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Q96M98

- PACRG_HUMAN

UniProt

Q96M98 - PACRG_HUMAN

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Protein

Parkin coregulated gene protein

Gene

PACRG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.1 Publication

GO - Biological processi

  1. spermatid development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Parkin coregulated gene protein
Alternative name(s):
Molecular chaperone/chaperonin-binding protein
PARK2 coregulated gene protein
Gene namesi
Name:PACRG
Synonyms:GLUP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:19152. PACRG.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. nucleus Source: UniProt
  4. sperm midpiece Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

MIMi607572. phenotype.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA134909011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Parkin coregulated gene proteinPRO_0000058169Add
BLAST

Proteomic databases

PaxDbiQ96M98.
PRIDEiQ96M98.

PTM databases

PhosphoSiteiQ96M98.

Expressioni

Tissue specificityi

Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.1 Publication

Gene expression databases

BgeeiQ96M98.
CleanExiHS_PACRG.
GenevestigatoriQ96M98.

Interactioni

Subunit structurei

Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi126421. 21 interactions.
STRINGi9606.ENSP00000337946.

Structurei

3D structure databases

ProteinModelPortaliQ96M98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG254401.
GeneTreeiENSGT00530000063549.
HOGENOMiHOG000230829.
HOVERGENiHBG053487.
InParanoidiQ96M98.
OMAiCETVHPY.
OrthoDBiEOG793B8H.
PhylomeDBiQ96M98.
TreeFamiTF321123.

Family and domain databases

InterProiIPR019399. Parkin_co-regulated_protein.
[Graphical view]
PfamiPF10274. ParcG. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96M98-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN
60 70 80 90 100
SVVRGPPAAG AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI
110 120 130 140 150
EKLDYHHYLP LFFDGLCEMT FPYEFFARQG IHDMLEHGGN KILPVLPQLI
160 170 180 190 200
IPIKNALNLR NRQVICVTLK VLQHLVVSAE MVGKALVPYY RQILPVLNIF
210 220 230 240 250
KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA EIIVNSGDGI
260 270 280 290
DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN

Note: No experimental confirmation available.

Length:296
Mass (Da):33,342
Last modified:October 11, 2005 - v2
Checksum:i4A415741D430C7FB
GO
Isoform 2 (identifier: Q96M98-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-243: Missing.

Note: May be due to exon skipping.

Show »
Length:257
Mass (Da):29,312
Checksum:i76E319E0C76A98D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931K → R in BAB71410. (PubMed:14702039)Curated
Sequence conflicti185 – 1851A → T in AAH30642. (PubMed:15489334)Curated

Polymorphismi

Involved in susceptibility to leprosy (LPRS2) [MIMi:607572]. LPRS2 is associated with polymorphisms in the 5'-regulatory region shared by the PARK2 gene.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei205 – 24339Missing in isoform 2. 2 PublicationsVSP_010033Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546872 mRNA. Translation: AAN37911.1.
AK057286 mRNA. Translation: BAB71410.1.
AL354942
, AL031121, AL137182, AP001576 Genomic DNA. Translation: CAI16054.1.
AL137182
, AL031121, AL354942, AP001576 Genomic DNA. Translation: CAI19951.1.
AL031121
, AL137182, AL354942, AP001576 Genomic DNA. Translation: CAI21557.1.
AL078585 Genomic DNA. No translation available.
AL590286 Genomic DNA. No translation available.
AL603788 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47565.1.
CH471051 Genomic DNA. Translation: EAW47566.1.
BC030642 mRNA. Translation: AAH30642.1.
BC044227 mRNA. Translation: AAH44227.1.
BK001670 mRNA. Translation: DAA02134.1.
CCDSiCCDS43524.1. [Q96M98-2]
CCDS5284.1. [Q96M98-1]
RefSeqiNP_001073847.1. NM_001080378.1. [Q96M98-2]
NP_001073848.1. NM_001080379.1. [Q96M98-2]
NP_689623.2. NM_152410.2. [Q96M98-1]
XP_006715406.1. XM_006715343.1. [Q96M98-2]
UniGeneiHs.25791.

Genome annotation databases

EnsembliENST00000337019; ENSP00000337946; ENSG00000112530. [Q96M98-1]
ENST00000366888; ENSP00000355854; ENSG00000112530. [Q96M98-2]
ENST00000366889; ENSP00000355855; ENSG00000112530. [Q96M98-2]
GeneIDi135138.
KEGGihsa:135138.
UCSCiuc003qua.3. human. [Q96M98-1]
uc003qub.3. human. [Q96M98-2]

Polymorphism databases

DMDMi77416872.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546872 mRNA. Translation: AAN37911.1 .
AK057286 mRNA. Translation: BAB71410.1 .
AL354942
, AL031121 , AL137182 , AP001576 Genomic DNA. Translation: CAI16054.1 .
AL137182
, AL031121 , AL354942 , AP001576 Genomic DNA. Translation: CAI19951.1 .
AL031121
, AL137182 , AL354942 , AP001576 Genomic DNA. Translation: CAI21557.1 .
AL078585 Genomic DNA. No translation available.
AL590286 Genomic DNA. No translation available.
AL603788 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47565.1 .
CH471051 Genomic DNA. Translation: EAW47566.1 .
BC030642 mRNA. Translation: AAH30642.1 .
BC044227 mRNA. Translation: AAH44227.1 .
BK001670 mRNA. Translation: DAA02134.1 .
CCDSi CCDS43524.1. [Q96M98-2 ]
CCDS5284.1. [Q96M98-1 ]
RefSeqi NP_001073847.1. NM_001080378.1. [Q96M98-2 ]
NP_001073848.1. NM_001080379.1. [Q96M98-2 ]
NP_689623.2. NM_152410.2. [Q96M98-1 ]
XP_006715406.1. XM_006715343.1. [Q96M98-2 ]
UniGenei Hs.25791.

3D structure databases

ProteinModelPortali Q96M98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126421. 21 interactions.
STRINGi 9606.ENSP00000337946.

PTM databases

PhosphoSitei Q96M98.

Polymorphism databases

DMDMi 77416872.

Proteomic databases

PaxDbi Q96M98.
PRIDEi Q96M98.

Protocols and materials databases

DNASUi 135138.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337019 ; ENSP00000337946 ; ENSG00000112530 . [Q96M98-1 ]
ENST00000366888 ; ENSP00000355854 ; ENSG00000112530 . [Q96M98-2 ]
ENST00000366889 ; ENSP00000355855 ; ENSG00000112530 . [Q96M98-2 ]
GeneIDi 135138.
KEGGi hsa:135138.
UCSCi uc003qua.3. human. [Q96M98-1 ]
uc003qub.3. human. [Q96M98-2 ]

Organism-specific databases

CTDi 135138.
GeneCardsi GC06P163118.
HGNCi HGNC:19152. PACRG.
MIMi 607572. phenotype.
608427. gene.
neXtProti NX_Q96M98.
Orphaneti 2828. Young adult-onset Parkinsonism.
PharmGKBi PA134909011.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254401.
GeneTreei ENSGT00530000063549.
HOGENOMi HOG000230829.
HOVERGENi HBG053487.
InParanoidi Q96M98.
OMAi CETVHPY.
OrthoDBi EOG793B8H.
PhylomeDBi Q96M98.
TreeFami TF321123.

Miscellaneous databases

ChiTaRSi PACRG. human.
GeneWikii PACRG.
GenomeRNAii 135138.
NextBioi 83453.
PROi Q96M98.
SOURCEi Search...

Gene expression databases

Bgeei Q96M98.
CleanExi HS_PACRG.
Genevestigatori Q96M98.

Family and domain databases

InterProi IPR019399. Parkin_co-regulated_protein.
[Graphical view ]
Pfami PF10274. ParcG. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene linked to parkin via a bi-directional promoter."
    West A.B., Lockhart P.J., O'Farell C., Farrer M.J.
    J. Mol. Biol. 326:11-19(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  6. "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
    Imai Y., Soda M., Murakami T., Shoji M., Abe K., Takahashi R.
    J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, INTERACTION WITH STIP1; PARK2; GPR37; HSPA8; TCP1; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT7 AND CCT8.
  7. Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN SUSCEPTIBILITY TO LEPROSY.

Entry informationi

Entry nameiPACRG_HUMAN
AccessioniPrimary (citable) accession number: Q96M98
Secondary accession number(s): E1P5B5
, Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Linked to PARK2 in a head-to-head arrangement on opposite DNA strands and share a common 5'-flanking promoter region.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3