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Protein

Dynein heavy chain domain-containing protein 1

Gene

DNHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain domain-containing protein 1
Alternative name(s):
Dynein heavy chain domain 1-like protein
Protein CCDC35
Gene namesi
Name:DNHD1
Synonyms:C11orf47, CCDC35, DHCD1, DNHD1L
ORF Names:UNQ5781/PRO12970
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26532. DNHD1.

Subcellular locationi

GO - Cellular componenti

  • dynein complex Source: InterPro
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671968.

Polymorphism and mutation databases

BioMutaiDNHD1.
DMDMi300669633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 47534753Dynein heavy chain domain-containing protein 1PRO_0000311985Add
BLAST

Proteomic databases

EPDiQ96M86.
PaxDbiQ96M86.
PRIDEiQ96M86.

PTM databases

iPTMnetiQ96M86.
PhosphoSiteiQ96M86.

Expressioni

Gene expression databases

BgeeiQ96M86.
CleanExiHS_DNHD1.
ExpressionAtlasiQ96M86. baseline and differential.
GenevisibleiQ96M86. HS.

Organism-specific databases

HPAiHPA039698.

Interactioni

Protein-protein interaction databases

BioGridi126834. 5 interactions.
IntActiQ96M86. 1 interaction.
STRINGi9606.ENSP00000254579.

Structurei

3D structure databases

ProteinModelPortaliQ96M86.
SMRiQ96M86. Positions 1676-2146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili826 – 85833Sequence analysisAdd
BLAST
Coiled coili936 – 99156Sequence analysisAdd
BLAST
Coiled coili3125 – 3227103Sequence analysisAdd
BLAST
Coiled coili3590 – 365162Sequence analysisAdd
BLAST
Coiled coili4431 – 446030Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi886 – 89611Poly-ProAdd
BLAST
Compositional biasi2695 – 273238Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
ENOG410XZRW. LUCA.
GeneTreeiENSGT00670000098065.
HOGENOMiHOG000170725.
HOVERGENiHBG098330.
InParanoidiQ96M86.
OMAiLWLHEAQ.
OrthoDBiEOG7N63M6.
PhylomeDBiQ96M86.
TreeFamiTF337443.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR004273. Dynein_heavy_dom.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 8 hits.
PfamiPF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96M86-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPEERRVGL SSDETSSDSL KSWHSICVLD SKEQPLACQQ KQRQFVKPVT
60 70 80 90 100
ESEQPTVLEL LLAELRTLFS AVLQDSSPAA WRYLHAVLGL LPPYRELLVG
110 120 130 140 150
HLDLLPFLEQ LYCWAPWVQT HLHLDLLGAI VQAFPPDSSL LDSASHADCC
160 170 180 190 200
PQKRRLHHRP PCPACPFVQA QWSRQQVKEE LATWLRPLTL PELQRCLGIV
210 220 230 240 250
GAQVALEEAV WLDGLSLLPL ALAADIPVRY ESSDTDNAEV EPVGRKETRS
260 270 280 290 300
QLDYEVPREK AFQKSSTGFS PETSFLDSQV MTALKMERYL KKIHFLYLNV
310 320 330 340 350
APSRYFRPYS LMVVPPDKVN PEHYIFSPFG ILHVHPVEGS ETMTLGTWHH
360 370 380 390 400
HCVLWQQLQF IPFFKYCLLR KSFTCWKKNV RLQGLHRLQK FLENHLLLAV
410 420 430 440 450
PHFGAGLLHI SRLLQELHSV SWLPQELDRC YELLDLQTAL AEEKHKALRL
460 470 480 490 500
LHRCLNLCTS ILRLVHEDTY HMQQCLQERV QNCDRIRTGQ GSIYLQRVQH
510 520 530 540 550
KQLEQKLKQA EAWWLQLGKF ARLVDYMICQ SLISVLEEQI TSFVANILQA
560 570 580 590 600
PRQKPFLSSQ LVFDDHGQLS HVPCVENMIQ TLTGGLQSVK TSALQVVQSA
610 620 630 640 650
DLKTSSDSLY SEEEDEEEDS KDEFLMPKFQ GQPSDAVSIF CGPNVGLVWP
660 670 680 690 700
WKSHPIAGIL EVRGCRLRGQ YFPHNYKQLE EDLDNNPKIQ QALNIQQVLL
710 720 730 740 750
EGVLCKVQEF CREHHWITGI YEFLQSWGPQ KLEDMRGGPI KNYVTLVSRL
760 770 780 790 800
NVWQARVSSM PIELLTKGGL LLLSCHDVQA EMESKLNSIR KDILAHVQNE
810 820 830 840 850
CWNLSQQLMT ELTDFMHIFR TINSDIHAIA QCTQKLNEAN EQYVELEERM
860 870 880 890 900
EYVRALHELI RNHFSLFSAE NEALDISVRR QFGESPIPPC PPPPQPHLLH
910 920 930 940 950
CPLLAPQLLD MWEAFQFEKS QASEFLLSKR HAIMPKLQQL MAAALAELEG
960 970 980 990 1000
LLAKALSGPF MDPTQDQRST EHQLVSLERQ FQNTVSDLSE LHHAYAIFTE
1010 1020 1030 1040 1050
DETPVPLPIC GTRPIVQQQR IWHLYRVISE NISEWKCMAF AKFSPAMAQE
1060 1070 1080 1090 1100
KTEGWLTEAA RMSTTLELHS PVLQHCMRIL GEFRSYLPLL TKLGSLHPQS
1110 1120 1130 1140 1150
LNCQCLLRAL GLGSLQTIEL LTLGQLLTYP LLEFADRINQ VWQNENERIH
1160 1170 1180 1190 1200
AQETIRRLQR YWEARQLRLL NFILHVPYEP PASERSKRQV LRSPQWEVVD
1210 1220 1230 1240 1250
KDSGTFILSD YSNLQDSIQE SLQVLSKILA IEKSGDLNKI ALEWVAIMHG
1260 1270 1280 1290 1300
LGALLEVWLT FQQKWIFLNK VLHEMKIQFP NADLNSRFKV MDDQYRTLMR
1310 1320 1330 1340 1350
ISVADPMVLS LVVPSAERSP YFQGQQLQQL LQAGSVELEG IIMSLESVLY
1360 1370 1380 1390 1400
GVCAHFPRLF FLSDSELVAL LAARLESCEA QLWVRRCFPH VHAVSFRSCP
1410 1420 1430 1440 1450
TGEKNTDDWE SSPNTQTQVE ALAVLGAGGE EVKLQGPLPL HPDLPKWLAS
1460 1470 1480 1490 1500
LEKCLRLALV HMLQGCVAAR LARGPSLGEA LKQLPKQNKL YLQLYVQHWI
1510 1520 1530 1540 1550
DLVQAFPWQC VLVAEEVVWR AEMEEALLEW GTLAMVSMHM RKLEVLVNFM
1560 1570 1580 1590 1600
RAQRASQGGQ SLPSVRQTSL LSALLVMAVT HRDIAQLLEQ HQVSDLTDFH
1610 1620 1630 1640 1650
WVRQLKYHLG SPHIIPKSPL QSLKTIASSE PSLSPAACWI DVLGRSFLYN
1660 1670 1680 1690 1700
YEYLGPRLGP LPSLLPERPA LVLLLALEEV ACGTVLGPNG VGKRAIVNSL
1710 1720 1730 1740 1750
AQALGRQLVM LPCSPQIEAQ CLSNYLNGAL QGGAWLLLEK VHQLPPGLLS
1760 1770 1780 1790 1800
ALGQRLGELH HLYAPLYQEA SRNTSTIDPT QPQLLGSSFF EKHHVSVRLG
1810 1820 1830 1840 1850
YGCLLVLRAL SSAVPANLHL LLRPVALALP DLRQVAELTL LGAGMRDAFQ
1860 1870 1880 1890 1900
MATRLSKFFS LERELVSGPL PCRLPLLKQI LEDTIRTLNV TKEEPKCQKP
1910 1920 1930 1940 1950
RSLAAIEEAA LLRSPLFSIL NGLHLHNLRG LLCALFPSAS QVLAEPMTYK
1960 1970 1980 1990 2000
LMKPLVVEEL QQVGLDPSPD ILGSLEQLSQ ALSRASGILL LGPAGSGKTT
2010 2020 2030 2040 2050
CWHSLFKIQN RLAAMEDTST QGCQPVEITH LYPSGLSPQE FLGWLEGSCW
2060 2070 2080 2090 2100
HHGIFPKVLR AAGQCNNMGQ KRQTEESIGI QHWIICDGAS NGAWLDSITC
2110 2120 2130 2140 2150
LLSELPQLSL PSGQQIARPP GTFLLMEVAD TTGISPTVVG CCALVWCGGE
2160 2170 2180 2190 2200
QTWQCILSAL MASLPYEYRL QHRTVAELNH MAEVLVPATL RFLTCQGVSS
2210 2220 2230 2240 2250
LLQVHGQQAV CAGVAEVTSM ARILHSLLDL HLRLKEEKAP GPEDLSYSDP
2260 2270 2280 2290 2300
VAQSFRSSKS SFLNRSQVDS DDVPDKCREH LLAVSSFLFA LIWGFGAHLP
2310 2320 2330 2340 2350
SRFWPIFDTF IRDSISRLSN YPEPPPSALV FDLHVSPEDG TLVPFTGQYL
2360 2370 2380 2390 2400
SSHIKGTLGT FHPSIQTERL LYVVDLLLSG GQPVLLAGEA ATGKSAFVEV
2410 2420 2430 2440 2450
LVEPHHPYIY SPIHPAFSSS HLRLLLSRGI QGQTQASPQP GHHQDSKPSL
2460 2470 2480 2490 2500
LFLLEDLHLA TSDPEKSCQP VLETLRQAMD GTVYAHSTLE LQTLQPTVNF
2510 2520 2530 2540 2550
LATVTVPGYC ERPLCPRLFR LFTVLALESM TQATLLERHV PIIQAWLERF
2560 2570 2580 2590 2600
PSVERERALA RGLVRASVEA WEAVCNCFMP SPLHPHYHFS LHSVSHLLSS
2610 2620 2630 2640 2650
LQLLPNRTGS RGFVDYPNHQ EHLRRVSGLR GTCLTVMMAT RNVVRLWLHE
2660 2670 2680 2690 2700
AQRTFCDRLD SPRERSYCAK LLLVVAQSVF CCGPGPQHLG KDHQESEEEE
2710 2720 2730 2740 2750
EEERVPEVES EGELAQWEDF SNSNSETEEE EEPYGLQVAR VSNSRDPSLT
2760 2770 2780 2790 2800
PSIGPVSRGM KESISHKIRQ EKGTRASNYR LQVRRSFKTW WQKKPQMDLI
2810 2820 2830 2840 2850
SPLLLPVLLL HPQEKPSDLV FSQELILGPN SETPNLYLER QWEKLEEQLA
2860 2870 2880 2890 2900
TSAAQLKLSP HLARCHSMAQ HVARLVRVLA RPRQHGLLLS GALGTGRHTA
2910 2920 2930 2940 2950
ITLASSICQA HFFHLPSGSE EAILQCLRDA SWHAGMLSQP VALLVPSGVD
2960 2970 2980 2990 3000
LTTLHRLLAL ATSGSFPGQY TEADLDRIGE HLPRENLGVK QNIKKEMVLQ
3010 3020 3030 3040 3050
RFHQQVCSHL HLFFLIGDKQ AHKQLPSTLF LRLLQLATAS IDRYEPWDQA
3060 3070 3080 3090 3100
ALAKVAQHHL EGAQSVPLDD GSWKYPDLQA SIPSVAKAMA LIHLSATHYH
3110 3120 3130 3140 3150
EHLCPALPLV TPKTFLDFLD TFLMLQQQTI LKIKNKAQRV QNALENLRML
3160 3170 3180 3190 3200
IKEHGTHANL IFDLEQQLKD SGKSLSMFQQ QLEQSKLLYK QQLEECRHQE
3210 3220 3230 3240 3250
NLIENLARQR DALQAQREAF LEQMSKAFLE PLSQLQVADF EEIRSYRAPP
3260 3270 3280 3290 3300
ESVVRVTDAM CDLFHHETGW ASAKQLLCTE DFYQELVFFP KEKITDSELI
3310 3320 3330 3340 3350
KLHLILKAPG MDDAALRAVS RPAASLAAWL WAVLHYGLAH CRGLPTDLLL
3360 3370 3380 3390 3400
QQVEATLTRE QARLGYYQFQ AQETLEHNLA LAKMVEDAQA SHNCVAKTLS
3410 3420 3430 3440 3450
QAQCGQYHKW PMKAALLTPM RAWTTQLQKL KGRCMTVFGD TLLCSAAIIY
3460 3470 3480 3490 3500
LGPFPPLRRQ ELLDEWLALC RGFQEALGPD DVAQALKRKQ KSVSIPPKNP
3510 3520 3530 3540 3550
LLATHSPFSI LSLLSSESEQ YQWDGNLKPQ AKSAHLAGLL LRSPTHYSSC
3560 3570 3580 3590 3600
RWPLLLDPSN EALIWLDPLP LEENRSFAPA LTEGRGKGLM RNQKRESKTD
3610 3620 3630 3640 3650
MKEEDDESEE SNEAEDQTKE QKAEERKNEQ EKEQEENEEK EEEKTESQGS
3660 3670 3680 3690 3700
KPAYETQLPS LPYLSVLSGA DPELGSQLQE AAACGLPVLL TNVELGLGCE
3710 3720 3730 3740 3750
ELQWLLQREQ LSPPQVQPGF CLYLSTTLSL CAMEKVLGCE LLKGLNVLDL
3760 3770 3780 3790 3800
GLNMEILEEQ MLHEILCREY PELETRWQDL KIRALDTCKA VEAAEERLLT
3810 3820 3830 3840 3850
MLLFQNPKRQ KPAKFLRNIV RAQGKLCQLR AHCEELEGQK LQEMVLWAPY
3860 3870 3880 3890 3900
RPVVWHGMAM VKALSQLQNL LPLFCMSPEN WLAVTKQALD SMKPREINHG
3910 3920 3930 3940 3950
EDLASHLLQL RAHLTRQLLG STVTALGLTQ VPLVGALGAL ALLQATGKAS
3960 3970 3980 3990 4000
ELERLALWPG LAASPSTVHS KPVSDVARPA WLGPKAWHEC EMLELLPPFV
4010 4020 4030 4040 4050
GLCASLAGHS SAWQAYLSLS STVLGPAPGP GPEPLSLLQK LILWRVLRPE
4060 4070 4080 4090 4100
CLAGALADFT TSLLGRPLDE NTYAPTMPFK HSQATQPMLI LLPPPGHPSA
4110 4120 4130 4140 4150
TLHPLTVIQK LAAKYQQGQK QLQVIALGSE AWDPVSVVVS TLSQAMYEGH
4160 4170 4180 4190 4200
WLVLDNCHLM PHWPKELLQL LLELLGRAKV VADLESEQLL DQPESRNVST
4210 4220 4230 4240 4250
VHRDFRLWLI VPAESSASLP AVLTQHSMPV FWNQSLELGH VLIDSVELAQ
4260 4270 4280 4290 4300
QVLYMQPPTQ ALPLLLLHGL LLHRQLYGTR LQAHRGRWSQ VTLTQVLQTQ
4310 4320 4330 4340 4350
DQLWASLSNP RAAMQELAAS VFYGGPLGDT EDREALISLT QACLSPSSGS
4360 4370 4380 4390 4400
WVQPHTPQSL LATLMPLPEL RELDAMAECK AQMHLLPSPP EPRLCGLSEG
4410 4420 4430 4440 4450
PQAWLLRRQS RALLSALQRS SPVWVPESRR GAQLAERRLR QRLVQVNRRL
4460 4470 4480 4490 4500
ESLQDLLTHV IRQDESDAPW SVLGPNARRP LEGVLETEAL ELSQLVGTLQ
4510 4520 4530 4540 4550
RDLDCLLQQL KGAPPCPSRR CAAVAHALWT GRLPLPWRPH APAGPQPPWH
4560 4570 4580 4590 4600
WLRQLSRRGQ LLVRYLGVGA DASSDVPERV FHLSAFRHPR RLLLALRGEA
4610 4620 4630 4640 4650
ALDQNVPSSN FPGSRGSVSS QLQYKRLEMN SNPLHFRVEN GPNPTVPERG
4660 4670 4680 4690 4700
LLLIGLQVLH AEWDPIAGAL QDSPSSQPSP LPPVSISTQA PGTSDLPAPA
4710 4720 4730 4740 4750
DLTVYSCPVY MGGPLGTAKL QSRNIVMHLP LPTKLTPNTC VQRRVHVCSP

PLS
Length:4,753
Mass (Da):533,644
Last modified:July 13, 2010 - v2
Checksum:iADAB572B9861759B
GO
Isoform 2 (identifier: Q96M86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     597-597: V → F
     598-4753: Missing.

Show »
Length:597
Mass (Da):68,617
Checksum:i2DE1521BBDF5C31C
GO
Isoform 3 (identifier: Q96M86-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-311: Missing.
     597-597: V → F
     598-4753: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):33,338
Checksum:iF69CEF2124C00C11
GO

Sequence cautioni

The sequence AAQ89130.1 differs from that shown. Reason: Frameshift at position 637. Curated
The sequence BAB85004.1 differs from that shown.Intron retention.Curated
The sequence CAB70845.1 differs from that shown.Intron retention.Curated
The sequence EAW68692.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1312 – 13121V → P in BAB85004 (PubMed:12693554).Curated
Sequence conflicti1909 – 19091A → AALLH in BAB85004 (PubMed:12693554).Curated
Sequence conflicti1909 – 19091A → AALLH in CAB70845 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti240 – 2401V → E.
Corresponds to variant rs2555158 [ dbSNP | Ensembl ].
VAR_039308
Natural varianti279 – 2791Q → P.
Corresponds to variant rs11605196 [ dbSNP | Ensembl ].
VAR_056829
Natural varianti317 – 3171D → N.
Corresponds to variant rs2555152 [ dbSNP | Ensembl ].
VAR_039309
Natural varianti403 – 4031F → L.
Corresponds to variant rs11040904 [ dbSNP | Ensembl ].
VAR_056830
Natural varianti418 – 4181H → Y.
Corresponds to variant rs4758423 [ dbSNP | Ensembl ].
VAR_039310
Natural varianti560 – 5601Q → E.
Corresponds to variant rs11603869 [ dbSNP | Ensembl ].
VAR_039311
Natural varianti1358 – 13581R → C.
Corresponds to variant rs12574381 [ dbSNP | Ensembl ].
VAR_033353
Natural varianti1896 – 18961K → N.
Corresponds to variant rs16915277 [ dbSNP | Ensembl ].
VAR_033354
Natural varianti2041 – 20411F → L.
Corresponds to variant rs11825154 [ dbSNP | Ensembl ].
VAR_033355
Natural varianti3830 – 38301R → H.
Corresponds to variant rs10769699 [ dbSNP | Ensembl ].
VAR_037388
Natural varianti4666 – 46661I → T.
Corresponds to variant rs11604362 [ dbSNP | Ensembl ].
VAR_037389

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 311311Missing in isoform 3. 1 PublicationVSP_040682Add
BLAST
Alternative sequencei597 – 5971V → F in isoform 2 and isoform 3. 2 PublicationsVSP_040683
Alternative sequencei598 – 47534156Missing in isoform 2 and isoform 3. 2 PublicationsVSP_040684Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057314 mRNA. Translation: BAB71423.1.
AK093028 mRNA. Translation: BAC04023.1.
BC111765 mRNA. Translation: AAI11766.1.
BC117301 mRNA. Translation: AAI17302.1.
BC117303 mRNA. Translation: AAI17304.1.
AC009796 Genomic DNA. No translation available.
AC084337 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68692.1. Sequence problems.
CH471064 Genomic DNA. Translation: EAW68702.1.
AK074178 mRNA. Translation: BAB85004.1. Sequence problems.
AL137619 mRNA. Translation: CAB70845.1. Sequence problems.
AY358770 mRNA. Translation: AAQ89130.1. Frameshift.
CCDSiCCDS44532.1. [Q96M86-3]
CCDS7767.1. [Q96M86-4]
PIRiT46462.
RefSeqiNP_653267.2. NM_144666.2. [Q96M86-3]
NP_775860.3. NM_173589.3. [Q96M86-4]
UniGeneiHs.720080.

Genome annotation databases

EnsembliENST00000254579; ENSP00000254579; ENSG00000179532. [Q96M86-3]
ENST00000354685; ENSP00000346716; ENSG00000179532. [Q96M86-4]
ENST00000527990; ENSP00000436180; ENSG00000179532. [Q96M86-3]
GeneIDi144132.
KEGGihsa:144132.
UCSCiuc001mdp.4. human. [Q96M86-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057314 mRNA. Translation: BAB71423.1.
AK093028 mRNA. Translation: BAC04023.1.
BC111765 mRNA. Translation: AAI11766.1.
BC117301 mRNA. Translation: AAI17302.1.
BC117303 mRNA. Translation: AAI17304.1.
AC009796 Genomic DNA. No translation available.
AC084337 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68692.1. Sequence problems.
CH471064 Genomic DNA. Translation: EAW68702.1.
AK074178 mRNA. Translation: BAB85004.1. Sequence problems.
AL137619 mRNA. Translation: CAB70845.1. Sequence problems.
AY358770 mRNA. Translation: AAQ89130.1. Frameshift.
CCDSiCCDS44532.1. [Q96M86-3]
CCDS7767.1. [Q96M86-4]
PIRiT46462.
RefSeqiNP_653267.2. NM_144666.2. [Q96M86-3]
NP_775860.3. NM_173589.3. [Q96M86-4]
UniGeneiHs.720080.

3D structure databases

ProteinModelPortaliQ96M86.
SMRiQ96M86. Positions 1676-2146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126834. 5 interactions.
IntActiQ96M86. 1 interaction.
STRINGi9606.ENSP00000254579.

PTM databases

iPTMnetiQ96M86.
PhosphoSiteiQ96M86.

Polymorphism and mutation databases

BioMutaiDNHD1.
DMDMi300669633.

Proteomic databases

EPDiQ96M86.
PaxDbiQ96M86.
PRIDEiQ96M86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254579; ENSP00000254579; ENSG00000179532. [Q96M86-3]
ENST00000354685; ENSP00000346716; ENSG00000179532. [Q96M86-4]
ENST00000527990; ENSP00000436180; ENSG00000179532. [Q96M86-3]
GeneIDi144132.
KEGGihsa:144132.
UCSCiuc001mdp.4. human. [Q96M86-3]

Organism-specific databases

CTDi144132.
GeneCardsiDNHD1.
HGNCiHGNC:26532. DNHD1.
HPAiHPA039698.
neXtProtiNX_Q96M86.
PharmGKBiPA142671968.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
ENOG410XZRW. LUCA.
GeneTreeiENSGT00670000098065.
HOGENOMiHOG000170725.
HOVERGENiHBG098330.
InParanoidiQ96M86.
OMAiLWLHEAQ.
OrthoDBiEOG7N63M6.
PhylomeDBiQ96M86.
TreeFamiTF337443.

Miscellaneous databases

ChiTaRSiDNHD1. human.
GenomeRNAii144132.
NextBioi84846.
PROiQ96M86.

Gene expression databases

BgeeiQ96M86.
CleanExiHS_DNHD1.
ExpressionAtlasiQ96M86. baseline and differential.
GenevisibleiQ96M86. HS.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR004273. Dynein_heavy_dom.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 8 hits.
PfamiPF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3733-4753 (ISOFORM 1).
    Tissue: Spleen and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3699-4753 (ISOFORM 1).
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1312-2302 (ISOFORM 1).
    Tissue: Spleen.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1702-2302 (ISOFORM 1).
    Tissue: Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4175-4753 (ISOFORM 1).

Entry informationi

Entry nameiDNHD1_HUMAN
AccessioniPrimary (citable) accession number: Q96M86
Secondary accession number(s): Q2NKK8
, Q6UWI9, Q8NAA2, Q8TEE6, Q9NSZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 13, 2010
Last modified: March 16, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.