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Protein

Uncharacterized protein C9orf85

Gene

C9orf85

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C9orf85
Gene namesi
Name:C9orf85
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28784. C9orf85.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985322.

Polymorphism and mutation databases

BioMutaiC9orf85.
DMDMi68565262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 179178Uncharacterized protein C9orf85PRO_0000089720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei137 – 1371PhosphoserineBy similarity
Isoform 2 (identifier: Q96MD7-1)
Modified residuei137 – 1371PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96MD7.
MaxQBiQ96MD7.
PaxDbiQ96MD7.
PRIDEiQ96MD7.

PTM databases

PhosphoSiteiQ96MD7.

Expressioni

Gene expression databases

BgeeiQ96MD7.
CleanExiHS_C9orf85.
ExpressionAtlasiQ96MD7. baseline and differential.
GenevisibleiQ96MD7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334289.

Structurei

3D structure databases

ProteinModelPortaliQ96MD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 7957Lys-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG3241. Eukaryota.
ENOG4111SCC. LUCA.
GeneTreeiENSGT00440000033805.
HOGENOMiHOG000247051.
InParanoidiQ96MD7.
OMAiPQRHQNA.
OrthoDBiEOG7BP862.
PhylomeDBiQ96MD7.
TreeFamiTF324614.

Family and domain databases

InterProiIPR019351. DUF2039.
[Graphical view]
PfamiPF10217. DUF2039. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96MD7-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSQKGNVAR SRPQKHQNTF SFKNDKFDKS VQTKKINAKL HDGVCQRCKE
60 70 80 90 100
VLEWRVKYSK YKPLSKPKKC VKCLQKTVKD SYHIMCRPCA CELEVCAKCG
110 120 130 140 150
KKEDIVIPWS LPLLPRLECS GRILAHHNLR LPCSSDSPAS ASRVAGTTGA
160 170
HHHAQLIFVF LVEMGFHYVG QAGLELLTS
Length:179
Mass (Da):20,166
Last modified:December 1, 2001 - v1
Checksum:i2DD013912F969A01
GO
Isoform 2 (identifier: Q96MD7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-179: WSLPLLPRLE...GQAGLELLTS → LNKETEKIEH...EDTGGDHQMN

Show »
Length:157
Mass (Da):18,264
Checksum:i68DDB5171F36905F
GO
Isoform 3 (identifier: Q96MD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: K → C
     36-179: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:35
Mass (Da):4,059
Checksum:i4CCAD582C6C57517
GO

Sequence cautioni

The sequence CAH72769.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei35 – 351K → C in isoform 3. 1 PublicationVSP_014428
Alternative sequencei36 – 179144Missing in isoform 3. 1 PublicationVSP_014429Add
BLAST
Alternative sequencei109 – 17971WSLPL…ELLTS → LNKETEKIEHTENNLSSNHR RSCRRNEESDDDLDFDIDLE DTGGDHQMN in isoform 2. 1 PublicationVSP_014430Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057071 mRNA. No translation available.
AL138751 Genomic DNA. Translation: CAH72766.1.
AL138751 Genomic DNA. Translation: CAH72768.1.
AL138751 Genomic DNA. Translation: CAH72769.1. Sequence problems.
BC010179 mRNA. No translation available.
BC052375 mRNA. Translation: AAH52375.1.
CCDSiCCDS6639.1. [Q96MD7-1]
RefSeqiNP_872311.2. NM_182505.3. [Q96MD7-1]
UniGeneiHs.534190.

Genome annotation databases

EnsembliENST00000334731; ENSP00000334289; ENSG00000155621. [Q96MD7-1]
ENST00000377031; ENSP00000366230; ENSG00000155621. [Q96MD7-3]
ENST00000479413; ENSP00000433086; ENSG00000155621. [Q96MD7-2]
GeneIDi138241.
KEGGihsa:138241.
UCSCiuc004ain.4. human. [Q96MD7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057071 mRNA. No translation available.
AL138751 Genomic DNA. Translation: CAH72766.1.
AL138751 Genomic DNA. Translation: CAH72768.1.
AL138751 Genomic DNA. Translation: CAH72769.1. Sequence problems.
BC010179 mRNA. No translation available.
BC052375 mRNA. Translation: AAH52375.1.
CCDSiCCDS6639.1. [Q96MD7-1]
RefSeqiNP_872311.2. NM_182505.3. [Q96MD7-1]
UniGeneiHs.534190.

3D structure databases

ProteinModelPortaliQ96MD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334289.

PTM databases

PhosphoSiteiQ96MD7.

Polymorphism and mutation databases

BioMutaiC9orf85.
DMDMi68565262.

Proteomic databases

EPDiQ96MD7.
MaxQBiQ96MD7.
PaxDbiQ96MD7.
PRIDEiQ96MD7.

Protocols and materials databases

DNASUi138241.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334731; ENSP00000334289; ENSG00000155621. [Q96MD7-1]
ENST00000377031; ENSP00000366230; ENSG00000155621. [Q96MD7-3]
ENST00000479413; ENSP00000433086; ENSG00000155621. [Q96MD7-2]
GeneIDi138241.
KEGGihsa:138241.
UCSCiuc004ain.4. human. [Q96MD7-3]

Organism-specific databases

CTDi138241.
GeneCardsiC9orf85.
H-InvDBHIX0012312.
HIX0017333.
HIX0025737.
HGNCiHGNC:28784. C9orf85.
neXtProtiNX_Q96MD7.
PharmGKBiPA134985322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3241. Eukaryota.
ENOG4111SCC. LUCA.
GeneTreeiENSGT00440000033805.
HOGENOMiHOG000247051.
InParanoidiQ96MD7.
OMAiPQRHQNA.
OrthoDBiEOG7BP862.
PhylomeDBiQ96MD7.
TreeFamiTF324614.

Miscellaneous databases

ChiTaRSiC9orf85. human.
GenomeRNAii138241.
NextBioi83769.
PROiQ96MD7.

Gene expression databases

BgeeiQ96MD7.
CleanExiHS_C9orf85.
ExpressionAtlasiQ96MD7. baseline and differential.
GenevisibleiQ96MD7. HS.

Family and domain databases

InterProiIPR019351. DUF2039.
[Graphical view]
PfamiPF10217. DUF2039. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Kidney and Skin.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCI085_HUMAN
AccessioniPrimary (citable) accession number: Q96MD7
Secondary accession number(s): Q5W0N1
, Q5W0N3, Q6PJW9, Q86U95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.