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Protein

Parkin coregulated gene protein

Gene

PACRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.1 Publication

GO - Molecular functioni

  • actin binding Source: ParkinsonsUK-UCL
  • alpha-tubulin binding Source: ParkinsonsUK-UCL
  • beta-tubulin binding Source: ParkinsonsUK-UCL
  • chaperone binding Source: ParkinsonsUK-UCL
  • G-protein coupled receptor binding Source: ParkinsonsUK-UCL
  • heat shock protein binding Source: ParkinsonsUK-UCL
  • Hsp70 protein binding Source: ParkinsonsUK-UCL
  • Hsp90 protein binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • cellular response to unfolded protein Source: ParkinsonsUK-UCL
  • negative regulation of cell death Source: ParkinsonsUK-UCL
  • spermatid development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Parkin coregulated gene protein
Alternative name(s):
Molecular chaperone/chaperonin-binding protein
PARK2 coregulated gene protein
Gene namesi
Name:PACRG
Synonyms:GLUP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19152. PACRG.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: Ensembl
  • cytosol Source: ParkinsonsUK-UCL
  • mitochondrion Source: Ensembl
  • neuron projection Source: ParkinsonsUK-UCL
  • nucleus Source: UniProtKB
  • sperm midpiece Source: Ensembl
  • vesicle Source: ParkinsonsUK-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi135138.
MalaCardsiPACRG.
MIMi607572. phenotype.
OpenTargetsiENSG00000112530.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA134909011.

Polymorphism and mutation databases

BioMutaiPACRG.
DMDMi77416872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581691 – 296Parkin coregulated gene proteinAdd BLAST296

Proteomic databases

PaxDbiQ96M98.
PeptideAtlasiQ96M98.
PRIDEiQ96M98.

PTM databases

iPTMnetiQ96M98.
PhosphoSitePlusiQ96M98.

Expressioni

Tissue specificityi

Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.1 Publication

Gene expression databases

BgeeiENSG00000112530.
CleanExiHS_PACRG.
ExpressionAtlasiQ96M98. baseline and differential.
GenevisibleiQ96M98. HS.

Organism-specific databases

HPAiCAB006820.

Interactioni

Subunit structurei

Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1 (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: ParkinsonsUK-UCL
  • alpha-tubulin binding Source: ParkinsonsUK-UCL
  • beta-tubulin binding Source: ParkinsonsUK-UCL
  • chaperone binding Source: ParkinsonsUK-UCL
  • G-protein coupled receptor binding Source: ParkinsonsUK-UCL
  • heat shock protein binding Source: ParkinsonsUK-UCL
  • Hsp70 protein binding Source: ParkinsonsUK-UCL
  • Hsp90 protein binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi126421. 20 interactors.
IntActiQ96M98. 1 interactor.
STRINGi9606.ENSP00000337946.

Structurei

3D structure databases

ProteinModelPortaliQ96M98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3961. Eukaryota.
ENOG410XSXW. LUCA.
GeneTreeiENSGT00530000063549.
HOGENOMiHOG000230829.
HOVERGENiHBG053487.
InParanoidiQ96M98.
OMAiGLCETQH.
OrthoDBiEOG091G0HH5.
PhylomeDBiQ96M98.
TreeFamiTF321123.

Family and domain databases

InterProiIPR019399. Parkin_co-regulated_protein.
[Graphical view]
PfamiPF10274. ParcG. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96M98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN
60 70 80 90 100
SVVRGPPAAG AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI
110 120 130 140 150
EKLDYHHYLP LFFDGLCEMT FPYEFFARQG IHDMLEHGGN KILPVLPQLI
160 170 180 190 200
IPIKNALNLR NRQVICVTLK VLQHLVVSAE MVGKALVPYY RQILPVLNIF
210 220 230 240 250
KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA EIIVNSGDGI
260 270 280 290
DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN
Note: No experimental confirmation available.
Length:296
Mass (Da):33,342
Last modified:October 11, 2005 - v2
Checksum:i4A415741D430C7FB
GO
Isoform 2 (identifier: Q96M98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-243: Missing.

Note: May be due to exon skipping.
Show »
Length:257
Mass (Da):29,312
Checksum:i76E319E0C76A98D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93K → R in BAB71410 (PubMed:14702039).Curated1
Sequence conflicti185A → T in AAH30642 (PubMed:15489334).Curated1

Polymorphismi

Involved in susceptibility to leprosy (LPRS2) [MIMi:607572]. LPRS2 is associated with polymorphisms in the 5'-regulatory region shared by the PARK2 gene.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010033205 – 243Missing in isoform 2. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546872 mRNA. Translation: AAN37911.1.
AK057286 mRNA. Translation: BAB71410.1.
AL354942
, AL031121, AL137182, AP001576 Genomic DNA. Translation: CAI16054.1.
AL137182
, AL031121, AL354942, AP001576 Genomic DNA. Translation: CAI19951.1.
AL031121
, AL137182, AL354942, AP001576 Genomic DNA. Translation: CAI21557.1.
AL078585 Genomic DNA. No translation available.
AL590286 Genomic DNA. No translation available.
AL603788 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47565.1.
CH471051 Genomic DNA. Translation: EAW47566.1.
BC030642 mRNA. Translation: AAH30642.1.
BC044227 mRNA. Translation: AAH44227.1.
BK001670 mRNA. Translation: DAA02134.1.
CCDSiCCDS43524.1. [Q96M98-2]
CCDS5284.1. [Q96M98-1]
RefSeqiNP_001073847.1. NM_001080378.1. [Q96M98-2]
NP_001073848.1. NM_001080379.1. [Q96M98-2]
NP_689623.2. NM_152410.2. [Q96M98-1]
UniGeneiHs.25791.
Hs.653916.

Genome annotation databases

EnsembliENST00000337019; ENSP00000337946; ENSG00000112530. [Q96M98-1]
ENST00000366888; ENSP00000355854; ENSG00000112530. [Q96M98-2]
ENST00000366889; ENSP00000355855; ENSG00000112530. [Q96M98-2]
GeneIDi135138.
KEGGihsa:135138.
UCSCiuc003qua.4. human. [Q96M98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546872 mRNA. Translation: AAN37911.1.
AK057286 mRNA. Translation: BAB71410.1.
AL354942
, AL031121, AL137182, AP001576 Genomic DNA. Translation: CAI16054.1.
AL137182
, AL031121, AL354942, AP001576 Genomic DNA. Translation: CAI19951.1.
AL031121
, AL137182, AL354942, AP001576 Genomic DNA. Translation: CAI21557.1.
AL078585 Genomic DNA. No translation available.
AL590286 Genomic DNA. No translation available.
AL603788 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47565.1.
CH471051 Genomic DNA. Translation: EAW47566.1.
BC030642 mRNA. Translation: AAH30642.1.
BC044227 mRNA. Translation: AAH44227.1.
BK001670 mRNA. Translation: DAA02134.1.
CCDSiCCDS43524.1. [Q96M98-2]
CCDS5284.1. [Q96M98-1]
RefSeqiNP_001073847.1. NM_001080378.1. [Q96M98-2]
NP_001073848.1. NM_001080379.1. [Q96M98-2]
NP_689623.2. NM_152410.2. [Q96M98-1]
UniGeneiHs.25791.
Hs.653916.

3D structure databases

ProteinModelPortaliQ96M98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126421. 20 interactors.
IntActiQ96M98. 1 interactor.
STRINGi9606.ENSP00000337946.

PTM databases

iPTMnetiQ96M98.
PhosphoSitePlusiQ96M98.

Polymorphism and mutation databases

BioMutaiPACRG.
DMDMi77416872.

Proteomic databases

PaxDbiQ96M98.
PeptideAtlasiQ96M98.
PRIDEiQ96M98.

Protocols and materials databases

DNASUi135138.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337019; ENSP00000337946; ENSG00000112530. [Q96M98-1]
ENST00000366888; ENSP00000355854; ENSG00000112530. [Q96M98-2]
ENST00000366889; ENSP00000355855; ENSG00000112530. [Q96M98-2]
GeneIDi135138.
KEGGihsa:135138.
UCSCiuc003qua.4. human. [Q96M98-1]

Organism-specific databases

CTDi135138.
DisGeNETi135138.
GeneCardsiPACRG.
HGNCiHGNC:19152. PACRG.
HPAiCAB006820.
MalaCardsiPACRG.
MIMi607572. phenotype.
608427. gene.
neXtProtiNX_Q96M98.
OpenTargetsiENSG00000112530.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA134909011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3961. Eukaryota.
ENOG410XSXW. LUCA.
GeneTreeiENSGT00530000063549.
HOGENOMiHOG000230829.
HOVERGENiHBG053487.
InParanoidiQ96M98.
OMAiGLCETQH.
OrthoDBiEOG091G0HH5.
PhylomeDBiQ96M98.
TreeFamiTF321123.

Miscellaneous databases

ChiTaRSiPACRG. human.
GeneWikiiPACRG.
GenomeRNAii135138.
PROiQ96M98.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112530.
CleanExiHS_PACRG.
ExpressionAtlasiQ96M98. baseline and differential.
GenevisibleiQ96M98. HS.

Family and domain databases

InterProiIPR019399. Parkin_co-regulated_protein.
[Graphical view]
PfamiPF10274. ParcG. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPACRG_HUMAN
AccessioniPrimary (citable) accession number: Q96M98
Secondary accession number(s): E1P5B5
, Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Linked to PARK2 in a head-to-head arrangement on opposite DNA strands and share a common 5'-flanking promoter region.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.