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Protein

Neuroblastoma breakpoint family member 4

Gene

NBPF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 4
Gene namesi
Name:NBPF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196427.13.
HGNCiHGNC:26550. NBPF4.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671284.

Polymorphism and mutation databases

BioMutaiNBPF4.
DMDMi374095427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880391 – 638Neuroblastoma breakpoint family member 4Add BLAST638

Proteomic databases

PaxDbiQ96M43.
PeptideAtlasiQ96M43.
PRIDEiQ96M43.

PTM databases

iPTMnetiQ96M43.
PhosphoSitePlusiQ96M43.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000196427.
CleanExiHS_NBPF4.
ExpressionAtlasiQ96M43. baseline and differential.

Organism-specific databases

HPAiHPA045044.
HPA046411.
HPA047447.
HPA058050.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359055.

Structurei

3D structure databases

ProteinModelPortaliQ96M43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 261NBPF 1PROSITE-ProRule annotationAdd BLAST88
Domaini326 – 399NBPF 2PROSITE-ProRule annotationAdd BLAST74
Domaini400 – 503NBPF 3PROSITE-ProRule annotationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 43Sequence analysisAdd BLAST34
Coiled coili69 – 115Sequence analysisAdd BLAST47

Sequence similaritiesi

Belongs to the NBPF family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410J02M. Eukaryota.
ENOG4111C3E. LUCA.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000170832.
HOVERGENiHBG108178.
InParanoidiQ96M43.
PhylomeDBiQ96M43.
TreeFamiTF341151.

Family and domain databases

InterProiView protein in InterPro
IPR010630. NBPF_dom.
PfamiView protein in Pfam
PF06758. DUF1220. 4 hits.
SMARTiView protein in SMART
SM01148. DUF1220. 4 hits.
PROSITEiView protein in PROSITE
PS51316. NBPF. 3 hits.

Sequencei

Sequence statusi: Complete.

Q96M43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSADPLSS ERAEMNILEI NQELRSQLAE SNQQFRDLKE KFLITQATAY
60 70 80 90 100
SLANQLKKYK CEEYKDIIDS VLRDELQSME KLAEKLRQAE ELRQYKALVH
110 120 130 140 150
SQAKELTQLR EKLREGRDAS RWLNKHLKTL LTPDDPDKSQ GQDLREQLAE
160 170 180 190 200
GHRLAEHLVH KLSPENDEDE DEDEDDKDEE VEKVQESPAP REVQKTEEKE
210 220 230 240 250
VPQDSLEECA VTCSNSHNPS NSNQPHRSTK ITFKEHEVDS ALVVESEHPH
260 270 280 290 300
DEEEEALNIP PENQNDHEEE EGKAPVPPRH HDKSNSYRHR EVSFLALDEQ
310 320 330 340 350
KVCSAQDVAR DYSNPKWDET SLGFLEKQSD LEEVKGQETV APRLSRGPLR
360 370 380 390 400
VDKHEIPQES LDGCCLTPSI LPDLTPSYHP YWSTLYSFED KQVSLALVDK
410 420 430 440 450
IKKDQEEIED QSPPCPRLSQ ELPEVKEQEV PEDSVNEVYL TPSVHHDVSD
460 470 480 490 500
CHQPYSSTLS SLEDQLACSA LDVASPTEAA CPQGTWSGDL SHHQSEVQVS
510 520 530 540 550
QAQLEPSTLV PSCLRLQLDQ GFHCGNGLAQ RGLSSTTCSF SANADSGNQW
560 570 580 590 600
PFQELVLEPS LGMKNPPQLE DDALEGSASN TQGRQVTGRI RASLVLILKT
610 620 630
IRRRLPFSKW RLAFRFAGPH AESAEIPNTA GRTQRMAG
Length:638
Mass (Da):72,053
Last modified:January 25, 2012 - v2
Checksum:iB0BA8313311D1DA8
GO

Sequence cautioni

The sequence BAB71469 differs from that shown. Aberrant splicing.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057395 mRNA. Translation: BAB71469.1. Sequence problems.
AK302318 mRNA. Translation: BAG63656.1.
AL359258 Genomic DNA. No translation available.
CCDSiCCDS44182.1.
RefSeqiNP_001137461.1. NM_001143989.2.
UniGeneiHs.511849.

Genome annotation databases

EnsembliENST00000415641; ENSP00000389237; ENSG00000196427.
GeneIDi148545.
KEGGihsa:148545.
UCSCiuc009weo.3. human.

Similar proteinsi

Entry informationi

Entry nameiNBPF4_HUMAN
AccessioniPrimary (citable) accession number: Q96M43
Secondary accession number(s): Q5T483
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 25, 2012
Last modified: October 25, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families