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Q96M98

- PACRG_HUMAN

UniProt

Q96M98 - PACRG_HUMAN

Protein

Parkin coregulated gene protein

Gene

PACRG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.1 Publication

    GO - Biological processi

    1. spermatid development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parkin coregulated gene protein
    Alternative name(s):
    Molecular chaperone/chaperonin-binding protein
    PARK2 coregulated gene protein
    Gene namesi
    Name:PACRG
    Synonyms:GLUP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:19152. PACRG.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProt
    4. sperm midpiece Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    MIMi607572. phenotype.
    Orphaneti2828. Young adult-onset Parkinsonism.
    PharmGKBiPA134909011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Parkin coregulated gene proteinPRO_0000058169Add
    BLAST

    Proteomic databases

    PaxDbiQ96M98.
    PRIDEiQ96M98.

    PTM databases

    PhosphoSiteiQ96M98.

    Expressioni

    Tissue specificityi

    Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.

    Gene expression databases

    BgeeiQ96M98.
    CleanExiHS_PACRG.
    GenevestigatoriQ96M98.

    Interactioni

    Subunit structurei

    Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi126421. 20 interactions.
    STRINGi9606.ENSP00000337946.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96M98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG254401.
    HOGENOMiHOG000230829.
    HOVERGENiHBG053487.
    InParanoidiQ96M98.
    OMAiCETVHPY.
    OrthoDBiEOG793B8H.
    PhylomeDBiQ96M98.
    TreeFamiTF321123.

    Family and domain databases

    InterProiIPR019399. Parkin_co-regulated_protein.
    [Graphical view]
    PfamiPF10274. ParcG. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96M98-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN    50
    SVVRGPPAAG AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI 100
    EKLDYHHYLP LFFDGLCEMT FPYEFFARQG IHDMLEHGGN KILPVLPQLI 150
    IPIKNALNLR NRQVICVTLK VLQHLVVSAE MVGKALVPYY RQILPVLNIF 200
    KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA EIIVNSGDGI 250
    DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN 296

    Note: No experimental confirmation available.

    Length:296
    Mass (Da):33,342
    Last modified:October 11, 2005 - v2
    Checksum:i4A415741D430C7FB
    GO
    Isoform 2 (identifier: Q96M98-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         205-243: Missing.

    Note: May be due to exon skipping.

    Show »
    Length:257
    Mass (Da):29,312
    Checksum:i76E319E0C76A98D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931K → R in BAB71410. (PubMed:14702039)Curated
    Sequence conflicti185 – 1851A → T in AAH30642. (PubMed:15489334)Curated

    Polymorphismi

    Involved in susceptibility to leprosy (LPRS2) [MIMi:607572]. LPRS2 is associated with polymorphisms in the 5'-regulatory region shared by the PARK2 gene.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei205 – 24339Missing in isoform 2. 2 PublicationsVSP_010033Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF546872 mRNA. Translation: AAN37911.1.
    AK057286 mRNA. Translation: BAB71410.1.
    AL354942
    , AL031121, AL137182, AP001576 Genomic DNA. Translation: CAI16054.1.
    AL137182
    , AL031121, AL354942, AP001576 Genomic DNA. Translation: CAI19951.1.
    AL031121
    , AL137182, AL354942, AP001576 Genomic DNA. Translation: CAI21557.1.
    AL078585 Genomic DNA. No translation available.
    AL590286 Genomic DNA. No translation available.
    AL603788 Genomic DNA. No translation available.
    CH471051 Genomic DNA. Translation: EAW47565.1.
    CH471051 Genomic DNA. Translation: EAW47566.1.
    BC030642 mRNA. Translation: AAH30642.1.
    BC044227 mRNA. Translation: AAH44227.1.
    BK001670 mRNA. Translation: DAA02134.1.
    CCDSiCCDS43524.1. [Q96M98-2]
    CCDS5284.1. [Q96M98-1]
    RefSeqiNP_001073847.1. NM_001080378.1. [Q96M98-2]
    NP_001073848.1. NM_001080379.1. [Q96M98-2]
    NP_689623.2. NM_152410.2. [Q96M98-1]
    XP_006715406.1. XM_006715343.1. [Q96M98-2]
    UniGeneiHs.25791.

    Genome annotation databases

    EnsembliENST00000337019; ENSP00000337946; ENSG00000112530. [Q96M98-1]
    ENST00000366888; ENSP00000355854; ENSG00000112530. [Q96M98-2]
    ENST00000366889; ENSP00000355855; ENSG00000112530. [Q96M98-2]
    GeneIDi135138.
    KEGGihsa:135138.
    UCSCiuc003qua.3. human. [Q96M98-1]
    uc003qub.3. human. [Q96M98-2]

    Polymorphism databases

    DMDMi77416872.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF546872 mRNA. Translation: AAN37911.1 .
    AK057286 mRNA. Translation: BAB71410.1 .
    AL354942
    , AL031121 , AL137182 , AP001576 Genomic DNA. Translation: CAI16054.1 .
    AL137182
    , AL031121 , AL354942 , AP001576 Genomic DNA. Translation: CAI19951.1 .
    AL031121
    , AL137182 , AL354942 , AP001576 Genomic DNA. Translation: CAI21557.1 .
    AL078585 Genomic DNA. No translation available.
    AL590286 Genomic DNA. No translation available.
    AL603788 Genomic DNA. No translation available.
    CH471051 Genomic DNA. Translation: EAW47565.1 .
    CH471051 Genomic DNA. Translation: EAW47566.1 .
    BC030642 mRNA. Translation: AAH30642.1 .
    BC044227 mRNA. Translation: AAH44227.1 .
    BK001670 mRNA. Translation: DAA02134.1 .
    CCDSi CCDS43524.1. [Q96M98-2 ]
    CCDS5284.1. [Q96M98-1 ]
    RefSeqi NP_001073847.1. NM_001080378.1. [Q96M98-2 ]
    NP_001073848.1. NM_001080379.1. [Q96M98-2 ]
    NP_689623.2. NM_152410.2. [Q96M98-1 ]
    XP_006715406.1. XM_006715343.1. [Q96M98-2 ]
    UniGenei Hs.25791.

    3D structure databases

    ProteinModelPortali Q96M98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126421. 20 interactions.
    STRINGi 9606.ENSP00000337946.

    PTM databases

    PhosphoSitei Q96M98.

    Polymorphism databases

    DMDMi 77416872.

    Proteomic databases

    PaxDbi Q96M98.
    PRIDEi Q96M98.

    Protocols and materials databases

    DNASUi 135138.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337019 ; ENSP00000337946 ; ENSG00000112530 . [Q96M98-1 ]
    ENST00000366888 ; ENSP00000355854 ; ENSG00000112530 . [Q96M98-2 ]
    ENST00000366889 ; ENSP00000355855 ; ENSG00000112530 . [Q96M98-2 ]
    GeneIDi 135138.
    KEGGi hsa:135138.
    UCSCi uc003qua.3. human. [Q96M98-1 ]
    uc003qub.3. human. [Q96M98-2 ]

    Organism-specific databases

    CTDi 135138.
    GeneCardsi GC06P163118.
    HGNCi HGNC:19152. PACRG.
    MIMi 607572. phenotype.
    608427. gene.
    neXtProti NX_Q96M98.
    Orphaneti 2828. Young adult-onset Parkinsonism.
    PharmGKBi PA134909011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254401.
    HOGENOMi HOG000230829.
    HOVERGENi HBG053487.
    InParanoidi Q96M98.
    OMAi CETVHPY.
    OrthoDBi EOG793B8H.
    PhylomeDBi Q96M98.
    TreeFami TF321123.

    Miscellaneous databases

    ChiTaRSi PACRG. human.
    GeneWikii PACRG.
    GenomeRNAii 135138.
    NextBioi 83453.
    PROi Q96M98.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96M98.
    CleanExi HS_PACRG.
    Genevestigatori Q96M98.

    Family and domain databases

    InterProi IPR019399. Parkin_co-regulated_protein.
    [Graphical view ]
    Pfami PF10274. ParcG. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene linked to parkin via a bi-directional promoter."
      West A.B., Lockhart P.J., O'Farell C., Farrer M.J.
      J. Mol. Biol. 326:11-19(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    6. "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
      Imai Y., Soda M., Murakami T., Shoji M., Abe K., Takahashi R.
      J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, INTERACTION WITH STIP1; PARK2; GPR37; HSPA8; TCP1; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT7 AND CCT8.
    7. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO LEPROSY.

    Entry informationi

    Entry nameiPACRG_HUMAN
    AccessioniPrimary (citable) accession number: Q96M98
    Secondary accession number(s): E1P5B5
    , Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Linked to PARK2 in a head-to-head arrangement on opposite DNA strands and share a common 5'-flanking promoter region.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3