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Q96M43

- NBPF4_HUMAN

UniProt

Q96M43 - NBPF4_HUMAN

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Protein

Neuroblastoma breakpoint family member 4

Gene

NBPF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 4
Gene namesi
Name:NBPF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26550. NBPF4.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Neuroblastoma breakpoint family member 4PRO_0000288039Add
BLAST

Proteomic databases

PaxDbiQ96M43.
PRIDEiQ96M43.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiQ96M43.
CleanExiHS_NBPF4.
ExpressionAtlasiQ96M43. baseline.
GenevestigatoriQ96M43.

Structurei

3D structure databases

ProteinModelPortaliQ96M43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 26188NBPF 1PROSITE-ProRule annotationAdd
BLAST
Domaini326 – 39974NBPF 2PROSITE-ProRule annotationAdd
BLAST
Domaini400 – 503104NBPF 3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 4334Sequence AnalysisAdd
BLAST
Coiled coili69 – 11547Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 3 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG116348.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000170832.
HOVERGENiHBG108178.
InParanoidiQ96M43.
OMAiWGFTANT.
OrthoDBiEOG7GBFWV.
PhylomeDBiQ96M43.
TreeFamiTF341151.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 3 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96M43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVSADPLSS ERAEMNILEI NQELRSQLAE SNQQFRDLKE KFLITQATAY
60 70 80 90 100
SLANQLKKYK CEEYKDIIDS VLRDELQSME KLAEKLRQAE ELRQYKALVH
110 120 130 140 150
SQAKELTQLR EKLREGRDAS RWLNKHLKTL LTPDDPDKSQ GQDLREQLAE
160 170 180 190 200
GHRLAEHLVH KLSPENDEDE DEDEDDKDEE VEKVQESPAP REVQKTEEKE
210 220 230 240 250
VPQDSLEECA VTCSNSHNPS NSNQPHRSTK ITFKEHEVDS ALVVESEHPH
260 270 280 290 300
DEEEEALNIP PENQNDHEEE EGKAPVPPRH HDKSNSYRHR EVSFLALDEQ
310 320 330 340 350
KVCSAQDVAR DYSNPKWDET SLGFLEKQSD LEEVKGQETV APRLSRGPLR
360 370 380 390 400
VDKHEIPQES LDGCCLTPSI LPDLTPSYHP YWSTLYSFED KQVSLALVDK
410 420 430 440 450
IKKDQEEIED QSPPCPRLSQ ELPEVKEQEV PEDSVNEVYL TPSVHHDVSD
460 470 480 490 500
CHQPYSSTLS SLEDQLACSA LDVASPTEAA CPQGTWSGDL SHHQSEVQVS
510 520 530 540 550
QAQLEPSTLV PSCLRLQLDQ GFHCGNGLAQ RGLSSTTCSF SANADSGNQW
560 570 580 590 600
PFQELVLEPS LGMKNPPQLE DDALEGSASN TQGRQVTGRI RASLVLILKT
610 620 630
IRRRLPFSKW RLAFRFAGPH AESAEIPNTA GRTQRMAG
Length:638
Mass (Da):72,053
Last modified:January 25, 2012 - v2
Checksum:iB0BA8313311D1DA8
GO

Sequence cautioni

The sequence BAB71469.1 differs from that shown. Reason: Aberrant splicing.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057395 mRNA. Translation: BAB71469.1. Sequence problems.
AK302318 mRNA. Translation: BAG63656.1.
AL359258 Genomic DNA. Translation: CAI14514.1.
CCDSiCCDS44182.1.
RefSeqiNP_001137461.1. NM_001143989.2.
UniGeneiHs.511849.

Genome annotation databases

EnsembliENST00000415641; ENSP00000389237; ENSG00000196427.
GeneIDi148545.
KEGGihsa:148545.
UCSCiuc009weo.2. human.

Polymorphism databases

DMDMi374095427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057395 mRNA. Translation: BAB71469.1 . Sequence problems.
AK302318 mRNA. Translation: BAG63656.1 .
AL359258 Genomic DNA. Translation: CAI14514.1 .
CCDSi CCDS44182.1.
RefSeqi NP_001137461.1. NM_001143989.2.
UniGenei Hs.511849.

3D structure databases

ProteinModelPortali Q96M43.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 374095427.

Proteomic databases

PaxDbi Q96M43.
PRIDEi Q96M43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000415641 ; ENSP00000389237 ; ENSG00000196427 .
GeneIDi 148545.
KEGGi hsa:148545.
UCSCi uc009weo.2. human.

Organism-specific databases

CTDi 148545.
GeneCardsi GC01M108765.
H-InvDB HIX0000833.
HGNCi HGNC:26550. NBPF4.
MIMi 613994. gene.
neXtProti NX_Q96M43.
PharmGKBi PA142671284.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116348.
GeneTreei ENSGT00420000029746.
HOGENOMi HOG000170832.
HOVERGENi HBG108178.
InParanoidi Q96M43.
OMAi WGFTANT.
OrthoDBi EOG7GBFWV.
PhylomeDBi Q96M43.
TreeFami TF341151.

Miscellaneous databases

GenomeRNAii 148545.
NextBioi 85951.
PROi Q96M43.
SOURCEi Search...

Gene expression databases

Bgeei Q96M43.
CleanExi HS_NBPF4.
ExpressionAtlasi Q96M43. baseline.
Genevestigatori Q96M43.

Family and domain databases

InterProi IPR010630. NBPF_dom.
[Graphical view ]
Pfami PF06758. DUF1220. 3 hits.
[Graphical view ]
PROSITEi PS51316. NBPF. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Testis.
  3. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
    Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
    Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNBPF4_HUMAN
AccessioniPrimary (citable) accession number: Q96M43
Secondary accession number(s): Q5T483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 25, 2012
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3