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Protein

Neuroblastoma breakpoint family member 4

Gene

NBPF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 4
Gene namesi
Name:NBPF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26550. NBPF4.

Subcellular locationi

  1. Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671284.

Polymorphism and mutation databases

BioMutaiNBPF4.
DMDMi374095427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Neuroblastoma breakpoint family member 4PRO_0000288039Add
BLAST

Proteomic databases

PaxDbiQ96M43.
PRIDEiQ96M43.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiQ96M43.
CleanExiHS_NBPF4.
ExpressionAtlasiQ96M43. baseline.
GenevestigatoriQ96M43.

Organism-specific databases

HPAiHPA045044.
HPA046411.
HPA047447.
HPA058050.

Structurei

3D structure databases

ProteinModelPortaliQ96M43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 26188NBPF 1PROSITE-ProRule annotationAdd
BLAST
Domaini326 – 39974NBPF 2PROSITE-ProRule annotationAdd
BLAST
Domaini400 – 503104NBPF 3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 4334Sequence AnalysisAdd
BLAST
Coiled coili69 – 11547Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 3 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG116348.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000170832.
HOVERGENiHBG108178.
InParanoidiQ96M43.
OMAiWGFTANT.
OrthoDBiEOG7GBFWV.
PhylomeDBiQ96M43.
TreeFamiTF341151.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 3 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96M43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSADPLSS ERAEMNILEI NQELRSQLAE SNQQFRDLKE KFLITQATAY
60 70 80 90 100
SLANQLKKYK CEEYKDIIDS VLRDELQSME KLAEKLRQAE ELRQYKALVH
110 120 130 140 150
SQAKELTQLR EKLREGRDAS RWLNKHLKTL LTPDDPDKSQ GQDLREQLAE
160 170 180 190 200
GHRLAEHLVH KLSPENDEDE DEDEDDKDEE VEKVQESPAP REVQKTEEKE
210 220 230 240 250
VPQDSLEECA VTCSNSHNPS NSNQPHRSTK ITFKEHEVDS ALVVESEHPH
260 270 280 290 300
DEEEEALNIP PENQNDHEEE EGKAPVPPRH HDKSNSYRHR EVSFLALDEQ
310 320 330 340 350
KVCSAQDVAR DYSNPKWDET SLGFLEKQSD LEEVKGQETV APRLSRGPLR
360 370 380 390 400
VDKHEIPQES LDGCCLTPSI LPDLTPSYHP YWSTLYSFED KQVSLALVDK
410 420 430 440 450
IKKDQEEIED QSPPCPRLSQ ELPEVKEQEV PEDSVNEVYL TPSVHHDVSD
460 470 480 490 500
CHQPYSSTLS SLEDQLACSA LDVASPTEAA CPQGTWSGDL SHHQSEVQVS
510 520 530 540 550
QAQLEPSTLV PSCLRLQLDQ GFHCGNGLAQ RGLSSTTCSF SANADSGNQW
560 570 580 590 600
PFQELVLEPS LGMKNPPQLE DDALEGSASN TQGRQVTGRI RASLVLILKT
610 620 630
IRRRLPFSKW RLAFRFAGPH AESAEIPNTA GRTQRMAG
Length:638
Mass (Da):72,053
Last modified:January 25, 2012 - v2
Checksum:iB0BA8313311D1DA8
GO

Sequence cautioni

The sequence BAB71469.1 differs from that shown.Aberrant splicing.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057395 mRNA. Translation: BAB71469.1. Sequence problems.
AK302318 mRNA. Translation: BAG63656.1.
AL359258 Genomic DNA. Translation: CAI14514.1.
CCDSiCCDS44182.1.
RefSeqiNP_001137461.1. NM_001143989.2.
UniGeneiHs.511849.

Genome annotation databases

EnsembliENST00000415641; ENSP00000389237; ENSG00000196427.
GeneIDi148545.
KEGGihsa:148545.
UCSCiuc009weo.2. human.

Polymorphism and mutation databases

BioMutaiNBPF4.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057395 mRNA. Translation: BAB71469.1. Sequence problems.
AK302318 mRNA. Translation: BAG63656.1.
AL359258 Genomic DNA. Translation: CAI14514.1.
CCDSiCCDS44182.1.
RefSeqiNP_001137461.1. NM_001143989.2.
UniGeneiHs.511849.

3D structure databases

ProteinModelPortaliQ96M43.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiNBPF4.
DMDMi374095427.

Proteomic databases

PaxDbiQ96M43.
PRIDEiQ96M43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415641; ENSP00000389237; ENSG00000196427.
GeneIDi148545.
KEGGihsa:148545.
UCSCiuc009weo.2. human.

Organism-specific databases

CTDi148545.
GeneCardsiGC01M108765.
H-InvDBHIX0000833.
HGNCiHGNC:26550. NBPF4.
HPAiHPA045044.
HPA046411.
HPA047447.
HPA058050.
MIMi613994. gene.
neXtProtiNX_Q96M43.
PharmGKBiPA142671284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116348.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000170832.
HOVERGENiHBG108178.
InParanoidiQ96M43.
OMAiWGFTANT.
OrthoDBiEOG7GBFWV.
PhylomeDBiQ96M43.
TreeFamiTF341151.

Miscellaneous databases

GenomeRNAii148545.
NextBioi85951.
PROiQ96M43.
SOURCEiSearch...

Gene expression databases

BgeeiQ96M43.
CleanExiHS_NBPF4.
ExpressionAtlasiQ96M43. baseline.
GenevestigatoriQ96M43.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 3 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Testis.
  3. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
    Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
    Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNBPF4_HUMAN
AccessioniPrimary (citable) accession number: Q96M43
Secondary accession number(s): Q5T483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 25, 2012
Last modified: April 29, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.