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Q96M93

- ADAD1_HUMAN

UniProt

Q96M93 - ADAD1_HUMAN

Protein

Adenosine deaminase domain-containing protein 1

Gene

ADAD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Plays a role in spermatogenesis. Binds to RNA but not to DNA By similarity.By similarity

    GO - Molecular functioni

    1. adenosine deaminase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. RNA processing Source: InterPro
    3. spermatid development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine deaminase domain-containing protein 1
    Alternative name(s):
    Testis nuclear RNA-binding protein
    Gene namesi
    Name:ADAD1
    Synonyms:TENR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:30713. ADAD1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162375590.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Adenosine deaminase domain-containing protein 1PRO_0000309520Add
    BLAST

    Proteomic databases

    PaxDbiQ96M93.
    PRIDEiQ96M93.

    PTM databases

    PhosphoSiteiQ96M93.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96M93.
    BgeeiQ96M93.
    CleanExiHS_ADAD1.
    GenevestigatoriQ96M93.

    Organism-specific databases

    HPAiHPA044080.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000296513.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96M93.
    SMRiQ96M93. Positions 209-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini96 – 16469DRBMPROSITE-ProRule annotationAdd
    BLAST
    Domaini249 – 574326A to I editasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ADAD family.Curated
    Contains 1 A to I editase domain.PROSITE-ProRule annotation
    Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG309601.
    HOGENOMiHOG000033798.
    HOVERGENiHBG058021.
    InParanoidiQ96M93.
    OMAiWIVKSPC.
    OrthoDBiEOG7K0ZC7.
    PhylomeDBiQ96M93.
    TreeFamiTF315806.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    InterProiIPR002466. A_deamin.
    IPR014720. dsRNA-bd_dom.
    [Graphical view]
    PfamiPF02137. A_deamin. 1 hit.
    PF00035. dsrm. 1 hit.
    [Graphical view]
    SMARTiSM00552. ADEAMc. 1 hit.
    SM00358. DSRM. 1 hit.
    [Graphical view]
    PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
    PS50137. DS_RBD. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96M93-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASNNHWFQS SQVPSFAQML KKNLPVQPAT KTITTPTGWS SESYGLSKMA    50
    SKVTQVTGNF PEPLLSKNLS SISNPVLPPK KIPKEFIMKY KRGEINPVSA 100
    LHQFAQMQRV QLDLKETVTT GNVMGPYFAF CAVVDGIQYK TGLGQNKKES 150
    RSNAAKLALD ELLQLDEPEP RILETSGPPP FPAEPVVLSE LAYVSKVHYE 200
    GRHIQYAKIS QIVKERFNQL ISNRSEYLKY SSSLAAFIIE RAGQHEVVAI 250
    GTGEYNYSQD IKPDGRVLHD THAVVTARRS LLRYFYRQLL LFYSKNPAMM 300
    EKSIFCTEPT SNLLTLKQNI NICLYMNQLP KGSAQIKSQL RLNPHSISAF 350
    EANEELCLHV AVEGKIYLTV YCPKDGVNRI SSMSSSDKLT RWEVLGVQGA 400
    LLSHFIQPVY ISSILIGDGN CSDTRGLEIA IKQRVDDALT SKLPMFYLVN 450
    RPHISLVPSA YPLQMNLEYK FLSLNWAQGD VSLEIVDGLS GKITESSPFK 500
    SGMSMASRLC KAAMLSRFNL LAKEAKKELL EAGTYHAAKC MSASYQEAKC 550
    KLKSYLQQHG YGSWIVKSPC IEQFNM 576
    Length:576
    Mass (Da):64,411
    Last modified:December 1, 2001 - v1
    Checksum:i379A6849ABDEEFAB
    GO
    Isoform 2 (identifier: Q96M93-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         283-293: Missing.

    Show »
    Length:565
    Mass (Da):62,847
    Checksum:iCFF0F974AE08AFD8
    GO
    Isoform 3 (identifier: Q96M93-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: MASNNHWFQSSQVPSFAQM → M

    Show »
    Length:558
    Mass (Da):62,363
    Checksum:iABCF6E031C9300AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981H → Y in BAC04125. (PubMed:14702039)Curated
    Sequence conflicti407 – 4071Q → R in BAC04125. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1919MASNN…SFAQM → M in isoform 3. 1 PublicationVSP_029225Add
    BLAST
    Alternative sequencei283 – 29311Missing in isoform 2. 1 PublicationVSP_029226Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057303 mRNA. Translation: BAB71416.1.
    AK093297 mRNA. Translation: BAC04125.1.
    AC022489 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05228.1.
    CH471056 Genomic DNA. Translation: EAX05229.1.
    CH471056 Genomic DNA. Translation: EAX05234.1.
    CH471056 Genomic DNA. Translation: EAX05230.1.
    CH471056 Genomic DNA. Translation: EAX05231.1.
    CH471056 Genomic DNA. Translation: EAX05232.1.
    BC040229 mRNA. Translation: AAH40229.1.
    CCDSiCCDS34058.1. [Q96M93-1]
    CCDS54800.1. [Q96M93-2]
    CCDS54801.1. [Q96M93-3]
    RefSeqiNP_001152757.1. NM_001159285.1. [Q96M93-2]
    NP_001152767.1. NM_001159295.1. [Q96M93-3]
    NP_640336.1. NM_139243.3. [Q96M93-1]
    XP_005262798.1. XM_005262741.1. [Q96M93-1]
    XP_005262799.1. XM_005262742.1. [Q96M93-1]
    XP_005262800.1. XM_005262743.1. [Q96M93-1]
    XP_005262801.1. XM_005262744.1. [Q96M93-2]
    UniGeneiHs.518957.

    Genome annotation databases

    EnsembliENST00000296513; ENSP00000296513; ENSG00000164113. [Q96M93-1]
    ENST00000388724; ENSP00000373376; ENSG00000164113. [Q96M93-2]
    ENST00000388725; ENSP00000373377; ENSG00000164113. [Q96M93-3]
    GeneIDi132612.
    KEGGihsa:132612.
    UCSCiuc003ieo.3. human. [Q96M93-1]
    uc003iep.3. human. [Q96M93-2]

    Polymorphism databases

    DMDMi74732329.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057303 mRNA. Translation: BAB71416.1 .
    AK093297 mRNA. Translation: BAC04125.1 .
    AC022489 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05228.1 .
    CH471056 Genomic DNA. Translation: EAX05229.1 .
    CH471056 Genomic DNA. Translation: EAX05234.1 .
    CH471056 Genomic DNA. Translation: EAX05230.1 .
    CH471056 Genomic DNA. Translation: EAX05231.1 .
    CH471056 Genomic DNA. Translation: EAX05232.1 .
    BC040229 mRNA. Translation: AAH40229.1 .
    CCDSi CCDS34058.1. [Q96M93-1 ]
    CCDS54800.1. [Q96M93-2 ]
    CCDS54801.1. [Q96M93-3 ]
    RefSeqi NP_001152757.1. NM_001159285.1. [Q96M93-2 ]
    NP_001152767.1. NM_001159295.1. [Q96M93-3 ]
    NP_640336.1. NM_139243.3. [Q96M93-1 ]
    XP_005262798.1. XM_005262741.1. [Q96M93-1 ]
    XP_005262799.1. XM_005262742.1. [Q96M93-1 ]
    XP_005262800.1. XM_005262743.1. [Q96M93-1 ]
    XP_005262801.1. XM_005262744.1. [Q96M93-2 ]
    UniGenei Hs.518957.

    3D structure databases

    ProteinModelPortali Q96M93.
    SMRi Q96M93. Positions 209-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000296513.

    PTM databases

    PhosphoSitei Q96M93.

    Polymorphism databases

    DMDMi 74732329.

    Proteomic databases

    PaxDbi Q96M93.
    PRIDEi Q96M93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296513 ; ENSP00000296513 ; ENSG00000164113 . [Q96M93-1 ]
    ENST00000388724 ; ENSP00000373376 ; ENSG00000164113 . [Q96M93-2 ]
    ENST00000388725 ; ENSP00000373377 ; ENSG00000164113 . [Q96M93-3 ]
    GeneIDi 132612.
    KEGGi hsa:132612.
    UCSCi uc003ieo.3. human. [Q96M93-1 ]
    uc003iep.3. human. [Q96M93-2 ]

    Organism-specific databases

    CTDi 132612.
    GeneCardsi GC04P123300.
    HGNCi HGNC:30713. ADAD1.
    HPAi HPA044080.
    MIMi 614130. gene.
    neXtProti NX_Q96M93.
    PharmGKBi PA162375590.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309601.
    HOGENOMi HOG000033798.
    HOVERGENi HBG058021.
    InParanoidi Q96M93.
    OMAi WIVKSPC.
    OrthoDBi EOG7K0ZC7.
    PhylomeDBi Q96M93.
    TreeFami TF315806.

    Miscellaneous databases

    GenomeRNAii 132612.
    NextBioi 83106.
    PROi Q96M93.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96M93.
    Bgeei Q96M93.
    CleanExi HS_ADAD1.
    Genevestigatori Q96M93.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    InterProi IPR002466. A_deamin.
    IPR014720. dsRNA-bd_dom.
    [Graphical view ]
    Pfami PF02137. A_deamin. 1 hit.
    PF00035. dsrm. 1 hit.
    [Graphical view ]
    SMARTi SM00552. ADEAMc. 1 hit.
    SM00358. DSRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50141. A_DEAMIN_EDITASE. 1 hit.
    PS50137. DS_RBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiADAD1_HUMAN
    AccessioniPrimary (citable) accession number: Q96M93
    Secondary accession number(s): A6NKN4
    , B7WPB0, D3DNX2, Q8IWG6, Q8NA06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3