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Q96MC6 (HIAT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hippocampus abundant transcript 1 protein
Alternative name(s):
Putative tetracycline transporter-like protein
Gene names
Name:HIAT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence caution

The sequence BAC04836.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC11473.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Hippocampus abundant transcript 1 protein
PRO_0000084856

Regions

Topological domain1 – 4040Extracellular Potential
Transmembrane41 – 6121Helical; Name=1; Potential
Topological domain62 – 7413Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 1038Extracellular Potential
Transmembrane104 – 12421Helical; Name=3; Potential
Topological domain125 – 1262Cytoplasmic Potential
Transmembrane127 – 14721Helical; Name=4; Potential
Topological domain148 – 16013Extracellular Potential
Transmembrane161 – 18121Helical; Name=5; Potential
Topological domain182 – 1887Cytoplasmic Potential
Transmembrane189 – 20921Helical; Name=6; Potential
Topological domain210 – 24334Extracellular Potential
Transmembrane244 – 26421Helical; Name=7; Potential
Topological domain265 – 28420Cytoplasmic Potential
Transmembrane285 – 30521Helical; Name=8; Potential
Topological domain306 – 3138Extracellular Potential
Transmembrane314 – 33421Helical; Name=9; Potential
Topological domain335 – 3373Cytoplasmic Potential
Transmembrane338 – 35821Helical; Name=10; Potential
Topological domain359 – 37921Extracellular Potential
Transmembrane380 – 40021Helical; Name=11; Potential
Topological domain401 – 42727Cytoplasmic Potential
Transmembrane428 – 44821Helical; Name=12; Potential
Topological domain449 – 49042Extracellular Potential
Compositional bias5 – 84Poly-Lys

Amino acid modifications

Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation4531N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1421V → M in BAB71375. Ref.1
Sequence conflict4471F → L in CAB70819. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96MC6 [UniParc].

Last modified October 11, 2004. Version 2.
Checksum: 1244693E149F95AD

FASTA49053,027
        10         20         30         40         50         60 
MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA WGLLTAPTLV 

        70         80         90        100        110        120 
VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKSFLLLTVF FTCAPIPLMK 

       130        140        150        160        170        180 
ISPWWYFAVI SVSGVFAVTF SVVFAYVADI TQEHERSMAY GLVSATFAAS LVTSPAIGAY 

       190        200        210        220        230        240 
LGRVYGDSLV VVLATAIALL DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV 

       250        260        270        280        290        300 
GQDSIVLLIC ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV 

       310        320        330        340        350        360 
LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT FPAVSALVSR 

       370        380        390        400        410        420 
TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL KELPITGTDL GTNTSPQHHF 

       430        440        450        460        470        480 
EQNSIIPGPP FLFGACSVLL ALLVALFIPE HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA 

       490 
KEPLLQDTNV 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Stomach.
[2]"Lexicon Genetics incorporated full-length cloning."
Mathur B.N., Turner C.A. Jr.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-490.
Tissue: Brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-490.
Tissue: Duodenum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057172 mRNA. Translation: BAB71375.1.
AK075208 mRNA. Translation: BAC11473.1. Different initiation.
AK096669 mRNA. Translation: BAC04836.1. Different initiation.
AF427492 mRNA. Translation: AAL25115.1.
AL137576 mRNA. Translation: CAB70819.2.
BC064409 mRNA. Translation: AAH64409.1.
CCDSCCDS763.1.
PIRT46272.
RefSeqNP_149044.2. NM_033055.2.
UniGeneHs.124156.

3D structure databases

ProteinModelPortalQ96MC6.
SMRQ96MC6. Positions 370-395.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122223. 2 interactions.
STRING9606.ENSP00000359171.

PTM databases

PhosphoSiteQ96MC6.

Polymorphism databases

DMDM54036072.

Proteomic databases

MaxQBQ96MC6.
PaxDbQ96MC6.
PRIDEQ96MC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370152; ENSP00000359171; ENSG00000156875.
GeneID64645.
KEGGhsa:64645.
UCSCuc001dst.3. human.

Organism-specific databases

CTD64645.
GeneCardsGC01P100503.
HGNCHGNC:23363. HIAT1.
neXtProtNX_Q96MC6.
PharmGKBPA134910737.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000007094.
HOVERGENHBG051902.
InParanoidQ96MC6.
OMAHPHSPQA.
OrthoDBEOG712TW3.
PhylomeDBQ96MC6.
TreeFamTF313511.

Gene expression databases

BgeeQ96MC6.
CleanExHS_HIAT1.
GenevestigatorQ96MC6.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSPR01035. TCRTETA.
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHIAT1. human.
GenomeRNAi64645.
NextBio66589.
PROQ96MC6.

Entry information

Entry nameHIAT1_HUMAN
AccessionPrimary (citable) accession number: Q96MC6
Secondary accession number(s): Q6P2N7 expand/collapse secondary AC list , Q8N8K2, Q8NBV3, Q96NY0, Q9NT25
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM