJ.
PhylomeDBiQ96ME1.
TreeFamiTF331865.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96ME1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL
60 70 80 90 100
NVRRTCRKLA ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS
110 120 130 140 150
MAGCYWLPGS TVEHVARCRS LVKVNLSGCH LTSLRLSKML SALQHLRSLA
160 170 180 190 200
IDVSPGFDAS QLSSECKATL SRVRELKQTL FTPSYGVVPC CTSLEKLLLY
210 220 230 240 250
FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG YINQEVVRLY
260 270 280 290 300
LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS
310 320 330 340 350
WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL
360 370 380 390 400
SGCVHCLSPD SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG
410 420 430 440 450
LGRHLCQLLA RLRHLRSLSL PVCSVADSAP RADRAPAQPA MHAVPRGFGK
460 470 480 490 500
KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK NLPFLEHLEL IGSNFSSAMP
510 520 530 540 550
RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ LPSVLTGSGL
560 570 580 590 600
VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF
610 620 630 640 650
SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT
660 670 680 690 700
GESLATCKSL QQSLLRRWGE VTGRRPQLFT ELREEPSART SRATGRRQPC
710 720 730 740 750
LPDSGVVCCP CGRPLAVSGI ILVGVSPSLV VKTTCVYRVL FKNLDYASIF
760 770 780 790 800
FLVCLFETES HSVVQAGVQW RDLSSLQPLL SGLQPQPPEQ LENELEIGFS

YCFVI
Note: No experimental confirmation available.
Length:805
Mass (Da):88,341
Last modified:March 15, 2005 - v2
Checksum:i823FDC403787809C
GO
Isoform 2 (identifier: Q96ME1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-668: RW → SR
     669-805: Missing.

Note: No experimental confirmation available.
Show »
Length:668
Mass (Da):73,159
Checksum:iD3D385AFB3D1E6E5
GO
Isoform 3 (identifier: Q96ME1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-365: RK → CR
     366-805: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):40,223
Checksum:iC5D7F25C9AFE44F4
GO
Isoform 4 (identifier: Q96ME1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-718: RWGEVTGRRP...CPCGRPLAVS → SFQAERPALN...VAEEPPNLWW
     719-805: Missing.

Note: No experimental confirmation available.
Show »
Length:718
Mass (Da):78,919
Checksum:iA4BB27A1195DE07B
GO

Sequence cautioni

The sequence BAB13838.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti555 – 5551L → P in BAB13838 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti552 – 5521N → K.
Corresponds to variant rs33941092 [ dbSNP | Ensembl ].
VAR_055800

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei364 – 3652RK → CR in isoform 3. 1 PublicationVSP_013009
Alternative sequencei366 – 805440Missing in isoform 3. 1 PublicationVSP_013010Add
BLAST
Alternative sequencei667 – 71852RWGEV…PLAVS → SFQAERPALNVVIFPLLHEG LTDVIRDVPLVHLDEITLFK SRVAEEPPNLWW in isoform 4. 1 PublicationVSP_013011Add
BLAST
Alternative sequencei667 – 6682RW → SR in isoform 2. 1 PublicationVSP_013012
Alternative sequencei669 – 805137Missing in isoform 2. 1 PublicationVSP_013013Add
BLAST
Alternative sequencei719 – 80587Missing in isoform 4. 1 PublicationVSP_013014Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021529 mRNA. Translation: BAB13838.1. Different initiation.
AK057042 mRNA. Translation: BAB71354.1.
BC004228 mRNA. Translation: AAH04228.1.
BC006426 mRNA. Translation: AAH06426.2.
BC024256 mRNA. Translation: AAH24256.1.
CCDSiCCDS43546.1. [Q96ME1-4]
UniGeneiHs.623974.
Hs.706587.

Genome annotation databases

EnsembliENST00000382368; ENSP00000371805; ENSG00000155034. [Q96ME1-4]
ENST00000415009; ENSP00000415064; ENSG00000155034. [Q96ME1-2]
ENST00000453700; ENSP00000444797; ENSG00000155034. [Q96ME1-3]
KEGGihsa:80028.
UCSCiuc003son.5. human. [Q96ME1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021529 mRNA. Translation: BAB13838.1. Different initiation.
AK057042 mRNA. Translation: BAB71354.1.
BC004228 mRNA. Translation: AAH04228.1.
BC006426 mRNA. Translation: AAH06426.2.
BC024256 mRNA. Translation: AAH24256.1.
CCDSiCCDS43546.1. [Q96ME1-4]
UniGeneiHs.623974.
Hs.706587.

3D structure databases

ProteinModelPortaliQ96ME1.
SMRiQ96ME1. Positions 380-424, 529-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123080. 40 interactions.
IntActiQ96ME1. 2 interactions.
STRINGi9606.ENSP00000371805.

PTM databases

iPTMnetiQ96ME1.
PhosphoSiteiQ96ME1.

Polymorphism and mutation databases

BioMutaiFBXL18.
DMDMi61213731.

Proteomic databases

EPDiQ96ME1.
MaxQBiQ96ME1.
PaxDbiQ96ME1.
PeptideAtlasiQ96ME1.
PRIDEiQ96ME1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382368; ENSP00000371805; ENSG00000155034. [Q96ME1-4]
ENST00000415009; ENSP00000415064; ENSG00000155034. [Q96ME1-2]
ENST00000453700; ENSP00000444797; ENSG00000155034. [Q96ME1-3]
KEGGihsa:80028.
UCSCiuc003son.5. human. [Q96ME1-1]

Organism-specific databases

CTDi80028.
GeneCardsiFBXL18.
HGNCiHGNC:21874. FBXL18.
MIMi609084. gene.
neXtProtiNX_Q96ME1.
PharmGKBiPA134949446.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEMD. Eukaryota.
ENOG410ZR0R. LUCA.
GeneTreeiENSGT00390000015109.
HOGENOMiHOG000112676.
HOVERGENiHBG051676.
InParanoidiQ96ME1.
KOiK10284.
OMAiMCHMFMG.
OrthoDBiEOG7X3QQJ.
PhylomeDBiQ96ME1.
TreeFamiTF331865.

Miscellaneous databases

ChiTaRSiFBXL18. human.
GenomeRNAii80028.
PROiQ96ME1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96ME1.
CleanExiHS_FBXL18.
ExpressionAtlasiQ96ME1. baseline and differential.
GenevisibleiQ96ME1. HS.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 424-805 (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 476-805 (ISOFORM 4).
    Tissue: Skin.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFXL18_HUMAN
AccessioniPrimary (citable) accession number: Q96ME1
Secondary accession number(s): Q9BR90, Q9BTC7, Q9HAK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.