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Q96M98 (PACRG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parkin coregulated gene protein
Alternative name(s):
Molecular chaperone/chaperonin-binding protein
PARK2 coregulated gene protein
Gene names
Name:PACRG
Synonyms:GLUP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. Ref.6

Subunit structure

Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1 By similarity. Ref.6

Tissue specificity

Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.

Polymorphism

Involved in susceptibility to leprosy (LPRS2) [MIM:607572]. LPRS2 is associated with polymorphisms in the 5'-regulatory region shared by the PARK2 gene.

Miscellaneous

Linked to PARK2 in a head-to-head arrangement on opposite DNA strands and share a common 5'-flanking promoter region.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processspermatid development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell body

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from electronic annotation. Source: Ensembl

sperm midpiece

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96M98-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q96M98-2)

The sequence of this isoform differs from the canonical sequence as follows:
     205-243: Missing.
Note: May be due to exon skipping.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Parkin coregulated gene protein
PRO_0000058169

Natural variations

Alternative sequence205 – 24339Missing in isoform 2.
VSP_010033

Experimental info

Sequence conflict931K → R in BAB71410. Ref.2
Sequence conflict1851A → T in AAH30642. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 2.
Checksum: 4A415741D430C7FB

FASTA29633,342
        10         20         30         40         50         60 
MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN SVVRGPPAAG 

        70         80         90        100        110        120 
AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI EKLDYHHYLP LFFDGLCEMT 

       130        140        150        160        170        180 
FPYEFFARQG IHDMLEHGGN KILPVLPQLI IPIKNALNLR NRQVICVTLK VLQHLVVSAE 

       190        200        210        220        230        240 
MVGKALVPYY RQILPVLNIF KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA 

       250        260        270        280        290 
EIIVNSGDGI DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN 

« Hide

Isoform 2 [UniParc].

Checksum: 76E319E0C76A98D0
Show »

FASTA25729,312

References

« Hide 'large scale' references
[1]"Identification of a novel gene linked to parkin via a bi-directional promoter."
West A.B., Lockhart P.J., O'Farell C., Farrer M.J.
J. Mol. Biol. 326:11-19(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[6]"A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
Imai Y., Soda M., Murakami T., Shoji M., Abe K., Takahashi R.
J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, FUNCTION, INTERACTION WITH STIP1; PARK2; GPR37; HSPA8; TCP1; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT7 AND CCT8.
[7]"Susceptibility to leprosy is associated with PARK2 and PACRG."
Mira M.T., Alcais A., Nguyen V.T., Moraes M.O., Di Flumeri C., Vu H.T., Mai C.P., Nguyen T.H., Nguyen N.B., Pham X.K., Sarno E.N., Alter A., Montpetit A., Moraes M.E., Moraes J.R., Dore C., Gallant C.J., Lepage P. expand/collapse author list , Verner A., Van De Vosse E., Hudson T.J., Abel L., Schurr E.
Nature 427:636-640(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO LEPROSY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF546872 mRNA. Translation: AAN37911.1.
AK057286 mRNA. Translation: BAB71410.1.
AL354942 expand/collapse EMBL AC list , AL031121, AL137182, AP001576 Genomic DNA. Translation: CAI16054.1.
AL137182 expand/collapse EMBL AC list , AL031121, AL354942, AP001576 Genomic DNA. Translation: CAI19951.1.
AL031121 expand/collapse EMBL AC list , AL137182, AL354942, AP001576 Genomic DNA. Translation: CAI21557.1.
AL078585 Genomic DNA. No translation available.
AL590286 Genomic DNA. No translation available.
AL603788 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47565.1.
CH471051 Genomic DNA. Translation: EAW47566.1.
BC030642 mRNA. Translation: AAH30642.1.
BC044227 mRNA. Translation: AAH44227.1.
BK001670 mRNA. Translation: DAA02134.1.
RefSeqNP_001073847.1. NM_001080378.1.
NP_001073848.1. NM_001080379.1.
NP_689623.2. NM_152410.2.
UniGeneHs.25791.

3D structure databases

ProteinModelPortalQ96M98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126421. 20 interactions.
STRING9606.ENSP00000337946.

PTM databases

PhosphoSiteQ96M98.

Polymorphism databases

DMDM77416872.

Proteomic databases

PaxDbQ96M98.
PRIDEQ96M98.

Protocols and materials databases

DNASU135138.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000337019; ENSP00000337946; ENSG00000112530. [Q96M98-1]
ENST00000366888; ENSP00000355854; ENSG00000112530. [Q96M98-2]
ENST00000366889; ENSP00000355855; ENSG00000112530. [Q96M98-2]
GeneID135138.
KEGGhsa:135138.
UCSCuc003qua.3. human. [Q96M98-1]
uc003qub.3. human. [Q96M98-2]

Organism-specific databases

CTD135138.
GeneCardsGC06P163118.
HGNCHGNC:19152. PACRG.
MIM607572. phenotype.
608427. gene.
neXtProtNX_Q96M98.
Orphanet2828. Young adult-onset Parkinsonism.
PharmGKBPA134909011.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254401.
HOGENOMHOG000230829.
HOVERGENHBG053487.
InParanoidQ96M98.
OMAFERHGGE.
OrthoDBEOG793B8H.
PhylomeDBQ96M98.
TreeFamTF321123.

Gene expression databases

BgeeQ96M98.
CleanExHS_PACRG.
GenevestigatorQ96M98.

Family and domain databases

InterProIPR019399. Parkin_co-regulated_protein.
[Graphical view]
PfamPF10274. ParcG. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPACRG. human.
GeneWikiPACRG.
GenomeRNAi135138.
NextBio83453.
PROQ96M98.
SOURCESearch...

Entry information

Entry namePACRG_HUMAN
AccessionPrimary (citable) accession number: Q96M98
Secondary accession number(s): E1P5B5 expand/collapse secondary AC list , Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 11, 2005
Last modified: March 19, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM