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Protein

Hippocampus abundant transcript 1 protein

Gene

MFSD14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocampus abundant transcript 1 proteinImported
Alternative name(s):
Major facilitator superfamily domain-containing 14AImported
Putative tetracycline transporter-like protein
Gene namesi
Name:MFSD14AImported
Synonyms:HIAT1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23363. MFSD14A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini62 – 74CytoplasmicSequence analysisAdd BLAST13
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 103ExtracellularSequence analysis8
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 126CytoplasmicSequence analysis2
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 160ExtracellularSequence analysisAdd BLAST13
Transmembranei161 – 181Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini182 – 188CytoplasmicSequence analysis7
Transmembranei189 – 209Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini210 – 243ExtracellularSequence analysisAdd BLAST34
Transmembranei244 – 264Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini265 – 284CytoplasmicSequence analysisAdd BLAST20
Transmembranei285 – 305Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini306 – 313ExtracellularSequence analysis8
Transmembranei314 – 334Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini335 – 337CytoplasmicSequence analysis3
Transmembranei338 – 358Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini359 – 379ExtracellularSequence analysisAdd BLAST21
Transmembranei380 – 400Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini401 – 427CytoplasmicSequence analysisAdd BLAST27
Transmembranei428 – 448Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini449 – 490ExtracellularSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156875.
PharmGKBiPA134910737.

Polymorphism and mutation databases

BioMutaiHIAT1.
DMDMi54036072.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848561 – 490Hippocampus abundant transcript 1 proteinAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Glycosylationi453N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96MC6.
MaxQBiQ96MC6.
PaxDbiQ96MC6.
PeptideAtlasiQ96MC6.
PRIDEiQ96MC6.

PTM databases

iPTMnetiQ96MC6.
PhosphoSitePlusiQ96MC6.

Expressioni

Gene expression databases

BgeeiENSG00000156875.
CleanExiHS_HIAT1.
GenevisibleiQ96MC6. HS.

Interactioni

Protein-protein interaction databases

BioGridi122223. 1 interactor.
STRINGi9606.ENSP00000359171.

Structurei

3D structure databases

ProteinModelPortaliQ96MC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 8Poly-Lys4

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00510000046502.
HOGENOMiHOG000007094.
HOVERGENiHBG051902.
InParanoidiQ96MC6.
OMAiHPHSPQA.
OrthoDBiEOG091G088Z.
PhylomeDBiQ96MC6.
TreeFamiTF313511.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96MC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA
60 70 80 90 100
WGLLTAPTLV VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG
110 120 130 140 150
RKSFLLLTVF FTCAPIPLMK ISPWWYFAVI SVSGVFAVTF SVVFAYVADI
160 170 180 190 200
TQEHERSMAY GLVSATFAAS LVTSPAIGAY LGRVYGDSLV VVLATAIALL
210 220 230 240 250
DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV GQDSIVLLIC
260 270 280 290 300
ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV
310 320 330 340 350
LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT
360 370 380 390 400
FPAVSALVSR TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL
410 420 430 440 450
KELPITGTDL GTNTSPQHHF EQNSIIPGPP FLFGACSVLL ALLVALFIPE
460 470 480 490
HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA KEPLLQDTNV
Length:490
Mass (Da):53,027
Last modified:October 11, 2004 - v2
Checksum:i1244693E149F95AD
GO

Sequence cautioni

The sequence BAC04836 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11473 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142V → M in BAB71375 (PubMed:14702039).Curated1
Sequence conflicti447F → L in CAB70819 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057172 mRNA. Translation: BAB71375.1.
AK075208 mRNA. Translation: BAC11473.1. Different initiation.
AK096669 mRNA. Translation: BAC04836.1. Different initiation.
AF427492 mRNA. Translation: AAL25115.1.
AL137576 mRNA. Translation: CAB70819.2.
BC064409 mRNA. Translation: AAH64409.1.
CCDSiCCDS763.1.
PIRiT46272.
RefSeqiNP_149044.2. NM_033055.2.
UniGeneiHs.124156.

Genome annotation databases

EnsembliENST00000370152; ENSP00000359171; ENSG00000156875.
GeneIDi64645.
KEGGihsa:64645.
UCSCiuc001dst.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057172 mRNA. Translation: BAB71375.1.
AK075208 mRNA. Translation: BAC11473.1. Different initiation.
AK096669 mRNA. Translation: BAC04836.1. Different initiation.
AF427492 mRNA. Translation: AAL25115.1.
AL137576 mRNA. Translation: CAB70819.2.
BC064409 mRNA. Translation: AAH64409.1.
CCDSiCCDS763.1.
PIRiT46272.
RefSeqiNP_149044.2. NM_033055.2.
UniGeneiHs.124156.

3D structure databases

ProteinModelPortaliQ96MC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122223. 1 interactor.
STRINGi9606.ENSP00000359171.

PTM databases

iPTMnetiQ96MC6.
PhosphoSitePlusiQ96MC6.

Polymorphism and mutation databases

BioMutaiHIAT1.
DMDMi54036072.

Proteomic databases

EPDiQ96MC6.
MaxQBiQ96MC6.
PaxDbiQ96MC6.
PeptideAtlasiQ96MC6.
PRIDEiQ96MC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370152; ENSP00000359171; ENSG00000156875.
GeneIDi64645.
KEGGihsa:64645.
UCSCiuc001dst.4. human.

Organism-specific databases

CTDi64645.
GeneCardsiHIAT1.
HGNCiHGNC:23363. MFSD14A.
neXtProtiNX_Q96MC6.
OpenTargetsiENSG00000156875.
PharmGKBiPA134910737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00510000046502.
HOGENOMiHOG000007094.
HOVERGENiHBG051902.
InParanoidiQ96MC6.
OMAiHPHSPQA.
OrthoDBiEOG091G088Z.
PhylomeDBiQ96MC6.
TreeFamiTF313511.

Miscellaneous databases

ChiTaRSiHIAT1. human.
GenomeRNAii64645.
PROiQ96MC6.

Gene expression databases

BgeeiENSG00000156875.
CleanExiHS_HIAT1.
GenevisibleiQ96MC6. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMF14A_HUMAN
AccessioniPrimary (citable) accession number: Q96MC6
Secondary accession number(s): Q6P2N7
, Q8N8K2, Q8NBV3, Q96NY0, Q9NT25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.