Q96MC6 (HIAT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hippocampus abundant transcript 1 protein

Alternative name(s):
Putative tetracycline transporter-like protein

Gene names

Name:

HIAT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the major facilitator superfamily.
Sequence caution	The sequence BAC04836.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11473.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Hippocampus abundant transcript 1 protein		PRO_0000084856
Regions
	Topological domain	1 – 40	40	Extracellular Potential
	Transmembrane	41 – 61	21	Helical; Name=1; Potential
	Topological domain	62 – 74	13	Cytoplasmic Potential
	Transmembrane	75 – 95	21	Helical; Name=2; Potential
	Topological domain	96 – 103	8	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Name=3; Potential
	Topological domain	125 – 126	2	Cytoplasmic Potential
	Transmembrane	127 – 147	21	Helical; Name=4; Potential
	Topological domain	148 – 160	13	Extracellular Potential
	Transmembrane	161 – 181	21	Helical; Name=5; Potential
	Topological domain	182 – 188	7	Cytoplasmic Potential
	Transmembrane	189 – 209	21	Helical; Name=6; Potential
	Topological domain	210 – 243	34	Extracellular Potential
	Transmembrane	244 – 264	21	Helical; Name=7; Potential
	Topological domain	265 – 284	20	Cytoplasmic Potential
	Transmembrane	285 – 305	21	Helical; Name=8; Potential
	Topological domain	306 – 313	8	Extracellular Potential
	Transmembrane	314 – 334	21	Helical; Name=9; Potential
	Topological domain	335 – 337	3	Cytoplasmic Potential
	Transmembrane	338 – 358	21	Helical; Name=10; Potential
	Topological domain	359 – 379	21	Extracellular Potential
	Transmembrane	380 – 400	21	Helical; Name=11; Potential
	Topological domain	401 – 427	27	Cytoplasmic Potential
	Transmembrane	428 – 448	21	Helical; Name=12; Potential
	Topological domain	449 – 490	42	Extracellular Potential
	Compositional bias	5 – 8	4	Poly-Lys
Amino acid modifications
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	453	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	142	1	V → M in BAB71375. Ref.1
	Sequence conflict	447	1	F → L in CAB70819. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96MC6 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: 1244693E149F95AD	FASTA	490	53,027
	10 20 30 40 50 60 MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA WGLLTAPTLV 70 80 90 100 110 120 VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKSFLLLTVF FTCAPIPLMK 130 140 150 160 170 180 ISPWWYFAVI SVSGVFAVTF SVVFAYVADI TQEHERSMAY GLVSATFAAS LVTSPAIGAY 190 200 210 220 230 240 LGRVYGDSLV VVLATAIALL DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV 250 260 270 280 290 300 GQDSIVLLIC ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV 310 320 330 340 350 360 LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT FPAVSALVSR 370 380 390 400 410 420 TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL KELPITGTDL GTNTSPQHHF 430 440 450 460 470 480 EQNSIIPGPP FLFGACSVLL ALLVALFIPE HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA 490 KEPLLQDTNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Stomach.
[2]	"Lexicon Genetics incorporated full-length cloning." Mathur B.N., Turner C.A. Jr. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-490. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-490. Tissue: Duodenum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057172 mRNA. Translation: BAB71375.1. AK075208 mRNA. Translation: BAC11473.1. Different initiation. AK096669 mRNA. Translation: BAC04836.1. Different initiation. AF427492 mRNA. Translation: AAL25115.1. AL137576 mRNA. Translation: CAB70819.2. BC064409 mRNA. Translation: AAH64409.1.
IPI	IPI00307656.
PIR	T46272.
RefSeq	NP_149044.2. NM_033055.2.
UniGene	Hs.124156.
3D structure databases
ProteinModelPortal	Q96MC6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359171.
PTM databases
PhosphoSite	Q96MC6.
Polymorphism databases
DMDM	54036072.
Proteomic databases
PaxDb	Q96MC6.
PRIDE	Q96MC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370152; ENSP00000359171; ENSG00000156875.
GeneID	64645.
KEGG	hsa:64645.
UCSC	uc001dst.3. human.
Organism-specific databases
CTD	64645.
GeneCards	GC01P100503.
HGNC	HGNC:23363. HIAT1.
neXtProt	NX_Q96MC6.
PharmGKB	PA134910737.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000007094.
HOVERGEN	HBG051902.
InParanoid	Q96MC6.
OMA	HPHSPQA.
OrthoDB	EOG4B8JD1.
PhylomeDB	Q96MC6.
Gene expression databases
Bgee	Q96MC6.
CleanEx	HS_HIAT1.
Genevestigator	Q96MC6.
GermOnline	ENSG00000156875. Homo sapiens.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005829. Sugar_transporter_CS. IPR001958. Tet-R_TetA/multi-R_MdtG. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
PRINTS	PR01035. TCRTETA.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HIAT1. human.
GenomeRNAi	64645.
NextBio	66589.

Entry information

Entry name

HIAT1_HUMAN

Accession

Primary (citable) accession number: Q96MC6
Secondary accession number(s): Q6P2N7 , Q8N8K2, Q8NBV3, Q96NY0, Q9NT25

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.