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Protein

Doublesex- and mab-3-related transcription factor B1

Gene

DMRTB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi11 – 58DMPROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor B1
Gene namesi
Name:DMRTB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143006.7
HGNCiHGNC:13913 DMRTB1
MIMi614805 gene
neXtProtiNX_Q96MA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143006
PharmGKBiPA27386

Polymorphism and mutation databases

BioMutaiDMRTB1
DMDMi74752030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160121 – 342Doublesex- and mab-3-related transcription factor B1Add BLAST342

Proteomic databases

PaxDbiQ96MA1
PeptideAtlasiQ96MA1
PRIDEiQ96MA1

PTM databases

iPTMnetiQ96MA1
PhosphoSitePlusiQ96MA1

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiENSG00000143006
CleanExiHS_DMRTB1
GenevisibleiQ96MA1 HS

Organism-specific databases

HPAiHPA036490
HPA058553

Interactioni

Protein-protein interaction databases

BioGridi122012, 19 interactors
IntActiQ96MA1, 14 interactors
MINTiQ96MA1
STRINGi9606.ENSP00000360500

Structurei

3D structure databases

ProteinModelPortaliQ96MA1
SMRiQ96MA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 84Poly-Ala5
Compositional biasi85 – 304Pro-richAdd BLAST220

Sequence similaritiesi

Belongs to the DMRT family.Curated

Phylogenomic databases

eggNOGiKOG3815 Eukaryota
ENOG410XSK9 LUCA
GeneTreeiENSGT00550000074486
HOGENOMiHOG000112231
HOVERGENiHBG095592
InParanoidiQ96MA1
KOiK19492
OMAiCYLISER
OrthoDBiEOG091G0K2L
PhylomeDBiQ96MA1
TreeFamiTF317837

Family and domain databases

Gene3Di4.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR026607 DMRT/dsx/mab-3
PANTHERiPTHR12322 PTHR12322, 1 hit
PfamiView protein in Pfam
PF00751 DM, 1 hit
SMARTiView protein in SMART
SM00301 DM, 1 hit
SUPFAMiSSF82927 SSF82927, 1 hit
PROSITEiView protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96MA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKMVRTPK CSRCRNHGFL VPVKGHAGKC RWKQCLCEKC YLISERQKIM
60 70 80 90 100
AAQKVLKTQA AEEEQEAALC AQGPKQASGA AAAAPAPVPV PAASLRPLSP
110 120 130 140 150
GTPSGDADPG PEGRAAACFF EQPPRGRNPG PRALQPVLGG RSHVEPSERA
160 170 180 190 200
AVAMPSLAGP PFGAEAAGSG YPGPLDLRRP MRTVPGPLFT DFVRPLNINP
210 220 230 240 250
DRALGPEYPG GSSMHPYCPF PLGYLDAPPG VPLQQGFRHV SRSQYQGGGL
260 270 280 290 300
VSEPGGDFQP SYYLPPPPPP LPPLPPLPPQ PQFLPPGYLS ALHFLPPPPP
310 320 330 340
PPPPSSFSLT VLFDTDKENT DDQDAEVLSG EPSQPSSQEQ SD
Length:342
Mass (Da):36,205
Last modified:December 1, 2001 - v1
Checksum:i18B0D5B0A6DB03EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057273 mRNA Translation: BAB71407.1
AL365445 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06736.1
AJ291671 mRNA Translation: CAC40654.1
CCDSiCCDS581.1
RefSeqiNP_149056.1, NM_033067.2
UniGeneiHs.131654

Genome annotation databases

EnsembliENST00000371445; ENSP00000360500; ENSG00000143006
GeneIDi63948
KEGGihsa:63948
UCSCiuc001cvq.2 human

Similar proteinsi

Entry informationi

Entry nameiDMRTB_HUMAN
AccessioniPrimary (citable) accession number: Q96MA1
Secondary accession number(s): Q96SD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health