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Protein

Kelch-like protein 15

Gene

KLHL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 15
Gene namesi
Name:KLHL15
Synonyms:KIAA1677
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29347. KLHL15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934728.

Polymorphism and mutation databases

BioMutaiKLHL15.
DMDMi88909167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Kelch-like protein 15PRO_0000223949Add
BLAST

Proteomic databases

PaxDbiQ96M94.
PRIDEiQ96M94.

PTM databases

iPTMnetiQ96M94.
PhosphoSiteiQ96M94.

Expressioni

Gene expression databases

BgeeiQ96M94.
CleanExiHS_KLHL15.
ExpressionAtlasiQ96M94. baseline and differential.
GenevisibleiQ96M94. HS.

Organism-specific databases

HPAiHPA065730.

Interactioni

Subunit structurei

Interacts with CUL3.1 Publication

Protein-protein interaction databases

BioGridi123224. 42 interactions.
IntActiQ96M94. 4 interactions.
STRINGi9606.ENSP00000332791.

Structurei

3D structure databases

ProteinModelPortaliQ96M94.
SMRiQ96M94. Positions 4-237, 307-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9868BTBPROSITE-ProRule annotationAdd
BLAST
Domaini133 – 237105BACKAdd
BLAST
Repeati328 – 37952Kelch 1Add
BLAST
Repeati381 – 42646Kelch 2Add
BLAST
Repeati428 – 47346Kelch 3Add
BLAST
Repeati489 – 54254Kelch 4Add
BLAST
Repeati544 – 59047Kelch 5Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000231204.
HOVERGENiHBG096076.
InParanoidiQ96M94.
KOiK10452.
OMAiKMISHNG.
OrthoDBiEOG783MTV.
PhylomeDBiQ96M94.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030597. KLHL15.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF61. PTHR24412:SF61. 2 hits.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96M94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDVEGFCS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA
60 70 80 90 100
TQSDYFRIMF TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT
110 120 130 140 150
VHEILQAAMY VQLIEVVKFC CSFLLAKICL ENCAEIMRLL DDFGVNIEGV
160 170 180 190 200
REKLDTFLLD NFVPLMSRPD FLSYLSFEKL MSYLDNDHLS RFPEIELYEA
210 220 230 240 250
VQSWLRHDRR RWRHTDTIIQ NIRFCLMTPT SVFEKVKTSE FYRYSRQLRY
260 270 280 290 300
EVDQALNYFQ NVHQQPLLDM KSSRIRSAKP QTTVFRGMIG HSMVNSKILL
310 320 330 340 350
LKKPRVWWEL EGPQVPLRPD CLAIVNNFVF LLGGEELGPD GEFHASSKVF
360 370 380 390 400
RYDPRQNSWL QMADMSVPRS EFAVGVIGKF IYAVAGRTRD ETFYSTERYD
410 420 430 440 450
ITNDKWEFVD PYPVNKYGHE GTVLNNKLFI TGGITSSSTS KQVCVFDPSK
460 470 480 490 500
EGTIEQRTRR TQVVTNCWEN KSKMNYARCF HKMISYNGKL YVFGGVCVIL
510 520 530 540 550
RASFESQGCP STEVYNPETD QWTILASMPI GRSGHGVTVL DKQIMVLGGL
560 570 580 590 600
CYNGHYSDSI LTFDPDENKW KEDEYPRMPC KLDGLQVCNL HFPDYVLDEV

RRCN
Length:604
Mass (Da):69,775
Last modified:February 21, 2006 - v2
Checksum:iE37606E8AE367C83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971K → E in BAB71415 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057298 mRNA. Translation: BAB71415.1.
BC015415 mRNA. Translation: AAH15415.1.
BC109058 mRNA. Translation: AAI09059.1.
BC109059 mRNA. Translation: AAI09060.1.
AB051464 mRNA. Translation: BAB21768.1.
AL834313 mRNA. Translation: CAD38983.1.
CCDSiCCDS35217.1.
RefSeqiNP_085127.2. NM_030624.2.
XP_006724581.1. XM_006724518.1.
UniGeneiHs.495854.

Genome annotation databases

EnsembliENST00000328046; ENSP00000332791; ENSG00000174010.
GeneIDi80311.
KEGGihsa:80311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057298 mRNA. Translation: BAB71415.1.
BC015415 mRNA. Translation: AAH15415.1.
BC109058 mRNA. Translation: AAI09059.1.
BC109059 mRNA. Translation: AAI09060.1.
AB051464 mRNA. Translation: BAB21768.1.
AL834313 mRNA. Translation: CAD38983.1.
CCDSiCCDS35217.1.
RefSeqiNP_085127.2. NM_030624.2.
XP_006724581.1. XM_006724518.1.
UniGeneiHs.495854.

3D structure databases

ProteinModelPortaliQ96M94.
SMRiQ96M94. Positions 4-237, 307-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123224. 42 interactions.
IntActiQ96M94. 4 interactions.
STRINGi9606.ENSP00000332791.

PTM databases

iPTMnetiQ96M94.
PhosphoSiteiQ96M94.

Polymorphism and mutation databases

BioMutaiKLHL15.
DMDMi88909167.

Proteomic databases

PaxDbiQ96M94.
PRIDEiQ96M94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328046; ENSP00000332791; ENSG00000174010.
GeneIDi80311.
KEGGihsa:80311.

Organism-specific databases

CTDi80311.
GeneCardsiKLHL15.
HGNCiHGNC:29347. KLHL15.
HPAiHPA065730.
neXtProtiNX_Q96M94.
PharmGKBiPA134934728.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000231204.
HOVERGENiHBG096076.
InParanoidiQ96M94.
KOiK10452.
OMAiKMISHNG.
OrthoDBiEOG783MTV.
PhylomeDBiQ96M94.
TreeFamiTF328485.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii80311.
NextBioi70798.
PROiQ96M94.

Gene expression databases

BgeeiQ96M94.
CleanExiHS_KLHL15.
ExpressionAtlasiQ96M94. baseline and differential.
GenevisibleiQ96M94. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030597. KLHL15.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF61. PTHR24412:SF61. 2 hits.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Duodenum.
  3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-604.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 421-604.
    Tissue: Testis.
  5. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
    Furukawa M., He Y.J., Borchers C., Xiong Y.
    Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.

Entry informationi

Entry nameiKLH15_HUMAN
AccessioniPrimary (citable) accession number: Q96M94
Secondary accession number(s): Q32MN3
, Q8NDA3, Q96BM6, Q9C0I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: March 16, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.