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Protein

Hippocampus abundant transcript 1 protein

Gene

HIAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocampus abundant transcript 1 protein
Alternative name(s):
Putative tetracycline transporter-like protein
Gene namesi
Name:HIAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23363. HIAT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 7413CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 1038ExtracellularSequence Analysis
Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 1262CytoplasmicSequence Analysis
Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini148 – 16013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini182 – 1887CytoplasmicSequence Analysis
Transmembranei189 – 20921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini210 – 24334ExtracellularSequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini265 – 28420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini306 – 3138ExtracellularSequence Analysis
Transmembranei314 – 33421Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini335 – 3373CytoplasmicSequence Analysis
Transmembranei338 – 35821Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini359 – 37921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei380 – 40021Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini401 – 42727CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei428 – 44821Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini449 – 49042ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Hippocampus abundant transcript 1 proteinPRO_0000084856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96MC6.
PaxDbiQ96MC6.
PRIDEiQ96MC6.

PTM databases

PhosphoSiteiQ96MC6.

Expressioni

Gene expression databases

BgeeiQ96MC6.
CleanExiHS_HIAT1.
GenevestigatoriQ96MC6.

Interactioni

Protein-protein interaction databases

BioGridi122223. 2 interactions.
STRINGi9606.ENSP00000359171.

Structurei

3D structure databases

ProteinModelPortaliQ96MC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 84Poly-Lys

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00510000046502.
HOGENOMiHOG000007094.
HOVERGENiHBG051902.
InParanoidiQ96MC6.
OMAiHPHSPQA.
OrthoDBiEOG712TW3.
PhylomeDBiQ96MC6.
TreeFamiTF313511.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA
60 70 80 90 100
WGLLTAPTLV VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG
110 120 130 140 150
RKSFLLLTVF FTCAPIPLMK ISPWWYFAVI SVSGVFAVTF SVVFAYVADI
160 170 180 190 200
TQEHERSMAY GLVSATFAAS LVTSPAIGAY LGRVYGDSLV VVLATAIALL
210 220 230 240 250
DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV GQDSIVLLIC
260 270 280 290 300
ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV
310 320 330 340 350
LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT
360 370 380 390 400
FPAVSALVSR TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL
410 420 430 440 450
KELPITGTDL GTNTSPQHHF EQNSIIPGPP FLFGACSVLL ALLVALFIPE
460 470 480 490
HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA KEPLLQDTNV
Length:490
Mass (Da):53,027
Last modified:October 11, 2004 - v2
Checksum:i1244693E149F95AD
GO

Sequence cautioni

The sequence BAC04836.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC11473.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421V → M in BAB71375 (PubMed:14702039).Curated
Sequence conflicti447 – 4471F → L in CAB70819 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057172 mRNA. Translation: BAB71375.1.
AK075208 mRNA. Translation: BAC11473.1. Different initiation.
AK096669 mRNA. Translation: BAC04836.1. Different initiation.
AF427492 mRNA. Translation: AAL25115.1.
AL137576 mRNA. Translation: CAB70819.2.
BC064409 mRNA. Translation: AAH64409.1.
CCDSiCCDS763.1.
PIRiT46272.
RefSeqiNP_149044.2. NM_033055.2.
UniGeneiHs.124156.

Genome annotation databases

EnsembliENST00000370152; ENSP00000359171; ENSG00000156875.
GeneIDi64645.
KEGGihsa:64645.
UCSCiuc001dst.3. human.

Polymorphism databases

DMDMi54036072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057172 mRNA. Translation: BAB71375.1.
AK075208 mRNA. Translation: BAC11473.1. Different initiation.
AK096669 mRNA. Translation: BAC04836.1. Different initiation.
AF427492 mRNA. Translation: AAL25115.1.
AL137576 mRNA. Translation: CAB70819.2.
BC064409 mRNA. Translation: AAH64409.1.
CCDSiCCDS763.1.
PIRiT46272.
RefSeqiNP_149044.2. NM_033055.2.
UniGeneiHs.124156.

3D structure databases

ProteinModelPortaliQ96MC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122223. 2 interactions.
STRINGi9606.ENSP00000359171.

PTM databases

PhosphoSiteiQ96MC6.

Polymorphism databases

DMDMi54036072.

Proteomic databases

MaxQBiQ96MC6.
PaxDbiQ96MC6.
PRIDEiQ96MC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370152; ENSP00000359171; ENSG00000156875.
GeneIDi64645.
KEGGihsa:64645.
UCSCiuc001dst.3. human.

Organism-specific databases

CTDi64645.
GeneCardsiGC01P100503.
HGNCiHGNC:23363. HIAT1.
neXtProtiNX_Q96MC6.
PharmGKBiPA134910737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00510000046502.
HOGENOMiHOG000007094.
HOVERGENiHBG051902.
InParanoidiQ96MC6.
OMAiHPHSPQA.
OrthoDBiEOG712TW3.
PhylomeDBiQ96MC6.
TreeFamiTF313511.

Miscellaneous databases

ChiTaRSiHIAT1. human.
GenomeRNAii64645.
NextBioi66589.
PROiQ96MC6.

Gene expression databases

BgeeiQ96MC6.
CleanExiHS_HIAT1.
GenevestigatoriQ96MC6.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach.
  2. "Lexicon Genetics incorporated full-length cloning."
    Mathur B.N., Turner C.A. Jr.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-490.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-490.
    Tissue: Duodenum.

Entry informationi

Entry nameiHIAT1_HUMAN
AccessioniPrimary (citable) accession number: Q96MC6
Secondary accession number(s): Q6P2N7
, Q8N8K2, Q8NBV3, Q96NY0, Q9NT25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.