ID   MF14A_HUMAN             Reviewed;         490 AA.
AC   Q96MC6; Q6P2N7; Q8N8K2; Q8NBV3; Q96NY0; Q9NT25;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=Hippocampus abundant transcript 1 protein {ECO:0000312|HGNC:HGNC:23363};
DE   AltName: Full=Major facilitator superfamily domain-containing 14A {ECO:0000312|HGNC:HGNC:23363};
DE   AltName: Full=Putative tetracycline transporter-like protein;
GN   Name=MFSD14A {ECO:0000312|HGNC:HGNC:23363};
GN   Synonyms=HIAT1 {ECO:0000312|HGNC:HGNC:23363};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Stomach;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Mathur B.N., Turner C.A. Jr.;
RT   "Lexicon Genetics incorporated full-length cloning.";
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-490.
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-490.
RC   TISSUE=Duodenum;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   ACETYLATION AT MET-1.
RX   PubMed=25732826; DOI=10.1016/j.celrep.2015.01.053;
RA   Aksnes H., Van Damme P., Goris M., Starheim K.K., Marie M., Stoeve S.I.,
RA   Hoel C., Kalvik T.V., Hole K., Glomnes N., Furnes C., Ljostveit S.,
RA   Ziegler M., Niere M., Gevaert K., Arnesen T.;
RT   "An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N
RT   termini of transmembrane proteins and maintains Golgi integrity.";
RL   Cell Rep. 10:1362-1374(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04836.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC11473.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK057172; BAB71375.1; -; mRNA.
DR   EMBL; AK075208; BAC11473.1; ALT_INIT; mRNA.
DR   EMBL; AK096669; BAC04836.1; ALT_INIT; mRNA.
DR   EMBL; AF427492; AAL25115.1; -; mRNA.
DR   EMBL; AL137576; CAB70819.2; -; mRNA.
DR   EMBL; BC064409; AAH64409.1; -; mRNA.
DR   CCDS; CCDS763.1; -.
DR   PIR; T46272; T46272.
DR   RefSeq; NP_149044.2; NM_033055.2.
DR   AlphaFoldDB; Q96MC6; -.
DR   SMR; Q96MC6; -.
DR   BioGRID; 122223; 5.
DR   IntAct; Q96MC6; 1.
DR   MINT; Q96MC6; -.
DR   STRING; 9606.ENSP00000359171; -.
DR   TCDB; 2.A.1.2.104; the major facilitator superfamily (mfs).
DR   GlyCosmos; Q96MC6; 2 sites, No reported glycans.
DR   GlyGen; Q96MC6; 2 sites.
DR   iPTMnet; Q96MC6; -.
DR   PhosphoSitePlus; Q96MC6; -.
DR   SwissPalm; Q96MC6; -.
DR   BioMuta; MFSD14A; -.
DR   DMDM; 54036072; -.
DR   EPD; Q96MC6; -.
DR   jPOST; Q96MC6; -.
DR   MassIVE; Q96MC6; -.
DR   MaxQB; Q96MC6; -.
DR   PaxDb; 9606-ENSP00000359171; -.
DR   PeptideAtlas; Q96MC6; -.
DR   ProteomicsDB; 77333; -.
DR   Antibodypedia; 53425; 104 antibodies from 15 providers.
DR   DNASU; 64645; -.
DR   Ensembl; ENST00000370152.8; ENSP00000359171.3; ENSG00000156875.14.
DR   GeneID; 64645; -.
DR   KEGG; hsa:64645; -.
DR   MANE-Select; ENST00000370152.8; ENSP00000359171.3; NM_033055.3; NP_149044.2.
DR   UCSC; uc001dst.4; human.
DR   AGR; HGNC:23363; -.
DR   CTD; 64645; -.
DR   DisGeNET; 64645; -.
DR   GeneCards; MFSD14A; -.
DR   HGNC; HGNC:23363; MFSD14A.
DR   HPA; ENSG00000156875; Tissue enhanced (parathyroid).
DR   MIM; 620347; gene.
DR   neXtProt; NX_Q96MC6; -.
DR   OpenTargets; ENSG00000156875; -.
DR   PharmGKB; PA134910737; -.
DR   VEuPathDB; HostDB:ENSG00000156875; -.
DR   eggNOG; KOG2816; Eukaryota.
DR   GeneTree; ENSGT00940000157395; -.
DR   HOGENOM; CLU_001265_10_5_1; -.
DR   InParanoid; Q96MC6; -.
DR   OMA; GIFKMIV; -.
DR   OrthoDB; 1078604at2759; -.
DR   PhylomeDB; Q96MC6; -.
DR   TreeFam; TF313511; -.
DR   PathwayCommons; Q96MC6; -.
DR   SignaLink; Q96MC6; -.
DR   BioGRID-ORCS; 64645; 18 hits in 1138 CRISPR screens.
DR   ChiTaRS; MFSD14A; human.
DR   GenomeRNAi; 64645; -.
DR   Pharos; Q96MC6; Tbio.
DR   PRO; PR:Q96MC6; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q96MC6; Protein.
DR   Bgee; ENSG00000156875; Expressed in smooth muscle tissue and 101 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR   GO; GO:0030382; P:sperm mitochondrion organization; IEA:Ensembl.
DR   GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR   CDD; cd17387; MFS_MFSD14; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG-like.
DR   PANTHER; PTHR23504:SF77; HIPPOCAMPUS ABUNDANT TRANSCRIPT 1 PROTEIN; 1.
DR   PANTHER; PTHR23504; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   Genevisible; Q96MC6; HS.
PE   1: Evidence at protein level;
KW   Acetylation; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..490
FT                   /note="Hippocampus abundant transcript 1 protein"
FT                   /id="PRO_0000084856"
FT   TOPO_DOM        1..40
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        62..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..160
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..188
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..243
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..313
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..337
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        359..379
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        401..427
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        449..490
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          465..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000269|PubMed:25732826"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        453
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        142
FT                   /note="V -> M (in Ref. 1; BAB71375)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        447
FT                   /note="F -> L (in Ref. 3; CAB70819)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   490 AA;  53027 MW;  1244693E149F95AD CRC64;
     MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA WGLLTAPTLV
     VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKSFLLLTVF FTCAPIPLMK
     ISPWWYFAVI SVSGVFAVTF SVVFAYVADI TQEHERSMAY GLVSATFAAS LVTSPAIGAY
     LGRVYGDSLV VVLATAIALL DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV
     GQDSIVLLIC ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV
     LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT FPAVSALVSR
     TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL KELPITGTDL GTNTSPQHHF
     EQNSIIPGPP FLFGACSVLL ALLVALFIPE HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA
     KEPLLQDTNV
//