Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hippocampus abundant transcript 1 protein

Gene

MFSD14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.1.2.104 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocampus abundant transcript 1 proteinImported
Alternative name(s):
Major facilitator superfamily domain-containing 14AImported
Putative tetracycline transporter-like protein
Gene namesi
Name:MFSD14AImported
Synonyms:HIAT1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000156875.13
HGNCiHGNC:23363 MFSD14A
neXtProtiNX_Q96MC6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini62 – 74CytoplasmicSequence analysisAdd BLAST13
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 103ExtracellularSequence analysis8
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 126CytoplasmicSequence analysis2
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 160ExtracellularSequence analysisAdd BLAST13
Transmembranei161 – 181Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini182 – 188CytoplasmicSequence analysis7
Transmembranei189 – 209Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini210 – 243ExtracellularSequence analysisAdd BLAST34
Transmembranei244 – 264Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini265 – 284CytoplasmicSequence analysisAdd BLAST20
Transmembranei285 – 305Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini306 – 313ExtracellularSequence analysis8
Transmembranei314 – 334Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini335 – 337CytoplasmicSequence analysis3
Transmembranei338 – 358Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini359 – 379ExtracellularSequence analysisAdd BLAST21
Transmembranei380 – 400Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini401 – 427CytoplasmicSequence analysisAdd BLAST27
Transmembranei428 – 448Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini449 – 490ExtracellularSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156875
PharmGKBiPA134910737

Polymorphism and mutation databases

BioMutaiHIAT1
DMDMi54036072

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848561 – 490Hippocampus abundant transcript 1 proteinAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ96MC6
MaxQBiQ96MC6
PaxDbiQ96MC6
PeptideAtlasiQ96MC6
PRIDEiQ96MC6
ProteomicsDBi77333

PTM databases

iPTMnetiQ96MC6
PhosphoSitePlusiQ96MC6

Expressioni

Gene expression databases

BgeeiENSG00000156875
CleanExiHS_HIAT1
GenevisibleiQ96MC6 HS

Organism-specific databases

HPAiHPA073681

Interactioni

Protein-protein interaction databases

BioGridi122223, 1 interactor
STRINGi9606.ENSP00000359171

Structurei

3D structure databases

ProteinModelPortaliQ96MC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 8Poly-Lys4

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2816 Eukaryota
ENOG410ZVCA LUCA
GeneTreeiENSGT00510000046502
HOGENOMiHOG000007094
HOVERGENiHBG051902
InParanoidiQ96MC6
OMAiHPHSPQA
OrthoDBiEOG091G088Z
PhylomeDBiQ96MC6
TreeFamiTF313511

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR001958 Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PRINTSiPR01035 TCRTETA
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q96MC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA
60 70 80 90 100
WGLLTAPTLV VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG
110 120 130 140 150
RKSFLLLTVF FTCAPIPLMK ISPWWYFAVI SVSGVFAVTF SVVFAYVADI
160 170 180 190 200
TQEHERSMAY GLVSATFAAS LVTSPAIGAY LGRVYGDSLV VVLATAIALL
210 220 230 240 250
DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV GQDSIVLLIC
260 270 280 290 300
ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV
310 320 330 340 350
LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT
360 370 380 390 400
FPAVSALVSR TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL
410 420 430 440 450
KELPITGTDL GTNTSPQHHF EQNSIIPGPP FLFGACSVLL ALLVALFIPE
460 470 480 490
HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA KEPLLQDTNV
Length:490
Mass (Da):53,027
Last modified:October 11, 2004 - v2
Checksum:i1244693E149F95AD
GO

Sequence cautioni

The sequence BAC04836 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11473 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142V → M in BAB71375 (PubMed:14702039).Curated1
Sequence conflicti447F → L in CAB70819 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057172 mRNA Translation: BAB71375.1
AK075208 mRNA Translation: BAC11473.1 Different initiation.
AK096669 mRNA Translation: BAC04836.1 Different initiation.
AF427492 mRNA Translation: AAL25115.1
AL137576 mRNA Translation: CAB70819.2
BC064409 mRNA Translation: AAH64409.1
CCDSiCCDS763.1
PIRiT46272
RefSeqiNP_149044.2, NM_033055.2
UniGeneiHs.124156

Genome annotation databases

EnsembliENST00000370152; ENSP00000359171; ENSG00000156875
GeneIDi64645
KEGGihsa:64645
UCSCiuc001dst.4 human

Similar proteinsi

Entry informationi

Entry nameiMF14A_HUMAN
AccessioniPrimary (citable) accession number: Q96MC6
Secondary accession number(s): Q6P2N7
, Q8N8K2, Q8NBV3, Q96NY0, Q9NT25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 20, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health