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Protein

Adenosine deaminase domain-containing protein 1

Gene

ADAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).By similarity

GO - Molecular functioni

  1. adenosine deaminase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. RNA processing Source: InterPro
  3. spermatid development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase domain-containing protein 1
Alternative name(s):
Testis nuclear RNA-binding protein
Gene namesi
Name:ADAD1
Synonyms:TENR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:30713. ADAD1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Adenosine deaminase domain-containing protein 1PRO_0000309520Add
BLAST

Proteomic databases

PaxDbiQ96M93.
PRIDEiQ96M93.

PTM databases

PhosphoSiteiQ96M93.

Expressioni

Gene expression databases

BgeeiQ96M93.
CleanExiHS_ADAD1.
ExpressionAtlasiQ96M93. baseline and differential.
GenevestigatoriQ96M93.

Organism-specific databases

HPAiHPA044080.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296513.

Structurei

3D structure databases

ProteinModelPortaliQ96M93.
SMRiQ96M93. Positions 209-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 16469DRBMPROSITE-ProRule annotationAdd
BLAST
Domaini249 – 574326A to I editasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ADAD family.Curated
Contains 1 A to I editase domain.PROSITE-ProRule annotation
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG309601.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000033798.
HOVERGENiHBG058021.
InParanoidiQ96M93.
OMAiCIEQFSM.
OrthoDBiEOG7K0ZC7.
PhylomeDBiQ96M93.
TreeFamiTF315806.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR002466. A_deamin.
IPR014720. dsRNA-bd_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96M93-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNNHWFQS SQVPSFAQML KKNLPVQPAT KTITTPTGWS SESYGLSKMA
60 70 80 90 100
SKVTQVTGNF PEPLLSKNLS SISNPVLPPK KIPKEFIMKY KRGEINPVSA
110 120 130 140 150
LHQFAQMQRV QLDLKETVTT GNVMGPYFAF CAVVDGIQYK TGLGQNKKES
160 170 180 190 200
RSNAAKLALD ELLQLDEPEP RILETSGPPP FPAEPVVLSE LAYVSKVHYE
210 220 230 240 250
GRHIQYAKIS QIVKERFNQL ISNRSEYLKY SSSLAAFIIE RAGQHEVVAI
260 270 280 290 300
GTGEYNYSQD IKPDGRVLHD THAVVTARRS LLRYFYRQLL LFYSKNPAMM
310 320 330 340 350
EKSIFCTEPT SNLLTLKQNI NICLYMNQLP KGSAQIKSQL RLNPHSISAF
360 370 380 390 400
EANEELCLHV AVEGKIYLTV YCPKDGVNRI SSMSSSDKLT RWEVLGVQGA
410 420 430 440 450
LLSHFIQPVY ISSILIGDGN CSDTRGLEIA IKQRVDDALT SKLPMFYLVN
460 470 480 490 500
RPHISLVPSA YPLQMNLEYK FLSLNWAQGD VSLEIVDGLS GKITESSPFK
510 520 530 540 550
SGMSMASRLC KAAMLSRFNL LAKEAKKELL EAGTYHAAKC MSASYQEAKC
560 570
KLKSYLQQHG YGSWIVKSPC IEQFNM
Length:576
Mass (Da):64,411
Last modified:December 1, 2001 - v1
Checksum:i379A6849ABDEEFAB
GO
Isoform 2 (identifier: Q96M93-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-293: Missing.

Show »
Length:565
Mass (Da):62,847
Checksum:iCFF0F974AE08AFD8
GO
Isoform 3 (identifier: Q96M93-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MASNNHWFQSSQVPSFAQM → M

Show »
Length:558
Mass (Da):62,363
Checksum:iABCF6E031C9300AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981H → Y in BAC04125. (PubMed:14702039)Curated
Sequence conflicti407 – 4071Q → R in BAC04125. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MASNN…SFAQM → M in isoform 3. 1 PublicationVSP_029225Add
BLAST
Alternative sequencei283 – 29311Missing in isoform 2. 1 PublicationVSP_029226Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057303 mRNA. Translation: BAB71416.1.
AK093297 mRNA. Translation: BAC04125.1.
AC022489 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05228.1.
CH471056 Genomic DNA. Translation: EAX05229.1.
CH471056 Genomic DNA. Translation: EAX05234.1.
CH471056 Genomic DNA. Translation: EAX05230.1.
CH471056 Genomic DNA. Translation: EAX05231.1.
CH471056 Genomic DNA. Translation: EAX05232.1.
BC040229 mRNA. Translation: AAH40229.1.
CCDSiCCDS34058.1. [Q96M93-1]
CCDS54800.1. [Q96M93-2]
CCDS54801.1. [Q96M93-3]
RefSeqiNP_001152757.1. NM_001159285.1. [Q96M93-2]
NP_001152767.1. NM_001159295.1. [Q96M93-3]
NP_640336.1. NM_139243.3. [Q96M93-1]
XP_005262798.1. XM_005262741.1. [Q96M93-1]
XP_005262799.1. XM_005262742.1. [Q96M93-1]
XP_005262800.1. XM_005262743.1. [Q96M93-1]
XP_005262801.1. XM_005262744.1. [Q96M93-2]
UniGeneiHs.518957.

Genome annotation databases

EnsembliENST00000296513; ENSP00000296513; ENSG00000164113. [Q96M93-1]
ENST00000388724; ENSP00000373376; ENSG00000164113. [Q96M93-2]
ENST00000388725; ENSP00000373377; ENSG00000164113. [Q96M93-3]
GeneIDi132612.
KEGGihsa:132612.
UCSCiuc003ieo.3. human. [Q96M93-1]
uc003iep.3. human. [Q96M93-2]

Polymorphism databases

DMDMi74732329.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057303 mRNA. Translation: BAB71416.1.
AK093297 mRNA. Translation: BAC04125.1.
AC022489 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05228.1.
CH471056 Genomic DNA. Translation: EAX05229.1.
CH471056 Genomic DNA. Translation: EAX05234.1.
CH471056 Genomic DNA. Translation: EAX05230.1.
CH471056 Genomic DNA. Translation: EAX05231.1.
CH471056 Genomic DNA. Translation: EAX05232.1.
BC040229 mRNA. Translation: AAH40229.1.
CCDSiCCDS34058.1. [Q96M93-1]
CCDS54800.1. [Q96M93-2]
CCDS54801.1. [Q96M93-3]
RefSeqiNP_001152757.1. NM_001159285.1. [Q96M93-2]
NP_001152767.1. NM_001159295.1. [Q96M93-3]
NP_640336.1. NM_139243.3. [Q96M93-1]
XP_005262798.1. XM_005262741.1. [Q96M93-1]
XP_005262799.1. XM_005262742.1. [Q96M93-1]
XP_005262800.1. XM_005262743.1. [Q96M93-1]
XP_005262801.1. XM_005262744.1. [Q96M93-2]
UniGeneiHs.518957.

3D structure databases

ProteinModelPortaliQ96M93.
SMRiQ96M93. Positions 209-576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296513.

PTM databases

PhosphoSiteiQ96M93.

Polymorphism databases

DMDMi74732329.

Proteomic databases

PaxDbiQ96M93.
PRIDEiQ96M93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296513; ENSP00000296513; ENSG00000164113. [Q96M93-1]
ENST00000388724; ENSP00000373376; ENSG00000164113. [Q96M93-2]
ENST00000388725; ENSP00000373377; ENSG00000164113. [Q96M93-3]
GeneIDi132612.
KEGGihsa:132612.
UCSCiuc003ieo.3. human. [Q96M93-1]
uc003iep.3. human. [Q96M93-2]

Organism-specific databases

CTDi132612.
GeneCardsiGC04P123300.
HGNCiHGNC:30713. ADAD1.
HPAiHPA044080.
MIMi614130. gene.
neXtProtiNX_Q96M93.
PharmGKBiPA162375590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG309601.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000033798.
HOVERGENiHBG058021.
InParanoidiQ96M93.
OMAiCIEQFSM.
OrthoDBiEOG7K0ZC7.
PhylomeDBiQ96M93.
TreeFamiTF315806.

Miscellaneous databases

GenomeRNAii132612.
NextBioi83106.
PROiQ96M93.
SOURCEiSearch...

Gene expression databases

BgeeiQ96M93.
CleanExiHS_ADAD1.
ExpressionAtlasiQ96M93. baseline and differential.
GenevestigatoriQ96M93.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR002466. A_deamin.
IPR014720. dsRNA-bd_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiADAD1_HUMAN
AccessioniPrimary (citable) accession number: Q96M93
Secondary accession number(s): A6NKN4
, B7WPB0, D3DNX2, Q8IWG6, Q8NA06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.