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Q96M43

- NBPF4_HUMAN

UniProt

Q96M43 - NBPF4_HUMAN

Protein

Neuroblastoma breakpoint family member 4

Gene

NBPF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (25 Jan 2012)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroblastoma breakpoint family member 4
    Gene namesi
    Name:NBPF4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26550. NBPF4.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671284.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638Neuroblastoma breakpoint family member 4PRO_0000288039Add
    BLAST

    Proteomic databases

    PaxDbiQ96M43.
    PRIDEiQ96M43.

    Expressioni

    Tissue specificityi

    Expressed in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ96M43.
    BgeeiQ96M43.
    CleanExiHS_NBPF4.
    GenevestigatoriQ96M43.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96M43.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 26188NBPF 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini326 – 39974NBPF 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 503104NBPF 3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili10 – 4334Sequence AnalysisAdd
    BLAST
    Coiled coili69 – 11547Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NBPF family.Curated
    Contains 3 NBPF domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG116348.
    HOGENOMiHOG000170832.
    HOVERGENiHBG108178.
    OMAiWGFTANT.
    OrthoDBiEOG7GBFWV.
    PhylomeDBiQ96M43.
    TreeFamiTF341151.

    Family and domain databases

    InterProiIPR010630. NBPF_dom.
    [Graphical view]
    PfamiPF06758. DUF1220. 3 hits.
    [Graphical view]
    PROSITEiPS51316. NBPF. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96M43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVSADPLSS ERAEMNILEI NQELRSQLAE SNQQFRDLKE KFLITQATAY    50
    SLANQLKKYK CEEYKDIIDS VLRDELQSME KLAEKLRQAE ELRQYKALVH 100
    SQAKELTQLR EKLREGRDAS RWLNKHLKTL LTPDDPDKSQ GQDLREQLAE 150
    GHRLAEHLVH KLSPENDEDE DEDEDDKDEE VEKVQESPAP REVQKTEEKE 200
    VPQDSLEECA VTCSNSHNPS NSNQPHRSTK ITFKEHEVDS ALVVESEHPH 250
    DEEEEALNIP PENQNDHEEE EGKAPVPPRH HDKSNSYRHR EVSFLALDEQ 300
    KVCSAQDVAR DYSNPKWDET SLGFLEKQSD LEEVKGQETV APRLSRGPLR 350
    VDKHEIPQES LDGCCLTPSI LPDLTPSYHP YWSTLYSFED KQVSLALVDK 400
    IKKDQEEIED QSPPCPRLSQ ELPEVKEQEV PEDSVNEVYL TPSVHHDVSD 450
    CHQPYSSTLS SLEDQLACSA LDVASPTEAA CPQGTWSGDL SHHQSEVQVS 500
    QAQLEPSTLV PSCLRLQLDQ GFHCGNGLAQ RGLSSTTCSF SANADSGNQW 550
    PFQELVLEPS LGMKNPPQLE DDALEGSASN TQGRQVTGRI RASLVLILKT 600
    IRRRLPFSKW RLAFRFAGPH AESAEIPNTA GRTQRMAG 638
    Length:638
    Mass (Da):72,053
    Last modified:January 25, 2012 - v2
    Checksum:iB0BA8313311D1DA8
    GO

    Sequence cautioni

    The sequence BAB71469.1 differs from that shown. Reason: Aberrant splicing.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057395 mRNA. Translation: BAB71469.1. Sequence problems.
    AK302318 mRNA. Translation: BAG63656.1.
    AL359258 Genomic DNA. Translation: CAI14514.1.
    CCDSiCCDS44182.1.
    RefSeqiNP_001137461.1. NM_001143989.2.
    UniGeneiHs.511849.

    Genome annotation databases

    EnsembliENST00000415641; ENSP00000389237; ENSG00000196427.
    GeneIDi148545.
    KEGGihsa:148545.
    UCSCiuc009weo.2. human.

    Polymorphism databases

    DMDMi374095427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057395 mRNA. Translation: BAB71469.1 . Sequence problems.
    AK302318 mRNA. Translation: BAG63656.1 .
    AL359258 Genomic DNA. Translation: CAI14514.1 .
    CCDSi CCDS44182.1.
    RefSeqi NP_001137461.1. NM_001143989.2.
    UniGenei Hs.511849.

    3D structure databases

    ProteinModelPortali Q96M43.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 374095427.

    Proteomic databases

    PaxDbi Q96M43.
    PRIDEi Q96M43.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000415641 ; ENSP00000389237 ; ENSG00000196427 .
    GeneIDi 148545.
    KEGGi hsa:148545.
    UCSCi uc009weo.2. human.

    Organism-specific databases

    CTDi 148545.
    GeneCardsi GC01M108765.
    H-InvDB HIX0000833.
    HGNCi HGNC:26550. NBPF4.
    MIMi 613994. gene.
    neXtProti NX_Q96M43.
    PharmGKBi PA142671284.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116348.
    HOGENOMi HOG000170832.
    HOVERGENi HBG108178.
    OMAi WGFTANT.
    OrthoDBi EOG7GBFWV.
    PhylomeDBi Q96M43.
    TreeFami TF341151.

    Miscellaneous databases

    GenomeRNAii 148545.
    NextBioi 85951.
    PROi Q96M43.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96M43.
    Bgeei Q96M43.
    CleanExi HS_NBPF4.
    Genevestigatori Q96M43.

    Family and domain databases

    InterProi IPR010630. NBPF_dom.
    [Graphical view ]
    Pfami PF06758. DUF1220. 3 hits.
    [Graphical view ]
    PROSITEi PS51316. NBPF. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Tissue: Testis.
    3. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
      Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
      Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNBPF4_HUMAN
    AccessioniPrimary (citable) accession number: Q96M43
    Secondary accession number(s): Q5T483
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3