Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

KICSTOR complex protein C12orf66

Gene

C12orf66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.1 Publication

GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • cellular response to glucose starvation Source: UniProtKB
  • negative regulation of TORC1 signaling Source: UniProtKB
  • protein localization to lysosome Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
KICSTOR complex protein C12orf661 Publication
Gene namesi
Name:C12orf66Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26517. C12orf66.

Subcellular locationi

GO - Cellular componenti

  • KICSTOR complex Source: UniProtKB

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi144577.
PharmGKBiPA162377974.

Polymorphism and mutation databases

BioMutaiC12orf66.
DMDMi296439467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219021 – 445KICSTOR complex protein C12orf66Add BLAST445

Proteomic databases

MaxQBiQ96MD2.
PaxDbiQ96MD2.
PeptideAtlasiQ96MD2.
PRIDEiQ96MD2.

PTM databases

iPTMnetiQ96MD2.
PhosphoSitePlusiQ96MD2.

Expressioni

Gene expression databases

BgeeiENSG00000174206.
CleanExiHS_C12orf66.
ExpressionAtlasiQ96MD2. baseline and differential.
GenevisibleiQ96MD2. HS.

Organism-specific databases

HPAiHPA046743.
HPA052855.

Interactioni

Subunit structurei

Part of the KICSTOR complex composed of KPTN, ITFG2, C12orf66 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complexe in an amino acid-independent manner.1 Publication

Protein-protein interaction databases

BioGridi126862. 5 interactors.
STRINGi9606.ENSP00000381132.

Structurei

3D structure databases

ProteinModelPortaliQ96MD2.
SMRiQ96MD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0536 family.Curated

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ96MD2.
PhylomeDBiQ96MD2.
TreeFamiTF329125.

Family and domain databases

InterProiView protein in InterPro
IPR018544. DUF2003.
PfamiView protein in Pfam
PF09404. DUF2003. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96MD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESIPLAAP VPVEQAVLET FFSHLGIFSY DKAKDNVEKE REANKSAGGS
60 70 80 90 100
WLSLLAALAH LAAAEKVYHS LTYLGQKLGG QSFFSRKDSI RTIYTSLHNE
110 120 130 140 150
LKKVVTGRGA LGGTAPHVEE LLSHLSEQLC FFVQARMEMA DFYEKMYTLS
160 170 180 190 200
TQKFINAEEL VGLLDAIMKK YSSRFHHPIL SPLESSFQLE VDVLCHLLKA
210 220 230 240 250
QAQVSEWKFL PSLVNLHSAH TKLQTWGQIF EKQRETKKHL FGGQSQKAVQ
260 270 280 290 300
PPHLFLWLMK LKNMLLAKFS FYFHEALSRQ TTASEMKTLT AKANPDFFGK
310 320 330 340 350
ISSFIRKYDA ANVSLIFDNR GSESFQGHGY HHPHSYREAP KGVDQYPAVV
360 370 380 390 400
SLPSDRPVMH WPNVIMIMTD RTSDLNSLEK VVHFYDDKVQ STYFLTRPEP
410 420 430 440
HFTIVIIFES KKSERDSHFI SFLNEVSLAL KNPKVFASLK PGAKG
Length:445
Mass (Da):50,415
Last modified:May 18, 2010 - v4
Checksum:iE61D982C4BA04A6A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039371139M → I3 PublicationsCorresponds to variant dbSNP:rs2335390Ensembl.1
Natural variantiVAR_039372443A → S3 PublicationsCorresponds to variant dbSNP:rs699638Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057111 mRNA. Translation: BAB71367.1.
AC012158 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97124.1.
BC071634 mRNA. Translation: AAH71634.1.
CCDSiCCDS41803.1.
RefSeqiNP_689653.3. NM_152440.4.
UniGeneiHs.444671.
Hs.505871.

Genome annotation databases

EnsembliENST00000398055; ENSP00000381132; ENSG00000174206.
GeneIDi144577.
KEGGihsa:144577.
UCSCiuc001srw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057111 mRNA. Translation: BAB71367.1.
AC012158 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97124.1.
BC071634 mRNA. Translation: AAH71634.1.
CCDSiCCDS41803.1.
RefSeqiNP_689653.3. NM_152440.4.
UniGeneiHs.444671.
Hs.505871.

3D structure databases

ProteinModelPortaliQ96MD2.
SMRiQ96MD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126862. 5 interactors.
STRINGi9606.ENSP00000381132.

PTM databases

iPTMnetiQ96MD2.
PhosphoSitePlusiQ96MD2.

Polymorphism and mutation databases

BioMutaiC12orf66.
DMDMi296439467.

Proteomic databases

MaxQBiQ96MD2.
PaxDbiQ96MD2.
PeptideAtlasiQ96MD2.
PRIDEiQ96MD2.

Protocols and materials databases

DNASUi144577.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398055; ENSP00000381132; ENSG00000174206.
GeneIDi144577.
KEGGihsa:144577.
UCSCiuc001srw.5. human.

Organism-specific databases

CTDi144577.
DisGeNETi144577.
GeneCardsiC12orf66.
HGNCiHGNC:26517. C12orf66.
HPAiHPA046743.
HPA052855.
MIMi617420. gene.
neXtProtiNX_Q96MD2.
PharmGKBiPA162377974.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ96MD2.
PhylomeDBiQ96MD2.
TreeFamiTF329125.

Miscellaneous databases

ChiTaRSiC12orf66. human.
GenomeRNAii144577.
PROiPR:Q96MD2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174206.
CleanExiHS_C12orf66.
ExpressionAtlasiQ96MD2. baseline and differential.
GenevisibleiQ96MD2. HS.

Family and domain databases

InterProiView protein in InterPro
IPR018544. DUF2003.
PfamiView protein in Pfam
PF09404. DUF2003. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCL066_HUMAN
AccessioniPrimary (citable) accession number: Q96MD2
Secondary accession number(s): C9JX54, Q8IYA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: June 7, 2017
This is version 105 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.