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Protein

Protein TBATA

Gene

TBATA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TBATA
Alternative name(s):
Protein SPATIAL
Stromal protein associated with thymii and lymph node homolog
Thymus, brain and testes-associated protein
Gene namesi
Name:TBATA
Synonyms:C10orf27, SPATIAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23511. TBATA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi219793.
OpenTargetsiENSG00000166220.
PharmGKBiPA134924486.

Polymorphism and mutation databases

BioMutaiTBATA.
DMDMi317373509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897861 – 351Protein TBATAAdd BLAST351

Proteomic databases

PaxDbiQ96M53.
PRIDEiQ96M53.

PTM databases

iPTMnetiQ96M53.
PhosphoSitePlusiQ96M53.

Expressioni

Gene expression databases

BgeeiENSG00000166220.
CleanExiHS_C10orf27.
ExpressionAtlasiQ96M53. baseline and differential.
GenevisibleiQ96M53. HS.

Organism-specific databases

HPAiHPA040089.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299290.

Structurei

3D structure databases

ProteinModelPortaliQ96M53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TBATA family.Curated

Phylogenomic databases

eggNOGiENOG410IXP6. Eukaryota.
ENOG4111YVM. LUCA.
GeneTreeiENSGT00510000048896.
HOVERGENiHBG106634.
InParanoidiQ96M53.
PhylomeDBiQ96M53.
TreeFamiTF333401.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96M53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATDVQLADY PLMSPKAELK LEKKSGRKPR SPRDSGPQKE LVIPGIVDFE
60 70 80 90 100
RIRRALRTPK PQTPGTYCFG RLSHHSFFSR HHPHPQHVTH IQDLTGKPVC
110 120 130 140 150
VVRDFPAPLP ESTVFSGCQM GIPTISVPIG DPQSNRNPQL SSEAWKKELK
160 170 180 190 200
ELASRVAFLT KEDELKKKEK EQKEEPLREQ GAKYSAETGR LIPASTRAVG
210 220 230 240 250
RRRSHQGQQS QSSSRHEGVQ AFLLQDQELL VLELLCRILE TDLLSAIQFW
260 270 280 290 300
LLYAPPKEKD LALGLLQTAV AQLLPQPLVS IPTEKLLSQL PEVHEPPQEK
310 320 330 340 350
QEPPCSQSPK KTKISPFTKS EKPEYIGEAQ VLQMHSSQNT EKKTSKPRAE

S
Length:351
Mass (Da):39,460
Last modified:January 11, 2011 - v3
Checksum:iBF0368B1FCA9179E
GO
Isoform 2 (identifier: Q96M53-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-250: VLELLCRILETDLLSAIQFW → KKTSLWDSCRQQWLSSFPSP
     251-351: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):28,274
Checksum:i7746F653D8CCD517
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9D → G in BAB71459 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022998237R → Q.3 PublicationsCorresponds to variant rs2254174dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035483231 – 250VLELL…AIQFW → KKTSLWDSCRQQWLSSFPSP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_035484251 – 351Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057382 mRNA. Translation: BAB71459.1.
AL358817 Genomic DNA. Translation: CAI13855.1.
CH471083 Genomic DNA. Translation: EAW54411.1.
BC137543 mRNA. Translation: AAI37544.1.
BC137544 mRNA. Translation: AAI37545.1.
BC139728 mRNA. Translation: AAI39729.1.
CCDSiCCDS7308.1. [Q96M53-1]
RefSeqiNP_001305171.1. NM_001318242.1. [Q96M53-1]
NP_689923.3. NM_152710.3. [Q96M53-1]
UniGeneiHs.386698.

Genome annotation databases

EnsembliENST00000299290; ENSP00000299290; ENSG00000166220. [Q96M53-1]
GeneIDi219793.
KEGGihsa:219793.
UCSCiuc001jrj.1. human. [Q96M53-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057382 mRNA. Translation: BAB71459.1.
AL358817 Genomic DNA. Translation: CAI13855.1.
CH471083 Genomic DNA. Translation: EAW54411.1.
BC137543 mRNA. Translation: AAI37544.1.
BC137544 mRNA. Translation: AAI37545.1.
BC139728 mRNA. Translation: AAI39729.1.
CCDSiCCDS7308.1. [Q96M53-1]
RefSeqiNP_001305171.1. NM_001318242.1. [Q96M53-1]
NP_689923.3. NM_152710.3. [Q96M53-1]
UniGeneiHs.386698.

3D structure databases

ProteinModelPortaliQ96M53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299290.

PTM databases

iPTMnetiQ96M53.
PhosphoSitePlusiQ96M53.

Polymorphism and mutation databases

BioMutaiTBATA.
DMDMi317373509.

Proteomic databases

PaxDbiQ96M53.
PRIDEiQ96M53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299290; ENSP00000299290; ENSG00000166220. [Q96M53-1]
GeneIDi219793.
KEGGihsa:219793.
UCSCiuc001jrj.1. human. [Q96M53-1]

Organism-specific databases

CTDi219793.
DisGeNETi219793.
GeneCardsiTBATA.
HGNCiHGNC:23511. TBATA.
HPAiHPA040089.
MIMi612640. gene.
neXtProtiNX_Q96M53.
OpenTargetsiENSG00000166220.
PharmGKBiPA134924486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXP6. Eukaryota.
ENOG4111YVM. LUCA.
GeneTreeiENSGT00510000048896.
HOVERGENiHBG106634.
InParanoidiQ96M53.
PhylomeDBiQ96M53.
TreeFamiTF333401.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166220-MONOMER.

Miscellaneous databases

GenomeRNAii219793.
PROiQ96M53.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166220.
CleanExiHS_C10orf27.
ExpressionAtlasiQ96M53. baseline and differential.
GenevisibleiQ96M53. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTBATA_HUMAN
AccessioniPrimary (citable) accession number: Q96M53
Secondary accession number(s): A4QPA8, B2RPQ2, Q5T4G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.