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Protein

Leucine-rich repeat and guanylate kinase domain-containing protein

Gene

LRGUK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi421 – 4288ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and guanylate kinase domain-containing protein
Gene namesi
Name:LRGUK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21964. LRGUK.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesicleacrosome By similarity

  • Note: Localizes to the acrosome-acroplaxome-manchette-tail axis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394330.

Polymorphism and mutation databases

BioMutaiLRGUK.
DMDMi74732316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 825825Leucine-rich repeat and guanylate kinase domain-containing proteinPRO_0000326408Add
BLAST

Proteomic databases

PaxDbiQ96M69.
PRIDEiQ96M69.

PTM databases

iPTMnetiQ96M69.
PhosphoSiteiQ96M69.

Expressioni

Gene expression databases

BgeeiQ96M69.
CleanExiHS_LRGUK.
GenevisibleiQ96M69. HS.

Organism-specific databases

HPAiHPA021275.
HPA024584.
HPA029505.
HPA029506.

Interactioni

Subunit structurei

Interacts with HOOK2.By similarity

Protein-protein interaction databases

IntActiQ96M69. 1 interaction.
STRINGi9606.ENSP00000285928.

Structurei

3D structure databases

ProteinModelPortaliQ96M69.
SMRiQ96M69. Positions 132-372, 417-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati129 – 14921LRR 1Add
BLAST
Repeati150 – 17122LRR 2Add
BLAST
Repeati172 – 19322LRR 3Add
BLAST
Repeati194 – 21522LRR 4Add
BLAST
Repeati216 – 23722LRR 5Add
BLAST
Repeati238 – 25922LRR 6Add
BLAST
Repeati260 – 28021LRR 7Add
BLAST
Repeati281 – 30222LRR 8Add
BLAST
Repeati303 – 32422LRR 9Add
BLAST
Domaini337 – 37539LRRCTAdd
BLAST
Domaini414 – 597184Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
KOG0707. Eukaryota.
COG0194. LUCA.
COG4886. LUCA.
GeneTreeiENSGT00840000129809.
HOGENOMiHOG000113379.
HOVERGENiHBG108326.
InParanoidiQ96M69.
OMAiNQISEMC.
OrthoDBiEOG761BT3.
PhylomeDBiQ96M69.
TreeFamiTF329158.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
3.80.10.10. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96M69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSERALLR TRAASLLRGL GRSRTGARSL QFRAEKERQP CWSFPMGQKT
60 70 80 90 100
KGSSNIASSY LLQQLMHRYQ ELDSDGDEDQ GEGEAGSEES SESEMLNLEE
110 120 130 140 150
EFDGVLREEA VAKALHHLGR SGSGTEQVYL NLTLSGCNLI DVSILCGYVH
160 170 180 190 200
LQKLDLSANK IEDLSCVSCM PYLLELNASQ NNLTTFFNFK PPKNLKKADF
210 220 230 240 250
SHNQISEICD LSAYHALTKL ILDGNEIEEI SGLEMCNNLI HLSLANNKIT
260 270 280 290 300
TINGLNKLPI KILCLSNNQI EMITGLEDLK ALQNLDLSHN QISSLQGLEN
310 320 330 340 350
HDLLEVINLE DNKIAELREI EYIKNLPILR VLNLLENPIQ EKSEYWFFVI
360 370 380 390 400
FMLLRLTELD QKKIKVEEKV SAVNKYDPPP EVVAAQDHLT HVVNSVMQPQ
410 420 430 440 450
RIFDSTLPSL DAPYPMLILA GPEACGKREL AHRLCRQFST YFRYGACHTT
460 470 480 490 500
RPPYFGEGDR VDYHFISQDV FDEMVNMGKF ILTFSYGNHK YGLNRDTVEG
510 520 530 540 550
IARDGLASCI HMEIEGVRSL KYSYFEPRYI LVVPMNKEKY EGYLRRKGLF
560 570 580 590 600
SRAEIEFAVS RVDLYIKINQ NFPGYFDEVI NADDLDVAYQ KLSQLIREYL
610 620 630 640 650
GLTEEPAKSL ATTADVKTSH LKPEAHPTKY ISSNMGDFLH STDRNYLIKF
660 670 680 690 700
WAKLSAKKTP AERDSIHRQH EAARQALMGR IRPDHTLLFQ RGPVPAPLTS
710 720 730 740 750
GLHYYTTLEE LWKSFDLCED YFKPPFGPYP EKSGKDSLVS MKCSLFRFCP
760 770 780 790 800
WSKELPFQPP EGSISSHLGS GASDSETEET RKALPIQSFS HEKESHQHRQ
810 820
HSVPVISRPG SNVKPTLPPI PQGRR
Length:825
Mass (Da):93,618
Last modified:December 1, 2001 - v1
Checksum:i3A66F149DFE15E2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti606 – 6061P → L in AAI04900 (PubMed:15489334).Curated
Sequence conflicti606 – 6061P → L in AAI04898 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti302 – 3021D → Y.
Corresponds to variant rs17167553 [ dbSNP | Ensembl ].
VAR_040063
Natural varianti661 – 6611A → V.
Corresponds to variant rs35149449 [ dbSNP | Ensembl ].
VAR_040064

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057348 mRNA. Translation: BAB71441.1.
CH236950 Genomic DNA. Translation: EAL24072.1.
CH471070 Genomic DNA. Translation: EAW83807.1.
BC104897 mRNA. Translation: AAI04898.1.
BC104899 mRNA. Translation: AAI04900.1.
CCDSiCCDS5830.1.
RefSeqiNP_653249.1. NM_144648.1.
UniGeneiHs.149774.

Genome annotation databases

EnsembliENST00000285928; ENSP00000285928; ENSG00000155530.
GeneIDi136332.
KEGGihsa:136332.
UCSCiuc003vrm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057348 mRNA. Translation: BAB71441.1.
CH236950 Genomic DNA. Translation: EAL24072.1.
CH471070 Genomic DNA. Translation: EAW83807.1.
BC104897 mRNA. Translation: AAI04898.1.
BC104899 mRNA. Translation: AAI04900.1.
CCDSiCCDS5830.1.
RefSeqiNP_653249.1. NM_144648.1.
UniGeneiHs.149774.

3D structure databases

ProteinModelPortaliQ96M69.
SMRiQ96M69. Positions 132-372, 417-598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96M69. 1 interaction.
STRINGi9606.ENSP00000285928.

PTM databases

iPTMnetiQ96M69.
PhosphoSiteiQ96M69.

Polymorphism and mutation databases

BioMutaiLRGUK.
DMDMi74732316.

Proteomic databases

PaxDbiQ96M69.
PRIDEiQ96M69.

Protocols and materials databases

DNASUi136332.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285928; ENSP00000285928; ENSG00000155530.
GeneIDi136332.
KEGGihsa:136332.
UCSCiuc003vrm.2. human.

Organism-specific databases

CTDi136332.
GeneCardsiLRGUK.
HGNCiHGNC:21964. LRGUK.
HPAiHPA021275.
HPA024584.
HPA029505.
HPA029506.
MIMi616478. gene.
neXtProtiNX_Q96M69.
PharmGKBiPA162394330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
KOG0707. Eukaryota.
COG0194. LUCA.
COG4886. LUCA.
GeneTreeiENSGT00840000129809.
HOGENOMiHOG000113379.
HOVERGENiHBG108326.
InParanoidiQ96M69.
OMAiNQISEMC.
OrthoDBiEOG761BT3.
PhylomeDBiQ96M69.
TreeFamiTF329158.

Miscellaneous databases

GenomeRNAii136332.
NextBioi83586.
PROiQ96M69.
SOURCEiSearch...

Gene expression databases

BgeeiQ96M69.
CleanExiHS_LRGUK.
GenevisibleiQ96M69. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
3.80.10.10. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS51450. LRR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiLRGUK_HUMAN
AccessioniPrimary (citable) accession number: Q96M69
Secondary accession number(s): Q2M3I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.