SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96M93

- ADAD1_HUMAN

UniProt

Q96M93 - ADAD1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Adenosine deaminase domain-containing protein 1

Gene
ADAD1, TENR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in spermatogenesis. Binds to RNA but not to DNA By similarity.

GO - Molecular functioni

  1. adenosine deaminase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. RNA processing Source: InterPro
  3. spermatid development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase domain-containing protein 1
Alternative name(s):
Testis nuclear RNA-binding protein
Gene namesi
Name:ADAD1
Synonyms:TENR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:30713. ADAD1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Adenosine deaminase domain-containing protein 1PRO_0000309520Add
BLAST

Proteomic databases

PaxDbiQ96M93.
PRIDEiQ96M93.

PTM databases

PhosphoSiteiQ96M93.

Expressioni

Gene expression databases

ArrayExpressiQ96M93.
BgeeiQ96M93.
CleanExiHS_ADAD1.
GenevestigatoriQ96M93.

Organism-specific databases

HPAiHPA044080.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296513.

Structurei

3D structure databases

ProteinModelPortaliQ96M93.
SMRiQ96M93. Positions 209-576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 16469DRBMAdd
BLAST
Domaini249 – 574326A to I editaseAdd
BLAST

Sequence similaritiesi

Belongs to the ADAD family.

Phylogenomic databases

eggNOGiNOG309601.
HOGENOMiHOG000033798.
HOVERGENiHBG058021.
InParanoidiQ96M93.
OMAiWIVKSPC.
OrthoDBiEOG7K0ZC7.
PhylomeDBiQ96M93.
TreeFamiTF315806.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR002466. A_deamin.
IPR014720. dsRNA-bd_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96M93-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASNNHWFQS SQVPSFAQML KKNLPVQPAT KTITTPTGWS SESYGLSKMA    50
SKVTQVTGNF PEPLLSKNLS SISNPVLPPK KIPKEFIMKY KRGEINPVSA 100
LHQFAQMQRV QLDLKETVTT GNVMGPYFAF CAVVDGIQYK TGLGQNKKES 150
RSNAAKLALD ELLQLDEPEP RILETSGPPP FPAEPVVLSE LAYVSKVHYE 200
GRHIQYAKIS QIVKERFNQL ISNRSEYLKY SSSLAAFIIE RAGQHEVVAI 250
GTGEYNYSQD IKPDGRVLHD THAVVTARRS LLRYFYRQLL LFYSKNPAMM 300
EKSIFCTEPT SNLLTLKQNI NICLYMNQLP KGSAQIKSQL RLNPHSISAF 350
EANEELCLHV AVEGKIYLTV YCPKDGVNRI SSMSSSDKLT RWEVLGVQGA 400
LLSHFIQPVY ISSILIGDGN CSDTRGLEIA IKQRVDDALT SKLPMFYLVN 450
RPHISLVPSA YPLQMNLEYK FLSLNWAQGD VSLEIVDGLS GKITESSPFK 500
SGMSMASRLC KAAMLSRFNL LAKEAKKELL EAGTYHAAKC MSASYQEAKC 550
KLKSYLQQHG YGSWIVKSPC IEQFNM 576
Length:576
Mass (Da):64,411
Last modified:December 1, 2001 - v1
Checksum:i379A6849ABDEEFAB
GO
Isoform 2 (identifier: Q96M93-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-293: Missing.

Show »
Length:565
Mass (Da):62,847
Checksum:iCFF0F974AE08AFD8
GO
Isoform 3 (identifier: Q96M93-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MASNNHWFQSSQVPSFAQM → M

Show »
Length:558
Mass (Da):62,363
Checksum:iABCF6E031C9300AF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MASNN…SFAQM → M in isoform 3. VSP_029225Add
BLAST
Alternative sequencei283 – 29311Missing in isoform 2. VSP_029226Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981H → Y in BAC04125. 1 Publication
Sequence conflicti407 – 4071Q → R in BAC04125. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057303 mRNA. Translation: BAB71416.1.
AK093297 mRNA. Translation: BAC04125.1.
AC022489 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05228.1.
CH471056 Genomic DNA. Translation: EAX05229.1.
CH471056 Genomic DNA. Translation: EAX05234.1.
CH471056 Genomic DNA. Translation: EAX05230.1.
CH471056 Genomic DNA. Translation: EAX05231.1.
CH471056 Genomic DNA. Translation: EAX05232.1.
BC040229 mRNA. Translation: AAH40229.1.
CCDSiCCDS34058.1. [Q96M93-1]
CCDS54800.1. [Q96M93-2]
CCDS54801.1. [Q96M93-3]
RefSeqiNP_001152757.1. NM_001159285.1. [Q96M93-2]
NP_001152767.1. NM_001159295.1. [Q96M93-3]
NP_640336.1. NM_139243.3. [Q96M93-1]
XP_005262798.1. XM_005262741.1. [Q96M93-1]
XP_005262799.1. XM_005262742.1. [Q96M93-1]
XP_005262800.1. XM_005262743.1. [Q96M93-1]
XP_005262801.1. XM_005262744.1. [Q96M93-2]
UniGeneiHs.518957.

Genome annotation databases

EnsembliENST00000296513; ENSP00000296513; ENSG00000164113. [Q96M93-1]
ENST00000388724; ENSP00000373376; ENSG00000164113. [Q96M93-2]
ENST00000388725; ENSP00000373377; ENSG00000164113. [Q96M93-3]
GeneIDi132612.
KEGGihsa:132612.
UCSCiuc003ieo.3. human. [Q96M93-1]
uc003iep.3. human. [Q96M93-2]

Polymorphism databases

DMDMi74732329.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057303 mRNA. Translation: BAB71416.1 .
AK093297 mRNA. Translation: BAC04125.1 .
AC022489 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05228.1 .
CH471056 Genomic DNA. Translation: EAX05229.1 .
CH471056 Genomic DNA. Translation: EAX05234.1 .
CH471056 Genomic DNA. Translation: EAX05230.1 .
CH471056 Genomic DNA. Translation: EAX05231.1 .
CH471056 Genomic DNA. Translation: EAX05232.1 .
BC040229 mRNA. Translation: AAH40229.1 .
CCDSi CCDS34058.1. [Q96M93-1 ]
CCDS54800.1. [Q96M93-2 ]
CCDS54801.1. [Q96M93-3 ]
RefSeqi NP_001152757.1. NM_001159285.1. [Q96M93-2 ]
NP_001152767.1. NM_001159295.1. [Q96M93-3 ]
NP_640336.1. NM_139243.3. [Q96M93-1 ]
XP_005262798.1. XM_005262741.1. [Q96M93-1 ]
XP_005262799.1. XM_005262742.1. [Q96M93-1 ]
XP_005262800.1. XM_005262743.1. [Q96M93-1 ]
XP_005262801.1. XM_005262744.1. [Q96M93-2 ]
UniGenei Hs.518957.

3D structure databases

ProteinModelPortali Q96M93.
SMRi Q96M93. Positions 209-576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000296513.

PTM databases

PhosphoSitei Q96M93.

Polymorphism databases

DMDMi 74732329.

Proteomic databases

PaxDbi Q96M93.
PRIDEi Q96M93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296513 ; ENSP00000296513 ; ENSG00000164113 . [Q96M93-1 ]
ENST00000388724 ; ENSP00000373376 ; ENSG00000164113 . [Q96M93-2 ]
ENST00000388725 ; ENSP00000373377 ; ENSG00000164113 . [Q96M93-3 ]
GeneIDi 132612.
KEGGi hsa:132612.
UCSCi uc003ieo.3. human. [Q96M93-1 ]
uc003iep.3. human. [Q96M93-2 ]

Organism-specific databases

CTDi 132612.
GeneCardsi GC04P123300.
HGNCi HGNC:30713. ADAD1.
HPAi HPA044080.
MIMi 614130. gene.
neXtProti NX_Q96M93.
PharmGKBi PA162375590.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309601.
HOGENOMi HOG000033798.
HOVERGENi HBG058021.
InParanoidi Q96M93.
OMAi WIVKSPC.
OrthoDBi EOG7K0ZC7.
PhylomeDBi Q96M93.
TreeFami TF315806.

Miscellaneous databases

GenomeRNAii 132612.
NextBioi 83106.
PROi Q96M93.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96M93.
Bgeei Q96M93.
CleanExi HS_ADAD1.
Genevestigatori Q96M93.

Family and domain databases

Gene3Di 3.30.160.20. 1 hit.
InterProi IPR002466. A_deamin.
IPR014720. dsRNA-bd_dom.
[Graphical view ]
Pfami PF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
[Graphical view ]
SMARTi SM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
[Graphical view ]
PROSITEi PS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiADAD1_HUMAN
AccessioniPrimary (citable) accession number: Q96M93
Secondary accession number(s): A6NKN4
, B7WPB0, D3DNX2, Q8IWG6, Q8NA06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi