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Q96MC6

- HIAT1_HUMAN

UniProt

Q96MC6 - HIAT1_HUMAN

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Protein
Hippocampus abundant transcript 1 protein
Gene
HIAT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocampus abundant transcript 1 protein
Alternative name(s):
Putative tetracycline transporter-like protein
Gene namesi
Name:HIAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23363. HIAT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Extracellular Reviewed prediction
Add
BLAST
Transmembranei41 – 6121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini62 – 7413Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei75 – 9521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini96 – 1038Extracellular Reviewed prediction
Transmembranei104 – 12421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini125 – 1262Cytoplasmic Reviewed prediction
Transmembranei127 – 14721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini148 – 16013Extracellular Reviewed prediction
Add
BLAST
Transmembranei161 – 18121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini182 – 1887Cytoplasmic Reviewed prediction
Transmembranei189 – 20921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini210 – 24334Extracellular Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini265 – 28420Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei285 – 30521Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini306 – 3138Extracellular Reviewed prediction
Transmembranei314 – 33421Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini335 – 3373Cytoplasmic Reviewed prediction
Transmembranei338 – 35821Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini359 – 37921Extracellular Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini401 – 42727Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei428 – 44821Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini449 – 49042Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Hippocampus abundant transcript 1 protein
PRO_0000084856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi453 – 4531N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96MC6.
PaxDbiQ96MC6.
PRIDEiQ96MC6.

PTM databases

PhosphoSiteiQ96MC6.

Expressioni

Gene expression databases

BgeeiQ96MC6.
CleanExiHS_HIAT1.
GenevestigatoriQ96MC6.

Interactioni

Protein-protein interaction databases

BioGridi122223. 2 interactions.
STRINGi9606.ENSP00000359171.

Structurei

3D structure databases

ProteinModelPortaliQ96MC6.
SMRiQ96MC6. Positions 370-395.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 84Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000007094.
HOVERGENiHBG051902.
InParanoidiQ96MC6.
OMAiHPHSPQA.
OrthoDBiEOG712TW3.
PhylomeDBiQ96MC6.
TreeFamiTF313511.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MC6-1 [UniParc]FASTAAdd to Basket

« Hide

MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA    50
WGLLTAPTLV VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG 100
RKSFLLLTVF FTCAPIPLMK ISPWWYFAVI SVSGVFAVTF SVVFAYVADI 150
TQEHERSMAY GLVSATFAAS LVTSPAIGAY LGRVYGDSLV VVLATAIALL 200
DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV GQDSIVLLIC 250
ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV 300
LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT 350
FPAVSALVSR TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL 400
KELPITGTDL GTNTSPQHHF EQNSIIPGPP FLFGACSVLL ALLVALFIPE 450
HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA KEPLLQDTNV 490
Length:490
Mass (Da):53,027
Last modified:October 11, 2004 - v2
Checksum:i1244693E149F95AD
GO

Sequence cautioni

The sequence BAC04836.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11473.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421V → M in BAB71375. 1 Publication
Sequence conflicti447 – 4471F → L in CAB70819. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057172 mRNA. Translation: BAB71375.1.
AK075208 mRNA. Translation: BAC11473.1. Different initiation.
AK096669 mRNA. Translation: BAC04836.1. Different initiation.
AF427492 mRNA. Translation: AAL25115.1.
AL137576 mRNA. Translation: CAB70819.2.
BC064409 mRNA. Translation: AAH64409.1.
CCDSiCCDS763.1.
PIRiT46272.
RefSeqiNP_149044.2. NM_033055.2.
UniGeneiHs.124156.

Genome annotation databases

EnsembliENST00000370152; ENSP00000359171; ENSG00000156875.
GeneIDi64645.
KEGGihsa:64645.
UCSCiuc001dst.3. human.

Polymorphism databases

DMDMi54036072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057172 mRNA. Translation: BAB71375.1 .
AK075208 mRNA. Translation: BAC11473.1 . Different initiation.
AK096669 mRNA. Translation: BAC04836.1 . Different initiation.
AF427492 mRNA. Translation: AAL25115.1 .
AL137576 mRNA. Translation: CAB70819.2 .
BC064409 mRNA. Translation: AAH64409.1 .
CCDSi CCDS763.1.
PIRi T46272.
RefSeqi NP_149044.2. NM_033055.2.
UniGenei Hs.124156.

3D structure databases

ProteinModelPortali Q96MC6.
SMRi Q96MC6. Positions 370-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122223. 2 interactions.
STRINGi 9606.ENSP00000359171.

PTM databases

PhosphoSitei Q96MC6.

Polymorphism databases

DMDMi 54036072.

Proteomic databases

MaxQBi Q96MC6.
PaxDbi Q96MC6.
PRIDEi Q96MC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370152 ; ENSP00000359171 ; ENSG00000156875 .
GeneIDi 64645.
KEGGi hsa:64645.
UCSCi uc001dst.3. human.

Organism-specific databases

CTDi 64645.
GeneCardsi GC01P100503.
HGNCi HGNC:23363. HIAT1.
neXtProti NX_Q96MC6.
PharmGKBi PA134910737.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000007094.
HOVERGENi HBG051902.
InParanoidi Q96MC6.
OMAi HPHSPQA.
OrthoDBi EOG712TW3.
PhylomeDBi Q96MC6.
TreeFami TF313511.

Miscellaneous databases

ChiTaRSi HIAT1. human.
GenomeRNAii 64645.
NextBioi 66589.
PROi Q96MC6.

Gene expression databases

Bgeei Q96MC6.
CleanExi HS_HIAT1.
Genevestigatori Q96MC6.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
PRINTSi PR01035. TCRTETA.
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach.
  2. "Lexicon Genetics incorporated full-length cloning."
    Mathur B.N., Turner C.A. Jr.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-490.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-490.
    Tissue: Duodenum.

Entry informationi

Entry nameiHIAT1_HUMAN
AccessioniPrimary (citable) accession number: Q96MC6
Secondary accession number(s): Q6P2N7
, Q8N8K2, Q8NBV3, Q96NY0, Q9NT25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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