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Protein

Putative nuclease HARBI1

Gene

HARBI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.Curated2 Publications

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi149 – 1491Divalent metal cationSequence analysis
Metal bindingi199 – 1991Divalent metal cationSequence analysis
Metal bindingi225 – 2251Divalent metal cationSequence analysis
Metal bindingi261 – 2611Divalent metal cationSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nuclease HARBI1 (EC:3.1.-.-)
Alternative name(s):
Harbinger transposase-derived nuclease
Gene namesi
Name:HARBI1
Synonyms:C11orf77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26522. HARBI1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390577.

Polymorphism and mutation databases

BioMutaiHARBI1.
DMDMi74732341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Putative nuclease HARBI1PRO_0000263614Add
BLAST

Proteomic databases

MaxQBiQ96MB7.
PaxDbiQ96MB7.
PRIDEiQ96MB7.

Expressioni

Tissue specificityi

Detected in brain, eye, nerve tissue, kidney and lung.1 Publication

Gene expression databases

BgeeiQ96MB7.
CleanExiHS_HARBI1.
ExpressionAtlasiQ96MB7. baseline and differential.
GenevisibleiQ96MB7. HS.

Organism-specific databases

HPAiHPA038671.

Interactioni

Subunit structurei

Interacts with NAIF1.1 Publication

Protein-protein interaction databases

BioGridi129511. 1 interaction.
STRINGi9606.ENSP00000317743.

Structurei

3D structure databases

ProteinModelPortaliQ96MB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HARBI1 family.Curated

Phylogenomic databases

eggNOGiKOG4585. Eukaryota.
ENOG411206Y. LUCA.
GeneTreeiENSGT00530000063045.
HOGENOMiHOG000231449.
HOVERGENiHBG054543.
InParanoidiQ96MB7.
OMAiAHSATHN.
OrthoDBiEOG7NGQCN.
PhylomeDBiQ96MB7.
TreeFamiTF327972.

Family and domain databases

InterProiIPR026103. HARBI1_animal.
IPR027806. HARBI1_dom.
[Graphical view]
PANTHERiPTHR22930:SF36. PTHR22930:SF36. 1 hit.
PfamiPF13359. DDE_Tnp_4. 1 hit.
[Graphical view]
PRINTSiPR02086. PUTNUCHARBI1.

Sequencei

Sequence statusi: Complete.

Q96MB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPITVLDC DLLLYGRGHR TLDRFKLDDV TDEYLMSMYG FPRQFIYYLV
60 70 80 90 100
ELLGANLSRP TQRSRAISPE TQVLAALGFY TSGSFQTRMG DAIGISQASM
110 120 130 140 150
SRCVANVTEA LVERASQFIR FPADEASIQA LKDEFYGLAG MPGVMGVVDC
160 170 180 190 200
IHVAIKAPNA EDLSYVNRKG LHSLNCLMVC DIRGTLMTVE TNWPGSLQDC
210 220 230 240 250
AVLQQSSLSS QFEAGMHKDS WLLGDSSFFL RTWLMTPLHI PETPAEYRYN
260 270 280 290 300
MAHSATHSVI EKTFRTLCSR FRCLDGSKGA LQYSPEKSSH IILACCVLHN
310 320 330 340
ISLEHGMDVW SSPMTGPMEQ PPEEEYEHME SLDLEADRIR QELMLTHFS
Length:349
Mass (Da):39,146
Last modified:December 1, 2001 - v1
Checksum:iC424FDE6825A69F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057237 mRNA. Translation: BAB71391.1.
CH471064 Genomic DNA. Translation: EAW67992.1.
CH471064 Genomic DNA. Translation: EAW67993.1.
CH471064 Genomic DNA. Translation: EAW67994.1.
BC036925 mRNA. Translation: AAH36925.1.
CCDSiCCDS7920.1.
RefSeqiNP_776172.1. NM_173811.3.
UniGeneiHs.714463.

Genome annotation databases

EnsembliENST00000326737; ENSP00000317743; ENSG00000180423.
GeneIDi283254.
KEGGihsa:283254.
UCSCiuc001ncy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057237 mRNA. Translation: BAB71391.1.
CH471064 Genomic DNA. Translation: EAW67992.1.
CH471064 Genomic DNA. Translation: EAW67993.1.
CH471064 Genomic DNA. Translation: EAW67994.1.
BC036925 mRNA. Translation: AAH36925.1.
CCDSiCCDS7920.1.
RefSeqiNP_776172.1. NM_173811.3.
UniGeneiHs.714463.

3D structure databases

ProteinModelPortaliQ96MB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129511. 1 interaction.
STRINGi9606.ENSP00000317743.

Polymorphism and mutation databases

BioMutaiHARBI1.
DMDMi74732341.

Proteomic databases

MaxQBiQ96MB7.
PaxDbiQ96MB7.
PRIDEiQ96MB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326737; ENSP00000317743; ENSG00000180423.
GeneIDi283254.
KEGGihsa:283254.
UCSCiuc001ncy.4. human.

Organism-specific databases

CTDi283254.
GeneCardsiHARBI1.
HGNCiHGNC:26522. HARBI1.
HPAiHPA038671.
MIMi615086. gene.
neXtProtiNX_Q96MB7.
PharmGKBiPA162390577.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4585. Eukaryota.
ENOG411206Y. LUCA.
GeneTreeiENSGT00530000063045.
HOGENOMiHOG000231449.
HOVERGENiHBG054543.
InParanoidiQ96MB7.
OMAiAHSATHN.
OrthoDBiEOG7NGQCN.
PhylomeDBiQ96MB7.
TreeFamiTF327972.

Miscellaneous databases

GenomeRNAii283254.
NextBioi93767.
PROiQ96MB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96MB7.
CleanExiHS_HARBI1.
ExpressionAtlasiQ96MB7. baseline and differential.
GenevisibleiQ96MB7. HS.

Family and domain databases

InterProiIPR026103. HARBI1_animal.
IPR027806. HARBI1_dom.
[Graphical view]
PANTHERiPTHR22930:SF36. PTHR22930:SF36. 1 hit.
PfamiPF13359. DDE_Tnp_4. 1 hit.
[Graphical view]
PRINTSiPR02086. PUTNUCHARBI1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. "Harbinger transposons and an ancient HARBI1 gene derived from a transposase."
    Kapitonov V.V., Jurka J.
    DNA Cell Biol. 23:311-324(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR, TISSUE SPECIFICITY.
  5. "Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes."
    Sinzelle L., Kapitonov V.V., Grzela D.P., Jursch T., Jurka J., Izsvak Z., Ivics Z.
    Proc. Natl. Acad. Sci. U.S.A. 105:4715-4720(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NAIF1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHARB1_HUMAN
AccessioniPrimary (citable) accession number: Q96MB7
Secondary accession number(s): D3DQP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.