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Q96M93 (ADAD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosine deaminase domain-containing protein 1
Alternative name(s):
Testis nuclear RNA-binding protein
Gene names
Name:ADAD1
Synonyms:TENR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in spermatogenesis. Binds to RNA but not to DNA By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ADAD family.

Contains 1 A to I editase domain.

Contains 1 DRBM (double-stranded RNA-binding) domain.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandRNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

spermatid development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenosine deaminase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96M93-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96M93-2)

The sequence of this isoform differs from the canonical sequence as follows:
     283-293: Missing.
Isoform 3 (identifier: Q96M93-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MASNNHWFQSSQVPSFAQM → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Adenosine deaminase domain-containing protein 1
PRO_0000309520

Regions

Domain96 – 16469DRBM
Domain249 – 574326A to I editase

Natural variations

Alternative sequence1 – 1919MASNN…SFAQM → M in isoform 3.
VSP_029225
Alternative sequence283 – 29311Missing in isoform 2.
VSP_029226

Experimental info

Sequence conflict1981H → Y in BAC04125. Ref.1
Sequence conflict4071Q → R in BAC04125. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 379A6849ABDEEFAB

FASTA57664,411
        10         20         30         40         50         60 
MASNNHWFQS SQVPSFAQML KKNLPVQPAT KTITTPTGWS SESYGLSKMA SKVTQVTGNF 

        70         80         90        100        110        120 
PEPLLSKNLS SISNPVLPPK KIPKEFIMKY KRGEINPVSA LHQFAQMQRV QLDLKETVTT 

       130        140        150        160        170        180 
GNVMGPYFAF CAVVDGIQYK TGLGQNKKES RSNAAKLALD ELLQLDEPEP RILETSGPPP 

       190        200        210        220        230        240 
FPAEPVVLSE LAYVSKVHYE GRHIQYAKIS QIVKERFNQL ISNRSEYLKY SSSLAAFIIE 

       250        260        270        280        290        300 
RAGQHEVVAI GTGEYNYSQD IKPDGRVLHD THAVVTARRS LLRYFYRQLL LFYSKNPAMM 

       310        320        330        340        350        360 
EKSIFCTEPT SNLLTLKQNI NICLYMNQLP KGSAQIKSQL RLNPHSISAF EANEELCLHV 

       370        380        390        400        410        420 
AVEGKIYLTV YCPKDGVNRI SSMSSSDKLT RWEVLGVQGA LLSHFIQPVY ISSILIGDGN 

       430        440        450        460        470        480 
CSDTRGLEIA IKQRVDDALT SKLPMFYLVN RPHISLVPSA YPLQMNLEYK FLSLNWAQGD 

       490        500        510        520        530        540 
VSLEIVDGLS GKITESSPFK SGMSMASRLC KAAMLSRFNL LAKEAKKELL EAGTYHAAKC 

       550        560        570 
MSASYQEAKC KLKSYLQQHG YGSWIVKSPC IEQFNM 

« Hide

Isoform 2 [UniParc].

Checksum: CFF0F974AE08AFD8
Show »

FASTA56562,847
Isoform 3 [UniParc].

Checksum: ABCF6E031C9300AF
Show »

FASTA55862,363

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057303 mRNA. Translation: BAB71416.1.
AK093297 mRNA. Translation: BAC04125.1.
AC022489 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05228.1.
CH471056 Genomic DNA. Translation: EAX05229.1.
CH471056 Genomic DNA. Translation: EAX05234.1.
CH471056 Genomic DNA. Translation: EAX05230.1.
CH471056 Genomic DNA. Translation: EAX05231.1.
CH471056 Genomic DNA. Translation: EAX05232.1.
BC040229 mRNA. Translation: AAH40229.1.
CCDSCCDS34058.1. [Q96M93-1]
CCDS54800.1. [Q96M93-2]
CCDS54801.1. [Q96M93-3]
RefSeqNP_001152757.1. NM_001159285.1. [Q96M93-2]
NP_001152767.1. NM_001159295.1. [Q96M93-3]
NP_640336.1. NM_139243.3. [Q96M93-1]
XP_005262798.1. XM_005262741.1. [Q96M93-1]
XP_005262799.1. XM_005262742.1. [Q96M93-1]
XP_005262800.1. XM_005262743.1. [Q96M93-1]
XP_005262801.1. XM_005262744.1. [Q96M93-2]
UniGeneHs.518957.

3D structure databases

ProteinModelPortalQ96M93.
SMRQ96M93. Positions 209-576.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000296513.

PTM databases

PhosphoSiteQ96M93.

Polymorphism databases

DMDM74732329.

Proteomic databases

PaxDbQ96M93.
PRIDEQ96M93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296513; ENSP00000296513; ENSG00000164113. [Q96M93-1]
ENST00000388724; ENSP00000373376; ENSG00000164113. [Q96M93-2]
ENST00000388725; ENSP00000373377; ENSG00000164113. [Q96M93-3]
GeneID132612.
KEGGhsa:132612.
UCSCuc003ieo.3. human. [Q96M93-1]
uc003iep.3. human. [Q96M93-2]

Organism-specific databases

CTD132612.
GeneCardsGC04P123300.
HGNCHGNC:30713. ADAD1.
HPAHPA044080.
MIM614130. gene.
neXtProtNX_Q96M93.
PharmGKBPA162375590.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309601.
HOGENOMHOG000033798.
HOVERGENHBG058021.
InParanoidQ96M93.
OMAWIVKSPC.
OrthoDBEOG7K0ZC7.
PhylomeDBQ96M93.
TreeFamTF315806.

Gene expression databases

ArrayExpressQ96M93.
BgeeQ96M93.
CleanExHS_ADAD1.
GenevestigatorQ96M93.

Family and domain databases

Gene3D3.30.160.20. 1 hit.
InterProIPR002466. A_deamin.
IPR014720. dsRNA-bd_dom.
[Graphical view]
PfamPF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
[Graphical view]
SMARTSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
[Graphical view]
PROSITEPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi132612.
NextBio83106.
PROQ96M93.
SOURCESearch...

Entry information

Entry nameADAD1_HUMAN
AccessionPrimary (citable) accession number: Q96M93
Secondary accession number(s): A6NKN4 expand/collapse secondary AC list , B7WPB0, D3DNX2, Q8IWG6, Q8NA06
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM