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Q96MC6

- HIAT1_HUMAN

UniProt

Q96MC6 - HIAT1_HUMAN

Protein

Hippocampus abundant transcript 1 protein

Gene

HIAT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hippocampus abundant transcript 1 protein
    Alternative name(s):
    Putative tetracycline transporter-like protein
    Gene namesi
    Name:HIAT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23363. HIAT1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910737.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Hippocampus abundant transcript 1 proteinPRO_0000084856Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ96MC6.
    PaxDbiQ96MC6.
    PRIDEiQ96MC6.

    PTM databases

    PhosphoSiteiQ96MC6.

    Expressioni

    Gene expression databases

    BgeeiQ96MC6.
    CleanExiHS_HIAT1.
    GenevestigatoriQ96MC6.

    Interactioni

    Protein-protein interaction databases

    BioGridi122223. 2 interactions.
    STRINGi9606.ENSP00000359171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96MC6.
    SMRiQ96MC6. Positions 370-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 7413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 1038ExtracellularSequence Analysis
    Topological domaini125 – 1262CytoplasmicSequence Analysis
    Topological domaini148 – 16013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini182 – 1887CytoplasmicSequence Analysis
    Topological domaini210 – 24334ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini306 – 3138ExtracellularSequence Analysis
    Topological domaini335 – 3373CytoplasmicSequence Analysis
    Topological domaini359 – 37921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini401 – 42727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini449 – 49042ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 84Poly-Lys

    Sequence similaritiesi

    Belongs to the major facilitator superfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000007094.
    HOVERGENiHBG051902.
    InParanoidiQ96MC6.
    OMAiHPHSPQA.
    OrthoDBiEOG712TW3.
    PhylomeDBiQ96MC6.
    TreeFamiTF313511.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    IPR001958. Tet-R_TetA/multi-R_MdtG.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    PRINTSiPR01035. TCRTETA.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96MC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA    50
    WGLLTAPTLV VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG 100
    RKSFLLLTVF FTCAPIPLMK ISPWWYFAVI SVSGVFAVTF SVVFAYVADI 150
    TQEHERSMAY GLVSATFAAS LVTSPAIGAY LGRVYGDSLV VVLATAIALL 200
    DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV GQDSIVLLIC 250
    ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV 300
    LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT 350
    FPAVSALVSR TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL 400
    KELPITGTDL GTNTSPQHHF EQNSIIPGPP FLFGACSVLL ALLVALFIPE 450
    HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA KEPLLQDTNV 490
    Length:490
    Mass (Da):53,027
    Last modified:October 11, 2004 - v2
    Checksum:i1244693E149F95AD
    GO

    Sequence cautioni

    The sequence BAC04836.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11473.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421V → M in BAB71375. (PubMed:14702039)Curated
    Sequence conflicti447 – 4471F → L in CAB70819. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057172 mRNA. Translation: BAB71375.1.
    AK075208 mRNA. Translation: BAC11473.1. Different initiation.
    AK096669 mRNA. Translation: BAC04836.1. Different initiation.
    AF427492 mRNA. Translation: AAL25115.1.
    AL137576 mRNA. Translation: CAB70819.2.
    BC064409 mRNA. Translation: AAH64409.1.
    CCDSiCCDS763.1.
    PIRiT46272.
    RefSeqiNP_149044.2. NM_033055.2.
    UniGeneiHs.124156.

    Genome annotation databases

    EnsembliENST00000370152; ENSP00000359171; ENSG00000156875.
    GeneIDi64645.
    KEGGihsa:64645.
    UCSCiuc001dst.3. human.

    Polymorphism databases

    DMDMi54036072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057172 mRNA. Translation: BAB71375.1 .
    AK075208 mRNA. Translation: BAC11473.1 . Different initiation.
    AK096669 mRNA. Translation: BAC04836.1 . Different initiation.
    AF427492 mRNA. Translation: AAL25115.1 .
    AL137576 mRNA. Translation: CAB70819.2 .
    BC064409 mRNA. Translation: AAH64409.1 .
    CCDSi CCDS763.1.
    PIRi T46272.
    RefSeqi NP_149044.2. NM_033055.2.
    UniGenei Hs.124156.

    3D structure databases

    ProteinModelPortali Q96MC6.
    SMRi Q96MC6. Positions 370-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122223. 2 interactions.
    STRINGi 9606.ENSP00000359171.

    PTM databases

    PhosphoSitei Q96MC6.

    Polymorphism databases

    DMDMi 54036072.

    Proteomic databases

    MaxQBi Q96MC6.
    PaxDbi Q96MC6.
    PRIDEi Q96MC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370152 ; ENSP00000359171 ; ENSG00000156875 .
    GeneIDi 64645.
    KEGGi hsa:64645.
    UCSCi uc001dst.3. human.

    Organism-specific databases

    CTDi 64645.
    GeneCardsi GC01P100503.
    HGNCi HGNC:23363. HIAT1.
    neXtProti NX_Q96MC6.
    PharmGKBi PA134910737.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000007094.
    HOVERGENi HBG051902.
    InParanoidi Q96MC6.
    OMAi HPHSPQA.
    OrthoDBi EOG712TW3.
    PhylomeDBi Q96MC6.
    TreeFami TF313511.

    Miscellaneous databases

    ChiTaRSi HIAT1. human.
    GenomeRNAii 64645.
    NextBioi 66589.
    PROi Q96MC6.

    Gene expression databases

    Bgeei Q96MC6.
    CleanExi HS_HIAT1.
    Genevestigatori Q96MC6.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    IPR001958. Tet-R_TetA/multi-R_MdtG.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01035. TCRTETA.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Stomach.
    2. "Lexicon Genetics incorporated full-length cloning."
      Mathur B.N., Turner C.A. Jr.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-490.
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-490.
      Tissue: Duodenum.

    Entry informationi

    Entry nameiHIAT1_HUMAN
    AccessioniPrimary (citable) accession number: Q96MC6
    Secondary accession number(s): Q6P2N7
    , Q8N8K2, Q8NBV3, Q96NY0, Q9NT25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3