Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanoma-associated antigen B18

Gene

MAGEB18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176774-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B18
Alternative name(s):
MAGE-B18 antigen
Gene namesi
Name:MAGEB18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28515. MAGEB18.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176774.
PharmGKBiPA142671483.

Polymorphism and mutation databases

BioMutaiMAGEB18.
DMDMi296435512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567191 – 343Melanoma-associated antigen B18Add BLAST343

Proteomic databases

MaxQBiQ96M61.
PaxDbiQ96M61.
PeptideAtlasiQ96M61.
PRIDEiQ96M61.

PTM databases

iPTMnetiQ96M61.
PhosphoSitePlusiQ96M61.

Expressioni

Gene expression databases

BgeeiENSG00000176774.
CleanExiHS_MAGEB18.
GenevisibleiQ96M61. HS.

Organism-specific databases

HPAiHPA046141.
HPA050600.

Interactioni

Subunit structurei

Interacts with LNX1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CTAGE5O153203EBI-741835,EBI-1050253
GABPB1Q065473EBI-741835,EBI-618165
LNX1Q8TBB111EBI-741835,EBI-739832
TNIP1Q150255EBI-741835,EBI-357849

Protein-protein interaction databases

BioGridi130398. 8 interactors.
IntActiQ96M61. 8 interactors.
MINTiMINT-1459358.
STRINGi9606.ENSP00000314543.

Structurei

3D structure databases

ProteinModelPortaliQ96M61.
SMRiQ96M61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 306MAGEPROSITE-ProRule annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 343Interaction with LNX11 PublicationAdd BLAST244

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ96M61.
OMAiHMELAFG.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ96M61.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96M61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRHQARC ENQDLGATQA TVAEGESPSP AYLLFGDRPQ
60 70 80 90 100
NLPAAETPSI PEALQGAPST TNAIAPVSCS SNEGASSQDE KSLGSSREAE
110 120 130 140 150
GWKEDPLNKK VVSLVHFLLQ KYETKEPITK GDMIKFVIRK DKCHFNEILK
160 170 180 190 200
RASEHMELAL GVDLKEVDPI RHYYAFFSKL DLTYDETTSD EEKIPKTGLL
210 220 230 240 250
MIALGVIFLN GNRAPEEAVW EIMNMMGVYA DRKHFLYGDP RKVMTKDLVQ
260 270 280 290 300
LKYLEYQQVP NSDPPRYEFL WGPRAHAETS KMKVLEFVAK IHDTVPSAFP
310 320 330 340
SCYEEALRDE EQRTQARAAA RAHTAAMANA RSRTTSSSFS HAK
Length:343
Mass (Da):38,533
Last modified:May 18, 2010 - v2
Checksum:i58549E2E1D285B14
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05350040P → S.2 PublicationsCorresponds to variant rs5944317dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057361 mRNA. Translation: BAB71450.1.
AC129850 Genomic DNA. No translation available.
BC029525 mRNA. Translation: AAH29525.1.
CCDSiCCDS14216.1.
RefSeqiNP_775970.1. NM_173699.3.
UniGeneiHs.350683.

Genome annotation databases

EnsembliENST00000325250; ENSP00000314543; ENSG00000176774.
GeneIDi286514.
KEGGihsa:286514.
UCSCiuc004dbq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057361 mRNA. Translation: BAB71450.1.
AC129850 Genomic DNA. No translation available.
BC029525 mRNA. Translation: AAH29525.1.
CCDSiCCDS14216.1.
RefSeqiNP_775970.1. NM_173699.3.
UniGeneiHs.350683.

3D structure databases

ProteinModelPortaliQ96M61.
SMRiQ96M61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130398. 8 interactors.
IntActiQ96M61. 8 interactors.
MINTiMINT-1459358.
STRINGi9606.ENSP00000314543.

PTM databases

iPTMnetiQ96M61.
PhosphoSitePlusiQ96M61.

Polymorphism and mutation databases

BioMutaiMAGEB18.
DMDMi296435512.

Proteomic databases

MaxQBiQ96M61.
PaxDbiQ96M61.
PeptideAtlasiQ96M61.
PRIDEiQ96M61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325250; ENSP00000314543; ENSG00000176774.
GeneIDi286514.
KEGGihsa:286514.
UCSCiuc004dbq.3. human.

Organism-specific databases

CTDi286514.
GeneCardsiMAGEB18.
HGNCiHGNC:28515. MAGEB18.
HPAiHPA046141.
HPA050600.
neXtProtiNX_Q96M61.
OpenTargetsiENSG00000176774.
PharmGKBiPA142671483.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ96M61.
OMAiHMELAFG.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ96M61.
TreeFamiTF328505.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176774-MONOMER.

Miscellaneous databases

GenomeRNAii286514.
PROiQ96M61.

Gene expression databases

BgeeiENSG00000176774.
CleanExiHS_MAGEB18.
GenevisibleiQ96M61. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGBI_HUMAN
AccessioniPrimary (citable) accession number: Q96M61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.