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Protein

UPF0536 protein C12orf66

Gene

C12orf66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0536 protein C12orf66
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26517. C12orf66.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377974.

Polymorphism and mutation databases

BioMutaiC12orf66.
DMDMi296439467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445UPF0536 protein C12orf66PRO_0000321902Add
BLAST

Proteomic databases

MaxQBiQ96MD2.
PaxDbiQ96MD2.
PRIDEiQ96MD2.

PTM databases

iPTMnetiQ96MD2.
PhosphoSiteiQ96MD2.

Expressioni

Gene expression databases

BgeeiQ96MD2.
CleanExiHS_C12orf66.
ExpressionAtlasiQ96MD2. baseline and differential.
GenevisibleiQ96MD2. HS.

Organism-specific databases

HPAiHPA046743.
HPA052855.

Interactioni

Protein-protein interaction databases

BioGridi126862. 5 interactions.
STRINGi9606.ENSP00000381132.

Structurei

3D structure databases

ProteinModelPortaliQ96MD2.
SMRiQ96MD2. Positions 124-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0536 family.Curated

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ96MD2.
PhylomeDBiQ96MD2.
TreeFamiTF329125.

Family and domain databases

InterProiIPR018544. DUF2003.
[Graphical view]
PfamiPF09404. DUF2003. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESIPLAAP VPVEQAVLET FFSHLGIFSY DKAKDNVEKE REANKSAGGS
60 70 80 90 100
WLSLLAALAH LAAAEKVYHS LTYLGQKLGG QSFFSRKDSI RTIYTSLHNE
110 120 130 140 150
LKKVVTGRGA LGGTAPHVEE LLSHLSEQLC FFVQARMEMA DFYEKMYTLS
160 170 180 190 200
TQKFINAEEL VGLLDAIMKK YSSRFHHPIL SPLESSFQLE VDVLCHLLKA
210 220 230 240 250
QAQVSEWKFL PSLVNLHSAH TKLQTWGQIF EKQRETKKHL FGGQSQKAVQ
260 270 280 290 300
PPHLFLWLMK LKNMLLAKFS FYFHEALSRQ TTASEMKTLT AKANPDFFGK
310 320 330 340 350
ISSFIRKYDA ANVSLIFDNR GSESFQGHGY HHPHSYREAP KGVDQYPAVV
360 370 380 390 400
SLPSDRPVMH WPNVIMIMTD RTSDLNSLEK VVHFYDDKVQ STYFLTRPEP
410 420 430 440
HFTIVIIFES KKSERDSHFI SFLNEVSLAL KNPKVFASLK PGAKG
Length:445
Mass (Da):50,415
Last modified:May 18, 2010 - v4
Checksum:iE61D982C4BA04A6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391M → I.3 Publications
Corresponds to variant rs2335390 [ dbSNP | Ensembl ].
VAR_039371
Natural varianti443 – 4431A → S.3 Publications
Corresponds to variant rs699638 [ dbSNP | Ensembl ].
VAR_039372

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057111 mRNA. Translation: BAB71367.1.
AC012158 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97124.1.
BC071634 mRNA. Translation: AAH71634.1.
CCDSiCCDS41803.1.
RefSeqiNP_689653.3. NM_152440.4.
UniGeneiHs.444671.
Hs.505871.

Genome annotation databases

EnsembliENST00000398055; ENSP00000381132; ENSG00000174206.
GeneIDi144577.
KEGGihsa:144577.
UCSCiuc001srw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057111 mRNA. Translation: BAB71367.1.
AC012158 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97124.1.
BC071634 mRNA. Translation: AAH71634.1.
CCDSiCCDS41803.1.
RefSeqiNP_689653.3. NM_152440.4.
UniGeneiHs.444671.
Hs.505871.

3D structure databases

ProteinModelPortaliQ96MD2.
SMRiQ96MD2. Positions 124-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126862. 5 interactions.
STRINGi9606.ENSP00000381132.

PTM databases

iPTMnetiQ96MD2.
PhosphoSiteiQ96MD2.

Polymorphism and mutation databases

BioMutaiC12orf66.
DMDMi296439467.

Proteomic databases

MaxQBiQ96MD2.
PaxDbiQ96MD2.
PRIDEiQ96MD2.

Protocols and materials databases

DNASUi144577.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398055; ENSP00000381132; ENSG00000174206.
GeneIDi144577.
KEGGihsa:144577.
UCSCiuc001srw.5. human.

Organism-specific databases

CTDi144577.
GeneCardsiC12orf66.
HGNCiHGNC:26517. C12orf66.
HPAiHPA046743.
HPA052855.
neXtProtiNX_Q96MD2.
PharmGKBiPA162377974.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ96MD2.
PhylomeDBiQ96MD2.
TreeFamiTF329125.

Miscellaneous databases

ChiTaRSiC12orf66. human.
GenomeRNAii144577.
PROiQ96MD2.

Gene expression databases

BgeeiQ96MD2.
CleanExiHS_C12orf66.
ExpressionAtlasiQ96MD2. baseline and differential.
GenevisibleiQ96MD2. HS.

Family and domain databases

InterProiIPR018544. DUF2003.
[Graphical view]
PfamiPF09404. DUF2003. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-139 AND SER-443.
    Tissue: Spleen.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-139 AND SER-443.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-139 AND SER-443.

Entry informationi

Entry nameiCL066_HUMAN
AccessioniPrimary (citable) accession number: Q96MD2
Secondary accession number(s): C9JX54, Q8IYA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 97 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.